Advanced glycation end-products （AGEs） are products of non-enzymatic glycation of proteins, lipids or nucleic acids and other macromolecules. To be spe- cific, Nε-（carboxymethyl）-Iysine （CML） is one of the most...Advanced glycation end-products （AGEs） are products of non-enzymatic glycation of proteins, lipids or nucleic acids and other macromolecules. To be spe- cific, Nε-（carboxymethyl）-Iysine （CML） is one of the most important components of AGEs, which is wildly distributed in the body and can be formed in vivo or in food processing and heating processes. Previous studies have shown that CML is a ma- jor immunological epitope in AGEs and plays an important role in diabetes and its complications, as well as in the development and progression of aging. This review summarized recent advances in major source, toxicological hazard and control mea- sures of CML.展开更多
OBJECTIVE: To investigate the potential of medicinal plants used in traditional healing in Pakistan to inhibit the glycation process. This may be useful in combatting diabetes mellitus and its complications.METHODS: T...OBJECTIVE: To investigate the potential of medicinal plants used in traditional healing in Pakistan to inhibit the glycation process. This may be useful in combatting diabetes mellitus and its complications.METHODS: The in vitro antiglycation activity of 10 medicinal plants was examined by testing the ability of the extracts to inhibit the methyl-glyoxal-mediated development of fluorescence of bovine serumalbumin.RESULTS: Of the tested plants, Persicaria barbata,Geranium collinum and Berberis lyciumshowed significant inhibition of the formation of advanced glycation end products. The inhibitory capacity of these plants was 68.89%, 62.06% and 54.23%, respectively, compared with the positive control(rutin; 86%). All other plants inhibited AGE formation non-significantly.CONCLUSION:These findings will be helpful for further research into the use of traditional herbal medicines with antiglycation properties in the treatment of diabetes.展开更多
基金Supported by "Twelfth Five-Year" National Science and Technology Support Project of China(2012BAK01B03)National 863 Plan(2013AA102202)~~
文摘Advanced glycation end-products （AGEs） are products of non-enzymatic glycation of proteins, lipids or nucleic acids and other macromolecules. To be spe- cific, Nε-（carboxymethyl）-Iysine （CML） is one of the most important components of AGEs, which is wildly distributed in the body and can be formed in vivo or in food processing and heating processes. Previous studies have shown that CML is a ma- jor immunological epitope in AGEs and plays an important role in diabetes and its complications, as well as in the development and progression of aging. This review summarized recent advances in major source, toxicological hazard and control mea- sures of CML.
文摘OBJECTIVE: To investigate the potential of medicinal plants used in traditional healing in Pakistan to inhibit the glycation process. This may be useful in combatting diabetes mellitus and its complications.METHODS: The in vitro antiglycation activity of 10 medicinal plants was examined by testing the ability of the extracts to inhibit the methyl-glyoxal-mediated development of fluorescence of bovine serumalbumin.RESULTS: Of the tested plants, Persicaria barbata,Geranium collinum and Berberis lyciumshowed significant inhibition of the formation of advanced glycation end products. The inhibitory capacity of these plants was 68.89%, 62.06% and 54.23%, respectively, compared with the positive control(rutin; 86%). All other plants inhibited AGE formation non-significantly.CONCLUSION:These findings will be helpful for further research into the use of traditional herbal medicines with antiglycation properties in the treatment of diabetes.
