Aim A new solid SMEDDS (self-microemulsifying drug delivery system) capsule has been developed to increase the solubility and dissolution rate. Methods The solubilities of carvedilol in various bases were investigated...Aim A new solid SMEDDS (self-microemulsifying drug delivery system) capsule has been developed to increase the solubility and dissolution rate. Methods The solubilities of carvedilol in various bases were investigated. Ternary phase diagrams were used to evaluate the self-emulsification and self-microemulsfication domains. The particle size distribution and ζ-potential were determined. The mean diameter of the three formulae decreased with an increase of Lutrol F68. Results The in vitro dissolution rate of ...展开更多
Gate valve has various placements in the practical usages.Due to the effect of gravity,particle trajectories and erosions are distinct between placements.Thus in this study,gas-solid flow properties and erosion in gat...Gate valve has various placements in the practical usages.Due to the effect of gravity,particle trajectories and erosions are distinct between placements.Thus in this study,gas-solid flow properties and erosion in gate valve for horizontal placement and vertical placement are discussed and compared by using Euler-Lagrange simulation method.The structure of a gate valve and a simplified structure are investigated.The simulation procedure is validated in our published paper by comparing with the experiment data of a pipe and an elbow.The results show that for all investigated open degrees and Stokes numbers(St),there are little difference of gas flow properties and flow coefficients between two placements.It is also found that the trajectories of particles for two placements are mostly identical when St << 1,making the erosion independent of placement.With the increase of St,the distinction of trajectories between placements becomes more obvious,leading to an increasing difference of the erosion distributions.Besides,the total erosion ratio of surface T for horizontal placement is two orders of magnitudes larger than that for vertical placement when the particle diameter is 250 μm.展开更多
Many sensor network applications require location awareness,but it is often too expensive to equip a global positioning system(GPS) receiver for each network node.Hence,localization schemes for sensor networks typical...Many sensor network applications require location awareness,but it is often too expensive to equip a global positioning system(GPS) receiver for each network node.Hence,localization schemes for sensor networks typically use a small number of seed nodes that know their locations and protocols whereby other nodes estimate their locations from the messages they receive.For the inherent shortcomings of general particle filter(the sequential Monte Carlo method) this paper introduces particle swarm optimization and weighted centroid algorithm to optimize it.Based on improvement a distributed localization algorithm named WC-IPF(weighted centroid algorithm improved particle filter) has been proposed for localization.In this localization scheme the initial estimate position can be acquired by weighted centroid algorithm.Then the accurate position can be gotten via improved particle filter recursively.The extend simulation results show that the proposed algorithm is efficient for most condition.展开更多
文摘Aim A new solid SMEDDS (self-microemulsifying drug delivery system) capsule has been developed to increase the solubility and dissolution rate. Methods The solubilities of carvedilol in various bases were investigated. Ternary phase diagrams were used to evaluate the self-emulsification and self-microemulsfication domains. The particle size distribution and ζ-potential were determined. The mean diameter of the three formulae decreased with an increase of Lutrol F68. Results The in vitro dissolution rate of ...
基金supported by National Natural Science Foundation of China(Grant No.21276241)etc
文摘Gate valve has various placements in the practical usages.Due to the effect of gravity,particle trajectories and erosions are distinct between placements.Thus in this study,gas-solid flow properties and erosion in gate valve for horizontal placement and vertical placement are discussed and compared by using Euler-Lagrange simulation method.The structure of a gate valve and a simplified structure are investigated.The simulation procedure is validated in our published paper by comparing with the experiment data of a pipe and an elbow.The results show that for all investigated open degrees and Stokes numbers(St),there are little difference of gas flow properties and flow coefficients between two placements.It is also found that the trajectories of particles for two placements are mostly identical when St << 1,making the erosion independent of placement.With the increase of St,the distinction of trajectories between placements becomes more obvious,leading to an increasing difference of the erosion distributions.Besides,the total erosion ratio of surface T for horizontal placement is two orders of magnitudes larger than that for vertical placement when the particle diameter is 250 μm.
文摘Many sensor network applications require location awareness,but it is often too expensive to equip a global positioning system(GPS) receiver for each network node.Hence,localization schemes for sensor networks typically use a small number of seed nodes that know their locations and protocols whereby other nodes estimate their locations from the messages they receive.For the inherent shortcomings of general particle filter(the sequential Monte Carlo method) this paper introduces particle swarm optimization and weighted centroid algorithm to optimize it.Based on improvement a distributed localization algorithm named WC-IPF(weighted centroid algorithm improved particle filter) has been proposed for localization.In this localization scheme the initial estimate position can be acquired by weighted centroid algorithm.Then the accurate position can be gotten via improved particle filter recursively.The extend simulation results show that the proposed algorithm is efficient for most condition.
