自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每...自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每个年度即“世界抗痛年(Global Year Against Pain)”。2018~2019年“世界抗痛年”主题为“全球抗击老年幼年精神神经性疾病引起的疼痛(Global Year Against Pain in the Most Vulnerable)”。展开更多
自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每...自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每个年度即“世界抗痛年(Global Year Against Pain)”。2018~2019年“世界抗痛年”主题为“全球抗击老年幼年精神神经性疾病引起的疼痛(Global Year Against Pain in the Most Vulnerable)”。展开更多
Human endogenous retrovirus W env(HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis(MS). These diseases are accompanied by immunological reactions in th...Human endogenous retrovirus W env(HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis(MS). These diseases are accompanied by immunological reactions in the central nervous system(CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter – nitric oxide(NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase(hi NOS) and enhanced the promoter activity of hi NOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases.展开更多
文摘自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每个年度即“世界抗痛年(Global Year Against Pain)”。2018~2019年“世界抗痛年”主题为“全球抗击老年幼年精神神经性疾病引起的疼痛(Global Year Against Pain in the Most Vulnerable)”。
文摘自从2004年10月国际疼痛学会(IASP)倡议设立“世界镇痛日”以来,每年10月由IASP发布抗痛年主题,已经成为全球疼痛医学界最令人瞩目的大事。IASP确定每年10月第三个周一为“世界镇痛日(GlobalDay Against Pain)”,并冠以一个主题,成为每个年度即“世界抗痛年(Global Year Against Pain)”。2018~2019年“世界抗痛年”主题为“全球抗击老年幼年精神神经性疾病引起的疼痛(Global Year Against Pain in the Most Vulnerable)”。
基金supported by grants from the National Natural Sciences Foundation of China(No.31470264,No.81271820,No.30870789,and No.30300117)the Key Program of Natural Science Foundation of Hubei Province of China(No.2014CFA078)+1 种基金the Stanley Foundation from the Stanley Medical Research Institute(SMRI),USA(No.06R-1366),to Dr.Fan Zhuthe Scientific Innovation Team Project of Hubei Province of China(No.2015CFA009)
文摘Human endogenous retrovirus W env(HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis(MS). These diseases are accompanied by immunological reactions in the central nervous system(CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter – nitric oxide(NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase(hi NOS) and enhanced the promoter activity of hi NOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases.
