Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 w...Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.展开更多
This paper addresses multi-resource fair allocation: a fundamental research topic in cloud computing. To improve resource utilization under well-studied fairness constraints, we propose a new allocation mechanism call...This paper addresses multi-resource fair allocation: a fundamental research topic in cloud computing. To improve resource utilization under well-studied fairness constraints, we propose a new allocation mechanism called Dominant Resource with Bottlenecked Fairness(DRBF), which generalizes Bottleneck-aware Allocation(BAA) to the settings of Dominant Resource Fairness(DRF). We classify users into different queues by their dominant resources. The goals are to ensure that users in the same queue receive allocations in proportion to their fair shares while users in different queues receive allocations that maximize resource utilization subject to well-studied fairness properties such as those in DRF. Under DRBF, no user 1) is worse off sharing resources than dividing resources equally among all users; 2) prefers the allocation of another user; 3) can improve their own allocation without reducing other users' allocations; and(4) can benefit by misreporting their resource demands. Experiments demonstrate that the proposed allocation policy performs better in terms of high resource utilization than does DRF.展开更多
A new algorithm for segmentation of suspected lung ROI(regions of interest)by mean-shift clustering and multi-scale HESSIAN matrix dot filtering was proposed.Original image was firstly filtered by multi-scale HESSIAN ...A new algorithm for segmentation of suspected lung ROI(regions of interest)by mean-shift clustering and multi-scale HESSIAN matrix dot filtering was proposed.Original image was firstly filtered by multi-scale HESSIAN matrix dot filters,round suspected nodular lesions in the image were enhanced,and linear shape regions of the trachea and vascular were suppressed.Then,three types of information,such as,shape filtering value of HESSIAN matrix,gray value,and spatial location,were introduced to feature space.The kernel function of mean-shift clustering was divided into product form of three kinds of kernel functions corresponding to the three feature information.Finally,bandwidths were calculated adaptively to determine the bandwidth of each suspected area,and they were used in mean-shift clustering segmentation.Experimental results show that by the introduction of HESSIAN matrix of dot filtering information to mean-shift clustering,nodular regions can be segmented from blood vessels,trachea,or cross regions connected to the nodule,non-nodular areas can be removed from ROIs properly,and ground glass object(GGO)nodular areas can also be segmented.For the experimental data set of 127 different forms of nodules,the average accuracy of the proposed algorithm is more than 90%.展开更多
AIM:To investigate the effect of dietary fiber intake on constipation by a meta-analysis of randomized controlled trials(RCTs).METHODS:We searched Ovid MEDLINE(from 1946 to October 2011),Cochrane Library(2011),PubMed ...AIM:To investigate the effect of dietary fiber intake on constipation by a meta-analysis of randomized controlled trials(RCTs).METHODS:We searched Ovid MEDLINE(from 1946 to October 2011),Cochrane Library(2011),PubMed for articles on dietary fiber intake and constipation using the terms:constipation,fiber,cellulose,plant extracts,cereals,bran,psyllium,or plantago.References of important articles were searched manually for relevant studies.Articles were eligible for the meta-analysis if they were high-quality RCTs and reported data on stool frequency,stool consistency,treatment success,laxative use and gastrointestinal symptoms.The data were extracted independently by two researchers(Yang J and Wang HP) according to the described selection criteria.Review manager version 5 software was used for analysis and test.Weighted mean difference with 95%CI was used for quantitative data,odds ratio(OR)with 95%CI was used for dichotomous data.Both I2 statistic with a cut-off of ≥ 50% and the χ2 test with a P value < 0.10 were used to define a significant degree of heterogeneity.RESULTS:We searched 1322 potential relevant articles,19 of which were retrieved for further assessment,14 studies were excluded for various reasons,five studies were included in the analysis.Dietary fiber showed significant advantage over placebo in stool frequency(OR = 1.19;95%CI:0.58-1.80,P < 0.05).There was no significant difference in stool consistency,treatment success,laxative use and painful defecation between the two groups.Stool frequency were reported by five RCTs,all results showed either a trend or a significant difference in favor of the treatment group,number of stools per week increased in treatment group than in placebo group(OR = 1.19;95%CI:0.58-1.80,P < 0.05),with no significant heterogeneity among studies(I2= 0,P = 0.77).Four studies evaluated stool consistency,one of them presented outcome in terms of percentage of hard stool,which was different from others,so we included the other three studies for analysis.Two studies reported treatment success.There was significant heterogeneity between the studies(P < 0.1,I2 > 50%).Three studies reported laxative use,quantitative data was shown in one study,and the pooled analysis of the other two studies showed no significant difference between treatment and placebo groups in laxative use(OR = 1.07;95%CI 0.51-2.25),and no heterogeneity was found(P = 0.84,I2= 0).Three studies evaluated painful defecation:one study presented both quantitative and dichotomous data,the other two studies reported quantitative and dichotomous data separately.We used dichotomous data for analysis.CONCLUSION:Dietary fiber intake can obviously increase stool frequency in patients with constipation.It does not obviously improve stool consistency,treatment success,laxative use and painful defecation.展开更多
In this paper, we investigate conservation laws of a class of partial differential equations, which combines the nonlinear telegraph equations and the nonlinear diffusion-convection equations. Moreover, some special c...In this paper, we investigate conservation laws of a class of partial differential equations, which combines the nonlinear telegraph equations and the nonlinear diffusion-convection equations. Moreover, some special conservation laws of the combined equations are obtained by means of symmetry classifications of wave equations uxx = H （x）utt.展开更多
IN the presence of septic shock, every hour in delaying the administration of effective antibiotics is associated with a measurable increase in mortality. This is especially true for neutropenic patients with septic s...IN the presence of septic shock, every hour in delaying the administration of effective antibiotics is associated with a measurable increase in mortality. This is especially true for neutropenic patients with septic shock. As there is a higher incidence of involving multi-drug resistant pathogens for neutropenic patients, the decision on antibiotics regime remains a challenge for physicians.2 Immunosuppression and previous antibacterial use are factors that promote the spread of multi-drug resistant pathogens, and the possibility of co-existing multi-drug resistant pathogens should be suspected when treating patients with these risk factors who developed refractory shock. Here we present a case with neutropenic fever and refractory shock whose blood culture yielded multi-drug resistant Acinetobacter baumannii and carbapenem- resistant Klebsiella pneumoniae.展开更多
文摘Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P<0.01). (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification (P>0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.
基金financial support of the Oversea Study Program of the Guangzhou Elite Project(GEP)supported by the National Natural Science Foundation of China under Grant 61471173Guangdong Science Technology Project(no:2017A010101027)
文摘This paper addresses multi-resource fair allocation: a fundamental research topic in cloud computing. To improve resource utilization under well-studied fairness constraints, we propose a new allocation mechanism called Dominant Resource with Bottlenecked Fairness(DRBF), which generalizes Bottleneck-aware Allocation(BAA) to the settings of Dominant Resource Fairness(DRF). We classify users into different queues by their dominant resources. The goals are to ensure that users in the same queue receive allocations in proportion to their fair shares while users in different queues receive allocations that maximize resource utilization subject to well-studied fairness properties such as those in DRF. Under DRBF, no user 1) is worse off sharing resources than dividing resources equally among all users; 2) prefers the allocation of another user; 3) can improve their own allocation without reducing other users' allocations; and(4) can benefit by misreporting their resource demands. Experiments demonstrate that the proposed allocation policy performs better in terms of high resource utilization than does DRF.
基金Projects(61172002,61001047,60671050)supported by the National Natural Science Foundation of ChinaProject(N100404010)supported by Fundamental Research Grant Scheme for the Central Universities,China
文摘A new algorithm for segmentation of suspected lung ROI(regions of interest)by mean-shift clustering and multi-scale HESSIAN matrix dot filtering was proposed.Original image was firstly filtered by multi-scale HESSIAN matrix dot filters,round suspected nodular lesions in the image were enhanced,and linear shape regions of the trachea and vascular were suppressed.Then,three types of information,such as,shape filtering value of HESSIAN matrix,gray value,and spatial location,were introduced to feature space.The kernel function of mean-shift clustering was divided into product form of three kinds of kernel functions corresponding to the three feature information.Finally,bandwidths were calculated adaptively to determine the bandwidth of each suspected area,and they were used in mean-shift clustering segmentation.Experimental results show that by the introduction of HESSIAN matrix of dot filtering information to mean-shift clustering,nodular regions can be segmented from blood vessels,trachea,or cross regions connected to the nodule,non-nodular areas can be removed from ROIs properly,and ground glass object(GGO)nodular areas can also be segmented.For the experimental data set of 127 different forms of nodules,the average accuracy of the proposed algorithm is more than 90%.
文摘AIM:To investigate the effect of dietary fiber intake on constipation by a meta-analysis of randomized controlled trials(RCTs).METHODS:We searched Ovid MEDLINE(from 1946 to October 2011),Cochrane Library(2011),PubMed for articles on dietary fiber intake and constipation using the terms:constipation,fiber,cellulose,plant extracts,cereals,bran,psyllium,or plantago.References of important articles were searched manually for relevant studies.Articles were eligible for the meta-analysis if they were high-quality RCTs and reported data on stool frequency,stool consistency,treatment success,laxative use and gastrointestinal symptoms.The data were extracted independently by two researchers(Yang J and Wang HP) according to the described selection criteria.Review manager version 5 software was used for analysis and test.Weighted mean difference with 95%CI was used for quantitative data,odds ratio(OR)with 95%CI was used for dichotomous data.Both I2 statistic with a cut-off of ≥ 50% and the χ2 test with a P value < 0.10 were used to define a significant degree of heterogeneity.RESULTS:We searched 1322 potential relevant articles,19 of which were retrieved for further assessment,14 studies were excluded for various reasons,five studies were included in the analysis.Dietary fiber showed significant advantage over placebo in stool frequency(OR = 1.19;95%CI:0.58-1.80,P < 0.05).There was no significant difference in stool consistency,treatment success,laxative use and painful defecation between the two groups.Stool frequency were reported by five RCTs,all results showed either a trend or a significant difference in favor of the treatment group,number of stools per week increased in treatment group than in placebo group(OR = 1.19;95%CI:0.58-1.80,P < 0.05),with no significant heterogeneity among studies(I2= 0,P = 0.77).Four studies evaluated stool consistency,one of them presented outcome in terms of percentage of hard stool,which was different from others,so we included the other three studies for analysis.Two studies reported treatment success.There was significant heterogeneity between the studies(P < 0.1,I2 > 50%).Three studies reported laxative use,quantitative data was shown in one study,and the pooled analysis of the other two studies showed no significant difference between treatment and placebo groups in laxative use(OR = 1.07;95%CI 0.51-2.25),and no heterogeneity was found(P = 0.84,I2= 0).Three studies evaluated painful defecation:one study presented both quantitative and dichotomous data,the other two studies reported quantitative and dichotomous data separately.We used dichotomous data for analysis.CONCLUSION:Dietary fiber intake can obviously increase stool frequency in patients with constipation.It does not obviously improve stool consistency,treatment success,laxative use and painful defecation.
文摘In this paper, we investigate conservation laws of a class of partial differential equations, which combines the nonlinear telegraph equations and the nonlinear diffusion-convection equations. Moreover, some special conservation laws of the combined equations are obtained by means of symmetry classifications of wave equations uxx = H （x）utt.
文摘IN the presence of septic shock, every hour in delaying the administration of effective antibiotics is associated with a measurable increase in mortality. This is especially true for neutropenic patients with septic shock. As there is a higher incidence of involving multi-drug resistant pathogens for neutropenic patients, the decision on antibiotics regime remains a challenge for physicians.2 Immunosuppression and previous antibacterial use are factors that promote the spread of multi-drug resistant pathogens, and the possibility of co-existing multi-drug resistant pathogens should be suspected when treating patients with these risk factors who developed refractory shock. Here we present a case with neutropenic fever and refractory shock whose blood culture yielded multi-drug resistant Acinetobacter baumannii and carbapenem- resistant Klebsiella pneumoniae.
