It is impossible to plan in advance unpredictable phenomena at monitoring, diagnosis and control of industrial batch and continuous equipment and processes such as chemical composition of the raw materials, the proces...It is impossible to plan in advance unpredictable phenomena at monitoring, diagnosis and control of industrial batch and continuous equipment and processes such as chemical composition of the raw materials, the process leads to unexpected reactions and changes its parameters, etc. The agent is active, a program entity, has its own ideas how to perform the tasks of the own agenda. Agents perceive, behave ＂reasonably＂, communicate with other agents. Agents can represent equipment and operations in batch processes as recommended by the ISA $88. Jadex system is based on Java language and on FIPA org. recommendations. The description of ripening tank T406 and recipe for yogurt production in the holding of MADETA Corp. in the Czech Rep. It is described modeling and displaying of＂normal＂ and error, fault unit state of the ripening tank. Agents are within the Jadex system and describing the behavior of ripening tank T406 with state diagrams-automata and assist in diagnosing of fault states. States are described in XML language-SCXML （State Charts XML）. Jadex Control Center-JCC represents a major access point to use for operating in real time.展开更多
The T-tubule (TT) system forms the structural basis for excitation-contraction coupling in heart and muscle cells. The morphogenesis of the TT system is a key step in the maturation of heart cells because it does not ...The T-tubule (TT) system forms the structural basis for excitation-contraction coupling in heart and muscle cells. The morphogenesis of the TT system is a key step in the maturation of heart cells because it does not exist in neonatal cardiomyocytes. In the present study, we quantified the morphological changes in TTs during heart cell maturation and investigated the role of junctophilin-2 (JP2), a protein known to anchor the sarcoplasmic reticulum (SR) to TT, in changes to TT morphological parameters. Analysis of confocal images showed that the transverse elements of TTs increased, while longitudinal elements decreased during the maturation of TTs. Fourier transform analysis showed that the power of ~2 m spatial components increased with cardiomyocytes maturation. These changes were preceded by increased expression of JP2, and were reversed by JP2 knockdown. These findings indicate that JP2 is required for the morphogenesis of TTs during heart development.展开更多
文摘It is impossible to plan in advance unpredictable phenomena at monitoring, diagnosis and control of industrial batch and continuous equipment and processes such as chemical composition of the raw materials, the process leads to unexpected reactions and changes its parameters, etc. The agent is active, a program entity, has its own ideas how to perform the tasks of the own agenda. Agents perceive, behave ＂reasonably＂, communicate with other agents. Agents can represent equipment and operations in batch processes as recommended by the ISA $88. Jadex system is based on Java language and on FIPA org. recommendations. The description of ripening tank T406 and recipe for yogurt production in the holding of MADETA Corp. in the Czech Rep. It is described modeling and displaying of＂normal＂ and error, fault unit state of the ripening tank. Agents are within the Jadex system and describing the behavior of ripening tank T406 with state diagrams-automata and assist in diagnosing of fault states. States are described in XML language-SCXML （State Charts XML）. Jadex Control Center-JCC represents a major access point to use for operating in real time.
基金supported by the National Basic Research Program of China (2011CB809101)the National Natural Science Foundation of China (30730013)
文摘The T-tubule (TT) system forms the structural basis for excitation-contraction coupling in heart and muscle cells. The morphogenesis of the TT system is a key step in the maturation of heart cells because it does not exist in neonatal cardiomyocytes. In the present study, we quantified the morphological changes in TTs during heart cell maturation and investigated the role of junctophilin-2 (JP2), a protein known to anchor the sarcoplasmic reticulum (SR) to TT, in changes to TT morphological parameters. Analysis of confocal images showed that the transverse elements of TTs increased, while longitudinal elements decreased during the maturation of TTs. Fourier transform analysis showed that the power of ~2 m spatial components increased with cardiomyocytes maturation. These changes were preceded by increased expression of JP2, and were reversed by JP2 knockdown. These findings indicate that JP2 is required for the morphogenesis of TTs during heart development.
