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老年糖尿病患者的危险因素及护理分析 被引量:4
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作者 张凤莉 《中国实用医药》 2014年第9期215-216,共2页
目的:分析老年糖尿病患者危险因素,并探讨有效的护理方法及效果。方法选取本院自2011年8月~2013年8月收治的94例老年糖尿病患者随机分为观察组与参考组,各为47例,观察患者病变危险因素,分别给予患者不同护理干预,比较其病变发生... 目的:分析老年糖尿病患者危险因素,并探讨有效的护理方法及效果。方法选取本院自2011年8月~2013年8月收治的94例老年糖尿病患者随机分为观察组与参考组,各为47例,观察患者病变危险因素,分别给予患者不同护理干预,比较其病变发生率及患者血糖控制情况。结果年龄、收缩压、餐后2h血糖水平、糖化血红蛋白、C肽、胰岛素水平等为糖尿病病变的危险因素。观察组患者病变发生率明显低于参考组,患者空腹及餐后2 h血糖水平均明显低于参考组(P〈0.05)。结论年龄、收缩压等多种因素对糖尿病患者血管病变有着影响,通过优质护理干预能够良好控制血糖,减少病变发生。 展开更多
关键词 糖老年糖尿病 病变 危险因素 护理分析
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Rosiglitazone inhibits expression of acyl-coenzyme A:cholesterol acyltransferase-1 in THP-1 macrophages induced by advanced glycation end-products
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作者 Yang Qihong Xu Qiang +1 位作者 Zhang Hong Si Liangyi 《Journal of Medical Colleges of PLA(China)》 CAS 2008年第3期127-136,共10页
Objective: To investigate the effects of rosiglitazone, a synthetic ligand of peroxisome proliferators-activated receptor gamma (PPARγ), on the expression of acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-... Objective: To investigate the effects of rosiglitazone, a synthetic ligand of peroxisome proliferators-activated receptor gamma (PPARγ), on the expression of acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in phorbol myristate acetate (PMA)-pretreated THP-1 cells after the inducement of advanced glycation end products (AGEs). Methods: After THP-1 cells were cultured in the presence of 0.1 μmol/L PMA for 72 h to induce phagocytic differentiation, the obtained THP-1 macrophages were treated with rosiglitazone for 4 h at different concentrations (1, 5 or 10 μmol/L) and then exposed to AGEs-modified bovine serum albumin (AGEs-BSA) for 24 h at a concentration of 200 mg/L. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis were performed to detect the mRNA and protein expressions of ACAT-1 respectively. Results: Administration of AGEs-BSA (200 mg/L) into the THP-1 macrophages resulted in up-regulation of ACAT-1 at mRNA and protein levels when compared with the expressions in macrophages incubated with serum-free RPMI1640. Pretreatment of rosiglitazone inhibited significantly the increased expression of ACAT-1 induced by AGEs-BSA in a concentration-dependent manner. Conclusion: PPARy activation by rosiglitazone down-regulates ACAT-1 expression induced by AGEs in THP-1 macrophages, which might provide a new way for treating atherogenesis in diabetic patients. 展开更多
关键词 Advanced glycation end products Acyl-coenzyme A cholesterol acyltransferase-1 ROSIGLITAZONE Gene expression
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