目的探究辅助生殖技术中出生单胎新生儿第二性别比(secondary sex ratio,SSR)的影响因素。方法回顾性队列研究分析2000年1月至2018年12月期间在中国科学技术大学附属第一医院(安徽省立医院)生殖中心通过辅助生殖技术治疗出生的7020例单...目的探究辅助生殖技术中出生单胎新生儿第二性别比(secondary sex ratio,SSR)的影响因素。方法回顾性队列研究分析2000年1月至2018年12月期间在中国科学技术大学附属第一医院(安徽省立医院)生殖中心通过辅助生殖技术治疗出生的7020例单胎新生儿的临床资料,分析新生儿的母亲年龄、授精方式、移植胚胎类型、移植胚胎期别等因素对单胎新生儿性别的影响。结果在7020例新生儿中,男婴3730例,女婴3290例,总SSR为113∶100。体外受精(in vitro fertilization,IVF)方式出生新生儿SSR明显高于卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)授精方式(121∶100比95∶100,P<0.001),其他因素对出生新生儿SSR无显著影响。分层分析中,在IVF组和ICSI组间除了母亲年龄≥35岁组、囊胚期胚胎移植组的IVF和ICSI出生的SSR差异无统计学意义(P>0.05)外,其余各组的IVF出生新生儿的SSR都高于ICSI(<35岁组:P<0.001;新鲜胚胎组:P=0.001;冻融胚胎组:P=0.003;卵裂期胚胎移植组:P<0.001)。在IVF组内和ICSI组内分析显示各影响因素之间的SSR差异没有统计学意义(P>0.05)。单因素logistic回归分析显示,单胎妊娠中授精方式对新生儿SSR产生的影响有统计学意义(OR=0.792,95%CI=0.712~0.881,P<0.001)。去除混杂因素后logistic回归分析显示,单胎妊娠中授精方式对新生儿SSR影响有统计学意义(aOR=0.793,95%CI=0.713~0.883,P<0.001)。结论授精方式是辅助生殖技术中影响出生单胎SSR的因素,IVF较ICSI可提高SSR比值。展开更多
The Second China-EU Symposium on Gender Equality, sponsored by the All-China Women＇s Federation （ACWF） and European Women＇s Lobby （EWL）, in collaboration with the Shanghai Women＇s Federation, was held in Shangh...The Second China-EU Symposium on Gender Equality, sponsored by the All-China Women＇s Federation （ACWF） and European Women＇s Lobby （EWL）, in collaboration with the Shanghai Women＇s Federation, was held in Shanghai on November 14, 2017. Liu Yandong, Vice- Premier and Director of the National Working Committee on Children and Women under the State Council, and Tibor Navracsics, EU （European Union） Commissioner for Education, Culture, Youth and Sport, attended and delivered speeches. Xia Jie, Vice-President and Member of the Secretariat of the ACWF, presided over the event and delivered the keynote speech.展开更多
文摘The Second China-EU Symposium on Gender Equality, sponsored by the All-China Women＇s Federation （ACWF） and European Women＇s Lobby （EWL）, in collaboration with the Shanghai Women＇s Federation, was held in Shanghai on November 14, 2017. Liu Yandong, Vice- Premier and Director of the National Working Committee on Children and Women under the State Council, and Tibor Navracsics, EU （European Union） Commissioner for Education, Culture, Youth and Sport, attended and delivered speeches. Xia Jie, Vice-President and Member of the Secretariat of the ACWF, presided over the event and delivered the keynote speech.
