Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization ...Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization has changed the source, process and sink of urban NPS pollution, especially raised the pollution load of urban runoff NPS in receiving water. Urban runoff pollu- tion is a hot spot of research on NPS. This paper analyzed type, source and harm of the NPS pollutants of urban runoff and its influence on the receiving water. Through estimating NPS pollu- tion load of urban runoff and summarizing the law and character- istics of urban runoff NPS systemically, study on management and control of urban runoff NPS pollution was focused on the applica- tion of BMPs (best management practices). It is a fresh method- ology that management and control on NPS pollution from urban surface runoff was analyzed by methods of landscape ecology, environmental economics and environmental management. The paper provided a scientific reference for mitigating urban water environment pressure and an effective method for management and control of NPS pollution from urban surface runoff..展开更多
Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches ab...Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches about trust mechanism for Internet of Things (IoT) could be found in the literature, though we argue that considerable necessity is held for applying trust mechanism to IoT. In this paper, we establish a formal trust management control mechanism based on architecture modeling of IoT. We decompose the IoT into three layers, which are sensor layer, core layer and application layer, from aspects of network composition of loT. Each layer is controlled by trust management for special purpose: self-organized, affective routing and multi-service respectively. And the final decision-making is performed by service requester according to the collected trust information as well as requester' policy. Finally, we use a formal semantics-based and fuzzy set theory to realize all above trust mechanism, the result of which provides a general framework for the development of trust models of IoT.展开更多
Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert cl...Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert clinical guideline published in 2011. In spite of the wide knowledge accumulated on this disease, there are many areas where scientific data are missing, especially in regard to the disease's pathophysiology. Recent publications have suggested that other confounding factors modify the disease and may affect its clinicalphenotypic presentation. Those factors may include place of living, air pollution, race, genetic factors and other. In the present report we discussed and review those confounding factors, the new developments, and what direction we should go to further advance our knowledge of this disease.展开更多
Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay treatment for bile duct disease. The procedure is difficult per se, especially when a side-viewing duodenoscope is used, and when the p...Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay treatment for bile duct disease. The procedure is difficult per se, especially when a side-viewing duodenoscope is used, and when the patient has altered anatomical features, such as colonic interposition. Currently, there is no consensus on the standard approach for therapeutic ERCP in patients with total esophagectomy and colonic interposition. We describe a novel treatment design that involves the use of a side-viewing duodenoscope to perform therapeutic ERCP in patients with total esophagectomy and colonic interposition. A gastroscope was initially introduced into the interposed colon and a radio-opaque standard guidewire was advanced to a distance beyond the papilla of Vater, before the gastroscope was withdrawn. A sideviewing duodenoscope was then introduced along the guidewire under fluoroscopic guidance. After cannulation into the papilla of Vater, endoscopic retrograde chol-angiography (ERC) revealed a filling defect (maximum diameter: 15 cm) at the distal portion of the common bile duct (CBD). This defect was determined to be a stone, which was successfully retrieved by a Dormia basket after complete sphincterotomy. With this treatment design, it is possible to perform therapeutic ERCP in patients with colonic interposition, thereby precluding the need for percutaneous drainage or surgery.展开更多
The pervasive transcription of the genome creates many types of non-coding RNAs(nc RNAs).However,we know very little regarding the functions and the regulatory mechanisms of these nc RNAs.Exploring the interactions of...The pervasive transcription of the genome creates many types of non-coding RNAs(nc RNAs).However,we know very little regarding the functions and the regulatory mechanisms of these nc RNAs.Exploring the interactions of RNA and RNA binding proteins(RBPs) is vital because it can allow us to truly understand how these nc RNAs behave in vivo.High-throughput sequencing of RNA isolated by cross-linking immunoprecipitation(HITS-CLIP or CLIP-seq) and its variants have been successfully used as systemic techniques to study RBP binding sites.In this review,we will explain the major differences between the CLIP techniques,summarize successful applications of these techniques,discuss limitations of CLIP,present some suggested solutions and project their promising future roles in studying the RNA world.展开更多
Along with the development of space science and technology,miniature liquid helium temperature long life cryocooler is a focus subject in cryogenic study.Since it is the precondition of space detection researches,inst...Along with the development of space science and technology,miniature liquid helium temperature long life cryocooler is a focus subject in cryogenic study.Since it is the precondition of space detection researches,institutions of space in many countries do the research on it.In this article,we designed a compound cooling system.A three-stage high frequency thermal coupled pulse tube cryocooler was used to precool a Joule-Thomson(JT)cryocooler.This system has no moving parts at low temperatures and is hence suitable for space operation.Liquid helium temperature was successfully achieved in both open loop and closed cycle experiments.In the closed cycle experiment,when 473 W electric power was inputted,the cooling system reached a no-load temperature of 4.4 K,and a cooling capacity of 11.6 mW was provided at 4.54 K.It is the first miniature liquid helium temperature JT cryocooler in China and the research achievement paves a way for the space application of ultra-long wave infrared detection and THz technologies.展开更多
基金Key Program of Natural Science Foundation of China(No. 40576024).
文摘Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization has changed the source, process and sink of urban NPS pollution, especially raised the pollution load of urban runoff NPS in receiving water. Urban runoff pollu- tion is a hot spot of research on NPS. This paper analyzed type, source and harm of the NPS pollutants of urban runoff and its influence on the receiving water. Through estimating NPS pollu- tion load of urban runoff and summarizing the law and character- istics of urban runoff NPS systemically, study on management and control of urban runoff NPS pollution was focused on the applica- tion of BMPs (best management practices). It is a fresh method- ology that management and control on NPS pollution from urban surface runoff was analyzed by methods of landscape ecology, environmental economics and environmental management. The paper provided a scientific reference for mitigating urban water environment pressure and an effective method for management and control of NPS pollution from urban surface runoff..
文摘Trust management has been proven to be a useful technology for providing security service and as a consequence has been used in many applications such as P2P, Grid, ad hoc network and so on. However, few researches about trust mechanism for Internet of Things (IoT) could be found in the literature, though we argue that considerable necessity is held for applying trust mechanism to IoT. In this paper, we establish a formal trust management control mechanism based on architecture modeling of IoT. We decompose the IoT into three layers, which are sensor layer, core layer and application layer, from aspects of network composition of loT. Each layer is controlled by trust management for special purpose: self-organized, affective routing and multi-service respectively. And the final decision-making is performed by service requester according to the collected trust information as well as requester' policy. Finally, we use a formal semantics-based and fuzzy set theory to realize all above trust mechanism, the result of which provides a general framework for the development of trust models of IoT.
文摘Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert clinical guideline published in 2011. In spite of the wide knowledge accumulated on this disease, there are many areas where scientific data are missing, especially in regard to the disease's pathophysiology. Recent publications have suggested that other confounding factors modify the disease and may affect its clinicalphenotypic presentation. Those factors may include place of living, air pollution, race, genetic factors and other. In the present report we discussed and review those confounding factors, the new developments, and what direction we should go to further advance our knowledge of this disease.
文摘Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay treatment for bile duct disease. The procedure is difficult per se, especially when a side-viewing duodenoscope is used, and when the patient has altered anatomical features, such as colonic interposition. Currently, there is no consensus on the standard approach for therapeutic ERCP in patients with total esophagectomy and colonic interposition. We describe a novel treatment design that involves the use of a side-viewing duodenoscope to perform therapeutic ERCP in patients with total esophagectomy and colonic interposition. A gastroscope was initially introduced into the interposed colon and a radio-opaque standard guidewire was advanced to a distance beyond the papilla of Vater, before the gastroscope was withdrawn. A sideviewing duodenoscope was then introduced along the guidewire under fluoroscopic guidance. After cannulation into the papilla of Vater, endoscopic retrograde chol-angiography (ERC) revealed a filling defect (maximum diameter: 15 cm) at the distal portion of the common bile duct (CBD). This defect was determined to be a stone, which was successfully retrieved by a Dormia basket after complete sphincterotomy. With this treatment design, it is possible to perform therapeutic ERCP in patients with colonic interposition, thereby precluding the need for percutaneous drainage or surgery.
基金supported by the National Natural Science Foundation of China(31200593,31230042)the Guangdong Natural Science Foundation (S2011040001760)+1 种基金the Fundamental Research Funds for the Central Universities (13lgpy40)the National Basic Research Program of China (2011CB811300)
文摘The pervasive transcription of the genome creates many types of non-coding RNAs(nc RNAs).However,we know very little regarding the functions and the regulatory mechanisms of these nc RNAs.Exploring the interactions of RNA and RNA binding proteins(RBPs) is vital because it can allow us to truly understand how these nc RNAs behave in vivo.High-throughput sequencing of RNA isolated by cross-linking immunoprecipitation(HITS-CLIP or CLIP-seq) and its variants have been successfully used as systemic techniques to study RBP binding sites.In this review,we will explain the major differences between the CLIP techniques,summarize successful applications of these techniques,discuss limitations of CLIP,present some suggested solutions and project their promising future roles in studying the RNA world.
基金supported by the Strategic Pioneer Program on Space Science,Chinese Academy of Sciences(Grant No.XDA04074100)the National Natural Science Foundation of China(Grant No.51306196)
文摘Along with the development of space science and technology,miniature liquid helium temperature long life cryocooler is a focus subject in cryogenic study.Since it is the precondition of space detection researches,institutions of space in many countries do the research on it.In this article,we designed a compound cooling system.A three-stage high frequency thermal coupled pulse tube cryocooler was used to precool a Joule-Thomson(JT)cryocooler.This system has no moving parts at low temperatures and is hence suitable for space operation.Liquid helium temperature was successfully achieved in both open loop and closed cycle experiments.In the closed cycle experiment,when 473 W electric power was inputted,the cooling system reached a no-load temperature of 4.4 K,and a cooling capacity of 11.6 mW was provided at 4.54 K.It is the first miniature liquid helium temperature JT cryocooler in China and the research achievement paves a way for the space application of ultra-long wave infrared detection and THz technologies.