Opiate dependence has become one of the most urgent problems of modernsociety. Opiate dependence involves physical and psychical dependence. Although many addicts can bedetoxified, the relapse ratio of 95% in 5 a demo...Opiate dependence has become one of the most urgent problems of modernsociety. Opiate dependence involves physical and psychical dependence. Although many addicts can bedetoxified, the relapse ratio of 95% in 5 a demonstrates that opiate psychical dependence is aproblem more troublesome. It has been reported that acute and chronic administration of L- NNA canmarkedly retard the development of tolerance to physical dependence on morphine, and suppress theabstinence syndromes precipitated by naloxone in opiate dependent rodents, and even reverse theexisting morphine tolerance. However, the effect of L-NNA on the positive reinforcement ofpsychically active substances and its possible mechanism have not yet been reported. In presentstudy, the effect of L- NNA en the psychical dependence induced by opiates was evaluated on thebasis of conditioned place preference.展开更多
The purpose, classification, required accuracy and surveying methods of control work for close range photogrammetry have been briefly stated. The different methods for definition of space, object coordinate system are...The purpose, classification, required accuracy and surveying methods of control work for close range photogrammetry have been briefly stated. The different methods for definition of space, object coordinate system are also reviewed. It is suggested that the habitu-ally-practised rotation angle system for aerophotogrammetry in China should be used for the future teaching and resaarching work in the close range photogrammetry, and that the rotation angle system for terrestrial deformation photogrammetry should be left out in order to avoid the confuse and reduce the amount of expanse for making softwares. It has been emphasized that there are three improtant aspects in the close range control work with high accurary using the conventional method of engineering surveying: the use of standard scale for measurement of distance between two general stations, the accurate determination of start direction line between two general stations and the handling method of influence of 2C change. A method for setting up industrial surveying control net with extra-high accuracy ±(0.05–0.20) mm is presented by the author. This kind of industrial control net is necessary for batch process of large industrial components with purposes of measurement, inspect and lofting. There are some special methods of control work in the close range photogrammetry, including two methods presented by the author.展开更多
Lipophilic tea polyphenols (LTP) were prepared by catalytic esterification of green tea polyphenols (GTP) with hexadecanoyl chloride. A novel long chain acyl derivative of epigallocatechin 3 o gallate (EGCG) ...Lipophilic tea polyphenols (LTP) were prepared by catalytic esterification of green tea polyphenols (GTP) with hexadecanoyl chloride. A novel long chain acyl derivative of epigallocatechin 3 o gallate (EGCG) was first isolated from purification of LTP by high speed countercurrent chromatography (HSCCC) using a solvent system composed of n hexane ethyl acetate methanol water (1:1:1:1, v/v). The molecular structure of the acyl derivative, Epigallocatechin 3 O gallate 4′ O hexadecanate , was elucidated by means of elemental analysis, IR, 1H NMR and MS spectra.展开更多
Using the JQ-II high pressure hydrogenation micro-reactor unit, the reactivity of Athabasca bitumen derived heavy gas oil was studied over commercial and homemade hydrotreating catalysts. The effects of catalyst prepa...Using the JQ-II high pressure hydrogenation micro-reactor unit, the reactivity of Athabasca bitumen derived heavy gas oil was studied over commercial and homemade hydrotreating catalysts. The effects of catalyst preparation variables and the influences of operation conditions, such as pressure, temperature, hydrogen/oil ratio and space velocity were also examined. It was shown that the optimal concentrations of the active components were 5% of NiO, 20% of MoO3 and 3.5% of phosphorus (by mass), and the suitable operation conditions were determined experimentally.展开更多
The assessment of control configurations for an ideal heat integrated distillation column incorporated with an overhead condenser and a bottom reboiler (general HIDiC) is addressed in this work. It is found that doubl...The assessment of control configurations for an ideal heat integrated distillation column incorporated with an overhead condenser and a bottom reboiler (general HIDiC) is addressed in this work. It is found that double ratio control configuration, (L/D, V/B), is still the best one among all the possibilities. The control configuration,(Pr - Ps, q), appears to be a feasible one for the general HIDiC and the pressure difference between the rectifying and the stripping sections and feed thermal condition are expected to be consistent manipulative variables for the process. The performance of the general HIDiC can be substantially improved by employing effective multivariable control algorithms.展开更多
To investigate into the mechanisms underlying the irreversible sterility induced by gossypol, we studied the relationship between its inhibitory action on acrosomal enzymes and its antifertility effect.As shown by our...To investigate into the mechanisms underlying the irreversible sterility induced by gossypol, we studied the relationship between its inhibitory action on acrosomal enzymes and its antifertility effect.As shown by our result, after exposure to gossypol (l.25-60 μg/ml) for 15 min. in vitro,the sperms' ability to penetrate bovine cervical mucus and the fertility rate were significantly reduced. Also, following administration of gossypol (12.5 mg/kg/day) for six weeks, the rate of fertilization in vitro by hamster sperm was significantly decreased. In the gossypol-treated group, extracts of testis sperm delayed dispersion of cumulus cells, suggesting inhibition of hyaluronidase and other acrosomal enzymes. Furthermore, the acrosin and arylsulfatase activities were shown to be markedly inhibited. Thus, a parallelism was displayed between the reduction of fertility and the decreasc in acrosin and arylsulfatase activities in epididymis sperms.Besides, the inhibition was reversible and was dosage-and durationdependent. In conclusion, the assay of acrosin activity might serve as a useful tool for monitoring the irreversible sterility induced by gossypol,展开更多
AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be ...AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal.展开更多
Cholesterol represents one of the key constituents of small,dynamic,sterol-and sphingolipid-enriched domains on the plasma membrane.It has been reported that many viruses depend on plasma membrane cholesterol for effi...Cholesterol represents one of the key constituents of small,dynamic,sterol-and sphingolipid-enriched domains on the plasma membrane.It has been reported that many viruses depend on plasma membrane cholesterol for efficient infection.In this study,the role of the plasma membrane cholesterol in porcine reproductive and respiratory syndrome virus(PRRSV) infection of MARC-145 cells was investigated.Pretreatment of MARC-145 cells with methyl-β-cyclodextrin(MβCD),a drug used to deplete cholesterol from cellular membrane,significantly reduced PRRSV infection in a dose-dependent manner.This inhibition was partially reversed by supplementing exogenous cholesterol following MβCD treatment,suggesting that the inhibition of PRRSV infection was specifically mediated by removal of cellular cholesterol.Further detailed studies showed that depletion of cellular membrane cholesterol significantly inhibited virus entry,especially virus attachment and release.These results indicate that the presence of cholesterol in the cellular membrane is a key component of PRRSV infection.展开更多
基金ThisprojectwassupportedbyGrantofthePLALaboratoryforNewDrugEvaluation (No .96-0 2 )
文摘Opiate dependence has become one of the most urgent problems of modernsociety. Opiate dependence involves physical and psychical dependence. Although many addicts can bedetoxified, the relapse ratio of 95% in 5 a demonstrates that opiate psychical dependence is aproblem more troublesome. It has been reported that acute and chronic administration of L- NNA canmarkedly retard the development of tolerance to physical dependence on morphine, and suppress theabstinence syndromes precipitated by naloxone in opiate dependent rodents, and even reverse theexisting morphine tolerance. However, the effect of L-NNA on the positive reinforcement ofpsychically active substances and its possible mechanism have not yet been reported. In presentstudy, the effect of L- NNA en the psychical dependence induced by opiates was evaluated on thebasis of conditioned place preference.
文摘The purpose, classification, required accuracy and surveying methods of control work for close range photogrammetry have been briefly stated. The different methods for definition of space, object coordinate system are also reviewed. It is suggested that the habitu-ally-practised rotation angle system for aerophotogrammetry in China should be used for the future teaching and resaarching work in the close range photogrammetry, and that the rotation angle system for terrestrial deformation photogrammetry should be left out in order to avoid the confuse and reduce the amount of expanse for making softwares. It has been emphasized that there are three improtant aspects in the close range control work with high accurary using the conventional method of engineering surveying: the use of standard scale for measurement of distance between two general stations, the accurate determination of start direction line between two general stations and the handling method of influence of 2C change. A method for setting up industrial surveying control net with extra-high accuracy ±(0.05–0.20) mm is presented by the author. This kind of industrial control net is necessary for batch process of large industrial components with purposes of measurement, inspect and lofting. There are some special methods of control work in the close range photogrammetry, including two methods presented by the author.
文摘Lipophilic tea polyphenols (LTP) were prepared by catalytic esterification of green tea polyphenols (GTP) with hexadecanoyl chloride. A novel long chain acyl derivative of epigallocatechin 3 o gallate (EGCG) was first isolated from purification of LTP by high speed countercurrent chromatography (HSCCC) using a solvent system composed of n hexane ethyl acetate methanol water (1:1:1:1, v/v). The molecular structure of the acyl derivative, Epigallocatechin 3 O gallate 4′ O hexadecanate , was elucidated by means of elemental analysis, IR, 1H NMR and MS spectra.
文摘Using the JQ-II high pressure hydrogenation micro-reactor unit, the reactivity of Athabasca bitumen derived heavy gas oil was studied over commercial and homemade hydrotreating catalysts. The effects of catalyst preparation variables and the influences of operation conditions, such as pressure, temperature, hydrogen/oil ratio and space velocity were also examined. It was shown that the optimal concentrations of the active components were 5% of NiO, 20% of MoO3 and 3.5% of phosphorus (by mass), and the suitable operation conditions were determined experimentally.
基金Supported by the New-Energy and Industry Technology Development Organization(NEDO),through the Energy Conservation Center of Japan.
文摘The assessment of control configurations for an ideal heat integrated distillation column incorporated with an overhead condenser and a bottom reboiler (general HIDiC) is addressed in this work. It is found that double ratio control configuration, (L/D, V/B), is still the best one among all the possibilities. The control configuration,(Pr - Ps, q), appears to be a feasible one for the general HIDiC and the pressure difference between the rectifying and the stripping sections and feed thermal condition are expected to be consistent manipulative variables for the process. The performance of the general HIDiC can be substantially improved by employing effective multivariable control algorithms.
文摘To investigate into the mechanisms underlying the irreversible sterility induced by gossypol, we studied the relationship between its inhibitory action on acrosomal enzymes and its antifertility effect.As shown by our result, after exposure to gossypol (l.25-60 μg/ml) for 15 min. in vitro,the sperms' ability to penetrate bovine cervical mucus and the fertility rate were significantly reduced. Also, following administration of gossypol (12.5 mg/kg/day) for six weeks, the rate of fertilization in vitro by hamster sperm was significantly decreased. In the gossypol-treated group, extracts of testis sperm delayed dispersion of cumulus cells, suggesting inhibition of hyaluronidase and other acrosomal enzymes. Furthermore, the acrosin and arylsulfatase activities were shown to be markedly inhibited. Thus, a parallelism was displayed between the reduction of fertility and the decreasc in acrosin and arylsulfatase activities in epididymis sperms.Besides, the inhibition was reversible and was dosage-and durationdependent. In conclusion, the assay of acrosin activity might serve as a useful tool for monitoring the irreversible sterility induced by gossypol,
文摘AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal.
基金supported by the National Natural Science Foundation of China (Grant No. 30770082)National Basic Research Program of China (Grant No. 2005CB523200)
文摘Cholesterol represents one of the key constituents of small,dynamic,sterol-and sphingolipid-enriched domains on the plasma membrane.It has been reported that many viruses depend on plasma membrane cholesterol for efficient infection.In this study,the role of the plasma membrane cholesterol in porcine reproductive and respiratory syndrome virus(PRRSV) infection of MARC-145 cells was investigated.Pretreatment of MARC-145 cells with methyl-β-cyclodextrin(MβCD),a drug used to deplete cholesterol from cellular membrane,significantly reduced PRRSV infection in a dose-dependent manner.This inhibition was partially reversed by supplementing exogenous cholesterol following MβCD treatment,suggesting that the inhibition of PRRSV infection was specifically mediated by removal of cellular cholesterol.Further detailed studies showed that depletion of cellular membrane cholesterol significantly inhibited virus entry,especially virus attachment and release.These results indicate that the presence of cholesterol in the cellular membrane is a key component of PRRSV infection.
