Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman...Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg. All lesions completely resolved after topical applications of miltefosine. Tolerance was excellent and the patient remained disease- free 24 months after the end of the treatment. Discussion. Miltefosine, which might prove to be a simpleandeffectivealternativefortheusuallyheavytreatments proposed, warrants further assessment in this context.展开更多
Background:A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis(DCL),a disease with profound physical and psychosocial repercussions and no effective treatment at present,was treated wit...Background:A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis(DCL),a disease with profound physical and psychosocial repercussions and no effective treatment at present,was treated with miltefosine.Methods:The patient was treated for 120 days,100 mg/day for 1 week,then 150 mg/day subsequently.Results:Lesions were free of parasites at 43 days,and no signs of infiltration were present at day 76.No adverse side effects were observed.Conclusions:The dramatic clinical effect of miltefosine in this patient appearsto fully justify further evaluation of this experimental therapy in DCL.展开更多
文摘Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg. All lesions completely resolved after topical applications of miltefosine. Tolerance was excellent and the patient remained disease- free 24 months after the end of the treatment. Discussion. Miltefosine, which might prove to be a simpleandeffectivealternativefortheusuallyheavytreatments proposed, warrants further assessment in this context.
文摘Background:A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis(DCL),a disease with profound physical and psychosocial repercussions and no effective treatment at present,was treated with miltefosine.Methods:The patient was treated for 120 days,100 mg/day for 1 week,then 150 mg/day subsequently.Results:Lesions were free of parasites at 43 days,and no signs of infiltration were present at day 76.No adverse side effects were observed.Conclusions:The dramatic clinical effect of miltefosine in this patient appearsto fully justify further evaluation of this experimental therapy in DCL.
