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桂竹糖芥苷对肾小管功能及髓袢升支粗段管周膜50pS钾通道活性的影响 被引量:1
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作者 隋洪玉 赵晓莲 +5 位作者 齐淑芳 陈昆鹏 贾秀月 李莹 栾海艳 王毅 《黑龙江医药科学》 2013年第3期36-37,共2页
目的:探讨桂竹糖芥苷对肾小管功能及髓袢升支粗段管周膜50 pS钾通道活性的影响。方法:采用导尿法及细胞贴附式膜片钳技术测定尿量变化及对通道活性的影响。结果:桂竹糖芥苷可明显增加尿量,也可抑制髓袢升支粗段管周膜50 pS钾通道的活性(... 目的:探讨桂竹糖芥苷对肾小管功能及髓袢升支粗段管周膜50 pS钾通道活性的影响。方法:采用导尿法及细胞贴附式膜片钳技术测定尿量变化及对通道活性的影响。结果:桂竹糖芥苷可明显增加尿量,也可抑制髓袢升支粗段管周膜50 pS钾通道的活性(P<0.01)。结论:桂竹糖芥苷有利尿作用,而且这种利尿作用可能是通过抑制髓袢升支粗段管周膜50 pS钾通道活性实现的。 展开更多
关键词 桂竹糖芥苷 髓袢升支粗段 管周膜 钾通道
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肾髓袢升支粗段管周膜50 pS钾通道研究进展
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作者 隋洪玉 栾海艳 +2 位作者 孔淑敏 李文楠 谷瑞民 《生理科学进展》 CAS CSCD 北大核心 2012年第4期319-320,F0003,共3页
肾小管的钾通道分布于肾小管各段,既分布于管周膜,也分布于管腔膜,由于管周膜的膜片钳封接难度较大,故相关研究较少。但髓袢升支粗段(thick ascending limb,TAL)管周膜钾通道在肾小管的重吸收过程中是重要环节,对其研究具有重要意义。50... 肾小管的钾通道分布于肾小管各段,既分布于管周膜,也分布于管腔膜,由于管周膜的膜片钳封接难度较大,故相关研究较少。但髓袢升支粗段(thick ascending limb,TAL)管周膜钾通道在肾小管的重吸收过程中是重要环节,对其研究具有重要意义。50 pS钾通道是近年来在肾髓袢升支粗段管周膜上发现的主要K+通道,本文对其功能、特点及调控等方面进行简要综述。 展开更多
关键词 髓袢升支粗段 管周膜 50 pS钾通道
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TNF-α对糖尿病肾病大鼠髓袢升支粗段管周膜KCNJ10(Kir4.1)的调控
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作者 孟庆民 赵日新 +3 位作者 王伟群 张明月 郭思琪 隋洪玉 《广东化工》 CAS 2018年第4期39-40,共2页
目的:探讨TNF-α对糖尿病肾病形成中髓袢升支粗段管周膜KCNJ10(Kir4.1)的调控。方法:取SD雄性大鼠随机分成4组,正常对照组(NC)、糖尿病模型组(DM)、NC+TNFR:Fc组和DM+TNFR:Fc组,20天后用Western blot方法检测髓袢升支粗段中TNF-α、KCN... 目的:探讨TNF-α对糖尿病肾病形成中髓袢升支粗段管周膜KCNJ10(Kir4.1)的调控。方法:取SD雄性大鼠随机分成4组,正常对照组(NC)、糖尿病模型组(DM)、NC+TNFR:Fc组和DM+TNFR:Fc组,20天后用Western blot方法检测髓袢升支粗段中TNF-α、KCNJ10、PLA2和PTK的蛋白表达情况。结果:DM组TNF-α蛋白表达显著增加;DM组KCNJ10蛋白表达降低,而PLA2和PTK蛋白表达增加;DM+TNFR:Fc组KCNJ10蛋白表达增加,而PLA2和PTK蛋白表达降低。结论:在糖尿病肾病形成中,TNF-α通过激活PLA2和PTK依赖途径抑制髓袢升支粗段管周膜KCNJ10(Kir4.1)的活性。 展开更多
关键词 TNF—α糖尿病肾病 髓袢升支粗段 管周膜 KCNJ10(KiN.1)
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An ultra-sensitive and wide measuring range pressure sensor with paper-based CNT film/interdigitated structure 被引量:6
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作者 Chao Wang Xiaojuan Hou +7 位作者 Min Cui Junbin Yu Xueming Fan Jichao Qian Jian He Wenping Geng Jiliang Mu Xiujian Chou 《Science China Materials》 SCIE EI CSCD 2020年第3期403-412,共10页
Flexible pressure sensors have attracted great attention due to their potential in the wearable devices market and in particular in human-machine interactive interfaces.Pressure sensors with high sensitivity,wide meas... Flexible pressure sensors have attracted great attention due to their potential in the wearable devices market and in particular in human-machine interactive interfaces.Pressure sensors with high sensitivity,wide measurement range,and low-cost are now highly desired for such practical applications.In the present investigation,an ultrasensitive pressure sensor with wide measurement range has been successfully fabricated.Carbon nanotubes(CNTs)(uniformly sprayed on the surface of paper)comprise the sensitivity material,while lithographed interdigital electrodes comprise the substrate.Due to the synergistic effects of CNT’s high specific surface area,paper’s porous structure,interdigital electrodes’efficient contact with CNT,our pressure sensor realizes a wide measurement range from 0 to 140 kPa and exhibits excellent stability through 15,000 cycles of testing.For the paper-based CNT film/interdigitated structure(PCI)pressure sensor,the connection area between the sensitive material and interdigital electrodes dominates in the lowpressure region,while internal change within the sensitive materials plays the leading role in the high-pressure region.Additionally,the PCI pressure sensor not only displays a high sensitivity of 2.72 kPa–1(up to 35 kPa)but also can detect low pressures,such as that exerted by a resting mung bean(about 8 Pa).When attached to the surface of a human body,the pressure sensor can monitor physiological signals,such as wrist movement,pulse beats,or movement of throat muscles.Furthermore,the pressure sensor array can identify the spatial pressure distribution,with promising applications in humanmachine interactive interfaces. 展开更多
关键词 carbon nanotube interdigital structure pressure sensors paper-based carbon nanotube(CNT)film ultrabroad measuring range
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