The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is us...The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is useful for operating and controlling the temperature,especially in photovoltaic technology and solar panels.Motivated by these applications,the current study is based on the nanoparticle aggregation effect on magnetohydrodynamics(MHD)flow via rotating parallel plates with the chemical reaction.To achieve maximum heat transportation,the Bruggeman model is used to adapt the Maxwell model.Also,melting and thermal radiation effects are considered in the modeling to discuss heat transport.The Runge-Kutta-Fehlberg 4th−5th order method is used to attain numerical solutions.The main focus of this study is to see the thermodynamic behavior considering several aspects of nanoparticle aggregation.The heat transfer rate between the parallel plates is enhanced by improving the thermophoresis,radiation,and Brownian motion parameters.The rise in Schmidt number and chemical reaction rate parameter decreases the concentration distribution.This study will be helpful in enhancing the thermal efficiency of photovoltaic technology in solar plates,water purifying,thermal management of electronic devices,designing effective cooling systems,and other sustainable technologies.展开更多
Nano SiO2 was filled into gypsum particleboard. Effect of the amount of nano SiO2 particles filled, ultrasonic dissipating duration and treating the nano particles with different coupling agents on the mechanical prop...Nano SiO2 was filled into gypsum particleboard. Effect of the amount of nano SiO2 particles filled, ultrasonic dissipating duration and treating the nano particles with different coupling agents on the mechanical properties of the board were studied respectively. The results show that nano SiO2 is helpful for the improvement of the properties. Adding 3%(mass fraction) nano SiO2 is the best for the improvement of both modulus of rupture(MOR) and modulus of elasticity(MOE) of the boards formed at 30 ℃ or 40 ℃. For the boards formed at 30 ℃, their MOR and MOE can be improved by 8.77% and 12.24%, and MOR and MOE of the boards formed at 40 ℃ can be improved by 44.44% and 108.38%.3% is also the best addition proportion to improve internal bond(IB) of the boards formed at 30 ℃, while 5% is the best for that of the boards formed at 40 ℃. At room temperature, dissipating nano SiO2 into flake by ultrasonic has better effect on the properties of the final products. Through ultrasonic treating for 1 h and the best treating duration, the MOR and MOE can be increased by 41.99% and 47.80%. In addition, different coupling agents have different effects on the final properties too, and silane coupling agent KH570 is better for the improvement of properties of the boards formed at room temperature.展开更多
The effects of berbamine, an alkaloid of dibenzylisoquinoline, on PAF produc tion in human neutrophils and on platelet aggregation induced by PAF were studied and compared with those of the calcium antagonist verapam...The effects of berbamine, an alkaloid of dibenzylisoquinoline, on PAF produc tion in human neutrophils and on platelet aggregation induced by PAF were studied and compared with those of the calcium antagonist verapamil. Preincubation with berbamine (50 mmol / L, 100 mmol / L) or verapamil (10 mmol / L, 100 mmol / L) was shown to significantly inhibit A 23187 stimulated PAF synthesis. Berbamine and verapamil were found to inhibit platelet aggregation induced by PAF 70 pmol / L in a dose dependent manner. These results suggest that the inhibitory effects of berbamine and verapamil on A 23187 stimulated PAF synthesis in human neutrophils and PAF induced platelet aggregation are possibly brought about by inhibiting cellular calcium influx.展开更多
Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugate...Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugated nanoparticles and load mitoxantrone nanoparticles(FA-CSNP/MTX). Drug dissolution testing, CCK-8 method, and confocal microscopy were used to detect their controlled-release capability in different situations and the specific uptake by HONE1 cells. The experimental results show that the nanoparticles have uniform size distribution of 48-58 nm. The highest encapsulation rate of the particles on mitoxantrone hydrochloride(MTX) is(77.5±1.9)%, and the drug loading efficiency is(18.4±0.4)%. The sustained release effect, cell growth inhibition activity and targeting effect of the FA-CS/MTX nanoparticles are good in artificial gastric fluid and intestinal fluid. It is demonstrated that the FA-CSNP system is a potentially useful system for the targeted delivery of anticancer drug MTX.展开更多
In this paper, a 2-D airlift reactor was developed. The streamline and hydrodynamic parameters were measured in a 2-D airlift loop reactor(ALR)with different draft baffles. Three regimes were observed under different ...In this paper, a 2-D airlift reactor was developed. The streamline and hydrodynamic parameters were measured in a 2-D airlift loop reactor(ALR)with different draft baffles. Three regimes were observed under different conditions. Particle image velocimetry(PIV)measurement showed that the liquid velocity distribution in horizontal direction presented different profiles in the three regimes. The length, the height and the spacing of draft baffles were applied in the experiments to optimize the ALR structure. It was found that the draft tube structure is of great importance in determining the hydrodynamics of ALRs. Additionally, the experimental results may serve as a step to the further optimization and design of ALR.展开更多
Objective To observe the effect of electroacupuncture(EA)at the pressure points Zu San Li(ST36),San Yin Jiao(SP6)and Liang Men(ST21)on platelet-derived growth factor(PDGF)and the ultrastructure of mitochondria in rats...Objective To observe the effect of electroacupuncture(EA)at the pressure points Zu San Li(ST36),San Yin Jiao(SP6)and Liang Men(ST21)on platelet-derived growth factor(PDGF)and the ultrastructure of mitochondria in rats with diabetic gastroparesis(DGP).Methods Sixty Sprague Dawley(SD)rats were randomly separated into a normal control group(NC,n=10)and a modeling group(n=50).Rats in the modeling group received an injection of 2%streptozotocin(STZ)and a high-fat and highglucose diet for eight weeks to establish a DGP rat model.At the same time,blood glucose and a general symptom score were recorded every week.After modeling,30 successfully modeled rats were randomly separated into the following groups:the DGP group(n=10),the EA group(n=10)and the metoclopramide(MP)group(n=10).After three weeks of intervention,the gastrointestinal propulsive rate was measured by measuring the optical density(OD).The concentration of Ca2+was determined by fluorescence immunoassay,and levels of serum insulin(INS)and PDGF were determined by ELISA.The ultrastructure of mitochondria was observed with transmission electron microscopy.Results(1)After intervention,levels of blood glucose and the general symptom score were greatly decreased in the EA group compared to the DGP group(P<0.01).Compared with the DGP group,the gastric emptying rate and the intestinal propulsive rate of the EA group was significantly improved(P<0.01),and there was no statistically significant difference between the EA and the NC groups.(2)Compared with the NC group,the levels of INS in the DGP group markedly decreased(P<0.05),but there was no significant difference of INS levels between the EA and the MP roups.(3)Compared with the DGP group,theconcentration of Ca2+in the EA and the MP groups significantly increased(P<0.01,P<0.05,respectively).(4)Compared with the NC group,the average OD of PDGF in the DGP group was significantly higher(P<0.01).Compared with the DGP group,levels of PDGF in the EA group increased significantly(P<0.01).(5)There were abundant mitochondria with a clear structure and complete cristae in the NC group.However,in the DGP group,mitochondria were severely swollen,partly vacuolated,and cristae were either fractured,absent,or shortened.In the EA group,mitochondria were slightly swollen,with clear cristae.Conclusions Electroacupuncture at the points Zu San Li(ST36),San Yin Jiao(SP6)and Liang Men(ST21)may improve gastric motility in DGP by up-regulating the amount of PDGF and improving the ultrastructure of mitochondria.展开更多
The heavy-ion therapy is one of the modalities to treat a patient with body tumors. In the tumor therapy, we wish to irradiate only the tumors in order to keep the normal tissues/organs undamaged. Along the range of h...The heavy-ion therapy is one of the modalities to treat a patient with body tumors. In the tumor therapy, we wish to irradiate only the tumors in order to keep the normal tissues/organs undamaged. Along the range of heavy ion passing through the matter, most of ion energy deposits at the end of the range, forming a so called Bragg peak[1]. In order to accurately determine the irradiation profiles and positions of scanned展开更多
A numerical model was established for simulating wave impact on a horizontal deck by an improved incompressible smoothed particle hydrodynamics (ISPH). As a grid-less particle method, the ISPH method has been widely u...A numerical model was established for simulating wave impact on a horizontal deck by an improved incompressible smoothed particle hydrodynamics (ISPH). As a grid-less particle method, the ISPH method has been widely used in the free-surface hydrodynamic flows with good accuracy. The improvement includes the employment of a corrective function for enhancement of angular momentum conservation in a particle-based calculation and a new estimation method to predict the pressure on the horizontal deck. The simulation results show a good agreement with the experiment. The present numerical model can be used to study wave impact load on the horizontal deck.展开更多
Objective: To study the expression levels of platelet-derived growth factor (PDGF) and granulocyte colony-stimulatingfactor (G-CSF) in peripheral blood and their role in thepathogenesis of Condyloma acuminatum (CA). M...Objective: To study the expression levels of platelet-derived growth factor (PDGF) and granulocyte colony-stimulatingfactor (G-CSF) in peripheral blood and their role in thepathogenesis of Condyloma acuminatum (CA). Methods: Sera were taken from 70 patients with Condylomaacuminatum and compared with 35 healthy controls. PDGFand G-CSF in serum were quantitated using a dual antibodysandwich enzyme-linked immunoabsorbent assay (ELISA). Results: Serum concentrations of PDGF and G-CSF weresignificantly increased in patients with Condylomaacuminatum (CA) compared to controls (P<0.001 and P<0.005respectively). Serum levels of PDGF and G-CSF correlatedwith clinical severity of CA, but no significant difference wasobserved between different duration of disease groups. Asignificant positive correlation was noticed between neutrophilcount and G-CSF levels (γ=0.38, P<0.001), and the neutrophilcount showed no significant correlation with PDGE Conclusion: The results indicated that increased expressionof PDGF an -CSF in peripheral blood might be involved in pathogenesis of CA.展开更多
In this study, magnetic core–shell structure Fe3O4@MCM-41 nanoparticles were synthesized with vesicles as soft templates. In the preparation, Fe Cl2 and tetraethy orthosilicate(TEOS) were selected as Fe processor and...In this study, magnetic core–shell structure Fe3O4@MCM-41 nanoparticles were synthesized with vesicles as soft templates. In the preparation, Fe Cl2 and tetraethy orthosilicate(TEOS) were selected as Fe processor and Si precursor, respectively. Stable vesicles first formed in 0.03 mol·L-11:2 mixture of anionic surfactant sodium dodecyl sulfate and cationic surfactant cetyltrimethyl ammonium bromide. Then, TEOS was added in the vesicle aqueous solution, leading to a highly dispersed solution. After high-temperature calcination, Fe3O4@MCM-41 nanoparticles were obtained. Their structure and morphology were characterized by Saturn Digisizer, transmission electron microscope and vibrating sample magneto-meter. The results indicate that the vesicles are spherical and their size could be tuned between 20 and 50 nm. The average grain diameter of synthesize magnetic core–shell Fe3O4@MCM-41 particles is 100–150 nm and most of them are in elliptical shape. The dispersion of magnetic particles is very good and magnetization values are up to 33.44 emu·g-1, which are superior to that of other Fe3O4 materials reported.展开更多
Three-dimensional tracking of submicron particles in flows in a micro-channel was carried out using in-line holographic microscopy.A fixed single 0.5 μm fluorescent particle was identified and isolated from dust part...Three-dimensional tracking of submicron particles in flows in a micro-channel was carried out using in-line holographic microscopy.A fixed single 0.5 μm fluorescent particle was identified and isolated from dust particles or overlapped particle pair using the laser induced fluorescent(LIF) method.Then in-line microscopic holograms of the fixed single particle were obtained at different positions on the optical axis,i.e.the defocus distances.The holograms of the single particle were used as the model templates with the known defocus distances.The particles in the in-line microscopic holograms of flow in the microchannel were then identified and located to obtain their two-dimensional positions.The defocus distances of those particles were determined by matching each hologram pattern to one of the model templates obtained in the single particle test.Finally the three-dimensional position and velocity of each particle were obtained.展开更多
We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles (3--4 nm) embedded in three-dimensional (3D) graphene (SnO2@3DG). SnO2@3DG was fabricated by hydrothermal assembly w...We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles (3--4 nm) embedded in three-dimensional (3D) graphene (SnO2@3DG). SnO2@3DG was fabricated by hydrothermal assembly with ice-templated 3DG and a tin source. The structure and morphology analyses showed that 3DG has an interconnected porous architecture with a large pore volume of 0.578 cm^3·g^-1 and a high surface area of 470.5 m^2·g^-1. In comparison, SnO2@3DG exhibited a pore volume of 0.321 cmg.g^-1 and a surface area of 237.7 m^2·g^-1 with a homogeneous distribution of ultrasmall SnO2 nanoparticles in a 3DG network. SnO2@3DG showed a discharge capacity of 1,155 mA-h·g^-1 in the initial cycle, a reversible capacity of 432 mA·h·g^-1 after 200 cycles at 100 mA·g^-1 (with capacity retention of 85.7% relative to that in the second cycle), and a discharge capacity of 210 mAh·g^-1 at a high rate of 800 mA·g^-1 This is due to the high distribution of SnO2 nanoparticles in the 3DG network and the enhanced facilitation of electron/ion transport in the electrode.展开更多
In the field of disaster prevention mitigation and protection engineering,it is important to identify the mechanical behaviors of reinforced concrete(RC)under explosive load by simulation.A three dimensional beam-part...In the field of disaster prevention mitigation and protection engineering,it is important to identify the mechanical behaviors of reinforced concrete(RC)under explosive load by simulation.A three dimensional beam-particle model(BPM),which is suitable to simulate the fracture process of RC under explosive load,has been developed in the frame of discrete element method (DEM).In this model,only the elastic deformations of beams between concrete particles were considered.The matrix displacement method(MDM)was employed to describe the relationship between the deformation and forces of the beam.A fracture criterion expressed by stress was suggested to identify the state of the beam.A BPM for steel bar,which can simulate the deformation of steel bar under high loading rate,was also developed based on the Cowper-Symonds theory.A program has been coded using C++language.Experiments of RC slab under explosive load were carried out using the program.Good agreement was achieved between the experimental and simulated results.It is indicated that the proposed theoretical model can well simulate the fracture characteristics of RC slab under explosive load such as blasting pit formation,cracks extension, spallation formation,etc.展开更多
Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam generation.In this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system betw...Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam generation.In this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system between two baffles in a shell and tube heat exchanger for parallel and counter flows.The PIV and computational fluid dynamics results show the occurrence of some strong vectors near the bottom.These vectors are assumed due to the clearance between the inner tubes and the front baffle.Therefore,the major parts of the vectors are moved out through the bottom opening of the rear baffle,and other vectors produce a large circle between the two baffles.Numerical simulations are conducted to investigate the effects of the baffle on the heat exchanger using the Fluent software.The k-εturbulence model is employed to calculate the flows along the heat exchanger.展开更多
基金Large research project(RGP2/159/45)supported by the Deanship of Research and Graduate Studies at King Khalid University,Saudi Arabia。
文摘The heat transfer between two corresponding plates,disks,and concentric pipes has many applications,including water cleansing and lubrication.Furthermore,TiO_(2)-water-based nanofluids are used widely because it is useful for operating and controlling the temperature,especially in photovoltaic technology and solar panels.Motivated by these applications,the current study is based on the nanoparticle aggregation effect on magnetohydrodynamics(MHD)flow via rotating parallel plates with the chemical reaction.To achieve maximum heat transportation,the Bruggeman model is used to adapt the Maxwell model.Also,melting and thermal radiation effects are considered in the modeling to discuss heat transport.The Runge-Kutta-Fehlberg 4th−5th order method is used to attain numerical solutions.The main focus of this study is to see the thermodynamic behavior considering several aspects of nanoparticle aggregation.The heat transfer rate between the parallel plates is enhanced by improving the thermophoresis,radiation,and Brownian motion parameters.The rise in Schmidt number and chemical reaction rate parameter decreases the concentration distribution.This study will be helpful in enhancing the thermal efficiency of photovoltaic technology in solar plates,water purifying,thermal management of electronic devices,designing effective cooling systems,and other sustainable technologies.
基金Project (30371130) supported by the National Natural Science Foundation of China
文摘Nano SiO2 was filled into gypsum particleboard. Effect of the amount of nano SiO2 particles filled, ultrasonic dissipating duration and treating the nano particles with different coupling agents on the mechanical properties of the board were studied respectively. The results show that nano SiO2 is helpful for the improvement of the properties. Adding 3%(mass fraction) nano SiO2 is the best for the improvement of both modulus of rupture(MOR) and modulus of elasticity(MOE) of the boards formed at 30 ℃ or 40 ℃. For the boards formed at 30 ℃, their MOR and MOE can be improved by 8.77% and 12.24%, and MOR and MOE of the boards formed at 40 ℃ can be improved by 44.44% and 108.38%.3% is also the best addition proportion to improve internal bond(IB) of the boards formed at 30 ℃, while 5% is the best for that of the boards formed at 40 ℃. At room temperature, dissipating nano SiO2 into flake by ultrasonic has better effect on the properties of the final products. Through ultrasonic treating for 1 h and the best treating duration, the MOR and MOE can be increased by 41.99% and 47.80%. In addition, different coupling agents have different effects on the final properties too, and silane coupling agent KH570 is better for the improvement of properties of the boards formed at room temperature.
文摘The effects of berbamine, an alkaloid of dibenzylisoquinoline, on PAF produc tion in human neutrophils and on platelet aggregation induced by PAF were studied and compared with those of the calcium antagonist verapamil. Preincubation with berbamine (50 mmol / L, 100 mmol / L) or verapamil (10 mmol / L, 100 mmol / L) was shown to significantly inhibit A 23187 stimulated PAF synthesis. Berbamine and verapamil were found to inhibit platelet aggregation induced by PAF 70 pmol / L in a dose dependent manner. These results suggest that the inhibitory effects of berbamine and verapamil on A 23187 stimulated PAF synthesis in human neutrophils and PAF induced platelet aggregation are possibly brought about by inhibiting cellular calcium influx.
基金Projects(31201074,81371013) supported by the National Natural Science Foundation of ChinaProject(2011105102016) supported by the Key Program of Medical Health of Dongguan City,Guangdong Province,ChinaProject(2011108102026) supported by Dongguan Universities Program,China
文摘Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugated nanoparticles and load mitoxantrone nanoparticles(FA-CSNP/MTX). Drug dissolution testing, CCK-8 method, and confocal microscopy were used to detect their controlled-release capability in different situations and the specific uptake by HONE1 cells. The experimental results show that the nanoparticles have uniform size distribution of 48-58 nm. The highest encapsulation rate of the particles on mitoxantrone hydrochloride(MTX) is(77.5±1.9)%, and the drug loading efficiency is(18.4±0.4)%. The sustained release effect, cell growth inhibition activity and targeting effect of the FA-CS/MTX nanoparticles are good in artificial gastric fluid and intestinal fluid. It is demonstrated that the FA-CSNP system is a potentially useful system for the targeted delivery of anticancer drug MTX.
基金Supported by the National Natural Science Foundation of China(No.21406157)
文摘In this paper, a 2-D airlift reactor was developed. The streamline and hydrodynamic parameters were measured in a 2-D airlift loop reactor(ALR)with different draft baffles. Three regimes were observed under different conditions. Particle image velocimetry(PIV)measurement showed that the liquid velocity distribution in horizontal direction presented different profiles in the three regimes. The length, the height and the spacing of draft baffles were applied in the experiments to optimize the ALR structure. It was found that the draft tube structure is of great importance in determining the hydrodynamics of ALRs. Additionally, the experimental results may serve as a step to the further optimization and design of ALR.
基金the funding support from the National Natural Science Foundation of China(No.81774431)the Open Fund of the Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine(No.2018ZYX35)Innovation Project of Graduate Students of Hunan University of Chinese Medicine(No.2018CX06).
文摘Objective To observe the effect of electroacupuncture(EA)at the pressure points Zu San Li(ST36),San Yin Jiao(SP6)and Liang Men(ST21)on platelet-derived growth factor(PDGF)and the ultrastructure of mitochondria in rats with diabetic gastroparesis(DGP).Methods Sixty Sprague Dawley(SD)rats were randomly separated into a normal control group(NC,n=10)and a modeling group(n=50).Rats in the modeling group received an injection of 2%streptozotocin(STZ)and a high-fat and highglucose diet for eight weeks to establish a DGP rat model.At the same time,blood glucose and a general symptom score were recorded every week.After modeling,30 successfully modeled rats were randomly separated into the following groups:the DGP group(n=10),the EA group(n=10)and the metoclopramide(MP)group(n=10).After three weeks of intervention,the gastrointestinal propulsive rate was measured by measuring the optical density(OD).The concentration of Ca2+was determined by fluorescence immunoassay,and levels of serum insulin(INS)and PDGF were determined by ELISA.The ultrastructure of mitochondria was observed with transmission electron microscopy.Results(1)After intervention,levels of blood glucose and the general symptom score were greatly decreased in the EA group compared to the DGP group(P<0.01).Compared with the DGP group,the gastric emptying rate and the intestinal propulsive rate of the EA group was significantly improved(P<0.01),and there was no statistically significant difference between the EA and the NC groups.(2)Compared with the NC group,the levels of INS in the DGP group markedly decreased(P<0.05),but there was no significant difference of INS levels between the EA and the MP roups.(3)Compared with the DGP group,theconcentration of Ca2+in the EA and the MP groups significantly increased(P<0.01,P<0.05,respectively).(4)Compared with the NC group,the average OD of PDGF in the DGP group was significantly higher(P<0.01).Compared with the DGP group,levels of PDGF in the EA group increased significantly(P<0.01).(5)There were abundant mitochondria with a clear structure and complete cristae in the NC group.However,in the DGP group,mitochondria were severely swollen,partly vacuolated,and cristae were either fractured,absent,or shortened.In the EA group,mitochondria were slightly swollen,with clear cristae.Conclusions Electroacupuncture at the points Zu San Li(ST36),San Yin Jiao(SP6)and Liang Men(ST21)may improve gastric motility in DGP by up-regulating the amount of PDGF and improving the ultrastructure of mitochondria.
文摘The heavy-ion therapy is one of the modalities to treat a patient with body tumors. In the tumor therapy, we wish to irradiate only the tumors in order to keep the normal tissues/organs undamaged. Along the range of heavy ion passing through the matter, most of ion energy deposits at the end of the range, forming a so called Bragg peak[1]. In order to accurately determine the irradiation profiles and positions of scanned
基金the National High Technology Research and Development Program of China (863 Program,Grant No.2007AA11Z130)
文摘A numerical model was established for simulating wave impact on a horizontal deck by an improved incompressible smoothed particle hydrodynamics (ISPH). As a grid-less particle method, the ISPH method has been widely used in the free-surface hydrodynamic flows with good accuracy. The improvement includes the employment of a corrective function for enhancement of angular momentum conservation in a particle-based calculation and a new estimation method to predict the pressure on the horizontal deck. The simulation results show a good agreement with the experiment. The present numerical model can be used to study wave impact load on the horizontal deck.
文摘Objective: To study the expression levels of platelet-derived growth factor (PDGF) and granulocyte colony-stimulatingfactor (G-CSF) in peripheral blood and their role in thepathogenesis of Condyloma acuminatum (CA). Methods: Sera were taken from 70 patients with Condylomaacuminatum and compared with 35 healthy controls. PDGFand G-CSF in serum were quantitated using a dual antibodysandwich enzyme-linked immunoabsorbent assay (ELISA). Results: Serum concentrations of PDGF and G-CSF weresignificantly increased in patients with Condylomaacuminatum (CA) compared to controls (P<0.001 and P<0.005respectively). Serum levels of PDGF and G-CSF correlatedwith clinical severity of CA, but no significant difference wasobserved between different duration of disease groups. Asignificant positive correlation was noticed between neutrophilcount and G-CSF levels (γ=0.38, P<0.001), and the neutrophilcount showed no significant correlation with PDGE Conclusion: The results indicated that increased expressionof PDGF an -CSF in peripheral blood might be involved in pathogenesis of CA.
基金Supported by the Natural Science Foundation of Heilongjiang Province(B201010)the Education Department of Heilongjiang Province(12511595)
文摘In this study, magnetic core–shell structure Fe3O4@MCM-41 nanoparticles were synthesized with vesicles as soft templates. In the preparation, Fe Cl2 and tetraethy orthosilicate(TEOS) were selected as Fe processor and Si precursor, respectively. Stable vesicles first formed in 0.03 mol·L-11:2 mixture of anionic surfactant sodium dodecyl sulfate and cationic surfactant cetyltrimethyl ammonium bromide. Then, TEOS was added in the vesicle aqueous solution, leading to a highly dispersed solution. After high-temperature calcination, Fe3O4@MCM-41 nanoparticles were obtained. Their structure and morphology were characterized by Saturn Digisizer, transmission electron microscope and vibrating sample magneto-meter. The results indicate that the vesicles are spherical and their size could be tuned between 20 and 50 nm. The average grain diameter of synthesize magnetic core–shell Fe3O4@MCM-41 particles is 100–150 nm and most of them are in elliptical shape. The dispersion of magnetic particles is very good and magnetization values are up to 33.44 emu·g-1, which are superior to that of other Fe3O4 materials reported.
基金Supported by the National Natural Science Foundation of China (50736002,61072005)Changjiang Scholars and Innovative Team Development Plan (IRT0957)
文摘Three-dimensional tracking of submicron particles in flows in a micro-channel was carried out using in-line holographic microscopy.A fixed single 0.5 μm fluorescent particle was identified and isolated from dust particles or overlapped particle pair using the laser induced fluorescent(LIF) method.Then in-line microscopic holograms of the fixed single particle were obtained at different positions on the optical axis,i.e.the defocus distances.The holograms of the single particle were used as the model templates with the known defocus distances.The particles in the in-line microscopic holograms of flow in the microchannel were then identified and located to obtain their two-dimensional positions.The defocus distances of those particles were determined by matching each hologram pattern to one of the model templates obtained in the single particle test.Finally the three-dimensional position and velocity of each particle were obtained.
文摘We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles (3--4 nm) embedded in three-dimensional (3D) graphene (SnO2@3DG). SnO2@3DG was fabricated by hydrothermal assembly with ice-templated 3DG and a tin source. The structure and morphology analyses showed that 3DG has an interconnected porous architecture with a large pore volume of 0.578 cm^3·g^-1 and a high surface area of 470.5 m^2·g^-1. In comparison, SnO2@3DG exhibited a pore volume of 0.321 cmg.g^-1 and a surface area of 237.7 m^2·g^-1 with a homogeneous distribution of ultrasmall SnO2 nanoparticles in a 3DG network. SnO2@3DG showed a discharge capacity of 1,155 mA-h·g^-1 in the initial cycle, a reversible capacity of 432 mA·h·g^-1 after 200 cycles at 100 mA·g^-1 (with capacity retention of 85.7% relative to that in the second cycle), and a discharge capacity of 210 mAh·g^-1 at a high rate of 800 mA·g^-1 This is due to the high distribution of SnO2 nanoparticles in the 3DG network and the enhanced facilitation of electron/ion transport in the electrode.
基金supported by the National Natural Science Foundation of China(Grant No.51044003)the National Basic Research Program of China("973"Project)(Grant No.2007CB714104)
文摘In the field of disaster prevention mitigation and protection engineering,it is important to identify the mechanical behaviors of reinforced concrete(RC)under explosive load by simulation.A three dimensional beam-particle model(BPM),which is suitable to simulate the fracture process of RC under explosive load,has been developed in the frame of discrete element method (DEM).In this model,only the elastic deformations of beams between concrete particles were considered.The matrix displacement method(MDM)was employed to describe the relationship between the deformation and forces of the beam.A fracture criterion expressed by stress was suggested to identify the state of the beam.A BPM for steel bar,which can simulate the deformation of steel bar under high loading rate,was also developed based on the Cowper-Symonds theory.A program has been coded using C++language.Experiments of RC slab under explosive load were carried out using the program.Good agreement was achieved between the experimental and simulated results.It is indicated that the proposed theoretical model can well simulate the fracture characteristics of RC slab under explosive load such as blasting pit formation,cracks extension, spallation formation,etc.
基金supported by the RESEAT program funded by the Ministry of Science,ICT and Future Planningthe National Research Foundation of Koreathe Korea Lottery Commission grants
文摘Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam generation.In this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system between two baffles in a shell and tube heat exchanger for parallel and counter flows.The PIV and computational fluid dynamics results show the occurrence of some strong vectors near the bottom.These vectors are assumed due to the clearance between the inner tubes and the front baffle.Therefore,the major parts of the vectors are moved out through the bottom opening of the rear baffle,and other vectors produce a large circle between the two baffles.Numerical simulations are conducted to investigate the effects of the baffle on the heat exchanger using the Fluent software.The k-εturbulence model is employed to calculate the flows along the heat exchanger.