AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to st...AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage.展开更多
The phenomenon of electrical potential differences along the plant apoplast has been reported for more than a century. Earlier works of harvesting energy from trees reported nW range of power with a few hundred-mV ope...The phenomenon of electrical potential differences along the plant apoplast has been reported for more than a century. Earlier works of harvesting energy from trees reported nW range of power with a few hundred-mV open circuit voltage and near uA range short circuit current. In this work, we show that if we cut a stem into pieces, each segment would maintain nearly the same open circuit voltage and short circuit current regardless of length. Using a pico-ampere meter, we also found that the living cells in the vascular cambial and secondary xylem and phloem tissues are the source of electricity. They provide a relatively constant voltage and current to external environment for reasons still under investigation. We demonstrate that by cascading separated stems we can accumulate up to 2 V of open circuit voltage. We also demonstrate by connecting them in parallel we can increase the short circuit current.展开更多
基金Supported by a Grant-in-Aid from the Japanese Ministry of Education, Culture, Sports, Science and Technology (22790640)
文摘AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage.
基金Acknowledgments This material is based upon work supported by the National Science Foundation under Grant No. EEC-0540832. The authors also wish to acknowledge the contributions to discussions on plant electrophysiology by Dr. Dan Kostov and Dr. Xing Chen.
文摘The phenomenon of electrical potential differences along the plant apoplast has been reported for more than a century. Earlier works of harvesting energy from trees reported nW range of power with a few hundred-mV open circuit voltage and near uA range short circuit current. In this work, we show that if we cut a stem into pieces, each segment would maintain nearly the same open circuit voltage and short circuit current regardless of length. Using a pico-ampere meter, we also found that the living cells in the vascular cambial and secondary xylem and phloem tissues are the source of electricity. They provide a relatively constant voltage and current to external environment for reasons still under investigation. We demonstrate that by cascading separated stems we can accumulate up to 2 V of open circuit voltage. We also demonstrate by connecting them in parallel we can increase the short circuit current.
