Abstract:Objective To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI).Methods In a randomized trial, 822 patients with a first AMI received conventional medica...Abstract:Objective To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI).Methods In a randomized trial, 822 patients with a first AMI received conventional medical treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly allocated to captopril [dosage from the first 6.25?mg to 25?mg/t.i.d, 209 younger patients (≤64 years), 269 elderly patients (65-75 years)] or conventional treatment only (131 younger patients, 213 elderly). Survival in the four groups was calculated with the Kaplan-Meier method. Multivariate analysis was performed to understand the degree that multi-variables (including age) affect survival in patients taking captopril in the hospital or during long term follow-up.Results The survival of patients who took captopril correlated significantly with age (P<0.001). The survival of the elderly patients on captopril treatment did increase (P<0.0001), but not of the younger ones (P>0.05) during hospitalization. During follow-up, the survival of patients who took captopril correlated insignificantly with age (P>0.05), but both the elderly and the younger patients have good survival rates (all P<0.01) and lower cardiac events (all P<0.01) when they took captopril.Conclusions Captopril exerts a weak effect on the younger patients but a beneficial effect on the elderly patients during hospitalization after AMI. However, there is no difference between the younger and the elderly in the prognosis, both having good survival and lower cardiac events when they take captopril long term during follow-up.展开更多
Although conventional suturing techniques are commonly used in assisting wound closure,they do pose limited conduciveness and may lead to secondary injury to wound tissues.Inspired by marine organism mussels,we design...Although conventional suturing techniques are commonly used in assisting wound closure,they do pose limited conduciveness and may lead to secondary injury to wound tissues.Inspired by marine organism mussels,we designed and manufactured a bio-inspired hydrogel-based bandage with tough wet tissue adhesion to substitute traditional surgical suture,accelerate wound healing and avoid infection.Poly(γ-glutamic acid)was modified with 3,4-dihydroxyphenylalanine and glycidyl methacylate,then introduced into the acrylic acid-co-acrylamide hydrogel matrix with robust mechanical properties.The hydrogel bandage showed strong chemical linkage adhesion(70±2.1 kPa),which is 2.8 times that of commercial tissue adhesive fibrin glue(25±2.2 kPa).The hydrogel bandage can not only maintain the self-stability,but is also capable of self-tuning adhesive strength in the range of 14-70 kPa to achieve different adhesion effects by tuning constituent ratio.The bandage has desirable compression properties(0.7±0.11 MPa)and tensile elongation(about 25 times),which ensures its resistance to damages,especially in joint spaces.Secondly,the bandage was endowed with antioxidant and endogenous broad-spectrum antibacterial properties with its catechol structure.Results also demonstrated excellent cell compatibility and blood compatibility,certifying its eligible biological safety profile.In a rat full-thickness cutaneous deficiency model,we can clearly observe that the bandage possesses the ability to promote wound healing(only need 6 days).Above all,this research provides a new strategy for the emergency treatment of liver hemostasis and myocardial repair during disaster rescue.展开更多
文摘Abstract:Objective To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI).Methods In a randomized trial, 822 patients with a first AMI received conventional medical treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly allocated to captopril [dosage from the first 6.25?mg to 25?mg/t.i.d, 209 younger patients (≤64 years), 269 elderly patients (65-75 years)] or conventional treatment only (131 younger patients, 213 elderly). Survival in the four groups was calculated with the Kaplan-Meier method. Multivariate analysis was performed to understand the degree that multi-variables (including age) affect survival in patients taking captopril in the hospital or during long term follow-up.Results The survival of patients who took captopril correlated significantly with age (P<0.001). The survival of the elderly patients on captopril treatment did increase (P<0.0001), but not of the younger ones (P>0.05) during hospitalization. During follow-up, the survival of patients who took captopril correlated insignificantly with age (P>0.05), but both the elderly and the younger patients have good survival rates (all P<0.01) and lower cardiac events (all P<0.01) when they took captopril.Conclusions Captopril exerts a weak effect on the younger patients but a beneficial effect on the elderly patients during hospitalization after AMI. However, there is no difference between the younger and the elderly in the prognosis, both having good survival and lower cardiac events when they take captopril long term during follow-up.
基金supported by the National Natural Science Foundation of China(31771049)the Foundation of Key R&D Project of Jiangsu Province(BE2018731)+3 种基金the Research Foundation of State Key Laboratory of Materials-Oriented Chemical Engineering(ZK201806,KL18-06 and ZK201606)the Six Talent Peaks Project of Jiangsu Province(SWYY-046)the Natural Science Foundation of Jiangsu Province(BK20200682)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX20_0408).
文摘Although conventional suturing techniques are commonly used in assisting wound closure,they do pose limited conduciveness and may lead to secondary injury to wound tissues.Inspired by marine organism mussels,we designed and manufactured a bio-inspired hydrogel-based bandage with tough wet tissue adhesion to substitute traditional surgical suture,accelerate wound healing and avoid infection.Poly(γ-glutamic acid)was modified with 3,4-dihydroxyphenylalanine and glycidyl methacylate,then introduced into the acrylic acid-co-acrylamide hydrogel matrix with robust mechanical properties.The hydrogel bandage showed strong chemical linkage adhesion(70±2.1 kPa),which is 2.8 times that of commercial tissue adhesive fibrin glue(25±2.2 kPa).The hydrogel bandage can not only maintain the self-stability,but is also capable of self-tuning adhesive strength in the range of 14-70 kPa to achieve different adhesion effects by tuning constituent ratio.The bandage has desirable compression properties(0.7±0.11 MPa)and tensile elongation(about 25 times),which ensures its resistance to damages,especially in joint spaces.Secondly,the bandage was endowed with antioxidant and endogenous broad-spectrum antibacterial properties with its catechol structure.Results also demonstrated excellent cell compatibility and blood compatibility,certifying its eligible biological safety profile.In a rat full-thickness cutaneous deficiency model,we can clearly observe that the bandage possesses the ability to promote wound healing(only need 6 days).Above all,this research provides a new strategy for the emergency treatment of liver hemostasis and myocardial repair during disaster rescue.
