Objective To investigate the effective management approaches for mental retardat ion plus epilepsy in children.Method Sodium valproat 15～60mg /(kg·day)or nitrazepam0.5～1mg /(kg·day)and guanmaishu containin...Objective To investigate the effective management approaches for mental retardat ion plus epilepsy in children.Method Sodium valproat 15～60mg /(kg·day)or nitrazepam0.5～1mg /(kg·day)and guanmaishu containing hyoscyam ine(0.0045～0.045mg /(kg·day)as adjuvant were administered for 1.5～2consecutive years.EEG,three di mensional Doppler ultrasonic exami nation of cerebral vessels were performed.Result Favorable therapeutic effect was obtained in 25cases(48.1%),good effect in 12cases(23.1%).Conclusion Favorable therapeutic effect of hyoscyamine i n epilepsy is correlated with improved cerebral microcirculation,cortical choline receptor blocking ,red uced con-duction between synapses.These factors all inhibit onset of epilepsy.展开更多
文摘Objective To investigate the effective management approaches for mental retardat ion plus epilepsy in children.Method Sodium valproat 15～60mg /(kg·day)or nitrazepam0.5～1mg /(kg·day)and guanmaishu containing hyoscyam ine(0.0045～0.045mg /(kg·day)as adjuvant were administered for 1.5～2consecutive years.EEG,three di mensional Doppler ultrasonic exami nation of cerebral vessels were performed.Result Favorable therapeutic effect was obtained in 25cases(48.1%),good effect in 12cases(23.1%).Conclusion Favorable therapeutic effect of hyoscyamine i n epilepsy is correlated with improved cerebral microcirculation,cortical choline receptor blocking ,red uced con-duction between synapses.These factors all inhibit onset of epilepsy.
