汉代策书体式考述

汉代策书可分为册封、策免、吊唁三种体式。册封体式与策免体式的区别在于:前者句式多以四言为主,体现出古奥典雅的风格,一些语句形成模式化套语;后者的句式则没那么严整,也未形成固定的套语。究其原因,策书本源于周代的册命,在形制上已具备悠久的传统,册封策书正是符合册封仪式庄重、整肃的要求,适合在仪式上宣读。相较而言,策免策书更侧重于策免三公的功能性与实效性。吊唁策书则是对哀悼对象个人德行、经历或功绩的彰表,其功能决定了吊唁之辞不能一概而论,此类策书体式也并未形成固定的规制。

New Network Immunization Strategy ~tter than the EGP Strategy

This paper aims at designing a better net-work i,,imozatopm strategy to fight against the Sus- ceptible-Infected-Susceptible （SIS） type epidemic spreading in networks. Previous work used the nurrber of drops in the spectral radius of the net-work for evaluation and guiding the design of im-munization strategies. Instead, we propose using the infected node number in the steady state of SIS spreading as the appropriate metric. We use the metric to point out the limitations of the Equal Graph Partitioning （EGP） strategy and the ＂max-△λ＂ strategy, which are two representative network inmmnization strategies, and then identify the criti-cal role of epidemic spreading parameters in the e-valuation and design of network immuzization strat- egies. Based on all of these, we design a new immuzization strategy. Simulation results show that our strategy performs consistently better than the EGP strategy. In many cases, it uses only 50% less re-sources to achieve the same immuzization effect.

An Immunization Strategy for Social Network Worms Based on Network Vertex Influence

Along with the rapid development of social networks, social network worms have constituted one of the major internet security problems. The root of worm is the inevitable software vulnerability during the design and implementation process of software. So it is hard to completely avoid worms in the existing software engineering systems. Due to lots of bandwidth consumption, the patch cannot be transmitted simultaneously by the network administrator to all hosts. This paper studies how to prevent the propagation of social network worms through the immunization of key nodes. Unlike existing containment models for worm propagation, a novel immunization strategy is proposed based on network vertex influence. The strategy selects the critical vertices in the whole network. Then the immunization is applied on the selected vertices to achieve the maximal effect of worm containment with minimal cost. Different algorithms are implemented to select vertices. Simulation experiments are presented to analyze and evaluate the performance of different algorithms.

Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

Objective:Germline mutations in mismatch repair(MMR)genes cause Lynch syndrome(LS).LS is an inherited disease,and an important consequence of MMR deficiency is microsatellite instability(MSI)phenotype.MSI phenotype influences the efficacy of5 fluorouracil(5-FU)chemotherapy.Reproducible,cost effective,and easy to perform laboratory tests are required to include MSI detection in routine laboratory practice.Evaluation of CAT25 as monomorphic short tandem repeat sequence enables CAT25 to be an efficient screening tool among hereditary nonpolyposis colorectal cancer(HNPCC)patients compared with other methods used currently.Methods:Based on Amsterdam II criteria,31 patients in 31 families were shortlisted from a total number of 1,659 colorectal cancer patients.MSI status was examined in these patients using CAT25 and a commercially available Promega MSI five-markerbased detection system as well as immunohistochemical(IHC)staining of four important MMR proteins.Patients were scored as high microsatellite instable(MSI-H),low(MSI-L),or stable(MSS).MSI status determined by CAT25 single mononucleotide marker was compared with that of five mononucleotide markers,Promega commercial kit,and IHC method.Results:MMR protein deficiency was observed on 7/31 probands using IHC methodology and 6/31 categorized as MSI-H using commercial kit or CAT25 single marker.The sensitivity and specificity of the CAT25 single marker were the same as those detected by five-marker Promega commercial kit in our patients.Conclusions:Based on our results,the performance of the CAT25 single mononucleotide marker for MSI status determination in our HNPCC patients is the same as that of the five-marker-based commercial kit.

PREVENTING RUMOR SPREADING ON SMALL-WORLD NETWORKS

Since the spreading of harmful rumors can deeply endanger a society, it is valuable to investigate strategies that can efficiently prevent hazardous rumor propagation. To conduct this investigation, the authors modify the SIR model to describe rumor propagation on networks, and apply two major immunization strategies, namely, the random immunization and the targeted immunization to the rumor model on a small-world network. The authors find that when the average degree of the network is small, both two strategies are effective and when the average degree is large, neither strategy is efficient in preventing rumor propagation. In the latter case, the authors propose a new strategy by decreasing the credibility of the rumor and applying either the random or the targeted immunization at the same time. Numerical simulations indicate that this strategy is effective in preventing rumor spreading on the small-world network with large average degree.

Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization

This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of re- combinant DNA （pCCMp24） and recombinant attenuated vaccinia virus Tian Tan （rddVTT_ccMpe4）. Intramuscular immuniza- tion was performed on days 0 （prime） and 21 （boost）. The immunogenicity of the vaccine schedules was determined by meas- uring human immunodeficiency virus （HIV）-specific binding antibody levels and cytokine （interleukin-2 and interleukin-4） concentrations in peripheral blood, analyzing lymphocyte proliferation capacity against HIV epitopes and CD4~/CD8＋cell ratio, and monitoring interferon-gamma levels at different times post-immunization. The results showed that pCCMp24, rddVTT.ccMp24 and their prime-boost immunization induced humoral and cellular immune responses. The pCCMp24/ rddVTT.ccMp24 immunization strategy increased CD8＋ T cells and induced more IFN-7-secreting cells compared with sin- gle-shot rDNA. The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides. These results demonstrated that prime-boost immunization with rDNA and rddVTT_ccMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations, especially IFN-7 response, providing a basis for further studies.

KSHV strategies for host dsDNA sensing machinery

The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase(cGAS)to sense cytosolic double-stranded(ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi's Sarcoma-associated Herpesvirus(KSHV) and their contributions to KSHV life cycles.

Weathering the storm:COVID-19 infection in patients with hematological malignancies

The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents.In patients with COVID-19,underlying chronic diseases and comorbidities are associated with dismal treatment outcomes.Owing to their immunosuppressive status,patients with hematological malignancies(HMs)are at an increased risk of infection and have a worse prognosis than patients without HMs.Accordingly,intensive attention should be paid to this cohort.In this review,we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs.Furthermore,we briefly de-scribe customized management strategies and interventions for this susceptible cohort.This review is intended to guide clinical practice.

Management of chronic hepatitis B during pregnancy

Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma.Despite immunoprophylaxis against hepatitis B in pregnancy,perinatal transmission still occurs in at least 10%of the children born to a mother with high level of viremia.Decisions regarding hepatitis B therapy during pregnancy must take into account the benefits and safety for both the mother and the unborn baby.In this review,we summarize the current treatment options for chronic hepatitis B with a focus on management during pregnancy and the evidence-based strategies to prevent vertical transmission of hepatitis B virus(HBV).