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兔自体静脉移植物粥样硬化模型的建立 被引量:2
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作者 黄东 梁春 +4 位作者 罗育坤 张红旗 贾剑国 王克强 葛均波 《中国动脉硬化杂志》 CAS CSCD 2004年第1期96-99,共4页
为研究自体静脉移植物粥样硬化的发病机制以进行干预研究 ,建立家兔动物模型。将 30只雄性新西兰大白兔随机分为正常对照组 (n =6 )、单纯移植组 (n =12 )和高脂移植组 (n =12 ) ,分别给予普通饲料喂养、单纯自体颈外静脉移植加普通饲... 为研究自体静脉移植物粥样硬化的发病机制以进行干预研究 ,建立家兔动物模型。将 30只雄性新西兰大白兔随机分为正常对照组 (n =6 )、单纯移植组 (n =12 )和高脂移植组 (n =12 ) ,分别给予普通饲料喂养、单纯自体颈外静脉移植加普通饲料喂养和自体颈外静脉移植加高脂饲料喂养。实验 12周末处死动物 ,检测血脂水平 ,同时观察静脉移植段的形态特征。结果发现 ,高脂移植组出现明显的高脂血症 ,其颈静脉移植段出现较典型的粥样硬化病变 ,包括内皮细胞脱落、内膜增生、平滑肌细胞移行增殖、脂质沉积和泡沫细胞形成等 ;单纯移植组的颈静脉移植段仅有明显的内膜增生和平滑肌细胞表型转换及增殖 ,未见明显脂质沉积 ;而正常对照组及各移植组对侧颈外静脉未见明显异常。结果提示 ,自体颈外静脉移植结合高脂饲料喂养可成功建立兔自体静脉移植物粥样硬化模型 ,此模型可用于人自体静脉移植物粥样硬化发生机理及防治措施等的研究。 展开更多
关键词 医学实验动物学 静脉移植物粥样硬化模型 自体静脉移植 高脂饮食 内膜增生 家兔静脉 粥样硬化模型
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内皮损伤兔腹主动脉粥样硬化模型中网膜素与斑块VH-IVUS特征的相关性研究
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作者 陈伟杰 高修仁 +1 位作者 温展鹏 李恒 《岭南急诊医学杂志》 2019年第2期106-109,共4页
目的:研究内皮损伤兔腹主动脉粥样硬化模型中网膜素与斑块VH-IVUS特征的相关性。方法:采用Western blot检测血管网膜素水平,VH-IVUS检查斑块成份,分析血管网膜素与斑块VH-IVUS的相关性。结果:Western blot检测高脂饮食组及模型组血管网... 目的:研究内皮损伤兔腹主动脉粥样硬化模型中网膜素与斑块VH-IVUS特征的相关性。方法:采用Western blot检测血管网膜素水平,VH-IVUS检查斑块成份,分析血管网膜素与斑块VH-IVUS的相关性。结果:Western blot检测高脂饮食组及模型组血管网膜素水平显著高于对照组(P<0.01),模型组血管网膜素水平显著高于高脂饮食组(P<0.05)。VH-IVUS中,模型组的斑块体积绝对值大于高脂饮食组(P<0.01),模型组纤维组织绝对值体积大于高脂饮食组(P<0.05),血管网膜素表达水平与纤维组织体积绝对值呈正相关(r=0.408,P<0.05)。结论:网膜素在脂质代谢紊乱和内皮损伤的初期表达增加,可能与斑块的稳定性呈正相关。 展开更多
关键词 内皮损伤 兔腹主动脉粥样硬化模型 网膜素 VH-IVUS
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Primary Mechanisms for Novel Compound Pivanampeta Against Atherosclerosis in Rat and Rabbit Model of Atherosclerosis 被引量:1
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作者 山丽梅 张锦超 +1 位作者 赵艳玲 汪海 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第1期68-75,共8页
Aim To investigate the anti-atherosclerotic mechanisms of the novel compoundpivanampeta in the early and later stages of atherosclerosis evolution. Methods Rats or rabbits wererandomly assigned to the control, the mod... Aim To investigate the anti-atherosclerotic mechanisms of the novel compoundpivanampeta in the early and later stages of atherosclerosis evolution. Methods Rats or rabbits wererandomly assigned to the control, the model and the pivanampeta-treated groups. The rats or rabbitsin the model group and the pivanampeta-treated group were fed with hypercholesterol diet. Thecarotids of rabbits were cut into pieces and stained with HE. The rat or rabbit serum levels of TC,LDL-CHO, HDL-CHO, IL-8, ET-1, PGI_2, TXA_2, and NO were assayed. The expressions of MCP-1 and IL-8mRNA on rabbit carotid were determined by semi-quantitative RT-PCR. Results Pivanampeta exerted aninhibitory effect on TXA_2 formation without PGI_2 production in the early and later stages ofatherosclerosis. The significantly increased release of NO and the decreased release of IL-8 in theanimals in pivanampeta-treated group were both detected in the rat atherosclerosis model. In therabbit atherosclerosis model the expressions of IL-8 and MCP-1 mRNA in pivanampeta-treated groupwere decreased significantly. However, the treatment with pivanampeta had no effect on the levels ofplasma cholesterol, MDA and SOD. Conclusion The increase of serum NO contents and the decrease ofplasma TXA_2 level, as well as its inhibition of expression of IL-8 and MCP-1 are probably involvedin the mechanisms underlying the anti-atherosclerotic effects of pivanampeta. 展开更多
关键词 ATHEROSCLEROSIS nitric oxide PGI_2 TXA_2
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Computational Fluid Dynamics Simulation on Biomedical Stent Design
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作者 Hao-Mmg Hsiao Kuang-Huei Lee Ying-Chih Liao 《Journal of Chemistry and Chemical Engineering》 2011年第11期973-984,共12页
The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensu... The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensus that the stent implant may change the artery wall shear stress distribution and hence lead to the restenosis process. Computational fluid dynamics (CFD) has been widely used to analyze hemodynamics in stented arteries. In this paper, two CFD models (the axisymmetric model and the 3-D stent model) were developed to investigate the effects of strut geometry and blood rheology on the intra-stent hemodynamics. The velocity profile, flow recirculation, and wall shear stress distribution of various stent strut geometries were studied. Results show strong correlations between the intra-stent hemodynamics and strut geometry. The intra-stent blood flow is very sensitive to the strut height and fillet size. A round strut with a large fillet size shows 36% and 34% reductions in key parameters evaluating the restenosis risk for the axisymmetric model and the 3-D stent model, respectively. This suggests that electrochemical polishing, a surface-improving process during stent manufacturing, strongly influences the hemodynamic behavior in stented arteries and should be controlled precisely in order to achieve the best clinical outcome. Rheological effects on the wall shear stress are minor in both axisymmetric and 3-D stent models for the vessel diameter of 4 mm, with Newtonian flow simulation tending to give more conservative estimates ofrestenosis risk. Therefore, it is reasonable to simulate the blood flow as a Newtonian flow in stented arteries using the simpler axisymmetric model. These findings will provide great insights for stent design optimization for potential restenosis improvement. 展开更多
关键词 RESTENOSIS wall shear stress stent design HEMODYNAMICS computational fluid dynamics
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Role of C5a-C5aR axis in the development of atherosclerosis 被引量:6
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作者 AN GuiPeng REN GuoRui +1 位作者 AN FengShuang ZHANG Cheng 《Science China(Life Sciences)》 SCIE CAS 2014年第8期790-794,共5页
Complement component 5a(C5a)is a 74 amino acid glycoprotein and an important proinflammatory mediator that is cleaved enzymatically from its precursor,C5,on activation of the complement cascade.C5a is quickly metaboli... Complement component 5a(C5a)is a 74 amino acid glycoprotein and an important proinflammatory mediator that is cleaved enzymatically from its precursor,C5,on activation of the complement cascade.C5a is quickly metabolised by carboxypeptidases,forming the less-potent C5a desArg.C5a and C5a desArg interact with their receptors(C5aR and C5L2),which results in a number of effects which are essential to the immune response.C5a has a broad range of biological effects throughout the human body because the widespread expression of C5a receptors throughout the human organs enables C5a and C5a desArg to elicit a broad range of biological effects.Recently,accumulating evidence in humans and experimental animal models shows that the C5a-C5aR axis is involved in the development of atherosclerosis lesions.The absence or blockade of C5aRs greatly reduces the formation of atherosclerotic lesions or wire-injury-induced neointima formation in atherosclerosis-prone mice.Serum C5a level was related to the major adverse cardiovascular events in patients with advanced atherosclerosis and those with drug-eluting stent implantation.Thus,the C5a-C5aR axis may be a significant pathogenic driver of arteriosclerotic vascular disease,making C5a-C5aR inhibition an attractive therapeutic strategy. 展开更多
关键词 C5A C5a receptors ATHEROSCLEROSIS
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Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention 被引量:8
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作者 Li-jin PU Ying SHEN +6 位作者 Rui-yan ZHANG Qi ZHANG Lin LU Feng-hua DING Jian HU Zheng-kun YANG Wei-feng SHEN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2012年第8期631-637,共7页
Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated... Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention. 展开更多
关键词 Renal artery stenosis Transradial coronary angiography Resistant hypertension
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Effects of Suxiao Jiuxin Pill (速效救心丸) on Oxidative Stress and Inflammatory Response in Rats with Experimental Atherosclerosis 被引量:8
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作者 李春深 曲竹秋 +4 位作者 王莎莎 郝旭雯 张秀琴 关晶 韩霏 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2011年第2期107-111,共5页
Objective: To observe the preventive role of Suxiao Jiuxin Pill (SX速效救心丸) on atherosclerosis (AS) and to probe into the mechanism in the atherosclerosis rat model. Methods: The AS rat model was established by a h... Objective: To observe the preventive role of Suxiao Jiuxin Pill (SX速效救心丸) on atherosclerosis (AS) and to probe into the mechanism in the atherosclerosis rat model. Methods: The AS rat model was established by a high fat diet and a large dose of calcium (vitamin D3, 0.6 million U/kg, i.p, once). Sixty healthy male adult Sprague-Dawlay (SD) rats were randomly divided into 6 groups, a normal control group (N), a model group (M), a SX low dose group (SXL), a SX middle dose group (SXM), a SX high dose group (SXH), and an atorvastatin group (ATO) (n=10 in each group). The rats in the treatment groups were given with the specific drugs from the first day by oral administration, and the normal control group and the model group were given with normal saline for 12 weeks. Afterwards, the content of malondialdehyde (MDA), the activity of superoxide dismutase (SOD) and the content of oxidized low density lipoprotein (ox-LDL) in the serum were detected. In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) proteins were tested by Western-blot method. Results: The serum ox-LDL and MDA level significantly decreased, SOD activity increased in the SX middle, high dose groups and the atorvastatin group compared to the model group (all P<0.05). While the expression of PPARγ and NF-κb proteins significantly decreased in the SX low, middle, high dose groups and the atorvastatin group compared to the model group (all P<0.01), with the best effect in the SX high dose group .These results indicate that SX could elevate the activity of serum SOD, decrease serum level of MDA and ox-LDL, and reduce the expression of PPARγ and NF-κB proteins. Conclusion: SX plays an important role in anti-inflammation and inhibition of oxidative stress, which possibly are the mechanism of its preventing and treating atherosclerosis. 展开更多
关键词 ATHEROSCLEROSIS RATS Suxiao Jiuxin Pill oxidized low density lipoprotein MALONDIALDEHYDE superoxide dismutase
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