Using Baire metric, this paper proposes a generalized framework of transition system approximation by developing the notions of approximate reachability and approximate bisimulation equivalences. The proposed framewor...Using Baire metric, this paper proposes a generalized framework of transition system approximation by developing the notions of approximate reachability and approximate bisimulation equivalences. The proposed framework captures the traditional exact equivalence as a special case. Approximate reachability equivalence is coarser than approximate bisimulation equivalence, just like the hierarchy of the exact ones. Both approximate equivalences satisfy the transitive property, consequently, they can be used in transition system approximation.展开更多
Motivated by the need for improving the isolation performance, many research studies have been performed on isolators with nonlinear characteristics. Based on the shape of their phase portrait, such devices can be con...Motivated by the need for improving the isolation performance, many research studies have been performed on isolators with nonlinear characteristics. Based on the shape of their phase portrait, such devices can be configured as either a mono-or bi-stable isolator. This paper focuses on investigating the relative performance of these two classes under the same excitations. Force transmissibility is used to measure the isolation performance, which is defined in terms of the RMS of the ratio of the transmitted force to the excitation force. When the system is subjected to harmonic excitation, it is found that the maximum reduction of the force transmissibility in the isolation range using Quasi-Zero stiffness is achieved. When the system is subjected to random excitation, it has the same effect of Quasi-Zero stiffness. Further, optimum damping can be changed with stiffness and has minimum value.展开更多
This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar elect...This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar electricity delivered to grid is verified with the results from a computer simulation package (PVSYST) by adopting the installed component specifications, operation conditions, and weather data of the site. The results show high consistency between the values of energy delivered to the grid measured by the energy company and the energy estimated by system simulation. New system performance indicator is developed and called the optimum performance compliance ratio (PCR). It is a measure of the compliance of the output of the designed PV system with the output which would be produced by the same system with a solar tracker. This indicator provides system designers, contractors and energy providers with the actual capacity of the system that they can offer the end-users.展开更多
The objective of this work was to study the vibration transmissibility characteristics of the undamped and damped smart spring systems. The frequency response characteristics of them were analyzed by using the equival...The objective of this work was to study the vibration transmissibility characteristics of the undamped and damped smart spring systems. The frequency response characteristics of them were analyzed by using the equivalent linearization technique, and the possible types of the system motion were distinguished by using the starting and ending frequencies. The influences of system parameters on the vibration transmissibility characteristics were discussed. The following conclusions may be drawn from the analysis results. The undamped smart spring system may simultaneously have one starting frequency and one ending frequency or only have one starting frequency, and the damped system may simultaneously have two starting frequencies and one ending frequency. There is an optimal control parameter to make the peak value of the vibration transmissibility curve of the system be minimum. When the mass ratio is far away from the stiffness ratio, the vibration transmissibility is small. The effect of the damping ratio on the system vibration transmissibility is significant while the control parameter is less than its optimal value. But the influence of the relative damping ratio on the vibration transmissibility is small.展开更多
The study was conducted in a plastic tunnel in which the heat storage system was installed in the stone accumulator. The system consists of a suction pipe warm air fan and perforated pipes placed in the stone's accum...The study was conducted in a plastic tunnel in which the heat storage system was installed in the stone accumulator. The system consists of a suction pipe warm air fan and perforated pipes placed in the stone's accumulator. The accumulator used a bed of stone (porphyry-type stones of dimension in the range 37 mm to 65 ram). In the accumulator, there are four sections with dimensions of 1.7 m × 11 m, each of which contains a perforated pipe for hot air distribution within the battery, and separate conduits for supplying air to the interior of the tunnel. The paper presents the results of analysis related to performance (as a result of heat and mass transfer) in cycles of charging and discharging of the accumulator.展开更多
It is of great importance to improve the energy performance of the air-conditioning system for building energy conversation. Entransy provides a novel perspective to investigate the losses existing in the air-conditio...It is of great importance to improve the energy performance of the air-conditioning system for building energy conversation. Entransy provides a novel perspective to investigate the losses existing in the air-conditioning system. The progress of entransy analysis in the air-conditioning system is comprehensively investigated in the present study. Firstly missions and characteris- tics of the air-conditioning system are analyzed with emphasis on heat or mass transfer process. It is found that reducing the temperature difference, i.e. reducing the entransy dissipation helps to improve the performance. Entransy dissipations and thermal resistances of typical transfer processes in the air-conditioning system are presented. Characteristics of sensible heat transfer process and coupled heat and mass transfer processes are researched in terms of entransy dissipation analysis. Reasons leading to entransy dissipation are also clarified with the help of unmatched coefficient 4. Principles for reducing the entransy dissipation and constructing a high temperature cooling system are summarized on the basis of case studies in typical handling processes. It's recommended that reducing mixing process, improving match properties are main approaches to reduce the entransy dissipation. The present analysis is beneficial to casting light on the essence of the air-conditioning system and proposing novel approaches for performance optimization.展开更多
This paper presents a simple and cost-effective method for the production of micro-sized silicon carbide whiskers at high yield and the effect on heat transfer enhancement for the whisker laden fluids. For SiC whisker...This paper presents a simple and cost-effective method for the production of micro-sized silicon carbide whiskers at high yield and the effect on heat transfer enhancement for the whisker laden fluids. For SiC whisker synthesis, the starting powder mix- ture is obtained by milling short carbon fibers with the white ashes of rice hulls. Calcina:ion in argon, together with the subse- quent purification process, results in a high yield of SiC whiskers, which possess a diameter of 200-400 nm and a length of several tens of microns. The formation of the whiskers is discussed according to VS growth mechanism. Convective heat transfer performance in small channel tubes is then studied for fluid systems mixed with those micro-sized SiC whiskers at different concentrations. The heat transfer coefficient of SiC containing fluid can be significantly improved in comparison to the base fluid.展开更多
In this work, by virtue of the properties of weakly almost periodic points of a dynamical system (X, T) with at least two points, the authors prove that, if the measure center M(T) of T is the whole space, that is...In this work, by virtue of the properties of weakly almost periodic points of a dynamical system (X, T) with at least two points, the authors prove that, if the measure center M(T) of T is the whole space, that is, M(T) = X, then the following statements are equivalent: (1) (X, T) is ergodic mixing; (2) (X, T) is topologically double ergodic; (3) (X, T) is weak mixing; (4) (X, T) is extremely scattering; (5) (X, T) is strong scattering; (6) (X × X, T × T) is strong scattering; (7) (X × X, T × T) is extremely scattering; (8) For any subset S of N with upper density 1, there is a c-dense Fα-chaotic set with respect to S. As an application, the authors show that, for the sub-shift aA of finite type determined by a k × k-(0, 1) matrix A, erA is strong mixing if and only if aA is totally transitive.展开更多
Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery.Eight new spermine-based protonatable surfactants were designed,sy...Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery.Eight new spermine-based protonatable surfactants were designed,synthesized and evaluated as non-viral pH-sensitive gene carriers.These carriers formed stable complexes with plasmid DNA at an N/P ratio as low as 2.The sizes of the carrier/pDNA nanoparticles (N/P = 12) were in the range of 90–130 nm,smaller than that of Lipofectamine2000/pDNA nanoparticles.The pDNA nanoparticles of the carriers exhibited substantially increased hemolysis when pH decreased from 7.4 to 5.5.The DNA nanoparticles had low cytotocixity,similar to that of Lipofectamine-2000/pDNA nanoparticles.The pH-sensitive gene carriers with no helper lipids resulted in much higher intracellular transfection and gene expression in U87 cells than Lipofectamine-2000.[N,N′-Bis(oleoylcysteinyl)(β-alanyl-α-lysyl)]-spermine monoamide (SKACO) resulted in the highest luciferase transfection efficiency,more than 400 times higher than that of Lipofectamine-2000,and GFP expression in 71% of transfected U87 cells.SKACO was identified as a promising lead carrier for efficient gene delivery.These spermine-based pH-sensitive amphiphilic carriers have a potential to be further developed as efficient non-viral multifunctional gene delivery systems.展开更多
Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferat...Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological pro- cesses. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer's disease (AD). We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to: (i) act as potent regulators of hippocampai synapses and impact in learning and memory; (ii) regulate adult neurogenesis; and finally (iii) control AD pathogenesis.展开更多
There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clin-...There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clin- ical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite (y-Fe^03) or magnetite (Fe304) nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.展开更多
Missiles may be damaged when aeroservoelastic problem occurs,which is caused by the interaction of structure flexibility and flight control system.Because of the limit of wind tunnel test condition,numerical methods a...Missiles may be damaged when aeroservoelastic problem occurs,which is caused by the interaction of structure flexibility and flight control system.Because of the limit of wind tunnel test condition,numerical methods are mostly used in previous aeroservoelastic studies.However,series of assumptions and simplification on structures,aerodynamics and flight control systems are unavoidably introduced,and various nonlinear factors are also ignored,therefore,they result in considerable errors.A novel method called aeroservoelasticity semi-physical simulation test is proposed in this paper,which takes the flexible missile with control system as the test object.Vibration signals at several locations of the missile are measured by accelerometers,then corresponding unsteady aerodynamics is computed based on the fact that airflow at high Mach is nearly quasi-steady,and finally unsteady aerodynamics is exerted simultaneously by shakers at certain locations of the missile.The aeroservoelasticity semi-physical simulation test system can be constructed after the control system is closed.Open loop transfer function test and closed loop stability test are carried out in sequence.The test principle and method proposed in this paper are verified by the concordance between the results of numerical simulation and experiment.展开更多
The present study is concerned with construct two new semidynamical systems which are generated by two partial differential equations of Lasota type. In addition, this study discusses the asymptotic properties: Stron...The present study is concerned with construct two new semidynamical systems which are generated by two partial differential equations of Lasota type. In addition, this study discusses the asymptotic properties: Strong stability, exponential stability, periodic points, the density of periodic points, transitivity and chaos in two spaces: Lp space and Lp space.展开更多
基金Supported by the National Natural Science Foundation of China(No.11371003 and No.11461006)the Natural Science Foundation of Guangxi(No.2011GXNSFA018154 and No.2012GXNSFGA060003)
文摘Using Baire metric, this paper proposes a generalized framework of transition system approximation by developing the notions of approximate reachability and approximate bisimulation equivalences. The proposed framework captures the traditional exact equivalence as a special case. Approximate reachability equivalence is coarser than approximate bisimulation equivalence, just like the hierarchy of the exact ones. Both approximate equivalences satisfy the transitive property, consequently, they can be used in transition system approximation.
基金Foundation item: Supported by the National Natural Science Foundation of China (No. 51375103).
文摘Motivated by the need for improving the isolation performance, many research studies have been performed on isolators with nonlinear characteristics. Based on the shape of their phase portrait, such devices can be configured as either a mono-or bi-stable isolator. This paper focuses on investigating the relative performance of these two classes under the same excitations. Force transmissibility is used to measure the isolation performance, which is defined in terms of the RMS of the ratio of the transmitted force to the excitation force. When the system is subjected to harmonic excitation, it is found that the maximum reduction of the force transmissibility in the isolation range using Quasi-Zero stiffness is achieved. When the system is subjected to random excitation, it has the same effect of Quasi-Zero stiffness. Further, optimum damping can be changed with stiffness and has minimum value.
文摘This paper assesses 4 years of operation of a 1.75 kW roof top solar PV system installed in a Sydney suburban house. The system consists of 10 PV panels, a DC/AC inverter, and a grid connected gross meter. Solar electricity delivered to grid is verified with the results from a computer simulation package (PVSYST) by adopting the installed component specifications, operation conditions, and weather data of the site. The results show high consistency between the values of energy delivered to the grid measured by the energy company and the energy estimated by system simulation. New system performance indicator is developed and called the optimum performance compliance ratio (PCR). It is a measure of the compliance of the output of the designed PV system with the output which would be produced by the same system with a solar tracker. This indicator provides system designers, contractors and energy providers with the actual capacity of the system that they can offer the end-users.
基金Project(51375226)supported by the National Natural Science Foundation of ChinaProject(20113218110017)supported by the Doctoral Program Foundation of Institutions of Higher Education of China+2 种基金Project(PAPD)supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions,ChinaProject(CXZZ11_0199)supported by the Funding of Jiangsu Innovation Program for Graduate Education,ChinaProject(2014)supported by the the Fundamental Research Funds for the Central Universities,China
文摘The objective of this work was to study the vibration transmissibility characteristics of the undamped and damped smart spring systems. The frequency response characteristics of them were analyzed by using the equivalent linearization technique, and the possible types of the system motion were distinguished by using the starting and ending frequencies. The influences of system parameters on the vibration transmissibility characteristics were discussed. The following conclusions may be drawn from the analysis results. The undamped smart spring system may simultaneously have one starting frequency and one ending frequency or only have one starting frequency, and the damped system may simultaneously have two starting frequencies and one ending frequency. There is an optimal control parameter to make the peak value of the vibration transmissibility curve of the system be minimum. When the mass ratio is far away from the stiffness ratio, the vibration transmissibility is small. The effect of the damping ratio on the system vibration transmissibility is significant while the control parameter is less than its optimal value. But the influence of the relative damping ratio on the vibration transmissibility is small.
文摘The study was conducted in a plastic tunnel in which the heat storage system was installed in the stone accumulator. The system consists of a suction pipe warm air fan and perforated pipes placed in the stone's accumulator. The accumulator used a bed of stone (porphyry-type stones of dimension in the range 37 mm to 65 ram). In the accumulator, there are four sections with dimensions of 1.7 m × 11 m, each of which contains a perforated pipe for hot air distribution within the battery, and separate conduits for supplying air to the interior of the tunnel. The paper presents the results of analysis related to performance (as a result of heat and mass transfer) in cycles of charging and discharging of the accumulator.
基金supported by National Natural Science Foundation of China(Grant Nos.51422808&51521005)the National Science&Technology Pillar Program during the 12th Five-year Plan Period(Grant No.2014BAJ02B01)the China Postdoctoral Science Foundation(Grant No.2015M570107)
文摘It is of great importance to improve the energy performance of the air-conditioning system for building energy conversation. Entransy provides a novel perspective to investigate the losses existing in the air-conditioning system. The progress of entransy analysis in the air-conditioning system is comprehensively investigated in the present study. Firstly missions and characteris- tics of the air-conditioning system are analyzed with emphasis on heat or mass transfer process. It is found that reducing the temperature difference, i.e. reducing the entransy dissipation helps to improve the performance. Entransy dissipations and thermal resistances of typical transfer processes in the air-conditioning system are presented. Characteristics of sensible heat transfer process and coupled heat and mass transfer processes are researched in terms of entransy dissipation analysis. Reasons leading to entransy dissipation are also clarified with the help of unmatched coefficient 4. Principles for reducing the entransy dissipation and constructing a high temperature cooling system are summarized on the basis of case studies in typical handling processes. It's recommended that reducing mixing process, improving match properties are main approaches to reduce the entransy dissipation. The present analysis is beneficial to casting light on the essence of the air-conditioning system and proposing novel approaches for performance optimization.
基金supported by Louisiana Board of Regents ITRS Program(Grant Nos.LEQSF(2007-10)-RD-B-02 and CFAW-Ceramics LLC)
文摘This paper presents a simple and cost-effective method for the production of micro-sized silicon carbide whiskers at high yield and the effect on heat transfer enhancement for the whisker laden fluids. For SiC whisker synthesis, the starting powder mix- ture is obtained by milling short carbon fibers with the white ashes of rice hulls. Calcina:ion in argon, together with the subse- quent purification process, results in a high yield of SiC whiskers, which possess a diameter of 200-400 nm and a length of several tens of microns. The formation of the whiskers is discussed according to VS growth mechanism. Convective heat transfer performance in small channel tubes is then studied for fluid systems mixed with those micro-sized SiC whiskers at different concentrations. The heat transfer coefficient of SiC containing fluid can be significantly improved in comparison to the base fluid.
基金supported by the National Natural Science Foundation of China (No. 10971236)the Foundation of Jiangxi Provincial Education Department (No. GJJ11295)the Jiangxi Provincial Natural Science Foundation of China (No. 20114BAB201006)
文摘In this work, by virtue of the properties of weakly almost periodic points of a dynamical system (X, T) with at least two points, the authors prove that, if the measure center M(T) of T is the whole space, that is, M(T) = X, then the following statements are equivalent: (1) (X, T) is ergodic mixing; (2) (X, T) is topologically double ergodic; (3) (X, T) is weak mixing; (4) (X, T) is extremely scattering; (5) (X, T) is strong scattering; (6) (X × X, T × T) is strong scattering; (7) (X × X, T × T) is extremely scattering; (8) For any subset S of N with upper density 1, there is a c-dense Fα-chaotic set with respect to S. As an application, the authors show that, for the sub-shift aA of finite type determined by a k × k-(0, 1) matrix A, erA is strong mixing if and only if aA is totally transitive.
文摘Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery.Eight new spermine-based protonatable surfactants were designed,synthesized and evaluated as non-viral pH-sensitive gene carriers.These carriers formed stable complexes with plasmid DNA at an N/P ratio as low as 2.The sizes of the carrier/pDNA nanoparticles (N/P = 12) were in the range of 90–130 nm,smaller than that of Lipofectamine2000/pDNA nanoparticles.The pDNA nanoparticles of the carriers exhibited substantially increased hemolysis when pH decreased from 7.4 to 5.5.The DNA nanoparticles had low cytotocixity,similar to that of Lipofectamine-2000/pDNA nanoparticles.The pH-sensitive gene carriers with no helper lipids resulted in much higher intracellular transfection and gene expression in U87 cells than Lipofectamine-2000.[N,N′-Bis(oleoylcysteinyl)(β-alanyl-α-lysyl)]-spermine monoamide (SKACO) resulted in the highest luciferase transfection efficiency,more than 400 times higher than that of Lipofectamine-2000,and GFP expression in 71% of transfected U87 cells.SKACO was identified as a promising lead carrier for efficient gene delivery.These spermine-based pH-sensitive amphiphilic carriers have a potential to be further developed as efficient non-viral multifunctional gene delivery systems.
文摘Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological pro- cesses. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer's disease (AD). We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to: (i) act as potent regulators of hippocampai synapses and impact in learning and memory; (ii) regulate adult neurogenesis; and finally (iii) control AD pathogenesis.
基金financially funded by the National Natural Science Foundation of China (NSFC, 31370019, 61420106012)the project of National Key Basic Research Program of China (2013CB733804)+1 种基金The funding partially comes from the Fundamental Research Funds for the Central Universities (2242016K41072)Zhong Ying Young Scholar of Southeast University as well as the support fromthe Collaborative Innovation Center of Suzhou Nano Science and Technology
文摘There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clin- ical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite (y-Fe^03) or magnetite (Fe304) nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.
基金supported by the National Natural Science Foundation of China (Grant Nos. 90716006,10902006)
文摘Missiles may be damaged when aeroservoelastic problem occurs,which is caused by the interaction of structure flexibility and flight control system.Because of the limit of wind tunnel test condition,numerical methods are mostly used in previous aeroservoelastic studies.However,series of assumptions and simplification on structures,aerodynamics and flight control systems are unavoidably introduced,and various nonlinear factors are also ignored,therefore,they result in considerable errors.A novel method called aeroservoelasticity semi-physical simulation test is proposed in this paper,which takes the flexible missile with control system as the test object.Vibration signals at several locations of the missile are measured by accelerometers,then corresponding unsteady aerodynamics is computed based on the fact that airflow at high Mach is nearly quasi-steady,and finally unsteady aerodynamics is exerted simultaneously by shakers at certain locations of the missile.The aeroservoelasticity semi-physical simulation test system can be constructed after the control system is closed.Open loop transfer function test and closed loop stability test are carried out in sequence.The test principle and method proposed in this paper are verified by the concordance between the results of numerical simulation and experiment.
文摘The present study is concerned with construct two new semidynamical systems which are generated by two partial differential equations of Lasota type. In addition, this study discusses the asymptotic properties: Strong stability, exponential stability, periodic points, the density of periodic points, transitivity and chaos in two spaces: Lp space and Lp space.