采用流管元测量冰期流量及流速分布的方法

北方河流冰期测流需要在冰盖上沿断面打孔,再测量各孔垂线流速分布,最后通过流速积分得到冰盖下的总流量。这种传统的冰期测流是一项耗时耗力且高风险的工作,限制了冰期流量流速资料的采集。本文基于流管元法和爱因斯坦的断面分区方法,提出一种基于理论公式的冰期测流方法。该方法被用于实验条件下复式断面的流速分布和黄河不同断面的流量计算。结果显示新方法获得的断面流量、单宽流量分布和水深平均的流速分布与实验值和现场观测值符合良好。基于流管元的冰期测流方法能广泛用于明流、部分冰封和完全冰封河道断面的流量及流速分布测量,能有效减少冰期测流工作量、提高测量效率,进而减少测量人员安全风险,可在水文观测中推广应用。

基于改进Line-Pack模型的综合能源系统优化调度

针对Line-Pack模型无法考察天然气系统内部不同规模管道的动态特性问题,在分析输气管道压力与质量流动态平衡过程差异性的基础上,将输气管道分解为有限多个小规模等长管元,在每个管元上计及压力与质量流平衡时间差,将天然气在输气管道内的复杂运动过程近似等效为有限个管元的气体稳定运动,构建了计及气网多规模长输气管道的改进Line-Pack模型以融入优化调度模型,并给出了线性化处理方案以便于适应大规模问题求解。基于修改的比利时20节点天然气系统和IEEE 39节点电力系统构建了算例系统,采用Pipeline Studio商业油气仿真软件对所提模型计算得到的调度方案进行分析,验证了所提改进模型的合理性和有效性。

Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.

Genetic diversity and differentiation of the Dybowski's frog(Rana dybowskii) in Northeast China

The genetic diversity and population structure of the Dybowski＇s frog（Rana dybowskii） were investigated by using 11 polymorphic microsatellite loci.Total 75 individuals were sampled from six populations in Lesser Khingan Mountains and Changbai Mountains,China.Results showed that allele number of the 11 microsatellite loci was in the range of 2-10 in all populations,with the mean of 5.6.The average expected heterozygosity（HE） was 0.572,indicating a moderate polymorphism.The results of genetic differentiation coefficient（FST） showed that population genetic differentiation was significant between Changbai and Lesser Khingan Mountains（p〈0.001）.This result was verified further by Nei＇s genetic distance（DA） based on UPGMA phy-logenetic trees and by AMOVA analysis.In conclusion,the populations distributed in Lesser Khingan Mountains and Changbai Mountain are proposed to be two distinct management units（MUs） for their protection and management.

Ontology and metadata for online learning resource repository management based on semantic web

An ontology and metadata for online learning resource repository management is constructed. First, based on the analysis of the use-case diagram, the upper ontology is illustrated which includes resource library ontology and user ontology, and evaluated from its function and implementation; then the corresponding class diagram, resource description framework （RDF） schema and extensible markup language （XML） schema are given. Secondly, the metadata for online learning resource repository management is proposed based on the Dublin Core Metadata Initiative and the IEEE Learning Technologies Standards Committee Learning Object Metadata Working Group. Finally, the inference instance is shown, which proves the validity of ontology and metadata in online learning resource repository management.

Wavefield simulation in porous media saturated with two immiscible fluids

Wavefields in porous media saturated by two immiscible fluids are simulated in this paper.Based on the sealed system theory,the medium model considers both the relative motion between the fluids and the solid skeleton and the relaxation mechanisms of porosity and saturation（capillary pressure）.So it accurately simulates the numerical attenuation property of the wavefields and is much closer to actual earth media in exploration than the equivalent liquid model and the unsaturated porous medium model on the basis of open system theory.The velocity and attenuation for different wave modes in this medium have been discussed in previous literature but studies of the complete wave-field have not been reported.In our work,wave equations with the relaxation mechanisms of capillary pressure and the porosity are derived.Furthermore,the wavefield and its characteristics are studied using the numerical finite element method.The results show that the slow P3-wave in the non-wetting phase can be observed clearly in the seismic band.The relaxation of capillary pressure and the porosity greatly affect the displacement of the non-wetting phase.More specifically,the displacement decreases with increasing relaxation coefficient.

EXPERIMENTAL RESEARCH AND NONLINEAR FINITE ELEMENT ANALYSIS ON NEW TYPE JOINT BETWEEN COLUMN AND STEEL BEAM OF CONCRETE-FILLED RECTANGULAR STEEL TUBULAR

Experimental results of new type joints between the column and the. steel beam of concrete-filled rectangular steel tubular （CFRT） under reversed cyclic loads are presented. The earthquake resistant capacity of the joint is influenced by infilled concrete, stiffener length and relative dimensions of column and beam. It is found that the hysteresis curves obtained in the experiment are full and the joints have a good energy dissipation capacity. The nonlinear finite element models are also used to analyze the hysteresis behavior of the joints under reversed cyclic loads using ANSYS 8.0. The influences of the stiffener length and the infilled concrete are analyzed. Analytical results show that the stiffener length and the infilled concrete are critical for the joints. Furthermore, the skeleton curves of the finite element models are in good agreement with those of experiments.

FEM analysis of deepwater drilling risers under the operability and hang-off working conditions

In recent years, numerous exploration activities of oil and gas industry have been conducted in ultra deep water. The global offshore industry is building systems today for drilling in even deeper water, progressively using new technologies, and significantly extending existing technologies. This is the general trend in the offshore oil and gas industry. So the technology of ultra-deepwater risers, which is the main tool in drilling oil, is more and more standard. This paper manly focuses on the global analysis of the drilling risers. And it is divided into two parts, operability analysis and hang-off analysis that are used to check the design of the riser. In this paper, the rotation angle and stress of the riser in the drilling mode are calculated to determine the operability envelop. The number of the buoyancy modules has been determined and according to the API standard, all the worked out values have been checked out. From all the above, it is concluded that the operability envelop is relatively small under harsh condition and the number of the buoyancy modules is a little large. And above all, the design of this riser is successful.

Analysis of mechanical performance of braided esophageal stent structure and its wires

This paper aims to find the relationship between the structural parameters and the radial stiffness of the braided stent and to understand the stress distribution law of the wires. According to the equation of the space spiral curve, a three-dimensional parametrical geometrical model is constructed. The finite element model is built by using the beam-beam contact elements and 3D beam elements. The constituent nitinol wires are assumed to be linear elastic material. The finite element analysis figures out that the radial stiffness of the stent and the stress distribution of the wires are influenced by all the structural parameters. The helix pitch of the wires is the most important factor. Under the condition of the same load and other structural parameters remaining unchanged, when the number of wires is 24, the stress of the wire crosssection is at the minimum. A comparison between the vitro experimental results and the analytical results is conducted, and the data is consistent, which proves that the current finite element model can be used to appropriately predict the mechanical performance of the braided esophageal stents.

Finite element simulation of ball spinning of NiTi shape memory alloy tube based on variable temperature field

As a new attempt,ball spinning was used to manufacture the nickel-titanium shape memory alloy（NiTi SMA） tube at elevated temperature.The NiTi bar with a nominal composition of Ni50.9Ti49.1（mole fraction,%） was solution treated and was used as the original tube blank for ball spinning.Based on the variable temperature field and the constitutive equation,rigid-viscoplastic finite element method（FEM） was applied in order to simulate the ball spinning of NiTi SMA tube.The temperature field,the stress field,the strain field and the load prediction were obtained by means of FEM.FEM results reveal that there is a temperature increase of about 160 ℃ in the principal deformation zone of the spun part.It can be found from the stress fields and the strain fields that the outer wall of NiTi SMA tube is easier to meet the plastic yield criterion than the inner wall,and the plastic deformation zone is caused to be in a three-dimensional compressive stress state.The radial strain and the tangential strain are characterized by the compressive strain,while the axial strain belongs to the tensile strain.The variation of spinning loads with the progression of the ball is of great importance in predicting the stable flow of the spun part.

Effect of geometrical parameters on forming quality of high-strength TA18 titanium alloy tube in numerical control bending

The forming quality of high-strength TA18 titanium alloy tube during numerical control bending in changing bending angle β, relative bending radius R/D and tube sizes such as diameter D and wall thickness t was clarified by finite element simulation. The results show that the distribution of wall thickness change ratio Δt and cross section deformation ratio ΔD are very similar under different β; the Δt and ΔD decrease with the increase of R/D, and to obtain the qualified bent tube, the R/D must be greater than 2.0; the wall thinning ratio Δto slightly increases with larger D and t, while the wall thickening ratio Δti and ΔD increase with the larger D and smaller t; the Δto and ΔD firstly decrease and then increase, while the Δti increases, for the same D/t with the increase of D and t.

Analysis of barrel structure optimization for a mortar

Considering the maximum elastic limitation of the used material with newly advanced technology,the study focuses on optimization of a mortar barrel structure by thinning the wall to reduce the weight.Firstly,static analysis of barrel structure parameters is done based on finite element analysis（FEA）method and 3Dsolid model of the barrel is established based on Unigraphics NX（UG）.Secondly,the 3Dsolid model is simplified and transplanted to ANSYS for barrel wall pressure calculation.Thus,the change curves of the stress exerted on the barrel wall at different locations perpendicular to the axial direction with wall thinning are drawn.By analyzing all possible optimization schemes,the optimal design that enables the barrel to have higher bearing capacity is got.The optimized barrel structure is verified by means of fluid-solid coupling dynamic response analysis.The results show that the static analysis results are closer to real stress conditions than dynamic analysis results.Finally,the barrel weight is reduced by 13%after simulation optimization and the light weight design of the barrel is effective and reliable.

Distribution of wire deformation within strands of wire ropes

Using ANSYS software, we developed a modeling program for several kinds of wire ropes with metal cores and built a geometric model for the 6×19 IWS wire rope. Through proper grid partitioning, a finite element model for calculating the deforma-tion of wire rope was obtained. Completely constraining one end of the wire rope and applying an axial force to the other end, we established the boundary conditions for solving the model. In addition, we numerically simulated the stress and deformation of the wire, obtaining the deformation distribution of each wire within the wire rope under different laying directions. At the end, a tensile test of the 6×19 IWS wire rope was carried out and the results of simulation and experiment compared.

Power management unit chip design for automobile active-matrix organic light-emitting diode display module

A power management unit （PMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done.

Lithium inhibits proliferation of human esophageal cancer cell line Eca-109 by inducing a G_2/M cell cycle arrest

AIM： To investigate the effect of lithium on proliferation of esophageal cancer （EC） cells and its preliminary mechanisms. METHODS： Eca-109 cells were treated with lithium chloride, a highly selective inhibitor of glycogen synthase kinase 31） （GSK-31））, at different concentrations （2-30 mmol/L） and time points （0, 2, 4, 6 and 24 h）. Cell proliferative ability was evaluated by 3-（4,5-Dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide （MTT） assay, and Cell cycle distribution was examined by flow cytometry. Expressions of p-GSK-3β, β-catenin, cyclin B1, cdc2 and cyclin D1 protein were detected by Western blotting, and the subcellular localization of β-catenin was determined by immunofluorescence. The mRNA level of of cyclin B1 was detected by reverse transcription polymerase chain reaction （RT-PCR）. RESULTS： Lithium could inhibit the proliferation of Eca-109 cells. Lithium at a concentration of 20 mmol/L lithium for 24 h produced obvious changes in the distribution of cell cycle, and increased the number of cells in G2/M phase （P 〈 0.05 vs control group）. Western blotting showed that lithium inhibited GSK-β） by Ser-9 phosphorylation and stabilized free β-catenin in the cytoplasm. Immunofluorescence further confirmed that free β-catenin actively translocated to the nucleus. Horeover, lithium slightly elevated cyclin D1 protein expression, whereas lowered the cyclin B1 expression after 24 h lithium exposure and no obvious change was observed for cdc2 protein. CONCLUSION： Lithium can inhibit the proliferation of human esophageal cancer cell line Eca-109 by inducing a G2/H cell cycle arrest, which is mainly mediated through the inhibition of lithium-sensitive molecule, GSK-3β, and reduction of cyclin B1 expression.

Dynamics of vertical pipe in deep-ocean mining system

A 3-D geometrical nonlinear model for the entire lift system of 1000-m sea trial system of China Ocean Mineral Resources R&D Association was established with finite element method.The model was utilized to analyze the dynamic characteristics of the vertical pipe under the influence of moving velocity,current direction and wave.The simulation results show that the axial stress is dominant on the vertical pipe,its maximum is located at the pipe top,all stresses are much less than the allowable value of the vertical pipe and joint;the heave motion leads to violent fluctuation of the force and stress,but a period of 8 s is not likely to resonate the present pipe;against the current,0.50 m/s is the suggested moving velocity of the ship and miner,while along the current,the moving velocity can be slightly higher than 0.75 m/s.

Research on workflow meta model supporting activity based costing

Activity based costing (ABC) is a method which can solve many limitations of the traditional cost systems in manufacturing management. In this paper, we investigate how to integrate ABC with workflow technology, and build a workflow meta model supporting ABC. Firstly, the concept and concept model of activity based costing (ABC) are introduced. Next, the meta model of P -PROCE (Process, Product, Resource, Organization, and Cost & Evaluation) is presented. Then the cost meta model is defined by adding ABC to P -PROCE model. Object constraint language (OCL) is used to express meta model and constraints. Finally, we show an enterprise modeling and simulation tool based on the workflow meta model. We can systematically construct an enterprise model and easily and efficiently conduct simulation. Moreover it enables us to analyze and evaluate business processes and its costs.

The MMU Implementation of Unity-1 Microprocessor

Virtual memory management is always a very essential issue of the modern microprocessor design. A memory management unit (MMU) is designed to implement a virtual machine for user programs, and provides a management mechanism between the operating system and user programs. This paper analyzes the tradeoffs considered in the MMU design of Unity 11 CPU of Peking University, and introduces in detail the solution of pure hardware table walking with two level page table organization. The implementation takes care of required operations and high performances needed by modern operating systems and low costs needed by embedded systems. This solution has been silicon proven, and successfully porting the Linux 2.4.17 kernel, the XWindow system, GNOME and most application software onto the Unity platform.

Simulation of isothermal precision extrusion of NiTi shape memory alloy pipe coupling by combining finite element method with cellular automaton

In order to present the microstructures of dynamic recrystallization(DRX) in different deformation zones of hot extruded NiTi shape memory alloy(SMA) pipe coupling,a simulation approach combining finite element method(FEM) with cellular automaton(CA) was developed and the relationship between the macroscopic field variables and the microscopic internal variables was established.The results show that there exists a great distinction among the microstructures in different zones of pipe coupling because deformation histories of these regions are diverse.Large plastic deformation may result in fine recrystallized grains,whereas the recrystallized grains may grow very substantially if there is a rigid translation during the deformation,even if the final plastic strain is very large.As a consequence,the deformation history has a significant influence on the evolution path of the DRX as well as the final microstructures of the DRX,including the morphology,the mean grain size and the recrystallization fraction.

A Simple,Compact and Rigid Scanning Tunneling Microscope

We present a homebuilt scanning tunneling microscope(STM)which employs an inner-wall polished sapphire guiding tube as a rail for the scanner to form a short tip-sample mechanical loop.The scanner is mounted on a square rod which is housed in the guiding tube and held by a spring strip.The stiff sapphire guiding tube allows the STM body to be made in a simple,compact and rigid form.Also the material of sapphire improves the thermal stability of the STM for its good thermal conductivity.To demonstrate the performance of the STM,high quality atomic-resolution STM images of high oriented pyrolytic graphite were given.