目的:观察红灵五黄汤治疗2型糖尿病(T2DM)的临床效果。方法:将180例患者随机分为治疗组和对照组各90例,治疗组给予红灵五黄汤治疗,对照组给予格列喹酮片和二甲双胍联合治疗,2组均以2个月为1个疗程,1个疗程后,观察症状、体征变化,检测空...目的:观察红灵五黄汤治疗2型糖尿病(T2DM)的临床效果。方法:将180例患者随机分为治疗组和对照组各90例,治疗组给予红灵五黄汤治疗,对照组给予格列喹酮片和二甲双胍联合治疗,2组均以2个月为1个疗程,1个疗程后,观察症状、体征变化,检测空腹血糖(FBG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1C)、肿瘤坏死因子α(TNF-α)、胰岛素抵抗(IR)、血酶及血脂的变化情况。结果:总有效率治疗组为88.8%,对照组为77.7%,治疗组优于对照组(P<0.05)。FBG、2 h PG、Hb A1C、TNF-α、IR、血酶及血脂等指标2组治疗后与治疗前相比差异有统计学意义(P<0.05)。结论:红灵五黄汤治疗T2DM疗效显著,可能是通过健康胰岛B细胞,改善胰岛素抵抗,纠正血清酶的异常变化及降血糖、调血脂等过程而发挥作用的。展开更多
Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulatio...Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.展开更多
[Objective] The aim was to isolate a prodigiosin producing strain and study its pigment fractions.[Method] Red pigment-producing bacteria was identified by physiological and biochemical characteristics after isolation...[Objective] The aim was to isolate a prodigiosin producing strain and study its pigment fractions.[Method] Red pigment-producing bacteria was identified by physiological and biochemical characteristics after isolation in plate.By using column chromatography and thin-layer chromatography,pigment fractions were separated and purified from the extractives of the strain after fermentation in flask,and then pigment fractions were analyzed via UV-Vis and LC/MS.[Result] A red pigment-producing Serratia marcescens strain NS-17 sampled from soil of Nanchang was isolated and identified.2 pigment fractions showing similar UV-Vis and LC/MS characters were separated and purified,the characters of fraction 1 were identical to those of prodigiosin,while fraction 2 showed a special UV-Vis absorption spectrum that had not been reported.[Conclusion] A prodigiosin-producing Serratia marcescens strain NS-17 and its 2 pigment fractions were isolated.展开更多
文摘目的:观察红灵五黄汤治疗2型糖尿病(T2DM)的临床效果。方法:将180例患者随机分为治疗组和对照组各90例,治疗组给予红灵五黄汤治疗,对照组给予格列喹酮片和二甲双胍联合治疗,2组均以2个月为1个疗程,1个疗程后,观察症状、体征变化,检测空腹血糖(FBG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1C)、肿瘤坏死因子α(TNF-α)、胰岛素抵抗(IR)、血酶及血脂的变化情况。结果:总有效率治疗组为88.8%,对照组为77.7%,治疗组优于对照组(P<0.05)。FBG、2 h PG、Hb A1C、TNF-α、IR、血酶及血脂等指标2组治疗后与治疗前相比差异有统计学意义(P<0.05)。结论:红灵五黄汤治疗T2DM疗效显著,可能是通过健康胰岛B细胞,改善胰岛素抵抗,纠正血清酶的异常变化及降血糖、调血脂等过程而发挥作用的。
文摘Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.
文摘[Objective] The aim was to isolate a prodigiosin producing strain and study its pigment fractions.[Method] Red pigment-producing bacteria was identified by physiological and biochemical characteristics after isolation in plate.By using column chromatography and thin-layer chromatography,pigment fractions were separated and purified from the extractives of the strain after fermentation in flask,and then pigment fractions were analyzed via UV-Vis and LC/MS.[Result] A red pigment-producing Serratia marcescens strain NS-17 sampled from soil of Nanchang was isolated and identified.2 pigment fractions showing similar UV-Vis and LC/MS characters were separated and purified,the characters of fraction 1 were identical to those of prodigiosin,while fraction 2 showed a special UV-Vis absorption spectrum that had not been reported.[Conclusion] A prodigiosin-producing Serratia marcescens strain NS-17 and its 2 pigment fractions were isolated.
