目的在查阅文献的基础上,对紫姜的化学成分和药理作用的研究现状进行综述,为其进一步研究开发提供科学依据。方法系统查阅中国知网、万方、维普、PubMed、SpringerLink、Web of Science等国内外多个数据库,搜集紫姜化学成分及药理作用...目的在查阅文献的基础上,对紫姜的化学成分和药理作用的研究现状进行综述,为其进一步研究开发提供科学依据。方法系统查阅中国知网、万方、维普、PubMed、SpringerLink、Web of Science等国内外多个数据库,搜集紫姜化学成分及药理作用方面的文献,并对其进行归纳总结。结果紫姜具有抗炎、抗勃起功能障碍、抗癌、抗过敏、抗菌、抗高血压等主要作用。主要的活性部位为醇提物,且已发现的化学成分主要为甲氧基黄酮类。结论通过对紫姜的化学成分和药理作用的整理、介绍,为其进一步深度开发和临床应用提供科学依据。展开更多
Medicinal use of spices/herbs has been gradually increased in the developed countries, Zingiber officinale （Ginger） is known to possess potent antioxidant and anti inflammatory properties. Therefore, the aim of this...Medicinal use of spices/herbs has been gradually increased in the developed countries, Zingiber officinale （Ginger） is known to possess potent antioxidant and anti inflammatory properties. Therefore, the aim of this study is to determine the possible anti-mutagenic effect of ginger against the genotoxic effect of anti-cancer drug Taxol 0.6 mg/kg. This study is conducted by using two types of cytogenetic studies in bone marrow cell of mal albino mice Mus musculus （average weight 25-30 g）. The animals were randomly distributed into six groups, each of 14 mi[ce, （GI） was given the solvent, （G2） treatment of the medical dose of Taxol drug, （G3） treatment of ginger, （G4） a pre-treatment of ginger prior to treatment of drug, （G5） a simultaneous treatment of ginger and treatment of drug, （G6） a post-treatment of ginger after treatment drug. The study results show that significant increase in total chromosomal aberrations and significant increase in the number of micronuclei were observed after treatment drug. The significant structural aberrations were in the form of end-to-end associations. The numerical chromosomal aberrations were endomitosis and polyploid. The results showed that the frequencies of chromosomal aberrations and micronuclei in ginger treated group were not significantly different from control. Simultaneous treatment of ginger was found to be effective in reducing the genotoxic effects induced by drug Taxol especially in the total number of the chromosomal aberrations and the number of micronuclei.展开更多
Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatme...Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatment of PC-3 cells with El0 or docetaxel resulted in growth inhibition in a concentration-reliant fashion. Combinations of E10 and docetaxel inhibited the growth of PC-3 cells in a synergistic manner. Effects of a combination of E10 and docetaxel were associated with synergistic inhibition of the transcriptional activity of nuclear factor-kappa B （NF-KB）, and robust reductions in the levels of B-cell lymphoma-2 （Bcl-2） were found in PC-3 cells treated with a combination of E10 and docetaxel. Our data indicated that the effects of El0 in combination with docetaxel on PC-3 cells were associated with inhibition of NF-r,B and Bcl-2. Further studies using suitable animal models are necessary to determine the in vivo effect of this combination.展开更多
文摘目的在查阅文献的基础上,对紫姜的化学成分和药理作用的研究现状进行综述,为其进一步研究开发提供科学依据。方法系统查阅中国知网、万方、维普、PubMed、SpringerLink、Web of Science等国内外多个数据库,搜集紫姜化学成分及药理作用方面的文献,并对其进行归纳总结。结果紫姜具有抗炎、抗勃起功能障碍、抗癌、抗过敏、抗菌、抗高血压等主要作用。主要的活性部位为醇提物,且已发现的化学成分主要为甲氧基黄酮类。结论通过对紫姜的化学成分和药理作用的整理、介绍,为其进一步深度开发和临床应用提供科学依据。
文摘Medicinal use of spices/herbs has been gradually increased in the developed countries, Zingiber officinale （Ginger） is known to possess potent antioxidant and anti inflammatory properties. Therefore, the aim of this study is to determine the possible anti-mutagenic effect of ginger against the genotoxic effect of anti-cancer drug Taxol 0.6 mg/kg. This study is conducted by using two types of cytogenetic studies in bone marrow cell of mal albino mice Mus musculus （average weight 25-30 g）. The animals were randomly distributed into six groups, each of 14 mi[ce, （GI） was given the solvent, （G2） treatment of the medical dose of Taxol drug, （G3） treatment of ginger, （G4） a pre-treatment of ginger prior to treatment of drug, （G5） a simultaneous treatment of ginger and treatment of drug, （G6） a post-treatment of ginger after treatment drug. The study results show that significant increase in total chromosomal aberrations and significant increase in the number of micronuclei were observed after treatment drug. The significant structural aberrations were in the form of end-to-end associations. The numerical chromosomal aberrations were endomitosis and polyploid. The results showed that the frequencies of chromosomal aberrations and micronuclei in ginger treated group were not significantly different from control. Simultaneous treatment of ginger was found to be effective in reducing the genotoxic effects induced by drug Taxol especially in the total number of the chromosomal aberrations and the number of micronuclei.
基金The National Cancer Institute of China(Grant No.P30-CA072720)the National Natural Science Foundation of China(Gr ant No.81272452)the PhD Start-up Fund of Natural Science Foundation of Guangdong Province,China(Grant No.2014A030310329)
文摘Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatment of PC-3 cells with El0 or docetaxel resulted in growth inhibition in a concentration-reliant fashion. Combinations of E10 and docetaxel inhibited the growth of PC-3 cells in a synergistic manner. Effects of a combination of E10 and docetaxel were associated with synergistic inhibition of the transcriptional activity of nuclear factor-kappa B （NF-KB）, and robust reductions in the levels of B-cell lymphoma-2 （Bcl-2） were found in PC-3 cells treated with a combination of E10 and docetaxel. Our data indicated that the effects of El0 in combination with docetaxel on PC-3 cells were associated with inhibition of NF-r,B and Bcl-2. Further studies using suitable animal models are necessary to determine the in vivo effect of this combination.
