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糖尿病足汤治疗0级糖尿病足90例 被引量:6
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作者 李品川 张朝晖 +1 位作者 徐强 田影 《中医外治杂志》 2014年第2期11-13,共3页
目的:观察自拟糖尿病足汤治疗0级耱尿病足的临床疗效.方法:选取2009年12月~2013年1月0级糖尿病足患者180例,随机分为治疗组和对照组各90例,在常规治疗的基础上,治疗组采用自拟糖尿病足汤(由川乌、赤芍、桑枝等组成)足浴疗法,对照... 目的:观察自拟糖尿病足汤治疗0级耱尿病足的临床疗效.方法:选取2009年12月~2013年1月0级糖尿病足患者180例,随机分为治疗组和对照组各90例,在常规治疗的基础上,治疗组采用自拟糖尿病足汤(由川乌、赤芍、桑枝等组成)足浴疗法,对照组采用弥可保治疗.30 d后评定临床综合疗效.结果:观察治疗组临床综合疗效痊愈率11.11%,显效率42.22%,有效率41.11%,总有效率94.44%;对照组痊愈率8.89%,显效率40.00%,有效率38.98%,总有效率87.78%.两组疗效比较有显著性差异(P<0.05).结论:常规治疗基础上加糖尿病足汤浴足在治疗糖尿病0级足方面有明显优势,且未发生严重不良反应,值得在临床上推广. 展开更多
关键词 糖尿病 糖尿病足汤 弥可保
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糖尿病足汤配合双黄散治疗糖尿病足46例 被引量:3
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作者 方飞群 《河南中医》 2006年第9期46-47,共2页
关键词 糖尿病 糖尿病足汤 双黄散
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Linggui Zhugan Decoction Improves High Glucose-Induced Autophagy in Podocytes
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作者 Yuan-Yuan Wang Jian Qin +2 位作者 Ru-Lan Zhang Min-Ji Yu Ming-Hua Jin 《Chinese Medical Sciences Journal》 CAS 2024年第3期193-202,共10页
Objective To explore the influence of Linggui Zhugan Decoction(LGZGD)on high glucose induced podocyte autophagy Methods LGZGD containing serum were prepared by intragastric administation of 4.2 g·kg^(-1)(low dose... Objective To explore the influence of Linggui Zhugan Decoction(LGZGD)on high glucose induced podocyte autophagy Methods LGZGD containing serum were prepared by intragastric administation of 4.2 g·kg^(-1)(low dose),8.4 g·kg^(-1)(medium dose),and 12.6 g·kg^(-1)(high dose)LGZGD into SD rats respectively.MPC5 and AB8/13 cells were treated with 60 mmol/L glucose to establish diabetic nephropathy podocyte model in vitro.Podocytes,MPC5 and AB8.13,were divided into control group,high glucose group,low dose LGZGD group,medium dose LGZGD group,and high dose LGZGD group,respectively.For the three LGZGD groups,before LGZGD intervention,podocytes were treated with 60 mmol/L glucose for 3 days.After treated with LGZGD containing serum,cells were collected to analyze cell migration using Transwell assay,proliferation using CCK8,apoptosis and cell cycle using flow cytometry,,autophagosome formation using transmission electron microscopy,and expression levels of Beclin-1,Atg5,LC3II/I,and P62 proteins using western blot.Results Compared with the control group,the proliferation and migration of MPC5 and AB8.13 cells in high glucose group showed slightly decreased,whereas these parameters restored after intervention with low and medium concentrations of LGZGD,with the medium dose LGZGD having the best effect.Flow cytometry analysis showed that the medium dose LGZGD group had a lower apoptosis rate(P<0.05)and higher survival rate(P>0.05)compared to the high dose group.High glucose arrested podocytes in G1 phase,whereas LGZGD shifted podocytes from being predominant in G1 phase to increasing into G2.High dose LGZGD significanly reduced increased autophagosome formation due to high glucose in both podocytes(P<0.05).Western blot analysis showed that Beclin-1,Atg5,LC3Ⅱ/Ⅰ,and P62 expressions were increased in MPC5 cells treated with high glucose,and reversed after adminstration of low and medium doses of LGZGD(P<0.05).Conclusion LGZGD reduced apoptosis and enhanced autophagy in high glucose treated podocytes via regulating Beclin-1/LC3II/I/Atg5 expression. 展开更多
关键词 diabetic nephropathy podocyte Linggui Zhugan decoction apoptosis autophagy
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