Experimental study has been conducted for an interstitial free(IF) sheet steel on its surface roughness evolution and formability with respect to grain size and sheet thickness effect. The surface roughness of IF she...Experimental study has been conducted for an interstitial free(IF) sheet steel on its surface roughness evolution and formability with respect to grain size and sheet thickness effect. The surface roughness of IF sheet steel is proportional to effective strain, grain size and inversely proportional to sheet thickness; the larger grain reduces the formability by accelerating the surface roughening rate and enhance formability by raising the workhardening rate, while the latter effect plays the dominate role. The grain size effect on surface roughening and formability is more obvious when the sheets are thinner.展开更多
Based on grain size analysis for the offshore surface sediments of the Dalian Bay, the assemblages and distribution characteristics of grain size were acquired, and their sources and sedimentary environments as well a...Based on grain size analysis for the offshore surface sediments of the Dalian Bay, the assemblages and distribution characteristics of grain size were acquired, and their sources and sedimentary environments as well as the dominant factors were also discussed preliminarily. The results indicate that the silt has the highest content of 52% in average, followed by sand of 34%. Clay is enriched in the central plateau subregion with the average content of 14%. They are distributed with the strap-shape from east to west, which is consistent with the distribution pattern of minerals there. The coastal shallow-water slope in the north of the study area is characterized by the enrichment of coarser deposition, indicating strong hydrodynamic conditions and nearby source. With water depth increasing southward, silt and clay fraction, mainly enriched on a subaquatic platform with better sorting, are considered to be transported far away. To the further south of the study area with the deepest water off another subaquatic slop, coarse fraction is the highest, implying strong hydrodynamic conditions induced by tide currents which pass in and out the Bohai Sea and Yellow Sea Warm Current that enters the Bohai Sea.展开更多
Ti/TiN/Zr/ZrN multilayer coatings were deposited on Cr_17Ni_2 steel substrates with different surface roughnesses by vacuum cathodic arc deposition method. Microstructure, micro-hardness, adhesion strength and cross-s...Ti/TiN/Zr/ZrN multilayer coatings were deposited on Cr_17Ni_2 steel substrates with different surface roughnesses by vacuum cathodic arc deposition method. Microstructure, micro-hardness, adhesion strength and cross-sectional morphology of the obtained multilayer coatings were investigated. The results show that the Vickers hardness of Ti/TiN/Zr/ZrN multilayer coating, with a film thickness of 11.37 μm, is 29.36 GPa. The erosion and salt spray resistance performance of Cr_17Ni_2 steel substrates can be evidently improved by Ti/TiN/Zr/ZrN multilayer coating. The surface roughness of Cr_17Ni_2 steel substrates plays an important role in determining the mechanical and erosion performances of Ti/TiN/Zr/ZrN multilayer coatings. Overall, a low value of the surface roughness of substrates corresponds to an improved performance of erosion and salt spray resistance of multilayer coatings. The optimized performance of Ti/TiN/Zr/ZrN multilayer coatings can be achieved provided that the surface roughness of Cr_17Ni_2 steel substrates is lower than 0.4μm.展开更多
Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope(SEM),X-ray diffract...Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope(SEM),X-ray diffraction(XRD),particle size distribution(PSD), and by the determination of the specific surface area(SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of smalal agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.展开更多
The purpose of this study is to investigate the characteristics of soot particles in C2H4/CO2/O2/N2 com- bustion at equivalence ratio of 3.0-5.0. As the oxidant is switched from conventional air to CO2/O2/N2 mixture, ...The purpose of this study is to investigate the characteristics of soot particles in C2H4/CO2/O2/N2 com- bustion at equivalence ratio of 3.0-5.0. As the oxidant is switched from conventional air to CO2/O2/N2 mixture, the key species C2H2, C3H3 responsible for formation of first aromatic ring, the apical aromatics and 4zring aromatics total production rate all decrease greatly. In addition, with CO2 mole fraction from 0.2 to 0.5 in the mixture, the soot particle number density, volume fraction, surface area density, which are three most important parameters to soot oarticle orooertv, are suooressed obviously. Furthermore, the increasing content of C02 in the oxidizer influences mostly H, OH radical concentrations by two reactins CO + OH == CO2+ H and H + O2===O+ OH, and the procluction rate ofvo reactions declined, which revealed that C02 in mixture has an inhibiting ef- fect on soot particle generation.展开更多
Forty-eight surface sediments of the southern Yellow Sea are separated into three grain-size frac- tions. Four forms of extractable nitrogen (nitrogen in ion-exchangeable form (Nie), nitrogen in weak-acid ex- tractabl...Forty-eight surface sediments of the southern Yellow Sea are separated into three grain-size frac- tions. Four forms of extractable nitrogen (nitrogen in ion-exchangeable form (Nie), nitrogen in weak-acid ex- tractable form (Nwa), nitrogen in strong-alkali extractable form (Nsa) and nitrogen in strong-oxidant form (Nso)) are obtained by the sequential extraction. The results show that the contents and the distributions of the extract- able nitrogen in the southern Yellow Sea surface sediments are closely related to sediment grain size. The distri- butions of Nie, Nso and total nitrogen (TN) present positive correlations with fine particles content, while Nwa and Nsa does not have such correlation. The net contents of all the forms of nitrogen increase with sediment grain size finer.展开更多
A novel series of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (p(NIPAM-co-HEMA)) microgels were prepared through precipitation polymerization. Nuclear magnetic resonance (NMR), transmission electron micro...A novel series of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (p(NIPAM-co-HEMA)) microgels were prepared through precipitation polymerization. Nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV) and dynamic light scattering (DLS) were employed to characterize the microgels. The experimental results indicate that the prepared microgels with narrow distribution remain good temperature sensitivity after incorporation of functional-OH groups. In marked contrast to the general rule, incorporation of hydrophilic HEMA makes the volume-phase-transition temperature shift to the lower temperature due to the strong intermolecular H-bonding between amide and -OH groups, -OH and -OH groups.展开更多
AIM:To investigate the mechanisms of the biological roles of Dickkopf-3(Dkk-3) in cell invasion,survival and apoptosis in colon cancer cells.METHODS:Three human colon cancer cell lines,i.e.,HT-29,LoVo and SW480,were u...AIM:To investigate the mechanisms of the biological roles of Dickkopf-3(Dkk-3) in cell invasion,survival and apoptosis in colon cancer cells.METHODS:Three human colon cancer cell lines,i.e.,HT-29,LoVo and SW480,were used.Overexpression of Dkk-3 induced by pEGFP-N1-Dkk-3-GFP plasmid in LoVo cells was performed using Lipofectamine 2000 reagent.Reverse transcription polymerase chain reaction and Western blotting were performed to determine the mRNA and protein expression levels of Dkk-3,respectively.Cell proliferation assay,cell cycle analysis,hoechst 33258 assay and Matrigel invasion assay were performed on Dkk-3 overexpressing transfectants.RESULTS:The mRNA and protein expressions of Dkk-3 in HT-29(mRNA:0.06 ± 0.02,protein:0.06 ± 0.01) and LoVo(mRNA:0.07 ± 0.02,protein:0.07 ± 0.02) cells were significantly lower than that in SW480 cells(mRNA:0.92 ± 0.04,protein:0.69 ± 0.13;all P < 0.05),and the greatest levels of invasiveness wasin LoVo cells.Dkk-3 overexpression inhibited the proliferation and invasion of LoVo cells and induced cell cycle arrest at G0/G1 phase and subsequent apoptosis,as indicated by increased chromatin condensation and fragments,upregulated Bax and cytochrome c protein,downregulated survivin and Bcl-2 protein,and the activation of caspase-3 and caspase-9.Furthermore,Dkk-3 overexpression reduced the accumulation of cytosolic fraction of β-catenin.CONCLUSION:Dkk-3 overexpression induced apoptosis in human colon cancer possibly through the mitochondrial pathway.Dkk-3 may be involved in the Wnt/β-catenin signaling pathways in colon cancer.展开更多
Smoothed particle hydrodynamics (SPH) is a Lagrangian meshless particle method. It is one of the best method for simulating violent free surface flows in fluids and solving large fluid deformations. Dam breaking is a ...Smoothed particle hydrodynamics (SPH) is a Lagrangian meshless particle method. It is one of the best method for simulating violent free surface flows in fluids and solving large fluid deformations. Dam breaking is a typical example of these problems. The basis of SPH was reviewed, including some techniques for governing equation resolution, such as the stepping method and the boundary handling method. Then numerical results of a dam breaking simulation were discussed, and the benefits of concepts like artificial viscosity and position correction were analyzed in detail. When compared with dam breaking simulated by the volume of fluid (VOF) method, the wave profile generated by SPH had good agreement, but the pressure had only reasonable agreement. Improving pressure results is clearly an important next step for research.展开更多
A first principal modeling of the gasification of a char particle is performed using single step mechanism. The char particle is considered to be spherical in shape and only the physical and chemical properties can ch...A first principal modeling of the gasification of a char particle is performed using single step mechanism. The char particle is considered to be spherical in shape and only the physical and chemical properties can change in the radial direction. The carbon dioxide is used as the gasification agent that reacts with the char and form carbon monoxide. The presence of both solid and gaseous phase species makes the reaction heterogeneous. The char particle is considered with varying porosity that also allows the change in the surface area of the particle. A time invariant temperature and pressure profile is used at which the Arrhenius rate constant and diffusion is calculated. The mass conservation of model results in the form of two coupled partial differential and one ordinary differential equation. The equations are solved with a set of initial and boundary conditions using the bulk species concentration at the particle surface. A second order accurate central differencing scheme is used to discretize space while backward differencing is used to discretize time. Finally, the results are presented for the concentration distribution of CO and CO2 in radial direction with respect to time. It shows that, maximum concentration of CO is present at the center of the particle while the concentration gradient becomes higher near the particle surface. The nonlinear concentration trend due to the diffusion is effectively captured. The results show that, completed conversion of char depend upon the time provided for the reaction which can be reduced by decreasing the size of particle or increasing the reaction temperature. The sensitivity study of temperature and initial porosity also performed and showed that temperature has high impact on char conversion as compare to initial porosity.展开更多
To determine mirror surface finishing conditions and efficient and economical superfinishing conditions for pure titanium and titanium alloys, an abrasive film is used when superfinishing is performed under varying co...To determine mirror surface finishing conditions and efficient and economical superfinishing conditions for pure titanium and titanium alloys, an abrasive film is used when superfinishing is performed under varying conditions. These conditions include the workpiece rotation speed, the oscillation speed, the contact pressure of the roller, the hardness of the roller, and the type of abrasive film. The superfinishing device is applied to polishing a thin and long cylindrical bar. A micro-finishing film and a lapping film were used as abrasive films. A1203 grains or SiC grains were used as abrasives. The surface roughness of a polished workpiece was measured using a stylus-type surface-roughness measuring instrument. As a result, the conditions to improve the polishing surface efficiently include high values for the workpiece rotation speed, oscillation speed and contact pressure. The roller hardness has no effect on the efficient polishing conditions. The mirror finish of a surface can be created using lapping film of 3 μm with Al2O3 grains after polishing to a steady surface roughness under the efficient polishing conditions.展开更多
The phase transition of Heisenberg fluid has been investigated with the density functional theory in mean-field approximation (MF). The matrix of the second derivatives of the grand canonical potential Ω with respe...The phase transition of Heisenberg fluid has been investigated with the density functional theory in mean-field approximation (MF). The matrix of the second derivatives of the grand canonical potential Ω with respect to the particle density fluctuations and the magnetization fluctuations has been investigated and diagonalized. The smallest eigenvalue being 0 signalizes the phase instability and the related eigenvector characterizes this phase transition. We find a Curie line where the order parameter is pure magnetization and a spinodal where the order parameter is a mixture of particle density and magnetization. Along the spinodal, the character of phase instability changes continuously from predominant condensation to predominant ferromagnetic phase transition with the decrease of total density. The spinodal meets the Curie line at the critical endpoint with the reduced density p*=pσ3=0.224 and the reduced temperature T* =kT/ε=1.87 (σ is the diameter of Heisenberg hard sphere and e is the coupling constant).展开更多
To solve the highly nonlinear and non-Gaussian recursive state estimation problem in geomagnetic navigation, the unscented particle filter (UPF) was introduced to navigation system. The simulation indicates that geo...To solve the highly nonlinear and non-Gaussian recursive state estimation problem in geomagnetic navigation, the unscented particle filter (UPF) was introduced to navigation system. The simulation indicates that geomagnetic navigation using UPF could complete the position estimation with large initial horizontal position errors. However, this navigation system could only provide the position information. To provide all the kinematics states estimation of aircraft, a novel autonomous navigation algorithm, named unscented particle and Kalman hybrid navigation algorithm (UPKHNA), was proposed for geomagnetic navigation, The UPKHNA used the output of UPF and barometric altimeter as position measurement, and employed the Kahnan filter to estimate the kinematics states of aircraft. The simulation shows that geomagnetic navigation using UPKHNA could provide all the kinematics states estimation of aircraft continuously, and the horizontal positioning performance is better than that only using the UPF.展开更多
Suspended sediment concentration(SSC) is an important parameter in marine sedimentology. With the development of technology, many acoustic and optical devices, such as the Laser In-Situ Scattering and Transmissometry,...Suspended sediment concentration(SSC) is an important parameter in marine sedimentology. With the development of technology, many acoustic and optical devices, such as the Laser In-Situ Scattering and Transmissometry, have been designed to measure in situ SSC and grain size distribution. But due to fund or other restrictions, many experiments were only conducted in laboratory, using an indoor laser grain-size analyzer and gravimetric method to measure grain size distribution and concentration, respectively. In this study the laboratory experiment is simplified by omitting the tiring step of gravimetric method. The connections between SSC and other parameters(obscuration, D50 and sorting index) were investigated based on 124 surface sediment samples collected from different offshore areas. A new method is developed for determining SSC in laboratory using a laser grain-size analyzer.展开更多
The photos, which are done by electron microscope, of the condensed disperse phase, surrounding high-temperature metal particles are presented. The dependence of concentration of condensed dispersive phase which surro...The photos, which are done by electron microscope, of the condensed disperse phase, surrounding high-temperature metal particles are presented. The dependence of concentration of condensed dispersive phase which surrounds a high-temperature metal particle upon the temperature of the particle was obtained. The dependence of concentration of electrons in condensed dispersive phase upon the temperature of the particle was studied. The dependence of an equilibrium charge of a metal particle surrounded with condensed disperse phase on the temperature of a particle in a positive and negative region is presented. The dependence of a charge of a metal particle on time at the fixed temperature is obtained.展开更多
Four end members were inverted from surface sediment grain size data from the South Yellow Sea by using the end member(EM) model. The sediment provenance and hydrodynamic meanings of each EM were discussed based on th...Four end members were inverted from surface sediment grain size data from the South Yellow Sea by using the end member(EM) model. The sediment provenance and hydrodynamic meanings of each EM were discussed based on the frequency and spatial distributions of the EMs. EM1 and EM2 reflect the dynamic transport and sorting processes of the terrigenous sediment, and EM3 and EM4 reflect the modification of relic sand. The ocean front mainly affected transport of relatively coarse terrigenous sediment in the South Yellow Sea, and the fine terrigenous sediments were generally unaffected by the ocean front. Fine sediment could pass through the ocean front and deposit in the central South Yellow Sea under weak tidal condition to form most part of the Central Yellow Sea Mud(CYSM). The CYSM extended toward northwest and southwest. The sediment in the north part of the CYSM mainly consisted of sediment from the Yellow River(Huanghe) in the northwest, and the sediment in the southwest part of CYSM mainly consisted of Subei coastal sediments from both the Yangtze River(Changjiang) and the Yellow River. Compared to the traditional method of sediment grain size analysis, the EM model can determine the EMs and provide better explanations of the sediment provenance and dynamic regional sedimentary environment in the study area.展开更多
文摘Experimental study has been conducted for an interstitial free(IF) sheet steel on its surface roughness evolution and formability with respect to grain size and sheet thickness effect. The surface roughness of IF sheet steel is proportional to effective strain, grain size and inversely proportional to sheet thickness; the larger grain reduces the formability by accelerating the surface roughening rate and enhance formability by raising the workhardening rate, while the latter effect plays the dominate role. The grain size effect on surface roughening and formability is more obvious when the sheets are thinner.
文摘Based on grain size analysis for the offshore surface sediments of the Dalian Bay, the assemblages and distribution characteristics of grain size were acquired, and their sources and sedimentary environments as well as the dominant factors were also discussed preliminarily. The results indicate that the silt has the highest content of 52% in average, followed by sand of 34%. Clay is enriched in the central plateau subregion with the average content of 14%. They are distributed with the strap-shape from east to west, which is consistent with the distribution pattern of minerals there. The coastal shallow-water slope in the north of the study area is characterized by the enrichment of coarser deposition, indicating strong hydrodynamic conditions and nearby source. With water depth increasing southward, silt and clay fraction, mainly enriched on a subaquatic platform with better sorting, are considered to be transported far away. To the further south of the study area with the deepest water off another subaquatic slop, coarse fraction is the highest, implying strong hydrodynamic conditions induced by tide currents which pass in and out the Bohai Sea and Yellow Sea Warm Current that enters the Bohai Sea.
基金Project(2011B050400007)supported by the International Cooperation Program of Guangdong Province,China
文摘Ti/TiN/Zr/ZrN multilayer coatings were deposited on Cr_17Ni_2 steel substrates with different surface roughnesses by vacuum cathodic arc deposition method. Microstructure, micro-hardness, adhesion strength and cross-sectional morphology of the obtained multilayer coatings were investigated. The results show that the Vickers hardness of Ti/TiN/Zr/ZrN multilayer coating, with a film thickness of 11.37 μm, is 29.36 GPa. The erosion and salt spray resistance performance of Cr_17Ni_2 steel substrates can be evidently improved by Ti/TiN/Zr/ZrN multilayer coating. The surface roughness of Cr_17Ni_2 steel substrates plays an important role in determining the mechanical and erosion performances of Ti/TiN/Zr/ZrN multilayer coatings. Overall, a low value of the surface roughness of substrates corresponds to an improved performance of erosion and salt spray resistance of multilayer coatings. The optimized performance of Ti/TiN/Zr/ZrN multilayer coatings can be achieved provided that the surface roughness of Cr_17Ni_2 steel substrates is lower than 0.4μm.
基金supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia under the research project: “Electrochemical Synthesis and Characterization of Nanostructured Functional Materials for Application in New Technologies” (Project No. 172046)
文摘Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope(SEM),X-ray diffraction(XRD),particle size distribution(PSD), and by the determination of the specific surface area(SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of smalal agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.
基金* Supported by the National Natural Science Foundation of China (51176181), the National Basle Research of China (2012CB719704), and the National Key Technology Research and Development Program Of China (2011BAK07B01).
文摘The purpose of this study is to investigate the characteristics of soot particles in C2H4/CO2/O2/N2 com- bustion at equivalence ratio of 3.0-5.0. As the oxidant is switched from conventional air to CO2/O2/N2 mixture, the key species C2H2, C3H3 responsible for formation of first aromatic ring, the apical aromatics and 4zring aromatics total production rate all decrease greatly. In addition, with CO2 mole fraction from 0.2 to 0.5 in the mixture, the soot particle number density, volume fraction, surface area density, which are three most important parameters to soot oarticle orooertv, are suooressed obviously. Furthermore, the increasing content of C02 in the oxidizer influences mostly H, OH radical concentrations by two reactins CO + OH == CO2+ H and H + O2===O+ OH, and the procluction rate ofvo reactions declined, which revealed that C02 in mixture has an inhibiting ef- fect on soot particle generation.
基金This project is supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (No.KZCXI-SW-01-08) and the National Science Foundation for Outstanding Young Scientists in China (No.49925614)
文摘Forty-eight surface sediments of the southern Yellow Sea are separated into three grain-size frac- tions. Four forms of extractable nitrogen (nitrogen in ion-exchangeable form (Nie), nitrogen in weak-acid ex- tractable form (Nwa), nitrogen in strong-alkali extractable form (Nsa) and nitrogen in strong-oxidant form (Nso)) are obtained by the sequential extraction. The results show that the contents and the distributions of the extract- able nitrogen in the southern Yellow Sea surface sediments are closely related to sediment grain size. The distri- butions of Nie, Nso and total nitrogen (TN) present positive correlations with fine particles content, while Nwa and Nsa does not have such correlation. The net contents of all the forms of nitrogen increase with sediment grain size finer.
文摘A novel series of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (p(NIPAM-co-HEMA)) microgels were prepared through precipitation polymerization. Nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV) and dynamic light scattering (DLS) were employed to characterize the microgels. The experimental results indicate that the prepared microgels with narrow distribution remain good temperature sensitivity after incorporation of functional-OH groups. In marked contrast to the general rule, incorporation of hydrophilic HEMA makes the volume-phase-transition temperature shift to the lower temperature due to the strong intermolecular H-bonding between amide and -OH groups, -OH and -OH groups.
基金Supported by The Fundamental Research Funds for the Central Universities of China,No.20103020101000197
文摘AIM:To investigate the mechanisms of the biological roles of Dickkopf-3(Dkk-3) in cell invasion,survival and apoptosis in colon cancer cells.METHODS:Three human colon cancer cell lines,i.e.,HT-29,LoVo and SW480,were used.Overexpression of Dkk-3 induced by pEGFP-N1-Dkk-3-GFP plasmid in LoVo cells was performed using Lipofectamine 2000 reagent.Reverse transcription polymerase chain reaction and Western blotting were performed to determine the mRNA and protein expression levels of Dkk-3,respectively.Cell proliferation assay,cell cycle analysis,hoechst 33258 assay and Matrigel invasion assay were performed on Dkk-3 overexpressing transfectants.RESULTS:The mRNA and protein expressions of Dkk-3 in HT-29(mRNA:0.06 ± 0.02,protein:0.06 ± 0.01) and LoVo(mRNA:0.07 ± 0.02,protein:0.07 ± 0.02) cells were significantly lower than that in SW480 cells(mRNA:0.92 ± 0.04,protein:0.69 ± 0.13;all P < 0.05),and the greatest levels of invasiveness wasin LoVo cells.Dkk-3 overexpression inhibited the proliferation and invasion of LoVo cells and induced cell cycle arrest at G0/G1 phase and subsequent apoptosis,as indicated by increased chromatin condensation and fragments,upregulated Bax and cytochrome c protein,downregulated survivin and Bcl-2 protein,and the activation of caspase-3 and caspase-9.Furthermore,Dkk-3 overexpression reduced the accumulation of cytosolic fraction of β-catenin.CONCLUSION:Dkk-3 overexpression induced apoptosis in human colon cancer possibly through the mitochondrial pathway.Dkk-3 may be involved in the Wnt/β-catenin signaling pathways in colon cancer.
基金Supported by the National Natural Science Foundation of China under Grant No. 10572041 and 50779008
文摘Smoothed particle hydrodynamics (SPH) is a Lagrangian meshless particle method. It is one of the best method for simulating violent free surface flows in fluids and solving large fluid deformations. Dam breaking is a typical example of these problems. The basis of SPH was reviewed, including some techniques for governing equation resolution, such as the stepping method and the boundary handling method. Then numerical results of a dam breaking simulation were discussed, and the benefits of concepts like artificial viscosity and position correction were analyzed in detail. When compared with dam breaking simulated by the volume of fluid (VOF) method, the wave profile generated by SPH had good agreement, but the pressure had only reasonable agreement. Improving pressure results is clearly an important next step for research.
文摘A first principal modeling of the gasification of a char particle is performed using single step mechanism. The char particle is considered to be spherical in shape and only the physical and chemical properties can change in the radial direction. The carbon dioxide is used as the gasification agent that reacts with the char and form carbon monoxide. The presence of both solid and gaseous phase species makes the reaction heterogeneous. The char particle is considered with varying porosity that also allows the change in the surface area of the particle. A time invariant temperature and pressure profile is used at which the Arrhenius rate constant and diffusion is calculated. The mass conservation of model results in the form of two coupled partial differential and one ordinary differential equation. The equations are solved with a set of initial and boundary conditions using the bulk species concentration at the particle surface. A second order accurate central differencing scheme is used to discretize space while backward differencing is used to discretize time. Finally, the results are presented for the concentration distribution of CO and CO2 in radial direction with respect to time. It shows that, maximum concentration of CO is present at the center of the particle while the concentration gradient becomes higher near the particle surface. The nonlinear concentration trend due to the diffusion is effectively captured. The results show that, completed conversion of char depend upon the time provided for the reaction which can be reduced by decreasing the size of particle or increasing the reaction temperature. The sensitivity study of temperature and initial porosity also performed and showed that temperature has high impact on char conversion as compare to initial porosity.
基金work supported by the Second Stage of Brain Korea 21 Projects of Korea
文摘To determine mirror surface finishing conditions and efficient and economical superfinishing conditions for pure titanium and titanium alloys, an abrasive film is used when superfinishing is performed under varying conditions. These conditions include the workpiece rotation speed, the oscillation speed, the contact pressure of the roller, the hardness of the roller, and the type of abrasive film. The superfinishing device is applied to polishing a thin and long cylindrical bar. A micro-finishing film and a lapping film were used as abrasive films. A1203 grains or SiC grains were used as abrasives. The surface roughness of a polished workpiece was measured using a stylus-type surface-roughness measuring instrument. As a result, the conditions to improve the polishing surface efficiently include high values for the workpiece rotation speed, oscillation speed and contact pressure. The roller hardness has no effect on the efficient polishing conditions. The mirror finish of a surface can be created using lapping film of 3 μm with Al2O3 grains after polishing to a steady surface roughness under the efficient polishing conditions.
基金supported by the National Natural Science Foundation of China under Grant No.10325418
文摘The phase transition of Heisenberg fluid has been investigated with the density functional theory in mean-field approximation (MF). The matrix of the second derivatives of the grand canonical potential Ω with respect to the particle density fluctuations and the magnetization fluctuations has been investigated and diagonalized. The smallest eigenvalue being 0 signalizes the phase instability and the related eigenvector characterizes this phase transition. We find a Curie line where the order parameter is pure magnetization and a spinodal where the order parameter is a mixture of particle density and magnetization. Along the spinodal, the character of phase instability changes continuously from predominant condensation to predominant ferromagnetic phase transition with the decrease of total density. The spinodal meets the Curie line at the critical endpoint with the reduced density p*=pσ3=0.224 and the reduced temperature T* =kT/ε=1.87 (σ is the diameter of Heisenberg hard sphere and e is the coupling constant).
基金Project(HIT.NSRIF.2009006) supported by the Fundamental Research Funds for the Central Universities of China
文摘To solve the highly nonlinear and non-Gaussian recursive state estimation problem in geomagnetic navigation, the unscented particle filter (UPF) was introduced to navigation system. The simulation indicates that geomagnetic navigation using UPF could complete the position estimation with large initial horizontal position errors. However, this navigation system could only provide the position information. To provide all the kinematics states estimation of aircraft, a novel autonomous navigation algorithm, named unscented particle and Kalman hybrid navigation algorithm (UPKHNA), was proposed for geomagnetic navigation, The UPKHNA used the output of UPF and barometric altimeter as position measurement, and employed the Kahnan filter to estimate the kinematics states of aircraft. The simulation shows that geomagnetic navigation using UPKHNA could provide all the kinematics states estimation of aircraft continuously, and the horizontal positioning performance is better than that only using the UPF.
基金sponsored by Marine Commonweal Scientific Research Foundation (201005009)
文摘Suspended sediment concentration(SSC) is an important parameter in marine sedimentology. With the development of technology, many acoustic and optical devices, such as the Laser In-Situ Scattering and Transmissometry, have been designed to measure in situ SSC and grain size distribution. But due to fund or other restrictions, many experiments were only conducted in laboratory, using an indoor laser grain-size analyzer and gravimetric method to measure grain size distribution and concentration, respectively. In this study the laboratory experiment is simplified by omitting the tiring step of gravimetric method. The connections between SSC and other parameters(obscuration, D50 and sorting index) were investigated based on 124 surface sediment samples collected from different offshore areas. A new method is developed for determining SSC in laboratory using a laser grain-size analyzer.
文摘The photos, which are done by electron microscope, of the condensed disperse phase, surrounding high-temperature metal particles are presented. The dependence of concentration of condensed dispersive phase which surrounds a high-temperature metal particle upon the temperature of the particle was obtained. The dependence of concentration of electrons in condensed dispersive phase upon the temperature of the particle was studied. The dependence of an equilibrium charge of a metal particle surrounded with condensed disperse phase on the temperature of a particle in a positive and negative region is presented. The dependence of a charge of a metal particle on time at the fixed temperature is obtained.
基金supported by the National Natural Science Foundation of China(Grant Nos.41130856&41206053)the National Key Basic Research Program of China(Grant No.2010CB428901)
文摘Four end members were inverted from surface sediment grain size data from the South Yellow Sea by using the end member(EM) model. The sediment provenance and hydrodynamic meanings of each EM were discussed based on the frequency and spatial distributions of the EMs. EM1 and EM2 reflect the dynamic transport and sorting processes of the terrigenous sediment, and EM3 and EM4 reflect the modification of relic sand. The ocean front mainly affected transport of relatively coarse terrigenous sediment in the South Yellow Sea, and the fine terrigenous sediments were generally unaffected by the ocean front. Fine sediment could pass through the ocean front and deposit in the central South Yellow Sea under weak tidal condition to form most part of the Central Yellow Sea Mud(CYSM). The CYSM extended toward northwest and southwest. The sediment in the north part of the CYSM mainly consisted of sediment from the Yellow River(Huanghe) in the northwest, and the sediment in the southwest part of CYSM mainly consisted of Subei coastal sediments from both the Yangtze River(Changjiang) and the Yellow River. Compared to the traditional method of sediment grain size analysis, the EM model can determine the EMs and provide better explanations of the sediment provenance and dynamic regional sedimentary environment in the study area.