As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients contin...As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients continue to emerge from China and other part of the world.Herewith,from a systems medicine perspective,the authors analyze those experiences and categorize them into four major treatment principles:(1)focusing on eliminating toxins in the early stage of the disease,(2)tonifying deficiency of the body throughout the entire disease course,(3)treating the affected lung and intestine simultaneously based on visceral interactions,(4)cooling blood and removing blood stasis at the later stage,as well as interpret the rationale of these principles.This is helpful not only in reducing the complexity of promoting the CHM applications to enhance anti-COVID-19 efficacy,but also in ramping out the process of integrating traditional Chinese medicine with modern medical practices.展开更多
Objective:To explore the present situation and development of Medical Delivery System in China.Methods:The data in three Nation Health Service Investigations were compared and analyzed by applying literature meta-anal...Objective:To explore the present situation and development of Medical Delivery System in China.Methods:The data in three Nation Health Service Investigations were compared and analyzed by applying literature meta-analysis,Delphi and cross-sectional investigation,etc.Results:The Medical Ser- vice resource develops fast,and public cost for medical treatment keeps increasing.Organization structure presents a vertical and flat trend.Inhabitant health level rises year by year,and it is hard to resolve the problem of potential medical demand transformed.Conclusion:Medical Delivery System in China has formed,but the development of Medical Service System still exists structural problems in the deeper lay- er.The development trend predicts that the supervision of the government is gradually reinforcing and community health service develops step by step.展开更多
Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insu...Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insurance system of China＇s urban and rural structure background of two structures of serious, city residents, workers and rural residents is significantly difference in the payment period ,for this question ,the difference between our country will solve the basic medical insurance payment period, the relative level of regulating wages and medical people in our country and develop the medical insurance level, narrow the regional differences, reduce cost problem caused by population flow management, the basic medical insurance system for suggestions to improve the unified and promoting the social and economic level, people＇s medical security level, perfect improvement of physical insurance system of medical insurance according to the long-term sustainable development has a far-reaching significance.展开更多
Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstiti...Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment.展开更多
OBJECTIVE: The association of spleen system including both spleen and stomach with earth, one of the five elements, is a part of the theory of five elements. Practitioners of Traditional Chinese Medicine (TCM) used th...OBJECTIVE: The association of spleen system including both spleen and stomach with earth, one of the five elements, is a part of the theory of five elements. Practitioners of Traditional Chinese Medicine (TCM) used the theory as a reasoning tool to illustrate the Zang-Fu organs' physiological functions and the interaction among them.The exploration of how the theory of that spleen system is associated with earth was created may provide insights into how five-element theory is applied to TCM practice. METHODS: Using analogism as a method to explore the relationship between earth and spleen system inTCM. RESULTS: Chinese ancestors experienced and observed the features of earth from agricultural practice and used the knowledge for the explanation ofspleen system functions including physiological functions, pathological characteristics and for the treatment of related illnesses. CONCLUSION: The theory of the five elements in TCM is a kind of metaphor, which depends on observation and exploration of the natural world and experience of human beings.展开更多
Systems biology is an emerging science of the 21st century and its method and design of study resemble those of traditional Chinese medicine (TCM). Adopting systems biology technology will help to understand TCM Syndr...Systems biology is an emerging science of the 21st century and its method and design of study resemble those of traditional Chinese medicine (TCM). Adopting systems biology technology will help to understand TCM Syndromes and modernize Chinese herbal medicine. The technology platforms of systems biology, especially proteomics can provide useful tools for exploring essence of TCM syndromes and understanding principle of herbal formulation. Moreover, compared with methods of molecular biology, such as genomics and proteomics, metabolomics provide more direct, rapid, concise and effective methods for study of kidney disease especially in the case of prevention and treatment with TCM.展开更多
Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or ...Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.展开更多
文摘As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients continue to emerge from China and other part of the world.Herewith,from a systems medicine perspective,the authors analyze those experiences and categorize them into four major treatment principles:(1)focusing on eliminating toxins in the early stage of the disease,(2)tonifying deficiency of the body throughout the entire disease course,(3)treating the affected lung and intestine simultaneously based on visceral interactions,(4)cooling blood and removing blood stasis at the later stage,as well as interpret the rationale of these principles.This is helpful not only in reducing the complexity of promoting the CHM applications to enhance anti-COVID-19 efficacy,but also in ramping out the process of integrating traditional Chinese medicine with modern medical practices.
基金Supported by the National Natural Science Foundation of China(No.70333002)
文摘Objective:To explore the present situation and development of Medical Delivery System in China.Methods:The data in three Nation Health Service Investigations were compared and analyzed by applying literature meta-analysis,Delphi and cross-sectional investigation,etc.Results:The Medical Ser- vice resource develops fast,and public cost for medical treatment keeps increasing.Organization structure presents a vertical and flat trend.Inhabitant health level rises year by year,and it is hard to resolve the problem of potential medical demand transformed.Conclusion:Medical Delivery System in China has formed,but the development of Medical Service System still exists structural problems in the deeper lay- er.The development trend predicts that the supervision of the government is gradually reinforcing and community health service develops step by step.
文摘Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insurance system of China＇s urban and rural structure background of two structures of serious, city residents, workers and rural residents is significantly difference in the payment period ,for this question ,the difference between our country will solve the basic medical insurance payment period, the relative level of regulating wages and medical people in our country and develop the medical insurance level, narrow the regional differences, reduce cost problem caused by population flow management, the basic medical insurance system for suggestions to improve the unified and promoting the social and economic level, people＇s medical security level, perfect improvement of physical insurance system of medical insurance according to the long-term sustainable development has a far-reaching significance.
文摘Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment.
基金Supported by National Science Foundation of China (No.30973971)Ph.D. Programs Foundation of Ministry of Education of China (No. 20090013110012)
文摘OBJECTIVE: The association of spleen system including both spleen and stomach with earth, one of the five elements, is a part of the theory of five elements. Practitioners of Traditional Chinese Medicine (TCM) used the theory as a reasoning tool to illustrate the Zang-Fu organs' physiological functions and the interaction among them.The exploration of how the theory of that spleen system is associated with earth was created may provide insights into how five-element theory is applied to TCM practice. METHODS: Using analogism as a method to explore the relationship between earth and spleen system inTCM. RESULTS: Chinese ancestors experienced and observed the features of earth from agricultural practice and used the knowledge for the explanation ofspleen system functions including physiological functions, pathological characteristics and for the treatment of related illnesses. CONCLUSION: The theory of the five elements in TCM is a kind of metaphor, which depends on observation and exploration of the natural world and experience of human beings.
文摘Systems biology is an emerging science of the 21st century and its method and design of study resemble those of traditional Chinese medicine (TCM). Adopting systems biology technology will help to understand TCM Syndromes and modernize Chinese herbal medicine. The technology platforms of systems biology, especially proteomics can provide useful tools for exploring essence of TCM syndromes and understanding principle of herbal formulation. Moreover, compared with methods of molecular biology, such as genomics and proteomics, metabolomics provide more direct, rapid, concise and effective methods for study of kidney disease especially in the case of prevention and treatment with TCM.
文摘Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.
