目的通过比较分析全球现有的3个妊娠期用药危险性分级,为妊娠期合理用药提供证据。方法检索美国食品药品监督局(US Food and Drug Administration,FDA)、澳大利亚药品评估委员会(Australian Drug Evaluation Committee,ADEC)和瑞典(Swed...目的通过比较分析全球现有的3个妊娠期用药危险性分级,为妊娠期合理用药提供证据。方法检索美国食品药品监督局(US Food and Drug Administration,FDA)、澳大利亚药品评估委员会(Australian Drug Evaluation Committee,ADEC)和瑞典(Swedish Catalogue of Approved Drugs,FASS)3个妊娠期用药危险性分级,描述性分析3个分级在定义、药物各级分布、共有药物分级情况以及3目录差别大药物的异同。结果 1FDA采用药物使用的动物研究和人类观察研究说明在妊娠期使用的安全性,ADEC和FASS分级相似,使用人类使用经验和动物研究说明药物在妊娠期使用的安全性;23个目录共有3 167种药物,其中FDA分级有1 113种,ADEC分级有1 232种,FASS分级有983种,ADEC和FASS目录的A级药物多于FDA;3个目录共有367个药物重合,分别占FDA目录的33.0%,ADEC目录的29.8%,FASS目录的37.3%,ADEC和FASS分级目录的分布较为相似,但与FDA分级在A和X级药物的差别大;43个目录差别大的药物集中于FDA分级中X级和C级。结论全球现有的3个妊娠期用药危险性分级差别大,不能仅用分级评估妊娠期用药危险性。展开更多
Based on systematically analyzing the procedure of hazard and operability (HAZOP) study, the author introduces a method of modeling fault diagnosis with the Petri net with fuzzy colors, in which the fuzzy information ...Based on systematically analyzing the procedure of hazard and operability (HAZOP) study, the author introduces a method of modeling fault diagnosis with the Petri net with fuzzy colors, in which the fuzzy information can be represented effectively in the process of analysis. The author proposes the architecture of a knowledge base, which integrates HAZOP analysis and fault diagnosis, and provides the conditions for constructing the knowledge-based expert system. The author also presents a method of knowledge representation for on-line HAZOP analysis and on-line fault diagnosis is presented based on the technology of Petri net with fuzzy colors, which establishes a technological fundamental for integrating the automatic HAZOP analysis and fault diagnosis.展开更多
文摘目的通过比较分析全球现有的3个妊娠期用药危险性分级,为妊娠期合理用药提供证据。方法检索美国食品药品监督局(US Food and Drug Administration,FDA)、澳大利亚药品评估委员会(Australian Drug Evaluation Committee,ADEC)和瑞典(Swedish Catalogue of Approved Drugs,FASS)3个妊娠期用药危险性分级,描述性分析3个分级在定义、药物各级分布、共有药物分级情况以及3目录差别大药物的异同。结果 1FDA采用药物使用的动物研究和人类观察研究说明在妊娠期使用的安全性,ADEC和FASS分级相似,使用人类使用经验和动物研究说明药物在妊娠期使用的安全性;23个目录共有3 167种药物,其中FDA分级有1 113种,ADEC分级有1 232种,FASS分级有983种,ADEC和FASS目录的A级药物多于FDA;3个目录共有367个药物重合,分别占FDA目录的33.0%,ADEC目录的29.8%,FASS目录的37.3%,ADEC和FASS分级目录的分布较为相似,但与FDA分级在A和X级药物的差别大;43个目录差别大的药物集中于FDA分级中X级和C级。结论全球现有的3个妊娠期用药危险性分级差别大,不能仅用分级评估妊娠期用药危险性。
文摘Based on systematically analyzing the procedure of hazard and operability (HAZOP) study, the author introduces a method of modeling fault diagnosis with the Petri net with fuzzy colors, in which the fuzzy information can be represented effectively in the process of analysis. The author proposes the architecture of a knowledge base, which integrates HAZOP analysis and fault diagnosis, and provides the conditions for constructing the knowledge-based expert system. The author also presents a method of knowledge representation for on-line HAZOP analysis and on-line fault diagnosis is presented based on the technology of Petri net with fuzzy colors, which establishes a technological fundamental for integrating the automatic HAZOP analysis and fault diagnosis.