An IGBT subcircuit model is proposed and optimized,which is fully SPICE compatible.Based on analytical equations describing the semiconductor device physics,the model parameters are extracted accurately from the measu...An IGBT subcircuit model is proposed and optimized,which is fully SPICE compatible.Based on analytical equations describing the semiconductor device physics,the model parameters are extracted accurately from the measured data without device destruction.The IGBT n - layer conductivity modulated resistor is effectively modeled as a voltage controlled resistor.The proposed model can be used to accurately predict the IGBT output I-V characteristics and low current gain etc.The simulation results are verified by the comparison with measurements and found to be in good agreement with them.The error in average is within 8%,which is better than the results of semi-mathematical models reported previously.展开更多
A SIT-BJT model is proposed for static induction thyristors (SITh) operation in the blocking state. On the basis of the physical mechanism, this model is presented analytically in terms of governing equations that l...A SIT-BJT model is proposed for static induction thyristors (SITh) operation in the blocking state. On the basis of the physical mechanism, this model is presented analytically in terms of governing equations that link the electrical parameters to the structural parameters. The model is verified by numerical simulation and theoretical analysis. Based on the model, the variations of the electrical parameters such as the potential barrier, the anode junction voltage drop, and the current amplification factor are studied and discussed.展开更多
A high performance AlAs/In0.53 Ga0.47 As/InAs resonant tunneling diode (RTD) on InP substrate is fabricated by inductively coupled plasma etching. This RTD has a peak-to-valley current ratio (PVCR) of 7. 57 and a ...A high performance AlAs/In0.53 Ga0.47 As/InAs resonant tunneling diode (RTD) on InP substrate is fabricated by inductively coupled plasma etching. This RTD has a peak-to-valley current ratio (PVCR) of 7. 57 and a peak current density Jp = 39.08kA/cm^2 under forward bias at room temperature. Under reverse bias, the corresponding values are 7.93 and 34.56kA/cm^2 . A resistive cutoff frequency of 18.75GHz is obtained with the effect of a parasitic probe pad and wire. The slightly asymmetrical current-voltage characteristics with a nominally symmetrical structure are also discussed.展开更多
As a new attempt, equal channel angular extrusion (ECAE) of nickel-titanium shape memory alloy (NiTi SMA) tube was investigated by means of process experiment, finite element method (FEM) and microscopy. NiTi SM...As a new attempt, equal channel angular extrusion (ECAE) of nickel-titanium shape memory alloy (NiTi SMA) tube was investigated by means of process experiment, finite element method (FEM) and microscopy. NiTi SMA tube with the steel core in it was inserted into the steel can during ECAE of NiTi SMA tube. Based on rigid-viscoplastic FEM, multiple coupled boundary conditions and multiple constitutive models were used for finite element simulation of ECAE of NiTi SMA tube, where the effective stress field, the effective strain field and the velocity field were obtained. Finite element simulation results are in good accordance with the experimental ones. Finite element simulation results reveal that the velocity field shows the minimum value in the corner of NiTi SMA tube, where severe shear deformation occurs. Microstructural observation results reveal that severe plastic deformation leads to a certain grain orientation as well as occurrence of substructures in the grain interior and dynamic recovery occurs during ECAE of NiTi SMA tube. ECAE of NiTi SMA tube provides a new approach to manufacturing ultrafine-grained NiTi SMA tube.展开更多
The reverse snapback phenomena (RSP) on I-V characteristics of static induction thyristors (SITH) are physically researched. The I-V curves of the power SITH exhibit reverse snapback phenomena, and even turn to th...The reverse snapback phenomena (RSP) on I-V characteristics of static induction thyristors (SITH) are physically researched. The I-V curves of the power SITH exhibit reverse snapback phenomena, and even turn to the conducting-state,when the anode voltage in the forward blocking-state is increased to a critical value. The RSP I-V characteristics of the power SITH are analyzed in terms of operating mechanism, double carrier injection effect, space charge effect, electron-hole plasma in the channel, and the variation in carrier lifetime. The reverse snapback mechanism is theoretically pro- posed and the mathematical expressions to calculate the voltage and current values at the snapback point are presented. The computing results are compared with the experiment values.展开更多
The DFI-1 submarine pipeline was investigated using a dual-frequency side-scan sonar and a swath sounder system. More than a hundred scour pits under the pipeline were found, most of which have caused the span of the ...The DFI-1 submarine pipeline was investigated using a dual-frequency side-scan sonar and a swath sounder system. More than a hundred scour pits under the pipeline were found, most of which have caused the span of the pipeline to increase and threatened its safety. The maximum allowable free span length (MAFSL) of the pipeline was determined through the limitations re- garding maximum allowable stress under static or quasi-static loads and the onset of Vortex Induced Vibrations (VIV) under different hydrodynamic actions. The results show that the MAFSL under static conditions is 56m. However, the MAFSLs are 30m and 20m under ordinary weather conditions and hurricane-induced currents for the 100-year return period, respectively, to avoid VIV as cal- culated by using the highest safety class factor. It is suggested that spanning pipelines longer than 20 m should be supported. Addi- tionally, eight successive spans which may also threaten the pipeline were proposed. The most hazardous scour pits are along the pipeline section from KP42 to KP51.展开更多
Resonant tunneling diode (RTD) of AlAs/InGaAs/AlAs double barrier-single well structure was designed and fabricated. The devices showed current-voltage characteristics with peak-valley current ratio of 4 : 1 at roo...Resonant tunneling diode (RTD) of AlAs/InGaAs/AlAs double barrier-single well structure was designed and fabricated. The devices showed current-voltage characteristics with peak-valley current ratio of 4 : 1 at room temperature. The scattering parameter of RTD was measured by using an HP8510(C) network analyzer. Equivalent circuit parameters were obtained by curve fitting and optimized. The RTD switching time was estimated using the measured capacitance and average negative differential resistance. The minimum rise time of the sample was estimated to be 21 ps.展开更多
A Y-band frequency doubler is analyzed and designed with GaAs planar Schottky diode, which is flip-chip solded into a 50 μm thick quartz substrate. Diode embedding impedance is found by full- wave analysis with lumpe...A Y-band frequency doubler is analyzed and designed with GaAs planar Schottky diode, which is flip-chip solded into a 50 μm thick quartz substrate. Diode embedding impedance is found by full- wave analysis with lumped port to model the nonlinear junction for impedance matching without the need of diode equivalent circuit model. All the matching circuit is designed "on-chip" and the mul- tiplier is self-biasing. To the doubler, a conversion efficiency of 6.1% and output power of 5.4mW are measured at 214GHz with input power of 88mW, and the typical measured efficiency is 4.5% in 200 - 225 GHz.展开更多
AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies ev...AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic. RESULTS Initial search identified 721 reference articles, of which 53 were selected and reviewed. Twelve studies(n = 971) that met the inclusion criteria were included in this analysis. Among the total original LGD diagnoses in the included studies, only 37.49% reached the consensus LGD diagnosis after review by two or more expert pathologists. Total follow up period was 1532 patient-years. In the pooled consensus LGD patients, the annual incidence rate(AIR) of progression to HGD and or EAC was 10.35%(95%CI: 7.56-13.13) and progression to EAC was 5.18%(95%CI: 3.43-6.92). Among the patients down staged from original LGD diagnosis to No-dysplasia Barrett's esophagus, the AIR of progression to HGD and EAC was 0.65%(95%CI: 0.49-0.80). Among the patients down staged to Indefinite for dysplasia, the AIR of progression to HGD and EAC was 1.42%(95%CI: 1.19-1.65). In patients with consensus HGD diagnosis, the AIR of progression to EAC was 28.63%(95%CI: 13.98-43.27). CONCLUSION When LGD is diagnosed by consensus agreement of two or more expert pathologists, its progression towards malignancy seems to be at least three times the current estimates, however it could be up to 20 times the current estimates. Biopsies of all Barrett's esophagus patients with LGD should be reviewed by two expert gastroenterology pathologists. Follow-up strict surveillance programs should be in place for these patients.展开更多
An equivalent electrical network method is presented in this paper to analyze the cooling characteristics of a laser diode module (LDM).And a modified equivalent model of a thermoelectric cooler (TEC) with an adjuncti...An equivalent electrical network method is presented in this paper to analyze the cooling characteristics of a laser diode module (LDM).And a modified equivalent model of a thermoelectric cooler (TEC) with an adjunctive thermal resistance and a contact resistance is proposed.The performance of a commercial TEC has been simulated.The thermal analysis of a LDM incorporated with a TEC has been performed by using an equivalent circuit model of the LDM.In the analysis the change of LD current,TEC current,and the ambient temperature are all considered.It shows that the equivalent circuit approach is an effective tool for the qualitative analysis of TEC and LDM.展开更多
The fundamental case is considered in which flights from many destinations must be scheduled for arrival at a single congested airport having limited capacities.An air traffic control(ATC)model is developed in this ca...The fundamental case is considered in which flights from many destinations must be scheduled for arrival at a single congested airport having limited capacities.An air traffic control(ATC)model is developed in this case.A new and efficient algorithm for the optimal solution of ground holding strategy problem(GHSP)is put forward and verified by a numerical example.展开更多
AIM: To investigate changes in vasoactive intestinal polypeptide (VIP) and corticotrophin releasing factor (CRF) in the plasma and duodenum of chronic stress- induced depressed rats and the effects of fluoxetine hydro...AIM: To investigate changes in vasoactive intestinal polypeptide (VIP) and corticotrophin releasing factor (CRF) in the plasma and duodenum of chronic stress- induced depressed rats and the effects of fluoxetine hydrochloride (fluoxetine) treatment on depression- induced changes in VIP and CRF. METHODS: A Sprague-Dawley rat model of chronic stress-induced depression was produced. Thirty experimental rats were randomly divided into the following groups: control group, saline-treated depressed group, and fluoxetine-treated depressed group. Open- f ield testing was performed to assess the rats’ behavior. VIP and CRF levels in plasma were measured by ELISA. Immunofluorescence techniques combined with laser scanning confocal microscopy (LSCM) were used to investigate VIP and CRF expression in the duodenum. RESULTS: The open-field behavior, both crossing and rearing, of depression model rats, decreased signif icantly compared with those of normal control rats over 5 min. Defecation times increased significantly. Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 ± 2.54 vs 25.17 ± 4.63; plasma CRF: 11.82 ± 2.54 ng/L vs 25.17 ± 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased signif icantly (fluorescence intensity of duodenal VIP: 67.37 ± 18.90 vs 44.51 ± 16.37; plasmaVIP: 67.37 ± 18.90 ng/L vs 44.51 ± 16.37 ng/L, P < 0.01). Fluoxetine improved depressed behavior, increased VIP expression and decreased CRF expression in plasma and the duodenal tissue of depressed rats. CONCLUSION: Chronic stress can induce injury to the duodenum, accompanied by increasing CRF and decreasing VIP in the plasma and duodenum. Treatment with fluoxetine can ameliorate pathological changes in the duodenum of depressed rats, which suggests that antidepressants are an effective therapeutic agent for some duodenal diseases caused by chronic stress. VIP is a potential therapeutic strategy.展开更多
AIM: To verify the safety and efficacy of plasma shock wave lithotripsy (PSWL) in fragmenting impacted stones in the bile duct system. METHODS: From September 1988 to April 2005, 67 patients (26 men and 41 women...AIM: To verify the safety and efficacy of plasma shock wave lithotripsy (PSWL) in fragmenting impacted stones in the bile duct system. METHODS: From September 1988 to April 2005, 67 patients (26 men and 41 women) with impacted stones underwent various biliary operations with tube (or T-tube) drainage. Remnant and impacted stones in the bile duct system found by cholangiography after the operation were fragmented by PSWL and choledochofiberscopy. A total of 201 impacted stones were fragmented by PSWL setting the voltage at 2.5-3.5 kV, and the energy output at 2-3.1 for each pulse of PSWL. Then the fragmented stones were extracted by choledochofiberscopy. The safety and efficacy of PSWL were observed during and after the procedure. RESULTS: One hundred and ninety-nine of 201 impacted stones (99.0%) in the bile duct system were successfully fragmented using PSWL and extracted by choledochofiberscopy. The stone clearance rate for patients was 97% (65/67). Ten patients felt mild pain in the right upper quadrant of the abdomen, and could tolerate it well. Eleven patients had a small amount of bleeding from the mucosa of the bile duct. The bleeding was transient and stopped spontaneously within 2 min of normal saline irrigation. There were no significant complications during and after the procedure. CONCLUSION:PSWL is a safe and effective method for fragmenting impacted stones in the bile duct system.展开更多
The assembly of layered double hydroxides (LDHs) and multi-walled carbon nanotubes (MWCNTs) nanohybrids was prepared as MWCNTs/LDHs by co-precipitation. The synthesized nanoparticles were characterized by us...The assembly of layered double hydroxides (LDHs) and multi-walled carbon nanotubes (MWCNTs) nanohybrids was prepared as MWCNTs/LDHs by co-precipitation. The synthesized nanoparticles were characterized by using XRD, FT-IR, SEM/EDX, TGA and BET. XRD and SEM studies proved that MWCNTs phases did not enter into the interlayers of LDHs, they dispersed over the LDHs surface homogeneously. BET results showed that MWCNTs/LDHs possessed hierarchically porous nanostructure with large surface area (124.974 m^2/g) and great pore volume (0.604 cm^3/g). Batch experiments were conducted to study the adsorption efficiency of Congo red (CR). It was worthy to note that MWCNTs/LDHs exhibited excellent adsorption performance with the maximum CR adsorption capacity of 595.8 mg/g in weak acidic environment. The adsorption kinetics and isotherm parameters can be well described by the pseudo-second-order and the Langmuir isotherm models, respectively. The thermodynamic studies indicated that the adsorption process was spontaneous and endothermic.展开更多
Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake...Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps.展开更多
To carry out lower hybrid wave heating and current drive plasma experiment on tokamak, we need mega-watt order of microwave power generated by the parallel-running klystrons. Those klystrons must be driven by the micr...To carry out lower hybrid wave heating and current drive plasma experiment on tokamak, we need mega-watt order of microwave power generated by the parallel-running klystrons. Those klystrons must be driven by the microwave exciter. Now our microwave exciter is used for many years and its performance is decreased very much. It can not satisfy any more the hybrid wave heating and current drive plasma experiment. So we set out to design a new microwave exciter that is consist of the microwave solid components, amplitudestabilization control, modularization design with multitude-outputs, microwave phase control in order to satisfy the demand of the different work in the hybrid wave heating and current drive plasma experiment.展开更多
In this paper, we research on the higher education management mode of China and America based on the perspective of operation mechanism, separation of school and the government. As the thought of higher education mana...In this paper, we research on the higher education management mode of China and America based on the perspective of operation mechanism, separation of school and the government. As the thought of higher education management theory or a form, we jump out of the labyrinth of modernism manages view and the introduction of totally different from the modernist paradigm, from the angle of the theory research of postmodernism manages view. The paper is organized as the follows. In the first section, we generally introduce the basic concepts of higher education management and the relationship of the schools and government. Then, by comparing the pattern of the Chinese and the American, we analyze the difference in detail. Finally, we set up the prospect and the conclusion. In conclusion, our method combines the advantages of the American higher education management model which will be meaningful.展开更多
The authentication and privacy of a group member is important in multicast communication. This paper proposes a privacy-preserving authenticated group-key management protocol for the Mobile Peer-to-Peer Network ( MP2...The authentication and privacy of a group member is important in multicast communication. This paper proposes a privacy-preserving authenticated group-key management protocol for the Mobile Peer-to-Peer Network ( MP2PN ). The MP2PN contains some super peers and each super peer controls a subgroup composed of regular peers. An efficient attribute-based signature based on Cipertext-Policy Attribute-Based Encryption (CP-ABE) is proposed and used in this group-key rmnagement protocol to authenticate a peer's at- tributes and identity. A peer can be described by a set of attributes or one unique special identity at- tribute. Peers that have some attributes in common can form a group and conmmnicate with each other anonymously and securely. Any super peer can initiate a group and act as a group controller. The group controller can authenticate a peer's attributes and identity as well as remove malicious peers. Any peer with attributes that rmtches the access structure can join the group and provide its input to form the group key. The proposed protocol pro- vides backward and forward secrecy. The sinmlation results show that this protocol is applicable for mobile devices and can meet the MP2PN requirements of group communication.展开更多
Hong Kong Polytech University is the representative of tourism higher education in Hong Kong, offering various courses in hotel management and tourism management at the Doctor, Masters and Bachelor levels, whose curri...Hong Kong Polytech University is the representative of tourism higher education in Hong Kong, offering various courses in hotel management and tourism management at the Doctor, Masters and Bachelor levels, whose curriculum and education system have been quite perfect. The PolyU has cultivated a large number of high-quality professional people for the hotel and tourism industry. Excellent teachers, modem curriculum and the education concept of attaching great importance to the practice are the reasons why it can cultivate senior executives with international perspective, skills and social responsibility.展开更多
文摘An IGBT subcircuit model is proposed and optimized,which is fully SPICE compatible.Based on analytical equations describing the semiconductor device physics,the model parameters are extracted accurately from the measured data without device destruction.The IGBT n - layer conductivity modulated resistor is effectively modeled as a voltage controlled resistor.The proposed model can be used to accurately predict the IGBT output I-V characteristics and low current gain etc.The simulation results are verified by the comparison with measurements and found to be in good agreement with them.The error in average is within 8%,which is better than the results of semi-mathematical models reported previously.
文摘A SIT-BJT model is proposed for static induction thyristors (SITh) operation in the blocking state. On the basis of the physical mechanism, this model is presented analytically in terms of governing equations that link the electrical parameters to the structural parameters. The model is verified by numerical simulation and theoretical analysis. Based on the model, the variations of the electrical parameters such as the potential barrier, the anode junction voltage drop, and the current amplification factor are studied and discussed.
文摘A high performance AlAs/In0.53 Ga0.47 As/InAs resonant tunneling diode (RTD) on InP substrate is fabricated by inductively coupled plasma etching. This RTD has a peak-to-valley current ratio (PVCR) of 7. 57 and a peak current density Jp = 39.08kA/cm^2 under forward bias at room temperature. Under reverse bias, the corresponding values are 7.93 and 34.56kA/cm^2 . A resistive cutoff frequency of 18.75GHz is obtained with the effect of a parasitic probe pad and wire. The slightly asymmetrical current-voltage characteristics with a nominally symmetrical structure are also discussed.
基金Project(51071056)supported by the National Natural Science Foundation of ChinaProjects(HEUCF121712,HEUCF201317002)supported by the Fundamental Research Funds for the Central Universities of China
文摘As a new attempt, equal channel angular extrusion (ECAE) of nickel-titanium shape memory alloy (NiTi SMA) tube was investigated by means of process experiment, finite element method (FEM) and microscopy. NiTi SMA tube with the steel core in it was inserted into the steel can during ECAE of NiTi SMA tube. Based on rigid-viscoplastic FEM, multiple coupled boundary conditions and multiple constitutive models were used for finite element simulation of ECAE of NiTi SMA tube, where the effective stress field, the effective strain field and the velocity field were obtained. Finite element simulation results are in good accordance with the experimental ones. Finite element simulation results reveal that the velocity field shows the minimum value in the corner of NiTi SMA tube, where severe shear deformation occurs. Microstructural observation results reveal that severe plastic deformation leads to a certain grain orientation as well as occurrence of substructures in the grain interior and dynamic recovery occurs during ECAE of NiTi SMA tube. ECAE of NiTi SMA tube provides a new approach to manufacturing ultrafine-grained NiTi SMA tube.
文摘The reverse snapback phenomena (RSP) on I-V characteristics of static induction thyristors (SITH) are physically researched. The I-V curves of the power SITH exhibit reverse snapback phenomena, and even turn to the conducting-state,when the anode voltage in the forward blocking-state is increased to a critical value. The RSP I-V characteristics of the power SITH are analyzed in terms of operating mechanism, double carrier injection effect, space charge effect, electron-hole plasma in the channel, and the variation in carrier lifetime. The reverse snapback mechanism is theoretically pro- posed and the mathematical expressions to calculate the voltage and current values at the snapback point are presented. The computing results are compared with the experiment values.
基金supported by the National Basic Research Program of China (973 Program) (Grant No.2005CB422304)the Ocean University of China Scientific Research Start-up Funds Project for Introduced Talents
文摘The DFI-1 submarine pipeline was investigated using a dual-frequency side-scan sonar and a swath sounder system. More than a hundred scour pits under the pipeline were found, most of which have caused the span of the pipeline to increase and threatened its safety. The maximum allowable free span length (MAFSL) of the pipeline was determined through the limitations re- garding maximum allowable stress under static or quasi-static loads and the onset of Vortex Induced Vibrations (VIV) under different hydrodynamic actions. The results show that the MAFSL under static conditions is 56m. However, the MAFSLs are 30m and 20m under ordinary weather conditions and hurricane-induced currents for the 100-year return period, respectively, to avoid VIV as cal- culated by using the highest safety class factor. It is suggested that spanning pipelines longer than 20 m should be supported. Addi- tionally, eight successive spans which may also threaten the pipeline were proposed. The most hazardous scour pits are along the pipeline section from KP42 to KP51.
基金SUPPORTED BY NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA( NO. 60177010).
文摘Resonant tunneling diode (RTD) of AlAs/InGaAs/AlAs double barrier-single well structure was designed and fabricated. The devices showed current-voltage characteristics with peak-valley current ratio of 4 : 1 at room temperature. The scattering parameter of RTD was measured by using an HP8510(C) network analyzer. Equivalent circuit parameters were obtained by curve fitting and optimized. The RTD switching time was estimated using the measured capacitance and average negative differential resistance. The minimum rise time of the sample was estimated to be 21 ps.
基金Supported by the 12th Five-year Defense Pre-research Fund of China(No.51308030509)
文摘A Y-band frequency doubler is analyzed and designed with GaAs planar Schottky diode, which is flip-chip solded into a 50 μm thick quartz substrate. Diode embedding impedance is found by full- wave analysis with lumped port to model the nonlinear junction for impedance matching without the need of diode equivalent circuit model. All the matching circuit is designed "on-chip" and the mul- tiplier is self-biasing. To the doubler, a conversion efficiency of 6.1% and output power of 5.4mW are measured at 214GHz with input power of 88mW, and the typical measured efficiency is 4.5% in 200 - 225 GHz.
文摘AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert pathologists.METHODS Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic. RESULTS Initial search identified 721 reference articles, of which 53 were selected and reviewed. Twelve studies(n = 971) that met the inclusion criteria were included in this analysis. Among the total original LGD diagnoses in the included studies, only 37.49% reached the consensus LGD diagnosis after review by two or more expert pathologists. Total follow up period was 1532 patient-years. In the pooled consensus LGD patients, the annual incidence rate(AIR) of progression to HGD and or EAC was 10.35%(95%CI: 7.56-13.13) and progression to EAC was 5.18%(95%CI: 3.43-6.92). Among the patients down staged from original LGD diagnosis to No-dysplasia Barrett's esophagus, the AIR of progression to HGD and EAC was 0.65%(95%CI: 0.49-0.80). Among the patients down staged to Indefinite for dysplasia, the AIR of progression to HGD and EAC was 1.42%(95%CI: 1.19-1.65). In patients with consensus HGD diagnosis, the AIR of progression to EAC was 28.63%(95%CI: 13.98-43.27). CONCLUSION When LGD is diagnosed by consensus agreement of two or more expert pathologists, its progression towards malignancy seems to be at least three times the current estimates, however it could be up to 20 times the current estimates. Biopsies of all Barrett's esophagus patients with LGD should be reviewed by two expert gastroenterology pathologists. Follow-up strict surveillance programs should be in place for these patients.
文摘An equivalent electrical network method is presented in this paper to analyze the cooling characteristics of a laser diode module (LDM).And a modified equivalent model of a thermoelectric cooler (TEC) with an adjunctive thermal resistance and a contact resistance is proposed.The performance of a commercial TEC has been simulated.The thermal analysis of a LDM incorporated with a TEC has been performed by using an equivalent circuit model of the LDM.In the analysis the change of LD current,TEC current,and the ambient temperature are all considered.It shows that the equivalent circuit approach is an effective tool for the qualitative analysis of TEC and LDM.
文摘The fundamental case is considered in which flights from many destinations must be scheduled for arrival at a single congested airport having limited capacities.An air traffic control(ATC)model is developed in this case.A new and efficient algorithm for the optimal solution of ground holding strategy problem(GHSP)is put forward and verified by a numerical example.
基金Supported by Department of Mental Health Center andDepartment Gastroenterology of Renmin Hospital of WuhanUniversity, Hubei Province, China
文摘AIM: To investigate changes in vasoactive intestinal polypeptide (VIP) and corticotrophin releasing factor (CRF) in the plasma and duodenum of chronic stress- induced depressed rats and the effects of fluoxetine hydrochloride (fluoxetine) treatment on depression- induced changes in VIP and CRF. METHODS: A Sprague-Dawley rat model of chronic stress-induced depression was produced. Thirty experimental rats were randomly divided into the following groups: control group, saline-treated depressed group, and fluoxetine-treated depressed group. Open- f ield testing was performed to assess the rats’ behavior. VIP and CRF levels in plasma were measured by ELISA. Immunofluorescence techniques combined with laser scanning confocal microscopy (LSCM) were used to investigate VIP and CRF expression in the duodenum. RESULTS: The open-field behavior, both crossing and rearing, of depression model rats, decreased signif icantly compared with those of normal control rats over 5 min. Defecation times increased significantly. Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 ± 2.54 vs 25.17 ± 4.63; plasma CRF: 11.82 ± 2.54 ng/L vs 25.17 ± 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased signif icantly (fluorescence intensity of duodenal VIP: 67.37 ± 18.90 vs 44.51 ± 16.37; plasmaVIP: 67.37 ± 18.90 ng/L vs 44.51 ± 16.37 ng/L, P < 0.01). Fluoxetine improved depressed behavior, increased VIP expression and decreased CRF expression in plasma and the duodenal tissue of depressed rats. CONCLUSION: Chronic stress can induce injury to the duodenum, accompanied by increasing CRF and decreasing VIP in the plasma and duodenum. Treatment with fluoxetine can ameliorate pathological changes in the duodenum of depressed rats, which suggests that antidepressants are an effective therapeutic agent for some duodenal diseases caused by chronic stress. VIP is a potential therapeutic strategy.
文摘AIM: To verify the safety and efficacy of plasma shock wave lithotripsy (PSWL) in fragmenting impacted stones in the bile duct system. METHODS: From September 1988 to April 2005, 67 patients (26 men and 41 women) with impacted stones underwent various biliary operations with tube (or T-tube) drainage. Remnant and impacted stones in the bile duct system found by cholangiography after the operation were fragmented by PSWL and choledochofiberscopy. A total of 201 impacted stones were fragmented by PSWL setting the voltage at 2.5-3.5 kV, and the energy output at 2-3.1 for each pulse of PSWL. Then the fragmented stones were extracted by choledochofiberscopy. The safety and efficacy of PSWL were observed during and after the procedure. RESULTS: One hundred and ninety-nine of 201 impacted stones (99.0%) in the bile duct system were successfully fragmented using PSWL and extracted by choledochofiberscopy. The stone clearance rate for patients was 97% (65/67). Ten patients felt mild pain in the right upper quadrant of the abdomen, and could tolerate it well. Eleven patients had a small amount of bleeding from the mucosa of the bile duct. The bleeding was transient and stopped spontaneously within 2 min of normal saline irrigation. There were no significant complications during and after the procedure. CONCLUSION:PSWL is a safe and effective method for fragmenting impacted stones in the bile duct system.
基金Project(21476269)supported by the National Natural Science Foundation of ChinaProject(14JJ2014)supported by Natural Science Foundation of Hunan Province,China
文摘The assembly of layered double hydroxides (LDHs) and multi-walled carbon nanotubes (MWCNTs) nanohybrids was prepared as MWCNTs/LDHs by co-precipitation. The synthesized nanoparticles were characterized by using XRD, FT-IR, SEM/EDX, TGA and BET. XRD and SEM studies proved that MWCNTs phases did not enter into the interlayers of LDHs, they dispersed over the LDHs surface homogeneously. BET results showed that MWCNTs/LDHs possessed hierarchically porous nanostructure with large surface area (124.974 m^2/g) and great pore volume (0.604 cm^3/g). Batch experiments were conducted to study the adsorption efficiency of Congo red (CR). It was worthy to note that MWCNTs/LDHs exhibited excellent adsorption performance with the maximum CR adsorption capacity of 595.8 mg/g in weak acidic environment. The adsorption kinetics and isotherm parameters can be well described by the pseudo-second-order and the Langmuir isotherm models, respectively. The thermodynamic studies indicated that the adsorption process was spontaneous and endothermic.
基金financially supported by the Scholarship of Knowledge Innovation Project, Chinese Academy of Sciences (KZCX2-YW-332)
文摘Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps.
文摘To carry out lower hybrid wave heating and current drive plasma experiment on tokamak, we need mega-watt order of microwave power generated by the parallel-running klystrons. Those klystrons must be driven by the microwave exciter. Now our microwave exciter is used for many years and its performance is decreased very much. It can not satisfy any more the hybrid wave heating and current drive plasma experiment. So we set out to design a new microwave exciter that is consist of the microwave solid components, amplitudestabilization control, modularization design with multitude-outputs, microwave phase control in order to satisfy the demand of the different work in the hybrid wave heating and current drive plasma experiment.
文摘In this paper, we research on the higher education management mode of China and America based on the perspective of operation mechanism, separation of school and the government. As the thought of higher education management theory or a form, we jump out of the labyrinth of modernism manages view and the introduction of totally different from the modernist paradigm, from the angle of the theory research of postmodernism manages view. The paper is organized as the follows. In the first section, we generally introduce the basic concepts of higher education management and the relationship of the schools and government. Then, by comparing the pattern of the Chinese and the American, we analyze the difference in detail. Finally, we set up the prospect and the conclusion. In conclusion, our method combines the advantages of the American higher education management model which will be meaningful.
基金This paper was supported by the National Natural Science Foundation of China under Grant No. 61073042 the Fundamental Research Funds for the Central Universities under Grant No HEUCF100606 the Open Foundation of Network and Data Security Key Laboratory of Sichuan Province under Crant No 201107.
文摘The authentication and privacy of a group member is important in multicast communication. This paper proposes a privacy-preserving authenticated group-key management protocol for the Mobile Peer-to-Peer Network ( MP2PN ). The MP2PN contains some super peers and each super peer controls a subgroup composed of regular peers. An efficient attribute-based signature based on Cipertext-Policy Attribute-Based Encryption (CP-ABE) is proposed and used in this group-key rmnagement protocol to authenticate a peer's at- tributes and identity. A peer can be described by a set of attributes or one unique special identity at- tribute. Peers that have some attributes in common can form a group and conmmnicate with each other anonymously and securely. Any super peer can initiate a group and act as a group controller. The group controller can authenticate a peer's attributes and identity as well as remove malicious peers. Any peer with attributes that rmtches the access structure can join the group and provide its input to form the group key. The proposed protocol pro- vides backward and forward secrecy. The sinmlation results show that this protocol is applicable for mobile devices and can meet the MP2PN requirements of group communication.
文摘Hong Kong Polytech University is the representative of tourism higher education in Hong Kong, offering various courses in hotel management and tourism management at the Doctor, Masters and Bachelor levels, whose curriculum and education system have been quite perfect. The PolyU has cultivated a large number of high-quality professional people for the hotel and tourism industry. Excellent teachers, modem curriculum and the education concept of attaching great importance to the practice are the reasons why it can cultivate senior executives with international perspective, skills and social responsibility.