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钙剂联合活性维生素D对使用不同剂量糖皮质激素肾脏病患者骨密度的影响 被引量:5
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作者 刘宝莲 张湖海 +2 位作者 申兵冰 雷丽均 赵洪雯 《中国现代医学杂志》 CAS 2019年第20期59-63,共5页
目的观察钙剂联合活性维生素D对肾脏病患者初次接受糖皮质激素(GC)治疗后骨密度的影响。方法将78例接受GC治疗的肾脏病患者按激素使用剂量分为低剂量激素组(A组)和足量激素组(B组),每组根据不同的治疗方案再分为两组(A组分为A1组和A2组,... 目的观察钙剂联合活性维生素D对肾脏病患者初次接受糖皮质激素(GC)治疗后骨密度的影响。方法将78例接受GC治疗的肾脏病患者按激素使用剂量分为低剂量激素组(A组)和足量激素组(B组),每组根据不同的治疗方案再分为两组(A组分为A1组和A2组,B组分为B1组和B2组)。A1组予醋酸钙胶囊600 mg,A2组与B1组予醋酸钙胶囊600 mg联合骨化三醇0.25μg,B2组予醋酸钙胶囊1 200 mg联合骨化三醇0.5μg。收集第6和12个月腰椎L1~L4的骨密度,以及腰背部疼痛评分并记录不良反应。结果A1组患者治疗第12个月时骨密度比第6个月下降(P<0.05);A2组患者治疗第12个月时骨密度与第6个月相似(P>0.05)。A2组治疗第12个月时骨密度高于A1组(P<0.05)。B1组治疗第12个月时骨密度较第6个月下降(P<0.05),而B2组治疗第12个月时骨密度较第6个月上升(P<0.05)。B1与B2组治疗第6个月时骨密度比较,差异无统计学意义(P>0.05),B2组治疗第12个月时骨密度高于B1组(P<0.05)。结论对于接受中小剂量GC治疗的肾脏病患者,每日补充活性维生素D 0.25μg和醋酸钙胶囊600 mg,能有效防治骨质丢失;对于使用足量激素者,每日活性维生素D 0.5μg和醋酸钙胶囊1 200 mg的治疗不足以防治骨量流失。 展开更多
关键词 肾脏用药 糖皮质激素 骨密度 类钙剂 维生素D
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Protective Role of Ca Against NaCl Toxicity in Jerusalem Artichoke by Up-Regulation of Antioxidant Enzymes 被引量:38
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作者 XUE Yan-Feng LIU Ling +2 位作者 LIU Zhao-Pu S. K. MEHTA ZHAO Geng-Mao 《Pedosphere》 SCIE CAS CSCD 2008年第6期766-774,共9页
The ameliorative effect of external Ca^2+ on Jerusalem artichoke (Helianthus tuberosus L.) under salt stress was studied through biochemical and physiological analyses of Jerusalem artichoke seedlings treated with ... The ameliorative effect of external Ca^2+ on Jerusalem artichoke (Helianthus tuberosus L.) under salt stress was studied through biochemical and physiological analyses of Jerusalem artichoke seedlings treated with or without 10 mol L^-1 CaCl2, 150 mmol L^-1 NaCl, and/or 5 mmol L^-1 ethylene-bis(oxyethylenenitrilo)-tetraacetic acid (EGTA) for five days. Exposure to NaC1 (150 mmol L^-1) decreased growth, leaf chlorophyll content, and photosynthetic rate of Jerusalem artichoke seedlings. NaC1 treatment showed 59% and 37% higher lipid peroxidation and electrolyte leakage, respectively, than the control. The activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) were decreased by NaCl, indicating an impeded antioxidant defense mechanism of Jerusalem artichoke grown under salt stress. Addition of 10 mmol L^-1 CaCl2 to the salt solutions significantly decreased the damaging effect of NaC1 on growth and chlorophyll content and simultaneously restored the rate of photosynthesis almost to the level of the control. Ca^2+ addition decreased the leaf malondialdehyde (MDA) content and electrolyte leakage from NaCl-treated seedlings by 47% and 24%, respectively, and significantly improved the activities of SOD, POD, and CAT in NaCl-treated plants. Addition of EGTA, a specific chelator of Ca2+, decreased the growth, chlorophyll content, and photosynthesis, and increased level of MDA and electrolyte leakage from NaCl-treated plants and from the control plants. EGTA addition to the growth medium also repressed the activities of SOD, POD, and CAT in NaCl-treated and control seedlings. External Ca2+ might protect Jerusalem artichoke against NaC1 stress by up-regulating the activities of antioxidant enzymes and thereby decreasing the oxidative stress. 展开更多
关键词 antioxidant enzymes CALCIUM Jerusalem artichoke lipid peroxidation salt stress
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Effects of 4 Types of Remediation Agents on Reducing Cd Contents in Soil and Rice on Cd-contaminated Farmland 被引量:1
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作者 HU Qing-yun TANG You-gen +4 位作者 ZHANG Zhi-qiang LUO Ying ZHANG Xiao-yi XIAO Huan AO He-jun 《Agricultural Science & Technology》 CAS 2021年第3期7-12,共6页
A field experiment was carried out in Cd-contaminated rice fields in a county of Hengyang to explore the effects of different types of remediation agents on the contents of soil available Cd and rice Cd,and rice yield... A field experiment was carried out in Cd-contaminated rice fields in a county of Hengyang to explore the effects of different types of remediation agents on the contents of soil available Cd and rice Cd,and rice yield by using one rice variety Longliangyouhuazhan,and 4 kinds of remediation agents:DG foliar control agent,SMA microbial inoculant,XFJ organic fertilizer and LXM calcium-and silicon-based passivator as test materials.The results showed that compared with CK,after applying DG foliar control agent,soil available Cd content increased rather than decreased,whereas rice Cd content decreased,not reaching a significant level.When applied with SMA microbial inoculant,soil pH value,soil available Cd and rice Cd contents showed a downward then upward trend with the increase of its application rates.Between 3 levels of SMA treatments,the content of soil available Cd in SMA2 was the lowest,decreased by 8.59%in comparison with CK,contrarily,two other SMA treatments were increasing instead of decreasing in the content of soil available Cd.The application of XFJ organic fertilizer and LXM calcium-and silicon-based passivator increased soil pH value,and reduced soil available Cd and rice Cd contents;the contents of soil available Cd and rice Cd decreased with their application rates increasing.Compared with CK,XFJ3 reduced soil available Cd content by 9.40%,and significantly reduced rice Cd content by 57.28%.In LXM3 treatment,soil available Cd content reduced by 14.57%,rice Cd content was 71.57%lower than CK,reaching the lowest level.In general,LXM calcium-and silicon-based passivator had the best Cd reduction effect,with the optimal application amount of 6000 kg/hm^(2). 展开更多
关键词 RICE Remediation of Cd-contaminated farmland Foliar control agent Organic fertilizer Microbial inoculant Calcium-and silicon-based passivator Cd reduction effect
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温肾壮骨汤联合钙制剂及维生素D治疗老年性骨质疏松症临床研究 被引量:12
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作者 范琳燕 《国际中医中药杂志》 2016年第8期705-708,共4页
目的:评价温肾壮骨汤联合钙制剂及维生素 D 治疗老年性骨质疏松症(osteorosis pathological, OP)的疗效。方法将符合入选标准的82例老年OP患者采用随机数字表法分为2组各41例。对照组给予常规治疗(钙制剂、维生素D),观察组在对照... 目的:评价温肾壮骨汤联合钙制剂及维生素 D 治疗老年性骨质疏松症(osteorosis pathological, OP)的疗效。方法将符合入选标准的82例老年OP患者采用随机数字表法分为2组各41例。对照组给予常规治疗(钙制剂、维生素D),观察组在对照组基础上加服温肾壮骨汤。2组均连续治疗10周,随访3个月。观察治疗前后老年OP患者骨密度(bone mineral density, BMD)、骨钙素(osteocalcin, BGP)、骨碱性磷酸酶(bone-specific alkaline phosphatase, BALP)的变化,评价疗效及不良反应发生情况。结果观察组总有效率为90.24%(37/41)、对照组为70.73%(29/41),2组比较差异有统计学意义(χ2=4.970,P=0.026)。治疗后,观察组 BMD[(0.84±0.05)g/cm2比(0.78±0.06)g/cm2, t=4.919]、BGP[(28.64±12.14)ng/ml比(21.32±11.25)ng/ml,t=2.832]、BALP[(18.11±6.15)U/L比(14.54±6.21)U/L,t=2.615]高于对照组(P<0.01或 P<0.05)。治疗期间,观察组不良反应发生率为7.32%(3/41)、对照组为24.39%(10/41),2组比较差异有统计学意义(χ2=4.479,P=0.034)。随访3个月,对照组OP性骨折率为26.83%(11/41)、观察组为9.76%(4/41),2组比较差异有统计学意义(χ2=3.400,P=0.045)。结论温肾壮骨汤联合钙制剂及维生素D可改善老年OP患者症状,预防老年性OP骨折。 展开更多
关键词 骨质疏松 老年人 类钙剂 温肾壮骨汤 骨密度 骨钙素 碱性磷酸酶
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西那卡塞联合骨化三醇对血液透析患者难治性继发性甲状旁腺功能亢进的干预研究 被引量:28
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作者 费良玉 李浩 张宝文 《中国医师杂志》 CAS 2018年第4期584-586,共3页
目的探讨西那卡塞联合骨化三醇治疗维持性血液透析(MHD)患者伴难治性继发性甲状旁腺功能亢进(SHPT)的临床效果。方法选取本院血液透析室MHD伴难治性SHPT患者20例,予以西那卡塞联合小剂量骨化三醇治疗6个月,观察患者治疗前后血清钙(SCa)... 目的探讨西那卡塞联合骨化三醇治疗维持性血液透析(MHD)患者伴难治性继发性甲状旁腺功能亢进(SHPT)的临床效果。方法选取本院血液透析室MHD伴难治性SHPT患者20例,予以西那卡塞联合小剂量骨化三醇治疗6个月,观察患者治疗前后血清钙(SCa)、血磷(SP)、全段甲状旁腺素(iPTH)、钙磷乘积(Ca×P)、碱性磷酸酶(ALP)、白蛋白(ALB)、甲状旁腺体积(PGV)的变化及临床症状。结果西那卡塞联合小剂量骨化三醇治疗后,SCa、SP、Ca×P、iPTH、ALP、PGV均较治疗前下降,差异均有统计学意义(P<0.01),但ALB差异无统计学意义(P=0.97)。患者皮肤瘙痒、骨痛及皮下软组织钙化均有不同程度缓解。结论西那卡塞联合骨化三醇对MHD伴SHPT患者有明显的临床疗效,且不良反应及风险小,对于不能耐受手术的尿毒症患者亦是一种较好的治疗方法。 展开更多
关键词 类钙剂/投药和剂量 骨化三醇/投药和剂量 肾透析/副作用 甲状旁腺功能亢进症 继发性/病因学/药物疗法
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