AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were...AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.展开更多
To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden...To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden oil-spill from the offshore pipeline has been raised. In this paper, we proposed an optimized model to analyze the main causes(probability) of spill and the consequence with the fuzzy comprehensive assessment model. Considering the complicated assessment process for oil-spill, the assessment factor system involving the spill probability and consequence was established based on the operative manual and statistic leakage/damage data of offshore pipeline in order to estimate the integrated spill risk score automatically. The evaluated factors of spill probability could be grouped into five aspects: corrosion, fatigue, national damage, third party, and operational fault; the consequence evaluated factors of spill included hazard of oil and impact-controlling capability. With some modifications based on experts' opinions, each of the evaluated factors in our work was developed with a relative weight and evaluation criterion. A test example for an offshore pipeline in the Bohai waters was described to show how the model can be used for an actual case in more detail. By using the oil-spill risk assessment model, it is easy to determine the risk level associated with the ongoing activity and management level and hence to take the risk mitigation action immediately.展开更多
文摘AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
基金the Marine Public Welfare Research Project of China (No. 201205012)Preferential Funding of Tianjin
文摘To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden oil-spill from the offshore pipeline has been raised. In this paper, we proposed an optimized model to analyze the main causes(probability) of spill and the consequence with the fuzzy comprehensive assessment model. Considering the complicated assessment process for oil-spill, the assessment factor system involving the spill probability and consequence was established based on the operative manual and statistic leakage/damage data of offshore pipeline in order to estimate the integrated spill risk score automatically. The evaluated factors of spill probability could be grouped into five aspects: corrosion, fatigue, national damage, third party, and operational fault; the consequence evaluated factors of spill included hazard of oil and impact-controlling capability. With some modifications based on experts' opinions, each of the evaluated factors in our work was developed with a relative weight and evaluation criterion. A test example for an offshore pipeline in the Bohai waters was described to show how the model can be used for an actual case in more detail. By using the oil-spill risk assessment model, it is easy to determine the risk level associated with the ongoing activity and management level and hence to take the risk mitigation action immediately.
