慢性心力衰竭红细胞L-精氨酸/一氧化氮系统的变化

目的 :探讨慢性心力衰竭 (CHF)患者红细胞 L-精氨酸 (L- Arg) /一氧化氮 (NO)系统的变化。方法 :实验分为 CHF组 (n=2 5 )和对照组 (n=2 0 )。通过核素标记测定红细胞 3H- L- Arg转运的特征 ;一氧化氮合酶 (NOS)改良法测定红细胞 NOS活性。结果 :CHF组红细胞 L- Arg摄入总转运 Vmax及 Y+通道介导的转运 Vmax较正常对照组明显增加 ,Km两组无明显差异。 Y+ L通道介导的转运 Vmax与正常组无变化 ,Km较正常组下降 ,红细胞 NOS生成量及 NOS活性均增加。结论 :CHF时红细胞膜上 Y+ 通道介导的 L-

Deformation and Motion of a Red Blood Cell in a Shear Flow Simulated by a Lattice Boltzmann Model

A lattice Boltzmann model is presented to simulate the deformation and motions of a red blood cell （RBC） in a shear flow. The curvatures of the membrane of a static RBC with different chemical potentiM drops calculated by our model agree with those computed by a shooting method very well. Our simulation results show that in a shear flow, biconcave RBC becomes highly flattened and undergoes tank-treading motion. With intrinsically parallel dynamics, this lattice Boltzmann method is expected to find wide applications to both single and multi-vesicles suspension as well as complex open membranes in various fluid flows for a wide range of Reynolds numbers.

慢性阻塞性肺疾病急性加重期患者体液离子含量的变化

目的:了解慢性阻塞性肺疾病(COPD)患者体液离子含量的变化。方法:选择46例合并肺心病的COPD急性加重期患者,测定其血清、红细胞、白细胞及24 h尿K、Na、Ca、Mg离子含量。结果:患者白细胞Ca增高,红细胞Ca、Mg、K及白细胞Mg、血清Mg、Na均显著降低。红细胞Mg与白细胞Mg显著正相关。该组患者尿Ca增多占54%,尿K、Na、Mg减低者分别占92%,65%及32%。结论:COPD患者存在K、Mg缺失,用红细胞Mg评价机体的Mg状态更具有实用性。