AIM: Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. The...AIM: Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. Therefore, a perspective, double-blind, randomized comparison of esomeprazole tablets 40 mg (Nexium(?)) vs omeprazole capsules 20 mg (Losec(?)) in treating Chinese subjects with erosive/ulcerative reflux esophagitis (EE) was conducted. METHODS: A total of 48 EE patients were enrolled and randomized into two treatment groups under 8-wk therapy: 25 receiving esomeprazole, while another 23 receiving omeprazole treatment. Finally, 44 completed the whole 8-wk therapy. RESULTS: The difference in healing EE between two groups was 22.7% (72.7% vs 50.0%), not reaching significant value (P = 0.204). The median of the first time needed in relieving heartburn sensation was 1 d for both groups and the remission rates for heartburn on the 1st d after treatment were 77.3% and 65%, respectively (NS). The scores of various reflux relieving symptoms evaluated either by patients or by investigators were not different. Regarding drug safety, 28% of esomeprazole group and 26.1% of omeprazole group reported at least one episode of adverse effects, while constipation and skin dryness were the common side effects in both groups (NS). CONCLUSION: Esomeprazole 40 mg is an effective and safe drug at least comparable to omeprazole in treating Chinese EE patients.展开更多
AIM： To study the effect of proton pump inhibitor （PPI） treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor （EGFR） expression. METHODS： Af...AIM： To study the effect of proton pump inhibitor （PPI） treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor （EGFR） expression. METHODS： After informed consent was obtained, gastric biopsies of the antrum were taken from patients with reflux oesophagitis prior to and after 6 mo of 20 mg omeprazole （n = 24） or 40 mg esomeprazole （n = 22） therapy. Patients did not take any other medications known to affect the gastric mucosa. All patients were Helicobacter pylori negative as confirmed by rapid urease test and histology, respectively. Cell proliferation, apoptosis, EGFR, and p53 expression were measured by immunohistochemical techniques. At least 600 glandular epithelial cells were encountered and results were expressed as percentage of total cells counted. Was considered statistically significant. RESULTS： Although there was a trend towards increase of cell proliferation and EGFR expression both in omeprazole and esomeprazole treated group, the difference was not statistically significant. Neither apoptosis nor p53 expression was affected. CONCLUSION： Long-term PPI treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 expression.展开更多
The paper describes and analyzes the chronology of radical Islamism activities in Georgia, the threats and challenges for Georgian state coming from terrorist organizations, the spread of Ideas of Militant Islamism an...The paper describes and analyzes the chronology of radical Islamism activities in Georgia, the threats and challenges for Georgian state coming from terrorist organizations, the spread of Ideas of Militant Islamism and Jihadism, the possibilities of using Georgian territories by the foreign and local fighters and steps taken by Georgian State. Also popularization of the idea of creation world Islamic Caliphate in the Middle East and ISIL Caucasus Province, joining the terrorist organizations ISIL and A1-Nusra Front in Iraq and Syria by some of the Georgian Muslims. The author analyzes the factors of the popularization of radical Islamism ideas among the young generation, the problems of Georgian Muslim communities and gives the recommendations for state actors.展开更多
In this article the author would like to discuss the usage of Arabic language in South Georgia as language of religious and ethnical minority in circumstances of Russian rule. The best examples of this are Arabic insc...In this article the author would like to discuss the usage of Arabic language in South Georgia as language of religious and ethnical minority in circumstances of Russian rule. The best examples of this are Arabic inscriptions on gravestones. In this article the author describes several inscriptions from Trialeri, South Georgia, which, because of unknown reasons, have never been studied by scientists before. Another important reason why the author has paid importance to those inscriptions is their recent condition and danger to lose them forever. The author has studied inscriptions from three main cemeteries： Beshtasheni, Tikma-Dash, and Minayasar. As a result of his research the author can say that Arabic language have been used by Muslims of Turk origins in Trialeti till Soviet time. They were using this language to preserve their identity, but it used to work only about a century. Soviet rule tried to destroy all identities and religions and especially after WWII they have reached more or less success. Today the Muslim population of Trialtei does not understand Arabic, they just know that their religion is Islam and in the graves with Arabic inscriptions lay their predecessors.展开更多
基金Supported by the Research Foundation of Digestive Medicine,Taiwan, China
文摘AIM: Esomeprazole, an oral S-form of omeprazole, has been a greater acid inhibitor over omeprazole in treating acid-related diseases. Only less published data is available to confirm its efficacy for Asian people. Therefore, a perspective, double-blind, randomized comparison of esomeprazole tablets 40 mg (Nexium(?)) vs omeprazole capsules 20 mg (Losec(?)) in treating Chinese subjects with erosive/ulcerative reflux esophagitis (EE) was conducted. METHODS: A total of 48 EE patients were enrolled and randomized into two treatment groups under 8-wk therapy: 25 receiving esomeprazole, while another 23 receiving omeprazole treatment. Finally, 44 completed the whole 8-wk therapy. RESULTS: The difference in healing EE between two groups was 22.7% (72.7% vs 50.0%), not reaching significant value (P = 0.204). The median of the first time needed in relieving heartburn sensation was 1 d for both groups and the remission rates for heartburn on the 1st d after treatment were 77.3% and 65%, respectively (NS). The scores of various reflux relieving symptoms evaluated either by patients or by investigators were not different. Regarding drug safety, 28% of esomeprazole group and 26.1% of omeprazole group reported at least one episode of adverse effects, while constipation and skin dryness were the common side effects in both groups (NS). CONCLUSION: Esomeprazole 40 mg is an effective and safe drug at least comparable to omeprazole in treating Chinese EE patients.
基金Supported by the National Science Foundation (OTKA Grant No:T 034345)
文摘AIM： To study the effect of proton pump inhibitor （PPI） treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor （EGFR） expression. METHODS： After informed consent was obtained, gastric biopsies of the antrum were taken from patients with reflux oesophagitis prior to and after 6 mo of 20 mg omeprazole （n = 24） or 40 mg esomeprazole （n = 22） therapy. Patients did not take any other medications known to affect the gastric mucosa. All patients were Helicobacter pylori negative as confirmed by rapid urease test and histology, respectively. Cell proliferation, apoptosis, EGFR, and p53 expression were measured by immunohistochemical techniques. At least 600 glandular epithelial cells were encountered and results were expressed as percentage of total cells counted. Was considered statistically significant. RESULTS： Although there was a trend towards increase of cell proliferation and EGFR expression both in omeprazole and esomeprazole treated group, the difference was not statistically significant. Neither apoptosis nor p53 expression was affected. CONCLUSION： Long-term PPI treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 expression.
文摘The paper describes and analyzes the chronology of radical Islamism activities in Georgia, the threats and challenges for Georgian state coming from terrorist organizations, the spread of Ideas of Militant Islamism and Jihadism, the possibilities of using Georgian territories by the foreign and local fighters and steps taken by Georgian State. Also popularization of the idea of creation world Islamic Caliphate in the Middle East and ISIL Caucasus Province, joining the terrorist organizations ISIL and A1-Nusra Front in Iraq and Syria by some of the Georgian Muslims. The author analyzes the factors of the popularization of radical Islamism ideas among the young generation, the problems of Georgian Muslim communities and gives the recommendations for state actors.
文摘In this article the author would like to discuss the usage of Arabic language in South Georgia as language of religious and ethnical minority in circumstances of Russian rule. The best examples of this are Arabic inscriptions on gravestones. In this article the author describes several inscriptions from Trialeri, South Georgia, which, because of unknown reasons, have never been studied by scientists before. Another important reason why the author has paid importance to those inscriptions is their recent condition and danger to lose them forever. The author has studied inscriptions from three main cemeteries： Beshtasheni, Tikma-Dash, and Minayasar. As a result of his research the author can say that Arabic language have been used by Muslims of Turk origins in Trialeti till Soviet time. They were using this language to preserve their identity, but it used to work only about a century. Soviet rule tried to destroy all identities and religions and especially after WWII they have reached more or less success. Today the Muslim population of Trialtei does not understand Arabic, they just know that their religion is Islam and in the graves with Arabic inscriptions lay their predecessors.
