A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenos...A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed.展开更多
Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the fe...Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the feasibility of the proposals used for the network architecture evolution from 4G to 5G and first propose a compatible network architecture, which decouples the management plane, the control plane and the user plane based on NO Stack framework proposed in our previous study. We mainly design detail procedures including UE attachment, service request and dedicated bearer activation/deactivation for our proposal network architecture. Finally, we establish a clear analytical mode of the application and system states to evaluate the signaling loads of new architecture. Simulation results show that our proposal network architecture with elaborated signaling procedures has much impact on the total signaling loads of system and could obviously decrease the signaling overhead compared with LTE.展开更多
This paper analyses the demand of intelligent bookshelf system, designed the overall structure of intelligent Library shelves system based on RFID and create the system use case model. The analysis and design of the i...This paper analyses the demand of intelligent bookshelf system, designed the overall structure of intelligent Library shelves system based on RFID and create the system use case model. The analysis and design of the intelligent bookshelf system structure from two aspects of hardware and software, puts forward the three layer system structure model of intelligent bookshelf system based on RFID technology. The paper provide the analysis method and the design ideas of library intelligent bookshelf system, has the very high application value, contribute to the realization of library intelligent management and improve the level of library services, provide a useful reference to the development of current book positioning system and intelligent goods shelf system solution.展开更多
文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed.
基金supported by the Chinas 863 Project (No.2015AA01A706)the National Science and Technology Major Project (No. 2016ZX03001017)+1 种基金the Science and Technology Program of Beijing (No. D161100001016002)the Science and Technology Cooperation Projects (No. 2015DFT10160B)
文摘Present mobile communication system suffers from the exponentially increased mobile traffic and research on the fifth generation(5G) mobile network architectures is ongoing to solve this problem. We investigate the feasibility of the proposals used for the network architecture evolution from 4G to 5G and first propose a compatible network architecture, which decouples the management plane, the control plane and the user plane based on NO Stack framework proposed in our previous study. We mainly design detail procedures including UE attachment, service request and dedicated bearer activation/deactivation for our proposal network architecture. Finally, we establish a clear analytical mode of the application and system states to evaluate the signaling loads of new architecture. Simulation results show that our proposal network architecture with elaborated signaling procedures has much impact on the total signaling loads of system and could obviously decrease the signaling overhead compared with LTE.
文摘This paper analyses the demand of intelligent bookshelf system, designed the overall structure of intelligent Library shelves system based on RFID and create the system use case model. The analysis and design of the intelligent bookshelf system structure from two aspects of hardware and software, puts forward the three layer system structure model of intelligent bookshelf system based on RFID technology. The paper provide the analysis method and the design ideas of library intelligent bookshelf system, has the very high application value, contribute to the realization of library intelligent management and improve the level of library services, provide a useful reference to the development of current book positioning system and intelligent goods shelf system solution.
