无损探伤自动检测线上管号识别系统

在无损探伤自动检测线上,为了记录每根管材的有关参数,需在管端进行打号、读号处理。文章简要介绍了管号识别系统的硬件组成和各部件的主要功能。

Wnt/β-catenin Signaling Cascades in Cardiovascular Diseases

Cardiovascular diseases are a group of disorders of the heart and blood vessels,primarily including coronary heart disease,stroke,and other diseases.It is the world’s leading cause of death,and its incidence is increasing yearly.Hypertension is a major risk factor for cardiovascular disease.Wnt signaling comprises a series of highly conservative cascading events controlling fundamental biological processes.Wnt signaling pathways include the canonical Wnt pathway(or Wnt/β-catenin pathway),the non canonical planar cell-polarity pathway,and the non-canonical calcium-dependent pathways.Abnormal Wnt signaling promotes cell proliferation and differentiation,cardiac malformations,various malignancies,so drugs targeting Wnt signaling play a great therapeutic potential.Wnt/β-catenin pathway is involved in the occurrence and development of cardiovascular diseases such as atherosclerosis and stroke by regulating cell proliferation,migration,apoptosis,blood-brain barrier permeability,inflammation,oxidative stress,and immune response.Based on the latest research progress,this review summarizes the role of Wnt/β-catenin signaling in cardiovascular diseases,in order to provide new ideas for the prevention and treatment of cardiovascular diseases.

自动识别技术在大直径埋弧焊管生产线中的应用

介绍条码、射频识别在大直径焊管生产线物料识别中的应用及与MES的集成方案;通过在焊管生产线关键加工岗位设置条码扫描或射频识别设备,自动读取载体上的管号信息,并与生产管理系统中的信息进行校验,最终保证产品在加工过程质量追溯及跟踪的正确性,提高产品的质量保证水平。

Notch signaling dependent differentiation of cholangiocyte-like cells from rhesus monkey embryonic stem cells

Rhesus monkey embryonic stem（rES） cells have similar characteristics to human ES cells,and might be useful as a substitute model for preclinical research.Notch signaling is involved in the formation of bile ducts,which are composed of cholangiocytes.However,little is known about the role of Notch signaling in cholangiocytic commitment of ES cells.We analyzed the effect of Notch signaling on the induction of cholangiocyte-like cells from rES cells.About 80% of definitive endoderm（DE） cells were generated from rES cells after treatment with activin A.After treatment with BMP4 and FGF1 on matrigel coated wells in serum-free medium,rES-derived DE gave rise to cholangiocyte-like cells by expression of cholangiocytic specific proteins（CK7,CK18,CK19,CK20,and OV-6） and genes（GSTPi,IB4,and HNF1β）.At the same time,expression of Notch 1 and Notch 2 mRNA were detected during cell differentiation,as well as their downstream target genes such as Hes 1 and Hes 5.Inhibition of the Notch signal pathway by L-685458 resulted in decreased expression of Notch and their downstream genes.In addition,the proportion of cholangiocyte-like cells declined from ～90% to ～20%.These results suggest that Notch signaling may play a critical role in cholangiocytic development from ES cells.

条形码技术在钢管企业中的应用

简单分析了我国钢管企业标识钢管的现状。为了解决生产过程中钢管标识重号、错号的问题,开发了条形码技术。结合钢管生产企业计算机信息管理系统,成功将条形码技术应用于钢管生产过程,实现了全生产过程管号等信息的自动采集录入,提高了工作效率,降低了生产成本。

管系安装图的图形数据处理

根据船厂的实际出图需求，分析如何对三维模型进行图形处理，并按一定的算法自动出管系安装图，提高出图质量和效率。

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

The Fas/CD95 surface receptor mediates rapid death of various cell types, including autoreactive T cells with the potential for triggering autoimmunity. Here, we present novel aspects of Fas signalling that define a ＇social＇ dimension to receptor-induced apoptosis. Fas stimulation rapidly induces extensive membrane nanotube formation between neighbouring T cells. This is critically dependent on Rho GTPases but not on caspase activation. Bidirectional transfer of membrane and cytosolic elements including active caspases can be observed to occur via these nanotubes. Nanotube formation and intercellular exchanges of death signals are defective in T lymphocytes from patients with autoimmune iymphoproliferative syndrome harbouring mutations in the Fas receptor. We conclude that nanotuhemediated exchanges constitute a novel form of intercellular communication that augments the propagation of death signalling between neighbouring T cells.

Research on Magnetic Flux Leakage Detection Method for Subsea Pipeline

The intelligent pig based on the (MFL) is frequently used for in-line inspection of transportation pipelines. The article discusses the key technology of an MFL tool that includes the sensors structure, the constitution of tool hardware, software and the analysis method of MFL signal.

Compact passing algorithm for signalized intersection management based on vehicular network

To improve the traffic efficiency at signalized intersections, a compact passing algorithm is proposed based on a vehicular network. Its basic principle is that several waiting vehicles after the stop line of the considered intersection should simultaneously start in green periods. Thus, more vehicles can pass the intersection in a green period. Then, the having passed vehicles should follow the planned trajectories to enlarge their longitudinal clearances. Phase timing is not considered in the compact passing algorithm, and therefore, the proposed compact passing algorithm can be combined with other algorithms on phase timing to further improve their performances. Several simulations were designed and performed to verify the performance of the proposed algorithm. The simulation results show that the proposed algorithm can increase the number of completed vehicles and decrease the travel time in the signalized intersections managed by fixed-time and vehicle actuated algorithms, which indicates that the proposed algorithm is effective for improving the traffic efficiency at common signalized intersections.

Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic rats

AIM: The mechanism of decreased vascular reactivity to vasoconstrictors in portal hypertension is still unclear. In addition to nitric oxide, defects in post-receptor signal transduction pathway have been suggested to play a role.However, substantial evidences observed equivocal changes of vascular reactivity following different agonists that challenged the hypothesis of the post-receptor defect. The current study was to evaluate the vascular reactivity to different agonists and the inositol trisphosphate (IP3)changes in signal transduction cascade from cirrhotic rats with portal hypertension.METHODS: The endothelial denuded aortic rings from cirrhotic and sham-operated rats were obtained for ex vivo tension study and measurement of the corresponding [3H] IP3 formation following different receptor and nonreceptor-mediated agonists' stimulation. Additionally,iNOS protein expression was measured in thoracic aorta.The contractile response curves to phenylephrine were performed in endothelial denuded aortic rings with and without preincubation with a specific iNOS inhibitor (L-N (6)-(1-iminoethyl)-lysine, L-NIL).RESULTS: In endothelial denuded aortic rings of cirrhotic rats, the vascular responses were reduced with phenylephrine and arginine vasopressin (AVP) stimulation but were normal with U-46619, NaF/AlCl3, and phorbol esterdibutyrate (PdBU) stimulation. Compared to the corresponding control groups, the degree of the increment of [3H] IP3 formation from basal level was also decreased with phenylephrine and AVP stimulation, but was normal with U-46619 and NaF/AlCl3 stimulation. The preincubation with L-NIL did not modify the hyporesponsiveness to phenylephrine. Additionally, the iNOS protein expression in thoracic aorta was not different in cirrhotic and shamoperated rats.CONCLUSION: Without the influence of nitric oxide, vascular hyporeactivity to vasoconstrictors persisted in cirrhotic rats with portal hypertension. However, the decreased vascular reactivity is an agonist-specific phenomenon. In addition,G-protein and phospholipase C pathway associated with the IP3 productions may be intact in cirrhotic rats with portal hypertension.

Small Signal Circuit Model of Double Photodiodes

The transmission delay of photogenerated carriers in a CMOS-process-compatible double photodiode (DPD) is analyzed by using device simulation.The DPD small signal equivalent circuit model which includes transmission delay of photogenerated carriers is given.From analysis on the frequency domain of the circuit model the device has two poles.One has the relationship with junction capacitance and the DPD’s load,the other with the depth and the doping concentration of the N-well in the DPD.Different depth of the N-well and different area of the DPDs with bandwidth were compared.The analysis results are important to design the high speed DPDs.

Molecular signal transduction in vascular cell apoptosis

Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.

Impact of Channel Length and Width for Charge Transportation of Graphene Field Effect Transistor

The effect of channel length and width on the large and small-signal parameters of the graphene field effect transistor have been explored using an analytical approach.In the case of faster saturation as well as extremely high transit frequency,the graphene field effect transistor shows outstanding performance.From the transfer curve,it is observed that there is a positive shift of Dirac point from the voltage of 0.15 V to 0.35 V because of reducing channel length from 440 nm to 20 nm and this curve depicts that graphene shows ambipolar behavior.Besides,it is found that because of widening channel the drain current increases and the maximum current is found approximately 2.4 mA and 6 mA for channel width 2μm and 5μm respectively.Furthermore,an approximate symmetrical capacitance-voltage(C-V)characteristic of the graphene field effect transistor is obtained and the capacitance reduces when the channel length decreases but the capacitance can be increased by raising the channel width.In addition,a high transconductance,that demands high-speed radio frequency(RF)applications,of 6.4 mS at channel length 20 nm and 4.45 mS at channel width 5μm along with a high transit frequency of 3.95 THz have been found that demands high-speed radio frequency applications.

Clinical detection and movement recognition of neuro signals

Neuro signal has many more advantages than myoelectricity in providing information for prosthesis control, and can be an ideal source for developing new prosthesis. In this work, by implanting intrafascicular electrode clinically in the amputee’s upper extremity, collective signals from fascicules of three main nerves (radial nerve, ulnar nerve and medium nerve) were suc- cessfully detected with sufficient fidelity and without infection. Initial analysis of features under different actions was performed and movement recognition of detected samples was attempted. Singular value decomposition features (SVD) extracted from wavelet coefficients were used as inputs for neural network classifier to predict amputee’s movement intentions. The whole training rate was up to 80.94% and the test rate was 56.87% without over-training. This result gives inspiring prospect that col- lective signals from fascicules of the three main nerves are feasible sources for controlling prosthesis. Ways for improving accu- racy in developing prosthesis controlled by neuro signals are discussed in the end.

UROTENSIN II RECEPTOR IN THE RAT AIRWAY SMOOTH MUSCLE AND ITS EFFECT ON THE RAT AIRWAY SMOOTH MUSCLE CELLS PROLIFERATION

Objective. To investigate the characteristics of urotensin II (U II) receptor in the rat airway smooth muscle and the effect and signal transduction pathway of U II on the proliferation of airway smooth muscle cells. Methods. Using 125I UII binding assay to measure the Bmax and Kd of U II receptor. Using the 3H TdR incorporation to determine the effect of U II on the proliferation of airway smooth muscle cells and its signal transduction pathway. Using Fura 2/AM to measure the effect of U II on the cytosolic free calcium concentration. Results. 1. 125I UII binding increased with the time and reached saturation at 45min. The Bmax was (11.36±0.37)fmol/mg pr and Kd was (4.46±0.61)nmol/L. 2. U II increased 3H TdR incorporation of the airway smooth muscle cells in a dose dependent manner. 3. H7, PD98059 and nicardipine, inhibitors of PKC, MAPK, calcium channel, respectively, significantly inhibited U II stimulated 3H TdR incorporation of airway smooth muscle cells. W7, inhibitor of CaM PK, had no effect. 4. Cyclosporin A, inhibitor of CaN, inhibited 3H TdR incorporation of the airway smooth muscle cells induced by U II in a dose dependent manner. 5. U II promoted cytosolic free calcium concentration increase by 18%. Conclusions. 1. There was U II receptor in the rat airway smooth muscle. 2. The effect of U II stimulated 3H TdR incorporation of airway smooth muscle cells was mediated by such signal transduction pathway as Ca2+, PKC, MAPK and CaN, etc.

A Sample of Semi-Actuated Traffic Control versus Fixed-Time Traffic Control

Fixed-time control of traffic signals pursues the regulation of phases based on historical data of traffic demand, in this way, neglecting of the random arrival rates of traffic flow on different intersection streams causes increasing of the stops and delays and fuel consumption at the same time. Coordinated semi-actuated control due to ability to respond traffic demands on both main and secondary directions, based on road detector registration saves the coordinated features, serving the unused time to the main road, while the secondary clears early. In this paper, the authors analyzed and explained comparatively the results of LOS （level of service） parameters of the current state of control （fixed-time） with the proposed control （semi-actuated coordinated） of the artery of length 2,348 km consisted of four signalized T intersections. Highway Capacity Manual and Synchro/Sim Traffic software are used for analysis and optimization of parameters in this paper.

ROLE OF CALCINEURIN IN ANGIOTENSIN II- INDUCED CARDIAC MYOCYTE HYPERTROPHY OF RATS

The present study investigated the role of calcineurin in angiotensin II(AngII)- induced cardiac myocyte hypertrophy of rats. Method. The primary cardiac myocytes were cultured under the standard conditions. The calcineurin activity in AngII- treated cardiomyocytes was tested by using PNPP;protein synethsis rate was assessed by 3H- leucine incorporation; atrial natriuretic factor(ANF) mRNA level was determined by Northern blot analysis. Cell viability was estimated by lactate dehydrogenase(LDH) levels in cultured medium and by dyed cell numbers. Result. After stimulation of 10,100 and 1 000nmol/L of AngII, calcineurin activities in the cardiomyocytes were increased by 13％ ,57％ (P Conclusion. During AngII- induced cardiac myocyte hypertrophy, calcineurin signal pathway is activated, and inhibition of the pathway can attenuate AngII- induced cardiac myocyte hypertrophy, which suggests that the calcineurin signal pathway may play an important role in AngII- induced myocardial hypertrophy of rats.

Multiple hashes of single key with passcode for multiple accounts

A human's e-life needs multiple offline and online accounts. It is a balance between usability and security to set keys or passwords for these multiple accounts. Password reuse has to be avoided due to the domino effect of malicious administrators and crackers. However,human memorability constrains the number of keys. Single sign-on server,key hashing,key strengthening and petname system are used in the prior arts to use only one key for multiple online accounts. The unique site keys are derived from the common master secret and specific domain name. These methods cannot be applied to offline accounts such as file encryption. We invent a new method and system applicable to offline and online accounts. It does not depend on HTTP server and domain name,but numeric 4-digit passcode,key hashing,key strengthening and hash truncation. Domain name is only needed to resist spoofing and phishing attacks of online accounts.

A TIME-FREQUENCY BLIND SEPARATION METHOD FOR UNDERDETERMINED SPEECH MIXTURES

The proposed Blind Source Separation method(BSS),based on sparse representations,fuses time-frequency analysis and the clustering approach to separate underdetermined speech mixtures in the anechoic case regardless of the number of sources.The method remedies the insufficiency of the Degenerate Unmixing Estimation Technique(DUET) which assumes the number of sources a priori.In the proposed algorithm,the Short-Time Fourier Transform(STFT) is used to obtain the sparse rep-resentations,a clustering method called Unsupervised Robust C-Prototypes(URCP) which can ac-curately identify multiple clusters regardless of the number of them is adopted to replace the histo-gram-based technique in DUET,and the binary time-frequency masks are constructed to separate the mixtures.Experimental results indicate that the proposed method results in a substantial increase in the average Signal-to-Interference Ratio(SIR),and maintains good speech quality in the separation results.