As an important constituent of Glycyrrhiza uralensis Fisch.,glycyrrhetinic acid has been widely used in Chinese traditional medicine.In order to improve its water solubility and bio-avalability and to reduce its side ...As an important constituent of Glycyrrhiza uralensis Fisch.,glycyrrhetinic acid has been widely used in Chinese traditional medicine.In order to improve its water solubility and bio-avalability and to reduce its side effects,a new derivative of glycyrrhetinic acid,arginine glycyrrhetinate,was synthesized by the reaction of 18β-glycyrrhetinic acid with L-arginine.The chemical composition and structure of this new compound were determined by a series of spectral technology,including MS,NMR,UV and IR spectroscopy.This study will be useful to identification of compounds with similar structure and also be helpful to quality control during drug production.展开更多
文摘As an important constituent of Glycyrrhiza uralensis Fisch.,glycyrrhetinic acid has been widely used in Chinese traditional medicine.In order to improve its water solubility and bio-avalability and to reduce its side effects,a new derivative of glycyrrhetinic acid,arginine glycyrrhetinate,was synthesized by the reaction of 18β-glycyrrhetinic acid with L-arginine.The chemical composition and structure of this new compound were determined by a series of spectral technology,including MS,NMR,UV and IR spectroscopy.This study will be useful to identification of compounds with similar structure and also be helpful to quality control during drug production.
