In commercial applications of phase Doppler anemometry (PDA), the effectiveness of non sphericity of particles is present and the response of PDA system deviates from the theoretical prediction. In this paper, the st...In commercial applications of phase Doppler anemometry (PDA), the effectiveness of non sphericity of particles is present and the response of PDA system deviates from the theoretical prediction. In this paper, the statistic characteristics of PDA signal related to irregular particles is analyzed and a method of statistic classification of irregular particles is proposed.It proves that the parameter of PDA signal for irregular particles is an unbiased estimation for spherical ones, the mean of the phase difference is in direct proportion to the mean diameter of particles and the standard deviation of the phase difference increases linearly with the standard deviation of irregular particles. As an application of the identification of irregular objects, fuzzy patterns and similarities of haemocytes are used to recognize and quantify cell samples.The statistic classification of particles is more significant in practice.展开更多
A novel regularization method -- discriminative regularization (DR)is presented. The method provides a general way to incorporate the prior knowledge for the classification. By introducing the prior information into...A novel regularization method -- discriminative regularization (DR)is presented. The method provides a general way to incorporate the prior knowledge for the classification. By introducing the prior information into the regularization term, DR is used to minimize the empirical loss between the desired and actual outputs, as well as maximize the inter-class separability and minimize the intra-class compactness in the output space simultane- ously. Furthermore, by embedding equality constraints in the formulation, the solution of DR can solve a set of linear equations. Classification experiments show the superiority of the proposed DR.展开更多
Some dimensionality reduction (DR) approaches based on support vector machine (SVM) are proposed. But the acquirement of the projection matrix in these approaches only considers the between-class margin based on S...Some dimensionality reduction (DR) approaches based on support vector machine (SVM) are proposed. But the acquirement of the projection matrix in these approaches only considers the between-class margin based on SVM while ignoring the within-class information in data. This paper presents a new DR approach, call- ed the dimensionality reduction based on SVM and LDA (DRSL). DRSL considers the between-class margins from SVM and LDA, and the within-class compactness from LDA to obtain the projection matrix. As a result, DRSL can realize the combination of the between-class and within-class information and fit the between-class and within-class structures in data. Hence, the obtained projection matrix increases the generalization ability of subsequent classification techniques. Experiments applied to classification techniques show the effectiveness of the proposed method.展开更多
Noise-assisted multivariate empirical mode decomposition(NA-MEMD) is suitable to analyze multichannel electroencephalography(EEG) signals of non-stationarity and non-linearity natures due to the fact that it can provi...Noise-assisted multivariate empirical mode decomposition(NA-MEMD) is suitable to analyze multichannel electroencephalography(EEG) signals of non-stationarity and non-linearity natures due to the fact that it can provide a highly localized time-frequency representation.For a finite set of multivariate intrinsic mode functions(IMFs) decomposed by NA-MEMD,it still raises the question on how to identify IMFs that contain the information of inertest in an efficient way,and conventional approaches address it by use of prior knowledge.In this work,a novel identification method of relevant IMFs without prior information was proposed based on NA-MEMD and Jensen-Shannon distance(JSD) measure.A criterion of effective factor based on JSD was applied to select significant IMF scales.At each decomposition scale,three kinds of JSDs associated with the effective factor were evaluated:between IMF components from data and themselves,between IMF components from noise and themselves,and between IMF components from data and noise.The efficacy of the proposed method has been demonstrated by both computer simulations and motor imagery EEG data from BCI competition IV datasets.展开更多
Modularity is the key to improving the cost-variety trade-off in product development. To achieve the functional independency and structural independency of modules, a method of clustering components to identify module...Modularity is the key to improving the cost-variety trade-off in product development. To achieve the functional independency and structural independency of modules, a method of clustering components to identify modules based on functional and structural analysis was presented. Two stages were included in the method. In the first stage the products’ function was analyzed to determine the primary level of modules. Then the objective function for modules identifying was formulated to achieve functional independency of modules. Finally the genetic algorithm was used to solve the combinatorial optimization problem in modules identifying to form the primary modules of products. In the second stage the cohesion degree of modules and the coupling degree between modules were analyzed. Based on this structural analysis the modular scheme was refined according to the thinking of structural independency. A case study on the gear reducer was conducted to illustrate the validity of the presented method.展开更多
When using AdaBoost to select discriminant features from some feature space (e.g. Gabor feature space) for face recognition, cascade structure is usually adopted to leverage the asymmetry in the distribution of positi...When using AdaBoost to select discriminant features from some feature space (e.g. Gabor feature space) for face recognition, cascade structure is usually adopted to leverage the asymmetry in the distribution of positive and negative samples. Each node in the cascade structure is a classifier trained by AdaBoost with an asymmetric learning goal of high recognition rate but only moderate low false positive rate. One limitation of AdaBoost arises in the context of skewed example distribution and cascade classifiers: AdaBoost minimizes the classification error, which is not guaranteed to achieve the asymmetric node learning goal. In this paper, we propose to use the asymmetric AdaBoost (Asym- Boost) as a mechanism to address the asymmetric node learning goal. Moreover, the two parts of the selecting features and forming ensemble classifiers are decoupled, both of which occur simultaneously in AsymBoost and AdaBoost. Fisher Linear Discriminant Analysis (FLDA) is used on the selected fea- tures to learn a linear discriminant function that maximizes the separability of data among the different classes, which we think can improve the recognition performance. The proposed algorithm is dem- onstrated with face recognition using a Gabor based representation on the FERET database. Ex- perimental results show that the proposed algorithm yields better recognition performance than AdaBoost itself.展开更多
By utilizing hyperbolic tangent function,we constructed a novel hyperbolic tangent loss function to reduce the influences of outliers on support vector machine(SVM)classification problem.The new loss function not only...By utilizing hyperbolic tangent function,we constructed a novel hyperbolic tangent loss function to reduce the influences of outliers on support vector machine(SVM)classification problem.The new loss function not only limits the maximal loss value of outliers but also is smooth.Hyperbolic tangent SVM(HTSVM)is then proposed based on the new loss function.The experimental results show that HTSVM reduces the effects of outliers and gives better generalization performance than the classical SVM on both artificial data and UCI data sets.Therefore,the proposed hyperbolic tangent loss function and HTSVM are both effective.展开更多
This paper presents a novel bootstrap based method for Receiver Operating Characteristic (ROC) analysis of Fisher classifier. By defining Fisher classifier’s output as a statistic, the bootstrap technique is used to ...This paper presents a novel bootstrap based method for Receiver Operating Characteristic (ROC) analysis of Fisher classifier. By defining Fisher classifier’s output as a statistic, the bootstrap technique is used to obtain the sampling distributions of the outputs for the positive class and the negative class respectively. As a result, the ROC curve is a plot of all the (False Positive Rate (FPR), True Positive Rate (TPR)) pairs by varying the decision threshold over the whole range of the boot- strap sampling distributions. The advantage of this method is, the bootstrap based ROC curves are much stable than those of the holdout or cross-validation, indicating a more stable ROC analysis of Fisher classifier. Experiments on five data sets publicly available demonstrate the effectiveness of the proposed method.展开更多
Most of the developed immune based classifiers generate antibodies randomly, which has negative effect on the classification performance. In order to guide the antibody generation effectively, a decision hyper plane h...Most of the developed immune based classifiers generate antibodies randomly, which has negative effect on the classification performance. In order to guide the antibody generation effectively, a decision hyper plane heuristic based artificial immune network classification algorithm (DHPA1NC) is proposed. DHPAINC taboos the inner regions of the class domain, thus, the antibody generation is limited near the class domain boundary. Then, the antibodies are evaluated by their recognition abilities, and the antibodies of low recognition abilities are removed to avoid over-fitting. Finally, the high quality antibodies tend to be stable in the immune network. The algorithm was applied to two simulated datasets classification, and the results show that the decision hyper planes determined by the antibodies fit the class domain boundaries well. Moreover, the algorithm was applied to UCI datasets classification and emotional speech recognition, and the results show that the algorithm has good performance, which means that DHPAINC is a promising classifier.展开更多
Previously, a novel classifier called Kernel-based Nonlinear Discriminator (KND) was proposed to discriminate a pattern class from other classes by minimizing mean effect of the latter. To consider the effect of the t...Previously, a novel classifier called Kernel-based Nonlinear Discriminator (KND) was proposed to discriminate a pattern class from other classes by minimizing mean effect of the latter. To consider the effect of the target class, this paper introduces an oblique projection algorithm to determine the coefficients of a KND so that it is extended to a new version called extended KND (eKND). In eKND construction, the desired output vector of the target class is obliquely projected onto the relevant subspace along the subspace related to other classes. In addition, a simple technique is proposed to calculate the associated oblique projection operator. Experimental results on handwritten digit recognition show that the algorithm performes better than a KND classifier and some other commonly used classifiers.展开更多
Tensor representation is useful to reduce the overfitting problem in vector-based learning algorithm in pattern recognition.This is mainly because the structure information of objects in pattern analysis is a reasonab...Tensor representation is useful to reduce the overfitting problem in vector-based learning algorithm in pattern recognition.This is mainly because the structure information of objects in pattern analysis is a reasonable constraint to reduce the number of unknown parameters used to model a classifier.In this paper, we generalize the vector-based learning algorithm TWin Support Vector Machine(TWSVM) to the tensor-based method TWin Support Tensor Machines(TWSTM), which accepts general tensors as input.To examine the effectiveness of TWSTM, we implement the TWSTM method for Microcalcification Clusters(MCs) detection.In the tensor subspace domain, the MCs detection procedure is formulated as a supervised learning and classification problem, and TWSTM is used as a classifier to make decision for the presence of MCs or not.A large number of experiments were carried out to evaluate and compare the performance of the proposed MCs detection algorithm.By comparison with TWSVM, the tensor version reduces the overfitting problem.展开更多
In this paper, a discriminative structured dictionary learning algorithm is presented. To enhance the dictionary's discriminative power, the reconstruction error, classification error and inhomogeneous representat...In this paper, a discriminative structured dictionary learning algorithm is presented. To enhance the dictionary's discriminative power, the reconstruction error, classification error and inhomogeneous representation error are integrated into the objective function. The proposed approach learns a single structured dictionary and a linear classifier jointly. The learned dictionary encourages the samples from the same class to have similar sparse codes, and the samples from different classes to have dissimilar sparse codes. The solution to the objective function is achieved by employing a feature-sign search algorithm and Lagrange dual method. Experimental results on three public databases demonstrate that the proposed approach outperforms several recently proposed dictionary learning techniques for classification.展开更多
Multi-label data with high dimensionality often occurs,which will produce large time and energy overheads when directly used in classification tasks.To solve this problem,a novel algorithm called multi-label dimension...Multi-label data with high dimensionality often occurs,which will produce large time and energy overheads when directly used in classification tasks.To solve this problem,a novel algorithm called multi-label dimensionality reduction via semi-supervised discriminant analysis(MSDA) was proposed.It was expected to derive an objective discriminant function as smooth as possible on the data manifold by multi-label learning and semi-supervised learning.By virtue of the latent imformation,which was provided by the graph weighted matrix of sample attributes and the similarity correlation matrix of partial sample labels,MSDA readily made the separability between different classes achieve maximization and estimated the intrinsic geometric structure in the lower manifold space by employing unlabeled data.Extensive experimental results on several real multi-label datasets show that after dimensionality reduction using MSDA,the average classification accuracy is about 9.71% higher than that of other algorithms,and several evaluation metrices like Hamming-loss are also superior to those of other dimensionality reduction methods.展开更多
Clinical data have shown that survival rates vary considerably among brain tumor patients,according to the type and grade of the tumor.Metabolite profiles of intact tumor tissues measured with high-resolution magic-an...Clinical data have shown that survival rates vary considerably among brain tumor patients,according to the type and grade of the tumor.Metabolite profiles of intact tumor tissues measured with high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy (HRMAS 1H NMRS) can provide important information on tumor biology and metabolism.These metabolic fingerprints can then be used for tumor classification and grading,with great potential value for tumor diagnosis.We studied the metabolic characteristics of 30 neuroepithelial tumor biopsies,including two astrocytomas (grade I),12 astrocytomas (grade II),eight anaplastic astrocytomas (grade III),three glioblastomas (grade IV) and five medulloblastomas (grade IV) from 30 patients using HRMAS 1H NMRS.The results were correlated with pathological features using multivariate data analysis,including principal component analysis (PCA).There were significant differences in the levels of N-acetyl-aspartate (NAA),creatine,myo-inositol,glycine and lactate between tumors of different grades (P<0.05).There were also significant differences in the ratios of NAA/creatine,lactate/creatine,myo-inositol/creatine,glycine/creatine,scyllo-inositol/creatine and alanine/creatine (P<0.05).A soft independent modeling of class analogy model produced a predictive accuracy of 87% for high-grade (grade III-IV) brain tumors with a sensitivity of 87% and a specificity of 93%.HRMAS 1H NMR spectroscopy in conjunction with pattern recognition thus provides a potentially useful tool for the rapid and accurate classification of human brain tumor grades.展开更多
Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse patternrecognition receptors(PRRs), which are receptor kinases(RKs) and receptor proteins(RPs) specializ...Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse patternrecognition receptors(PRRs), which are receptor kinases(RKs) and receptor proteins(RPs) specialized to detect conserved pathogen/microbe-associated molecular patterns(PAMPs/MAMPs). Although only a handful of RKs and RPs are known PRRs,they belong to the receptor-like kinase(RLK) and receptor-like protein(RLP) superfamilies that undergo lineage-specific expansion, suggesting that many of these RLKs and RLPs are potential PRRs. Analyses of existing PRRs have uncovered ligand-induced RLK-RK or RLK-RP oligomerization as a common mechanism for immune activation. PRRs can recruit additional components to form dynamic receptor complexes, which mediate specific cellular responses. Detailed analyses of these components are shedding light on molecular mechanisms underlying the regulation of PRR activity and downstream signaling.展开更多
文摘In commercial applications of phase Doppler anemometry (PDA), the effectiveness of non sphericity of particles is present and the response of PDA system deviates from the theoretical prediction. In this paper, the statistic characteristics of PDA signal related to irregular particles is analyzed and a method of statistic classification of irregular particles is proposed.It proves that the parameter of PDA signal for irregular particles is an unbiased estimation for spherical ones, the mean of the phase difference is in direct proportion to the mean diameter of particles and the standard deviation of the phase difference increases linearly with the standard deviation of irregular particles. As an application of the identification of irregular objects, fuzzy patterns and similarities of haemocytes are used to recognize and quantify cell samples.The statistic classification of particles is more significant in practice.
基金Supported by the National Natural Science Foundation of China(60773061)the Natural Science Foundation of Jiangsu Province(BK2008381)~~
文摘A novel regularization method -- discriminative regularization (DR)is presented. The method provides a general way to incorporate the prior knowledge for the classification. By introducing the prior information into the regularization term, DR is used to minimize the empirical loss between the desired and actual outputs, as well as maximize the inter-class separability and minimize the intra-class compactness in the output space simultane- ously. Furthermore, by embedding equality constraints in the formulation, the solution of DR can solve a set of linear equations. Classification experiments show the superiority of the proposed DR.
文摘Some dimensionality reduction (DR) approaches based on support vector machine (SVM) are proposed. But the acquirement of the projection matrix in these approaches only considers the between-class margin based on SVM while ignoring the within-class information in data. This paper presents a new DR approach, call- ed the dimensionality reduction based on SVM and LDA (DRSL). DRSL considers the between-class margins from SVM and LDA, and the within-class compactness from LDA to obtain the projection matrix. As a result, DRSL can realize the combination of the between-class and within-class information and fit the between-class and within-class structures in data. Hence, the obtained projection matrix increases the generalization ability of subsequent classification techniques. Experiments applied to classification techniques show the effectiveness of the proposed method.
基金Projects(61201302,61372023,61671197)supported by the National Natural Science Foundation of ChinaProject(201308330297)supported by the State Scholarship Fund of ChinaProject(LY15F010009)supported by Zhejiang Provincial Natural Science Foundation,China
文摘Noise-assisted multivariate empirical mode decomposition(NA-MEMD) is suitable to analyze multichannel electroencephalography(EEG) signals of non-stationarity and non-linearity natures due to the fact that it can provide a highly localized time-frequency representation.For a finite set of multivariate intrinsic mode functions(IMFs) decomposed by NA-MEMD,it still raises the question on how to identify IMFs that contain the information of inertest in an efficient way,and conventional approaches address it by use of prior knowledge.In this work,a novel identification method of relevant IMFs without prior information was proposed based on NA-MEMD and Jensen-Shannon distance(JSD) measure.A criterion of effective factor based on JSD was applied to select significant IMF scales.At each decomposition scale,three kinds of JSDs associated with the effective factor were evaluated:between IMF components from data and themselves,between IMF components from noise and themselves,and between IMF components from data and noise.The efficacy of the proposed method has been demonstrated by both computer simulations and motor imagery EEG data from BCI competition IV datasets.
基金National Basic Research Programme of China (973 Program) (No. 2003CB317005)Key Project of Chinese Ministry of Educa-tion (No. 105065)
文摘Modularity is the key to improving the cost-variety trade-off in product development. To achieve the functional independency and structural independency of modules, a method of clustering components to identify modules based on functional and structural analysis was presented. Two stages were included in the method. In the first stage the products’ function was analyzed to determine the primary level of modules. Then the objective function for modules identifying was formulated to achieve functional independency of modules. Finally the genetic algorithm was used to solve the combinatorial optimization problem in modules identifying to form the primary modules of products. In the second stage the cohesion degree of modules and the coupling degree between modules were analyzed. Based on this structural analysis the modular scheme was refined according to the thinking of structural independency. A case study on the gear reducer was conducted to illustrate the validity of the presented method.
基金Supported by the NSFC-RGC Joint Research Fund (No.60518002)Talent Promotion Foundation of Anhui Province (No.2004Z026)The Science Research Fund of MOE-Microsoft Key Laboratory of Multimedia Com-puting and Communication (No.05071811)
文摘When using AdaBoost to select discriminant features from some feature space (e.g. Gabor feature space) for face recognition, cascade structure is usually adopted to leverage the asymmetry in the distribution of positive and negative samples. Each node in the cascade structure is a classifier trained by AdaBoost with an asymmetric learning goal of high recognition rate but only moderate low false positive rate. One limitation of AdaBoost arises in the context of skewed example distribution and cascade classifiers: AdaBoost minimizes the classification error, which is not guaranteed to achieve the asymmetric node learning goal. In this paper, we propose to use the asymmetric AdaBoost (Asym- Boost) as a mechanism to address the asymmetric node learning goal. Moreover, the two parts of the selecting features and forming ensemble classifiers are decoupled, both of which occur simultaneously in AsymBoost and AdaBoost. Fisher Linear Discriminant Analysis (FLDA) is used on the selected fea- tures to learn a linear discriminant function that maximizes the separability of data among the different classes, which we think can improve the recognition performance. The proposed algorithm is dem- onstrated with face recognition using a Gabor based representation on the FERET database. Ex- perimental results show that the proposed algorithm yields better recognition performance than AdaBoost itself.
基金National Natural Science Foundation of China(No.60705004)
文摘By utilizing hyperbolic tangent function,we constructed a novel hyperbolic tangent loss function to reduce the influences of outliers on support vector machine(SVM)classification problem.The new loss function not only limits the maximal loss value of outliers but also is smooth.Hyperbolic tangent SVM(HTSVM)is then proposed based on the new loss function.The experimental results show that HTSVM reduces the effects of outliers and gives better generalization performance than the classical SVM on both artificial data and UCI data sets.Therefore,the proposed hyperbolic tangent loss function and HTSVM are both effective.
基金the Natural Science Foundation of Zhejiang Province of China (No. Y104540)the Foundation of the Key Laboratory of Advanced Information Science and Network Technology of Beijing, China (No.TDXX0509).
文摘This paper presents a novel bootstrap based method for Receiver Operating Characteristic (ROC) analysis of Fisher classifier. By defining Fisher classifier’s output as a statistic, the bootstrap technique is used to obtain the sampling distributions of the outputs for the positive class and the negative class respectively. As a result, the ROC curve is a plot of all the (False Positive Rate (FPR), True Positive Rate (TPR)) pairs by varying the decision threshold over the whole range of the boot- strap sampling distributions. The advantage of this method is, the bootstrap based ROC curves are much stable than those of the holdout or cross-validation, indicating a more stable ROC analysis of Fisher classifier. Experiments on five data sets publicly available demonstrate the effectiveness of the proposed method.
基金Foundation item: Projects(61170199, 60874070) supported by the National Natural Science Foundation of China Project(11A004) supported by the Major Project of Education Department in Hunan Province, China Project(2010GK3067) supported by Science and Technology Planning of Hunan Province, China
文摘Most of the developed immune based classifiers generate antibodies randomly, which has negative effect on the classification performance. In order to guide the antibody generation effectively, a decision hyper plane heuristic based artificial immune network classification algorithm (DHPA1NC) is proposed. DHPAINC taboos the inner regions of the class domain, thus, the antibody generation is limited near the class domain boundary. Then, the antibodies are evaluated by their recognition abilities, and the antibodies of low recognition abilities are removed to avoid over-fitting. Finally, the high quality antibodies tend to be stable in the immune network. The algorithm was applied to two simulated datasets classification, and the results show that the decision hyper planes determined by the antibodies fit the class domain boundaries well. Moreover, the algorithm was applied to UCI datasets classification and emotional speech recognition, and the results show that the algorithm has good performance, which means that DHPAINC is a promising classifier.
基金Supported by the key project of Chinese Ministry of Education(No.1051150)
文摘Previously, a novel classifier called Kernel-based Nonlinear Discriminator (KND) was proposed to discriminate a pattern class from other classes by minimizing mean effect of the latter. To consider the effect of the target class, this paper introduces an oblique projection algorithm to determine the coefficients of a KND so that it is extended to a new version called extended KND (eKND). In eKND construction, the desired output vector of the target class is obliquely projected onto the relevant subspace along the subspace related to other classes. In addition, a simple technique is proposed to calculate the associated oblique projection operator. Experimental results on handwritten digit recognition show that the algorithm performes better than a KND classifier and some other commonly used classifiers.
基金Supported by the National Natural Science Foundation of China (No. 60771068)the Natural Science Basic Research Plan in Shaanxi Province of China (No. 2007F248)
文摘Tensor representation is useful to reduce the overfitting problem in vector-based learning algorithm in pattern recognition.This is mainly because the structure information of objects in pattern analysis is a reasonable constraint to reduce the number of unknown parameters used to model a classifier.In this paper, we generalize the vector-based learning algorithm TWin Support Vector Machine(TWSVM) to the tensor-based method TWin Support Tensor Machines(TWSTM), which accepts general tensors as input.To examine the effectiveness of TWSTM, we implement the TWSTM method for Microcalcification Clusters(MCs) detection.In the tensor subspace domain, the MCs detection procedure is formulated as a supervised learning and classification problem, and TWSTM is used as a classifier to make decision for the presence of MCs or not.A large number of experiments were carried out to evaluate and compare the performance of the proposed MCs detection algorithm.By comparison with TWSVM, the tensor version reduces the overfitting problem.
基金Supported by the National Natural Science Foundation of China(No.61379014)
文摘In this paper, a discriminative structured dictionary learning algorithm is presented. To enhance the dictionary's discriminative power, the reconstruction error, classification error and inhomogeneous representation error are integrated into the objective function. The proposed approach learns a single structured dictionary and a linear classifier jointly. The learned dictionary encourages the samples from the same class to have similar sparse codes, and the samples from different classes to have dissimilar sparse codes. The solution to the objective function is achieved by employing a feature-sign search algorithm and Lagrange dual method. Experimental results on three public databases demonstrate that the proposed approach outperforms several recently proposed dictionary learning techniques for classification.
基金Project(60425310) supported by the National Science Fund for Distinguished Young ScholarsProject(10JJ6094) supported by the Hunan Provincial Natural Foundation of China
文摘Multi-label data with high dimensionality often occurs,which will produce large time and energy overheads when directly used in classification tasks.To solve this problem,a novel algorithm called multi-label dimensionality reduction via semi-supervised discriminant analysis(MSDA) was proposed.It was expected to derive an objective discriminant function as smooth as possible on the data manifold by multi-label learning and semi-supervised learning.By virtue of the latent imformation,which was provided by the graph weighted matrix of sample attributes and the similarity correlation matrix of partial sample labels,MSDA readily made the separability between different classes achieve maximization and estimated the intrinsic geometric structure in the lower manifold space by employing unlabeled data.Extensive experimental results on several real multi-label datasets show that after dimensionality reduction using MSDA,the average classification accuracy is about 9.71% higher than that of other algorithms,and several evaluation metrices like Hamming-loss are also superior to those of other dimensionality reduction methods.
基金supported by the National Natural Science Foundation of China (Grant Nos. 20573132 and 20575074)China Postdoctoral Science Foundation (Grant No. 20090450065)State Key Laboratory of Mag-netic Resonance and Atomic and Molecular Physics (Grant No. T152805)
文摘Clinical data have shown that survival rates vary considerably among brain tumor patients,according to the type and grade of the tumor.Metabolite profiles of intact tumor tissues measured with high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy (HRMAS 1H NMRS) can provide important information on tumor biology and metabolism.These metabolic fingerprints can then be used for tumor classification and grading,with great potential value for tumor diagnosis.We studied the metabolic characteristics of 30 neuroepithelial tumor biopsies,including two astrocytomas (grade I),12 astrocytomas (grade II),eight anaplastic astrocytomas (grade III),three glioblastomas (grade IV) and five medulloblastomas (grade IV) from 30 patients using HRMAS 1H NMRS.The results were correlated with pathological features using multivariate data analysis,including principal component analysis (PCA).There were significant differences in the levels of N-acetyl-aspartate (NAA),creatine,myo-inositol,glycine and lactate between tumors of different grades (P<0.05).There were also significant differences in the ratios of NAA/creatine,lactate/creatine,myo-inositol/creatine,glycine/creatine,scyllo-inositol/creatine and alanine/creatine (P<0.05).A soft independent modeling of class analogy model produced a predictive accuracy of 87% for high-grade (grade III-IV) brain tumors with a sensitivity of 87% and a specificity of 93%.HRMAS 1H NMR spectroscopy in conjunction with pattern recognition thus provides a potentially useful tool for the rapid and accurate classification of human brain tumor grades.
基金supported by Chinese Ministry of Science and Technology(2015CB910201)Chinese Academy of Sciences Strategic Priority Research Program(XDB11020200)
文摘Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse patternrecognition receptors(PRRs), which are receptor kinases(RKs) and receptor proteins(RPs) specialized to detect conserved pathogen/microbe-associated molecular patterns(PAMPs/MAMPs). Although only a handful of RKs and RPs are known PRRs,they belong to the receptor-like kinase(RLK) and receptor-like protein(RLP) superfamilies that undergo lineage-specific expansion, suggesting that many of these RLKs and RLPs are potential PRRs. Analyses of existing PRRs have uncovered ligand-induced RLK-RK or RLK-RP oligomerization as a common mechanism for immune activation. PRRs can recruit additional components to form dynamic receptor complexes, which mediate specific cellular responses. Detailed analyses of these components are shedding light on molecular mechanisms underlying the regulation of PRR activity and downstream signaling.