独抒妙理 博采众方——谢士泰《删繁方》方论钩沉

阐述南北朝医家谢士泰《删繁方》的学术理论和临证医方特色。《删繁方》博采诸家,删繁存要,既有理论阐发,又有良方妙剂,理法方药俱全,尤以"五脏劳论"和"六极论"等最具学术价值。体现谢氏在脏腑辨证论治方面的学术成就。

《删繁方》对五脏咳的发挥

为溯洄五脏咳理论的发展源流,探寻五脏咳的治法和选方用药,对比了《素问》五脏咳与《删繁方》六极病相关条文,发现二者在病因病机、证候表现的描述上高度相似,《删繁方》可能是现存典籍中最早对五脏咳理论进行发挥并制定相关治法、处方的文献。《删繁方》结合五脏寒热虚实细化了五脏咳的发病机制,并根据六极病的辨证内容提出治法方药,对探究《素问》五脏咳理论的临床应用方法具有一定的学术价值与指导意义。

方术五法之繁方

随着疾病证型、症状有复杂化趋势的出现,此文以中医理论及诊病技术为基础提出方术繁方的概念,其主要理论特点是通过对疾病的病因、证型所表现的症状多样性与中药功效多样性的相关性进行探讨,在整体观念、辨证论治的基础上将中医组方配伍过程概括成全症配伍、药症合象、避毒选和等共五种方法,结合多味小量配伍方式提出中医方术五法繁方的概念,以药症合象为起点将中药的多效性和中医临床的多症状性进行结合,以期为临床诊断疾病探索一种具体的、易于实际处方的方剂配伍新模式。

《删繁方》对仲景方的继承和发展

六朝医家谢士泰编著的《删繁方》继承发展了张仲景辨证论治的精神和理法方药合一的诊疗模式,对于病证与《伤寒杂病论》一致的就直接引用仲景方剂,主病一致、证有微殊则灵活化裁,在仲景原方的基础上或直接加味,或进行加减变化,或合方图治,或沿袭其中药物基本配伍,随证施药,成为魏晋南北朝时期一部极具特色的医方著作。既可见六朝医家对仲景组方严谨、药专力宏的认同,又可以看到六朝医家辨证论治、不拘一格发展经方的精神,为中医药学的发展做出了有益的探索。

建中肾沥汤法诸丸方探析

[目的]探析建中肾沥汤法诸丸方的证治特点。[方法]以归纳总结古籍文献并结合临床实践经验的方法,对建中肾沥汤法诸丸方的证治源流、代表方剂、启示意义等三方面进行探析,并举验案以作示例。[结果]建中肾沥汤法诸丸方起源于张仲景,传承发展于葛洪、释僧深、谢士泰、孙思邈等,有补肾治虚之功。《深师方》乐令黄芪汤可疗虚劳里急,《删繁方》肾沥汤可疗骨极虚寒。建中肾沥汤法诸丸方丰富了《黄帝内经》中“调以甘药”的理论内涵,体现了《黄帝内经》中“劳者温之”的治疗法则,扩大了《伤寒论》中“可与不可”的选择范围。所举验案辨证属骨痹病和腹痛病,以乐令黄芪汤加减,疗效显著。[结论]建中肾沥汤法诸丸方可补肾益精血以疗虚损,可复营卫之气而济百病,对临床复杂性虚损病证的辨治极具启示意义。

《金匮要略》“补气加半夏”考

《金匮要略·血痹虚劳病脉证并治第六》的黄芪建中汤方后附有小字注文“及疗肺虚损不足,补气加半夏三两”,对于“补气加半夏”中医界历来争议很多。通过对比《金匮要略》不同传本以及《外台秘要》,可知这14字小字注文应当是引自《删繁方》“又建中汤,疗肺虚损不足,补气方”,宋臣诠次整理《金匮要略》时在黄芪建中汤后补充了这个用半夏三两的建中汤,但由于改易了部分原文所以产生了歧义,应当是此建中汤方有补气之功,而非半夏这味药可以补气。

Study on Biological Characters of Asparagus macowanii Baker.

Asparagus macowanfi Baker, is a climbing herbaceous foliage species in genus Asparagus of Liliaceae, This paper summarized its multiple uses, morphologi- cal characteristics, biological habit, reproduction methods, management after cultiva- tion, prevention and control of pests and disease, as well as harvest and grading, with the objective to provide references for the exploitation and utilization of As- paragus macowanii Baker.

Propagation methods for black locust (Robinia pseudoacacia L.) improvement in Hungary

Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. Black locust plants are commonly produced by two methods, by seed and by root cuttings. Tissue culture propagation can be considered as a relatively new method. Growing trees from seed is a relatively sim-ple method for reliably producing seedlings on a large scale under a variety of circumstances. Mechanization of the method is easy and the production cost is relatively low. Propagation from root cuttings and tissue culture are valuable for reproduction of superior individuals or varieties. By applying these methods, superior traits of the selected trees can be preserved in the clones. Recent experiments demonstrated that micropropagated trees could be successfully transplanted into soil, hardened and grown in the field.

Two New Free-Living Marine Nematode Species of the Genus Anoplostoma(Anoplostomatidae) from the Mangrove Habitats of Xiamen Bay,East China Sea

Two new species of free-living marine nematode from mangrove habitats in Xiamen Bay are identified.Anoplostoma tumidum sp.nov.is characterized by relatively short outer labial setae(0.86–1.00 h.d.),long tail(c 7.2–8.9,c' 8.3–10.5),an instinct swollen distal portion of slender spicule(Sc 94–101 μm),and well developed copulatory bursae without bursal papillae.A.tumidum sp.nov.differs from all valid species of genus Anoplostoma in copulatory apparatus of males with a distinct swollen distal portion of spicule,and a relatively obvious constriction of head.A.paraviviparum sp.nov.is characterized by relatively long outer labial setae(1.11–1.22 h.d.),and tail(c 6.6–8.5,c' 8.6–10.2);elongated spicules with distinct knob-like proximal and pointed distal ends(Sc 46–69 μm);distinct strip-like gubernaculum(length with 11–15μm);well developed copulatory bursae with precloacal papillae and post-cloacal papillae;and a distinct constriction of head.A.paraviviparum sp.nov.is similar to A.viviparum Bastian,1865,but differs in the reproductive mode of female and the constriction of head.

Agronomic Characters of Elymus dahuricus,Hordeum brevisubulatum and Their BC1F3

[ Objective] This study was to explore the inheritance of BC1 F3 to excellent characteristics of parents（ Elymus dahuricus, Hordeum brevisubu/atum）, heterosis and fertility restoration. E Methodl The agronomic characters such as growth period, growth rate, pollen fertility, fecundity, reproducibility and fresh grass output of Elymus dahudcus, Hordeum brevisubu/atum and BC1 F3 were comparatively studied. E Result l The growth dynamic of the BC1 F3 lined tended to like that of its parent Hordeum brevisubu/atum; although growing periods of various lines were different, they were close to that of Hordeurn brevisubulatum. There were differences in pollen fertility and seed setting, the pollen fertility rate of YF3-93 was higher than recurrent parent Hordeum brevisubulatum, its seed setting rate in open pollination was also higher. Some lines had low pollen fertility rate and seed setting rate, such as the pollen fertility rate of PF3-52. There were significant differences in the output among BC1 F3 lines, e.g. the heterosis （HP） of YF3-64, YF3-74 and YF3-83 were 75.53%, 75.12% and 66.16%, respectively; however, the yields of PF3- 52, PF3-15 and PF3-42 were lower than their parents. ~ Conclusion] This study provided reference for breeding new varieties of forage which is suitable to drought and saline environment.

Effect of salinity on growth and first sexual maturity of Exopalaemon carinicauda(Holthuis, 1950)

To determine the optimal salinity for growth and first sexual maturity of ExopaIaemon carinicauda, the effects of salinity on growth and reproductive performance of early juvenile prawns of E. carinicauda were evaluated under laboratory conditions. Postlarvae from the same female broodstock were reared at six salinity levels （5, 10, 15, 20, 25, and 30） for 12 weeks. The specific growth rate （SGR） and survival rate （SR） under different salinity levels in the first 6 weeks were calculated and compared. SGR was significantly influenced by salinity. Prawns reared in salinity of 10 grew significantly faster （P〈0.05） than those reared in salinities of 5, 20, 25, and 30. However, ANOVA confirmed that there was no significant effect among the six salinity levels on SR. For the next 6 weeks, the body length （BL）, body weight （BW） at the first sexual maturity, and the age at median sexual maturity （As0） of females were measured and compared. Female prawns reared at salinity of 10 presented significantly shorter A50, but no significant differences among the six salinity levels for BL and BW at the first sexual maturity were observed. Based on the above information, the optimal salinity for growth and first sexual maturity of juvenile E. carinicauda is approximately 10.

Mechanism of action of cracks water on rock landslide in rainfall

In worldwide, the most common triggering factor of rock landslides is extended and intense rainfall. However, different from the soil slope failure caused by softening action of infiltration rainwater, the mechanism of rock landslide in rainfall is not clear. From the view of fracture mechanics, the propagation of cracks on rock slope and the development of sliding surface were researched. Then based on hydraulics formulas and using Sweden arc method, the influence of crack water on stability of rock slope was quantitatively studied. Finally, an example was given to check the theoretical approach. The result shows that the development of sliding surface of rock slope is mainly caused by crack propagation under hydrostatic pressure when the stress intensity factor KI at crack tip is bigger than the toughness index of rock fractures Klc, and the failure of slope is the result of hydraulic action of crack water and the softening of materials on sliding surface when the depth of crack water is bigger than a minimum value hmin.

Plant Regeneration of Ziziphus spina-christi by in vivo and in vitro Methods

Christ's thorn (Ziziphus spina-christi L. Desf.) is ecologically and economically important in Iran. Since it is a cross-pollinated plant with a wide range of genetic variability, an investigation was carried out to determine the best method for mass and clonal propagation. Three vegetative methods were examined, including 1) cutting, where shoots with a 22-25 cm length and three shoot diameters were treated with two culture media; 2) layering, where air layering and trench layering treatments consisted of three growth regulators at three levels of concentration; and 3) tissue culture with nodal segments bearing axillary buds that were removed from shoots of mature trees at different seasons. Several experiments were carried out to determine the best disinfectant chemical, the best culture method, the best season, the appropriate explant characteristics and media type. Rooting was successful only on the sandy beds for cuttings with more than (S.O mm diameter. For the trench layering method, only one specimen in one replicate rooted a very small root, while for the air layering method, only seedlings with growth regulator treatments rooted successfully. The best season for explant harvesting was determined as mid summer, and among the disinfecting treatments, Ca(OCI)2 at a concentration of 0 5 g kg-1 for 20 minutes was the best. There were no significant differences for shoot weight and length with a Murashige and Skoog (MS) medium with and without a hormone.

Analysis of Three-dimensional Crack Propagation by Using Displacement Discontinuity Method

A technique for modelling of three-dimensional(3D)quasi-statically propagating cracks in elastic bodies by the displacement discontinuity method(DDM)was described.When the crack is closed,the Mohr-coulomb rule on the two contacted surfaces of the crack must be satisfied.A simple iterative method was adopted in order to consider three different states of cracks.Under the assumption that the advance of the point on the crack front would occur only in the normal plane which is through this edge point,the maximum energy release rate criterion is modified to be used as the criterion for the crack growth.With discretization,the process of crack propagation can be seen as the advance of the vertices of the crack front.The program MCP3D was developed based on these theories to simulate the 3D quasi-static crack propagation.A numerical example of a penny-shaped crack subject to tension and compression in an infinite elastic media was analyzed with MCP3D,and the results in comparison with others' show that the present method for 3D crack propagation is effective.

Determination of Physiological Biochemical Parameters and Reproductive Performance in Transgenic sFat-1 Gene Pigs

[Objective] The aim was to evaluate the health of transgenic sFat-1 gene pigs in order to provide a reference for the breeding selection of pig excellent individuals. [Method] 15 physiological biochemical parameters and reproductive performances of 21 negative control pigs and 20 transgenic sFat-1 gene pigs were determined. [Result] The liver functions of some transgenic sFat-1 gene pigs were hurted lightly,and the reproductive performance also decreased lightly. [Conclusion] The determination of physiological biochemical parameters and reproductive performance in transgenic pigs could be taken as one of effective methods in environmental safety evaluation of transgenic pigs.

An integrated model for predicting the flame propagation in crimped ribbon flame arresters

Crimped ribbon flame arresters are important safety devices in the chemical industry, especially for the danger- ous situations. Although proper design of arresters by the numerical simulation method is promising, its reliabil- ity and accuracy are dependent upon the mathematical model. In this work, an integrated mathematical model for the microchannel in the crimped ribbon flame attesters was set up; the fluid flow behavior and the sensitiv- ities of four chemical kinetics mechanisms of propane-air on the accuracy were analysed. It is shown that turbu- lence is predominant in the microchannel of the crimped ribbon flame arresters under the defiagration and detonation conditions, and a new quenching criterion for the numerical simulation is proposed. The kinetics mechanism of Mansouri et al. among the four ones is the most accurate due to the best agreement of the pre- dicted outlet temperature at the experimental flameproof velocity with the autoignition temperature of propane-air. The species mass fraction profiles and the temperature distribution, which are too difficult to mea- sure due to the tiny dimension of the microchannel in experiments, are captured. The fundamental insights into chemical reactions and heat loss are well portrayed. It can be concluded that the integrated mathematical model established in this work can be used as a reliable tool for modeling, selecting and designing such type of crimped ribbon flame attesters with the propane-air medium in the future.

Adaptive associative classification with emerging frequent patterns

In this paper, we propose an enhanced associative classification method by integrating the dynamic property in the process of associative classification. In the proposed method, we employ a support vector machine（SVM） based method to refine the discovered emerging ~equent patterns for classification rule extension for class label prediction. The empirical study shows that our method can be used to classify increasing resources efficiently and effectively.

Rapid Propagation of Virus-free Sugarcane Plantlets via Temporary Immersion Bioreactor System

By employing temporary immersion bioreactor system(TIBs),we studied virus-free culture of seedlings from sugarcane varieties ROC16 and ROC22,from medium recipe,inoculation amount,sucrose concentration,and variety difference. The results showed,using this method,that proliferation rate of ROC16 improved by 40 times,per flask generated about 800 plantlets; of ROC22 improved by 30 times,per flask generated about 400-600 plantlets. The results provided basis for using TIBs in rapid propagation of plantlets via tissue culture.

Effect of Dietary Nitrogen Corrected-True Metabolism Energy and Digestible Amino Acids on Broiler Breeder Reproductive Performance

A study was conducted to determine the effects of dietary digestible amino acids of feedstuffs and true metabolizable energy corrected for nitrogen on broiler breeder performance in 50 weeks to 64 weeks of age. 140 females and 20 males broiler breeders in 4 treatments with 5 replicates （7 females with a male） were used in the form of a completely randomized trial design 2 ~ 2 factorial. Four experimental diets were formulation based on two factors, first factor was included, two types of Apparent and True Metabolizable Energy corrected for Nitrogen （AMEn and TMEn） and the second factor was included, two types of Total Amino Acids （TAA） and Digestible （DAA） of feedstuffs. The result showed that egg weight, egg production （%） and egg mass （g/hen/day） was significantly different which was affected by diets formulation based on energy and interaction between energy and amino acids （P 〈 0.01）. Treatment 2 （AMEn ＋ DAA） was at the highest level significantly different （P 〈 0.01） in egg weight 68.97 g, egg production 62.45%, and egg mass 43. i g/hen/day. Hatching eggs were significantly different which was affected by diet formulation based on amino acids. Fertility, hatchability and number of chicks per hen were significant different, that were affected by diet formulation based on energy （P 〈 0.05）. Interaction between two factors, were significantly different in two reproductive traits fertility and hatchability （P 〈 0.05）. This experiment showed that diet formulation based on AMEn and DAA for broiler breeder was better and significant on performance.

Breathers and Rogue Waves Derived from an Extended Multi-dimensional N-Coupled Higher-Order Nonlinear Schrdinger Equation in Optical Communication Systems

In this paper, an extended multi-dimensional N-coupled higher-order nonlinear Schr¨odinger equation (NCHNLSE), which can describe the propagation of the ultrashort pulses in wavelength division multiplexing (WDM)systems, is investigated. By the bilinear method, we construct the breather solutions for the extended (1+1),(2+1) and(3+1)-dimensional N-CHNLSE. The rogue waves are derived as a limiting form of breathers with the aid of symbolic computation. The effect of group velocity dispersion (GVD), third-order dispersion (TOD) and nonlinearity on breathers and rogue waves solutions are discussed in the optical communication systems.