Migratory birds are known to use a number of different orientation cues to determine and maintain the direction of their movements. They are able to use at least three different sources of compass information, includi...Migratory birds are known to use a number of different orientation cues to determine and maintain the direction of their movements. They are able to use at least three different sources of compass information, including solar, stellar and geomagnetic cues. However, little is known about how these cues are calibrated into uniform reference direction information, while the hierarchy of these cues remains controversial. In recent studies, researchers suggest that avian migrants calibrate their geomagnetic compass on sunset cues, whereas others fail to find such patterns and insist on the prevalence of the magnetic compass. We carefully reviewed the existing literature and suggest that the conflicting results reported by different authors are due to genuine variation among species and propose hypotheses to explain this variation.展开更多
Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem c...Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future.展开更多
基金supported by grant 12-04-00296-a from the Russian Foundation for Basic ResearchX.L. was supported by grant 60905060 from the National Natural Science Foundation of China+3 种基金grant BS2010DX025 from the Scientific Research Foundation for Excellent Middle-Aged and Youth Scientists of Shandong Province of Chinagrant 2011B11114 from the Fundamental Research Funds for Central UniversitiesThe writing of this review was inspired by the Bilateral Sino-Russian symposium ‘Animal Magnetic Navigation’ supported by grant 11-04-91216-NSFC-z from the Russian Foundation for Basic Researchgrant 61010164 from the National Natural Science Foundation of China
文摘Migratory birds are known to use a number of different orientation cues to determine and maintain the direction of their movements. They are able to use at least three different sources of compass information, including solar, stellar and geomagnetic cues. However, little is known about how these cues are calibrated into uniform reference direction information, while the hierarchy of these cues remains controversial. In recent studies, researchers suggest that avian migrants calibrate their geomagnetic compass on sunset cues, whereas others fail to find such patterns and insist on the prevalence of the magnetic compass. We carefully reviewed the existing literature and suggest that the conflicting results reported by different authors are due to genuine variation among species and propose hypotheses to explain this variation.
基金supported by the "Strategic Priority Research Program of the Chinese Academy of Sciences" (XDA01030000)the key Research Program of the Chinese Academy of Sciences (ZDRW-ZS-2016-2)+3 种基金the National Natural Science Foundation of China (81572131, 81571213)the Natural Science Foundation of Jiangsu Province (BL2012004, BK20151210)the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe key Research and Development Program of Ministry of Science and Technology (2016YFC1101500)
文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future.
