AIM To establish a severe acute cholangitis(SAC) model in mice.METHODS Cholecystic catheterization was performed under the condition of bile duct ligation(BDL). Trans-cholecystic injection of lipopolysaccharide(LPS) w...AIM To establish a severe acute cholangitis(SAC) model in mice.METHODS Cholecystic catheterization was performed under the condition of bile duct ligation(BDL). Trans-cholecystic injection of lipopolysaccharide(LPS) was defined as the SAC animal model. Sham operation group, intraperitoneal injection of LPS without BDL group, intraperitoneal injection of LPS with BDL group and trans-cholecystic injection of normal saline with BDL group were defined as control groups. The survival rates and tissue injuries in liver, lungs and kidney were evaluated.RESULTS Mice in the SAC group showed a time-dependent mortality and much more severe tissue injuries in liver, lungs and kidney, compared with other groups. However, relieving biliary obstruction could effectively reduce mortality and attenuate liver injury in the SAC mouse model.CONCLUSION Trans-cholecystic injection of LPS under the condition of biliary obstruction could establish a repeatable and reversible mouse model of SAC.展开更多
Acute pancreatitis (AP) is a rare event in pregnancy, occurring in approximately 3 in 10 000 pregnancies. The spectrum of AP in pregnancy ranges from mild pancreatitis to serious pancreatitis associated with necrosis,...Acute pancreatitis (AP) is a rare event in pregnancy, occurring in approximately 3 in 10 000 pregnancies. The spectrum of AP in pregnancy ranges from mild pancreatitis to serious pancreatitis associated with necrosis, abscesses, pseudocysts and multiple organ dysfunction syndromes. Pregnancy related hematological and biochemical alterations infl uence the interpretation of diagnostic tests and assessment of severity of AP. As in any other disease associated with pregnancy, AP is associated with greater concerns as it deals with two lives rather than just one as in the non-pregnant population. The recent advances in clinical gastroenterology have improved the early diagnosis and effective management of biliary pancreatitis. Diagnostic studies such as endoscopic ultrasound, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography and therapeutic modalities that include endoscopic sphincterotomy, biliary stenting, common bile duct stone extraction and laparoscopic cholecystectomy are major milestones in gastroenterology. When properly managed AP in pregnancy does not carry a dismal prognosis as in the past.展开更多
To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Anim...To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Animals that underwent saline lung lavage to produce lung injury were randomized to one of the two treatment groups （ HFOV or CMV, n =6）. PaCO2 was maintained between 35 -45mmHg and arterial oxygen saturation （ SaO2 ） was maintain 〉 88% by adjusting corresponding ventilator parameters. Ventilation period was 6h. Lung fluids were aspirated before and at the end of ventilation for cell analysis. Then the animals were euthanized, lung tissue was removed for wet/dry weight measurement, light and electron microscopic examination. Besults The difference of artery blood gas analyses（pH, PaO2, PaCO2 ） between HFOV and CMV was insignificant. The difference between HFOV and CMV in cytological examination of lung fluids, wet/dry weight measurement was also insignificant. But compared with CMV, HFOV not only reduced the area of lung injury, but also reduced lung injury score in light and electron microscopic examination. Conclusion When same artery blood gas analysis was obtained, HFOV significantly reduced lung injury development in ARDS animal than CMV. As a lung protection strategy, HFOV can be used in the treatment of ARDS.展开更多
As the core part of reciprocating compressor,piston rod is easy to cause a serious accident when abrasion and breakage fault occur to it. Therefore,it is very important to monitor its running state. At present,a small...As the core part of reciprocating compressor,piston rod is easy to cause a serious accident when abrasion and breakage fault occur to it. Therefore,it is very important to monitor its running state. At present,a small number of reciprocating compressors have been installed on-line monitoring and diagnosis system,most of which can only monitor a single vertical subsidence of piston rod and it can't fully represent the running state of piston rod. Therefore,a method of monitoring the vertical and horizontal displacement of piston rod axis orbit is simultaneously used. In view of the characteristics that the piston rod axis orbit is disordered and difficult to extract features,purification of the axis orbit is carried out based on harmonic wavelet and then features are extracted such as vibration energy,natural frequency and the axis orbit envelope area. After that,a nonlinear local tangent space manifold learning algorithm is used to reduce the dimension of the features and obtain sensitive features. By analyzing the practical cases,the effectiveness of the method for fault monitoring and diagnosis of reciprocating compressor piston rod assembly has been verified. Finally,as BP neural network has the characteristics of solving complex nonlinear problems,the validity of the fault diagnosis method of reciprocating compressor piston rod based on harmonic wavelet and manifold learning is proved by actual case data analysis based on BP neural network.展开更多
Gradual shift has been observed lately of dam safety procedures from the conventional technical based towards a wider scope of risk management procedure based on risk analysis. The new approach considers the likelihoo...Gradual shift has been observed lately of dam safety procedures from the conventional technical based towards a wider scope of risk management procedure based on risk analysis. The new approach considers the likelihood level of occurrence of a multitude of hazards and the magnitude of the resulting possible consequences in case of failure using rational cause and effect arguments. Most dam owners are shifting towards the use of the new risk based procedures; and even governments themselves are moving towards formalizing the new trend. Legislations in the United States were promulgated [1] after serious dam failures and the adoption of stringent levels of scrutiny led such federal dam owners to pioneer in this field and in developing the concepts and methods required. The comer stone in risk analysis is the definition of the potential modes that may lead to failure and assessment of the likelihood levels of their occurrence and possible category of the consequences which, after thorough evaluation, will shape the decision making. This type of analysis was applied to Mosul Dam as a case study and resulted in definite recommendations.展开更多
Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） dur...Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） during general anesthesia with tracheal intubation. Methods： Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results： Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points （15min, 30min, lh, 2h, 3h, 6h, 12h and 24h aiter extubation） and the occurrence of cough, restlessness, postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion： The present meta-analysis indicates that intracuttlidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine.展开更多
Iatrogenic bile-duct injury post-laparoscopic cholecystectomy remains a major serious complication with unpredictable long-term results. We present a patient who underwent laparoscopic cholecystectomy for gallstones, ...Iatrogenic bile-duct injury post-laparoscopic cholecystectomy remains a major serious complication with unpredictable long-term results. We present a patient who underwent laparoscopic cholecystectomy for gallstones, in which the biliary injury was recognized intraoperatively. The surgical procedure was converted to an open one. The first surgeon repaired the injury over a T-tube without recognizing the anatomy and type of the biliary lesion, which led to an unusual biliary mal-repair. Immediately postoperatively, the abdominal drain brought a large amount of bile. A T-tube cholangiogram was performed. Despite the contrast medium leaking through the abdominal drain, the mal-repair was recognized intraoperatively. The surgical procedure was converted to an open one. The first surgeon repaired the injury over a T-tube without recognizing the anatomy and type of the biliary lesion, which led to an unusual biliary mal-repair. Immediately postoperatively, the abdominal drain brought a large amount of bile. A T-tube cholangiogram was performed. Despite the contrast medium leaking through the abdominal drain, the mal-repair was unrecognized. The patient was referred to our hospital for biliary leak. Ultrasound and cholangiography was repeated, which showed an unanatomical repair （right to left hepatic duct anastomosis over the T-tube）,with evidence of contrast medium coming out through the abdominal drain. Eventually the patient was subjected to a definitive surgical treatment. The biliary continuity was re-established by a Roux-en-Y hepaticojejunostomy, over transanastomotic external biliary stents. The patient is now doing well 4 years after the second surgical procedure. In reviewing the literature, we found a similar type of injury but we did not find a similar surgical real-repair. We propose an algorithm for the treatment of early and late biliary injuries.展开更多
Many engineering components, such as power-plant steam pipes, aero-engine turbine discs, etc., operate under severe loading/temperature conditions. As a result, cracks can initiate and subsequently propagate over time...Many engineering components, such as power-plant steam pipes, aero-engine turbine discs, etc., operate under severe loading/temperature conditions. As a result, cracks can initiate and subsequently propagate over time due to creep. The Liu and Murakami＇s model has proven to be a useful tool for the prediction of creep crack growth under such conditions. Previously, experimental conditions used in obtaining the constant ofmultiaxiality, a, have not reflected the multiaxial severity of the stress state ahead of a crack tip. Therefore, the present study presents a novel method for interpolating crack growth data to obtain a.展开更多
Chinese water resource management （CWRM） has passed through four stages： infancy, initial development, rapid development, and formation. In the last of these stages some problems persist and will affect management ...Chinese water resource management （CWRM） has passed through four stages： infancy, initial development, rapid development, and formation. In the last of these stages some problems persist and will affect management performance. CWRM was a decentralised, imperfectly codified and weakly implemented system that lacked a sound market policy, rational water prices, water conservation awareness, technical support and a performance appraisal system. The government of China proposed two new strategies in 2009： the Three Red Lines and the Interconnected River System Network （IRSN）. This paper analyses these two strategies and reflects on new CWRM concepts. Both strategies strive for the sustainable utilisation of water resources and human-water harmony. The concepts, quantification method and application of harmony theory to water resources management is discussed. Applications of harmony theory to water resources management include （i） harmony between humans and nature; （ii） a harmony strategy for water resources management; （iii） a rational allocation model for water resources among different areas and departments based on harmony theory; （iv） harmony-based water allocation issues associated with transboundary rivers; （v） harmony-based interbasin water transfer problems; and （vi） harmony-based control of pollution discharge. We conclude by discussing how harmony theory and its applications provide an appropriate pathway for water resource management in China.展开更多
基金Supported by Zhejiang Provincial Natural Science Foundation of China under grant No.LY17H030001 and No.LQ14H160001Zhejiang Provincial Public Welfare Technology Application Research Projects under grant No.2015C33293,No.2013C33214 and No.2011C33023Research Foundation of Health Bureau of Zhejiang Province under grant No.2014RCA031 and No.2016KYB300
文摘AIM To establish a severe acute cholangitis(SAC) model in mice.METHODS Cholecystic catheterization was performed under the condition of bile duct ligation(BDL). Trans-cholecystic injection of lipopolysaccharide(LPS) was defined as the SAC animal model. Sham operation group, intraperitoneal injection of LPS without BDL group, intraperitoneal injection of LPS with BDL group and trans-cholecystic injection of normal saline with BDL group were defined as control groups. The survival rates and tissue injuries in liver, lungs and kidney were evaluated.RESULTS Mice in the SAC group showed a time-dependent mortality and much more severe tissue injuries in liver, lungs and kidney, compared with other groups. However, relieving biliary obstruction could effectively reduce mortality and attenuate liver injury in the SAC mouse model.CONCLUSION Trans-cholecystic injection of LPS under the condition of biliary obstruction could establish a repeatable and reversible mouse model of SAC.
文摘Acute pancreatitis (AP) is a rare event in pregnancy, occurring in approximately 3 in 10 000 pregnancies. The spectrum of AP in pregnancy ranges from mild pancreatitis to serious pancreatitis associated with necrosis, abscesses, pseudocysts and multiple organ dysfunction syndromes. Pregnancy related hematological and biochemical alterations infl uence the interpretation of diagnostic tests and assessment of severity of AP. As in any other disease associated with pregnancy, AP is associated with greater concerns as it deals with two lives rather than just one as in the non-pregnant population. The recent advances in clinical gastroenterology have improved the early diagnosis and effective management of biliary pancreatitis. Diagnostic studies such as endoscopic ultrasound, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography and therapeutic modalities that include endoscopic sphincterotomy, biliary stenting, common bile duct stone extraction and laparoscopic cholecystectomy are major milestones in gastroenterology. When properly managed AP in pregnancy does not carry a dismal prognosis as in the past.
文摘To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Animals that underwent saline lung lavage to produce lung injury were randomized to one of the two treatment groups （ HFOV or CMV, n =6）. PaCO2 was maintained between 35 -45mmHg and arterial oxygen saturation （ SaO2 ） was maintain 〉 88% by adjusting corresponding ventilator parameters. Ventilation period was 6h. Lung fluids were aspirated before and at the end of ventilation for cell analysis. Then the animals were euthanized, lung tissue was removed for wet/dry weight measurement, light and electron microscopic examination. Besults The difference of artery blood gas analyses（pH, PaO2, PaCO2 ） between HFOV and CMV was insignificant. The difference between HFOV and CMV in cytological examination of lung fluids, wet/dry weight measurement was also insignificant. But compared with CMV, HFOV not only reduced the area of lung injury, but also reduced lung injury score in light and electron microscopic examination. Conclusion When same artery blood gas analysis was obtained, HFOV significantly reduced lung injury development in ARDS animal than CMV. As a lung protection strategy, HFOV can be used in the treatment of ARDS.
基金Supported by the National Basic Research Program of China(863Program)(No.2014AA041806)the National Key Research and Development Plan(No.2016YFF0203305)
文摘As the core part of reciprocating compressor,piston rod is easy to cause a serious accident when abrasion and breakage fault occur to it. Therefore,it is very important to monitor its running state. At present,a small number of reciprocating compressors have been installed on-line monitoring and diagnosis system,most of which can only monitor a single vertical subsidence of piston rod and it can't fully represent the running state of piston rod. Therefore,a method of monitoring the vertical and horizontal displacement of piston rod axis orbit is simultaneously used. In view of the characteristics that the piston rod axis orbit is disordered and difficult to extract features,purification of the axis orbit is carried out based on harmonic wavelet and then features are extracted such as vibration energy,natural frequency and the axis orbit envelope area. After that,a nonlinear local tangent space manifold learning algorithm is used to reduce the dimension of the features and obtain sensitive features. By analyzing the practical cases,the effectiveness of the method for fault monitoring and diagnosis of reciprocating compressor piston rod assembly has been verified. Finally,as BP neural network has the characteristics of solving complex nonlinear problems,the validity of the fault diagnosis method of reciprocating compressor piston rod based on harmonic wavelet and manifold learning is proved by actual case data analysis based on BP neural network.
文摘Gradual shift has been observed lately of dam safety procedures from the conventional technical based towards a wider scope of risk management procedure based on risk analysis. The new approach considers the likelihood level of occurrence of a multitude of hazards and the magnitude of the resulting possible consequences in case of failure using rational cause and effect arguments. Most dam owners are shifting towards the use of the new risk based procedures; and even governments themselves are moving towards formalizing the new trend. Legislations in the United States were promulgated [1] after serious dam failures and the adoption of stringent levels of scrutiny led such federal dam owners to pioneer in this field and in developing the concepts and methods required. The comer stone in risk analysis is the definition of the potential modes that may lead to failure and assessment of the likelihood levels of their occurrence and possible category of the consequences which, after thorough evaluation, will shape the decision making. This type of analysis was applied to Mosul Dam as a case study and resulted in definite recommendations.
文摘Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） during general anesthesia with tracheal intubation. Methods： Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results： Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points （15min, 30min, lh, 2h, 3h, 6h, 12h and 24h aiter extubation） and the occurrence of cough, restlessness, postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion： The present meta-analysis indicates that intracuttlidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine.
文摘Iatrogenic bile-duct injury post-laparoscopic cholecystectomy remains a major serious complication with unpredictable long-term results. We present a patient who underwent laparoscopic cholecystectomy for gallstones, in which the biliary injury was recognized intraoperatively. The surgical procedure was converted to an open one. The first surgeon repaired the injury over a T-tube without recognizing the anatomy and type of the biliary lesion, which led to an unusual biliary mal-repair. Immediately postoperatively, the abdominal drain brought a large amount of bile. A T-tube cholangiogram was performed. Despite the contrast medium leaking through the abdominal drain, the mal-repair was recognized intraoperatively. The surgical procedure was converted to an open one. The first surgeon repaired the injury over a T-tube without recognizing the anatomy and type of the biliary lesion, which led to an unusual biliary mal-repair. Immediately postoperatively, the abdominal drain brought a large amount of bile. A T-tube cholangiogram was performed. Despite the contrast medium leaking through the abdominal drain, the mal-repair was unrecognized. The patient was referred to our hospital for biliary leak. Ultrasound and cholangiography was repeated, which showed an unanatomical repair （right to left hepatic duct anastomosis over the T-tube）,with evidence of contrast medium coming out through the abdominal drain. Eventually the patient was subjected to a definitive surgical treatment. The biliary continuity was re-established by a Roux-en-Y hepaticojejunostomy, over transanastomotic external biliary stents. The patient is now doing well 4 years after the second surgical procedure. In reviewing the literature, we found a similar type of injury but we did not find a similar surgical real-repair. We propose an algorithm for the treatment of early and late biliary injuries.
文摘Many engineering components, such as power-plant steam pipes, aero-engine turbine discs, etc., operate under severe loading/temperature conditions. As a result, cracks can initiate and subsequently propagate over time due to creep. The Liu and Murakami＇s model has proven to be a useful tool for the prediction of creep crack growth under such conditions. Previously, experimental conditions used in obtaining the constant ofmultiaxiality, a, have not reflected the multiaxial severity of the stress state ahead of a crack tip. Therefore, the present study presents a novel method for interpolating crack growth data to obtain a.
基金National Social Science Fund Project (No. 12&ZD215)National Natural Science Foundation of China (No.51279183 andNo.51079132)Program for Innovative Research Team (in Science and Technology) in University of Henan Province (No.2013)
文摘Chinese water resource management （CWRM） has passed through four stages： infancy, initial development, rapid development, and formation. In the last of these stages some problems persist and will affect management performance. CWRM was a decentralised, imperfectly codified and weakly implemented system that lacked a sound market policy, rational water prices, water conservation awareness, technical support and a performance appraisal system. The government of China proposed two new strategies in 2009： the Three Red Lines and the Interconnected River System Network （IRSN）. This paper analyses these two strategies and reflects on new CWRM concepts. Both strategies strive for the sustainable utilisation of water resources and human-water harmony. The concepts, quantification method and application of harmony theory to water resources management is discussed. Applications of harmony theory to water resources management include （i） harmony between humans and nature; （ii） a harmony strategy for water resources management; （iii） a rational allocation model for water resources among different areas and departments based on harmony theory; （iv） harmony-based water allocation issues associated with transboundary rivers; （v） harmony-based interbasin water transfer problems; and （vi） harmony-based control of pollution discharge. We conclude by discussing how harmony theory and its applications provide an appropriate pathway for water resource management in China.
