素平液治疗宫颈糜烂的临床观察

宫颈糜烂是妇科的常见病和多发病之一，资料显示，30％以上的孕龄妇女患有此病，治疗方法有局部使用腐蚀性药物（如硝酸银、铬酸）及物理治疗（如电烫、冷冻、激光）等，但临床损伤较大。而以聚甲酚磺醛为主要成分的素平液（南京恒剩制药厂生产）能选择性作用于发生病变或异位的上皮细胞，使之凝固、变性、脱落，而对正常鳞状上皮无影响。为此我们将该制剂用于治疗宫颈糜烂，取得满意疗效，现将结果报告如下。

LEEP联合素平治疗重度宫颈糜烂疗效观察

宫颈糜烂是妇女常见病、多发病，轻者无症状，重者可引起不规则阴道出血、不孕，而且与宫颈癌的发生密切相关。目前治疗多为阴道用药和物理方法，我院目前常用的物理治疗方法有：微波、环形电切术（LEEP），微波治疗有一定的局限性，特别是对重度宫颈糜烂伴宫颈肥大者难以达到治疗效果，单纯环形电切术往往出现宫颈黏膜外翻而影响疗效。我院采用环形电切术联合素平治疗重度宫颈糜烂，取得较好的疗效。现报告如下：

Short-term application of low-dose growth hormone in surgical patients: Effects on nitrogen balance and blood glucose

AIM： To investigate the effectiveness and safety of recombinant human growth hormone （rhGH） in postoperative patients. METHODS： A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH （0.15 IU/kg） or placebo （menstruum） injections daily for 7 d after surgery. The two groups had similar nutritional intake. Blood samples for serum fibronecUn, albumin, prealbumin, transferrin and the total lymphocyte count, as well as glucose levels were collected to study the rhGH effect. Basal laboratory evaluation, and nutritional status were estimated on d 1 before as baseline and d 3 and 10 after operation using standard laboratory techniques. Nitrogen balance was measured from d 3 to 9 after operation. RESULTS： The cumulative nitrogen balance was significantly improved in rhGH group compared with the placebo group （11.37 ± 16.82 vs -9.11 ± 17.52, P = 0.0003）. Serum fibronectin was also significantly higher in the rhGH group than in the placebo group （104.77 ± 19.94 vs 93.03 ± 16.03, P 〈 0.05）, whereas changes in serum albumin, prealbumin, transferrin and total lymphocyte counts were not statistically significant. Mean blood glucose levels were significantly higher in the rhGH group from d 3 to 6 after operation. CONCLUSION： If blood glucose can be controlled, lowdose growth hormone together with hypocaloric nutrition is effective on improving positive nitrogen balance and protein conservation and safe is in postoperative patients.

Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer

AIM:To investigate the relationship between blood riboflavin levels and riboflavin transporter 2(RFT2) gene expression in gastric carcinoma(GC) development.METHODS:High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC.Real-time fluorogenic quantitative polymerase chain reaction and immunohistochemistry were used to analyze the expression of RFT2 mRNA and protein in samples from 60 GC patients consisting of both tumor and normal tissue.RESULTS:A significant decrease in the RFT2 mRNA levels was detected in GC samples compared with those in the normal mucous membrane(0.398 ± 0.149 vs 1.479 ± 0.587;P = 0.040).Tumors exhibited low RFT2 protein expression(75%,16.7%,8.3% and 0% for no RFT2 staining,weak staining,medium staining and strong staining,respectively),which was significantly lower than that in the normal mucous membrane(10%,16.7%,26.7% and 46.7% for no RFT2 staining,weak staining,medium staining and strong staining,respectively;P < 0.05).Tumors with low RFT2 expression were significantly associated with tumor stage and histological grade.Moreover,a significantly decrease in Uyghur patients was observed compared with Han patients.However,other parameters-gender,tumor location and lymph node metastasis-showed no significant relationship with RFT2 expression.Blood riboflavin levels were reverse correlated with development of GC(1.2000 ± 0.97 569 ng/mL in high tumor stage patients vs 2.5980 ± 1.31 129 ng/mL in low tumor stage patients;P < 0.05).A positive correlation of plasma riboflavin levels with defective expression of RFT2 protein was found in GC patients(2 = 2.619;P = 0.019).CONCLUSION:Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC.