Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking ...Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, the PCC （Pearson＇s Correlation Coefficient） was proposed and applied as： discarding criteria methodology, dynamic power management solution, environment observer method which selects automatically only the regions-of-interest; and taking place in the obstacle avoidance context, as a method for collision risk estimation for vehicles in dynamic and unknown environments. Even if the PCC is a great tool to help the autonomous or semi-autonomous navigation, distortions in the imaging system, pixel noise, slight variations in the object＇s position relative to the camera, and other factors produce a false PCC threshold. Whereas there are homogeneous regions in the image, in order to obtain a more realistic Pearson＇s correlation, we propose to use some prior known environment information.展开更多
The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry...The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC.In recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions.Here,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.展开更多
文摘Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, the PCC （Pearson＇s Correlation Coefficient） was proposed and applied as： discarding criteria methodology, dynamic power management solution, environment observer method which selects automatically only the regions-of-interest; and taking place in the obstacle avoidance context, as a method for collision risk estimation for vehicles in dynamic and unknown environments. Even if the PCC is a great tool to help the autonomous or semi-autonomous navigation, distortions in the imaging system, pixel noise, slight variations in the object＇s position relative to the camera, and other factors produce a false PCC threshold. Whereas there are homogeneous regions in the image, in order to obtain a more realistic Pearson＇s correlation, we propose to use some prior known environment information.
基金supported by the National Institutes of Health(Grant No. 5R01HL097111)to Mohamed Trebak
文摘The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC.In recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions.Here,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.
