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真性红细胞增多症并发脑梗塞4例
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作者 和姬苓 王润菊 +1 位作者 段建平 耿虹 《医学理论与实践》 1996年第7期304-305,共2页
例1、男,67岁。头痛眩晕10年,渐记忆力减退。因言语不清,左侧肢体力弱,吞咽困难5天入院。查体:神清,运动性失语,左鼻唇沟浅,咽反射迟钝,左侧肌力3级,右侧肌力5级。双掌颏反射(+),左病理征(+)。口唇四肢末稍发绀,脾于左锁骨中线肋下4.5cm... 例1、男,67岁。头痛眩晕10年,渐记忆力减退。因言语不清,左侧肢体力弱,吞咽困难5天入院。查体:神清,运动性失语,左鼻唇沟浅,咽反射迟钝,左侧肌力3级,右侧肌力5级。双掌颏反射(+),左病理征(+)。口唇四肢末稍发绀,脾于左锁骨中线肋下4.5cm,中度硬,触痛。血红蛋白144—210g/L,红细胞计数5.09—6.62×10^(12)/L,红细胞压积0.53—0.77,血粘度6.0—6.6,血小板,肝功能,心电图正常。 展开更多
关键词 红细胞增 并发症 脑梗塞 治疗
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眼区嗜伊红细胞增生性淋巴肉芽肿——附3例临床病理分析
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作者 夏文魁 《吉林医学情报》 1991年第5期63-63,共1页
关键词 眼区嗜伊红细胞增生性淋巴肉芽肿 临床病理 诊断
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55例新生儿红细胞增多症病因及相关治疗分析 被引量:3
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作者 张硕 宋振辉 +2 位作者 刘艳龙 侯建文 杨晨然 《中国小儿血液》 2001年第6期271-272,共2页
关键词 新生儿红细胞增复症 病因 治疗 病例分析
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遗传性舞蹈样运动-棘红细胞增多症一家系三例 被引量:4
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作者 崔爱勤 李扬波 +3 位作者 刘玉玺 陈玉平 李德让 徐家立 《中华医学遗传学杂志》 CAS CSCD 2004年第5期421-421,共1页
关键词 遗传性舞蹈样运动-棘红细胞增多症 家系调查 红细胞增 常染色体隐性遗传
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活血化瘀法在骨髓增生性疾病中的应用概况 被引量:5
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作者 赵珍品 张惠臣 古学奎 《广州中医药大学学报》 CAS 2001年第1期88-91,共4页
骨髓增生性疾病临床上普遍存在瘀血证 ,活血化瘀法是中医治疗本病的常用方法。介绍了根据中医辨证论治原则 ,以活血化瘀为主 ,辨证治疗该病的临床及机理研究情况。认为随着对活血化瘀药物研究的不断深入 。
关键词 骨髓生性疾病 活血祛瘀 中医药疗法 骨髓纤维化 辩证论治 真性红细胞增
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中国抗肿瘤第一人——金显宅
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作者 郝希山 《药物与人》 2003年第9期34-34,共1页
2004年是金显宅先生诞辰100周年。他曾经为中国抗癌事业做出了卓越贡献,为继承他的风范、激励后人向他学习,1994年2月,经中宣部批准在天津市肿瘤医院塑立了金老的铜像。原全国政协主席李瑞环同志亲自为铜像题词:'德高医粹',表... 2004年是金显宅先生诞辰100周年。他曾经为中国抗癌事业做出了卓越贡献,为继承他的风范、激励后人向他学习,1994年2月,经中宣部批准在天津市肿瘤医院塑立了金老的铜像。原全国政协主席李瑞环同志亲自为铜像题词:'德高医粹',表达了党和人民对他一生学识和贡献的充分肯定。 展开更多
关键词 金显宅 医务工作者 肿瘤 舌癌根治性联合切除术 嗜伊红细胞增生性淋巴肉芽肿病
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高原剖宫产手术麻醉临床应用的体会
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作者 余中良 《西藏医药》 2013年第3期18-19,共2页
孕妇在临产期,心脏容量较孕早期增加10%,平均心率要增加10~15次/分,血容量增加约35%,由于血浆增加约1000ml,红细胞增加500ml,出现血液稀释。血压变化情况一般不大,孕妇的体位改变,出现一定程度的变化,孕期孕妇的脉压稍增... 孕妇在临产期,心脏容量较孕早期增加10%,平均心率要增加10~15次/分,血容量增加约35%,由于血浆增加约1000ml,红细胞增加500ml,出现血液稀释。血压变化情况一般不大,孕妇的体位改变,出现一定程度的变化,孕期孕妇的脉压稍增加。孕期的肺功能每分钟通气量增加40%,残气量减少20%,肺泡换气增加65%.由于我院地处海拔3400米的高原,氧压低,从而使当地的孕妇增加了循环系统和呼吸系统的负担。因此,也对我院麻醉科,在剖宫产手术麻醉时,对于麻醉的实施和管理上有了更高的要求。 展开更多
关键词 剖宫产手术 麻醉科 临床应用 高原 每分钟通气量 心脏容量 平均心率 红细胞增
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Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases 被引量:1
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作者 Sebnem Ustun Nevin Turgay +1 位作者 Songul Bayram Delibas Hatice Ertabaklar 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第24期3643-3646,共4页
AIM:Intestinal parasitic diseases are commonly accompanied with diarrhoeal symptoms and allergic reactions.Eosinophilia occurs as a result of IL-5 synthesized from Th2 cells during allergic reactions.IL-5 acts as a fa... AIM:Intestinal parasitic diseases are commonly accompanied with diarrhoeal symptoms and allergic reactions.Eosinophilia occurs as a result of IL-5 synthesized from Th2 cells during allergic reactions.IL-5 acts as a factor activating eosinophils. The aim of this study was to compare the IL-5 cytokine measurements in serum samples and cell cultures.And also to compare eosinophilia observed in helminth infections and protozoon infections accompanied with allergy. METHODS:Twenty-three patients who presented with diarrhoeal symptoms and allergic complaints were tested positive for intestinal parasites,as well as 21 controls with allergic complaints who did not have any intestinal parasites were included in this study.IL-5 production in in vitro cell cultures prepared by using phytohemaglutinin (PHA) to stimulate peripheral blood mononuclear cells (PBMC) obtained from the blood samples taken from these patients were compared with the IL-5 level in serum.Furthermore, the IL-5 production in protozoon and helminth infections was also compared.Absolute eosinophil values in 1 mm^3 of blood were calculated by means of peripheral smear in both groups within the scope of the study. RESULTS:Parasites such as helminth detected in 15 (65.2%) and protozoon in 8 (34.8%) of the patients were included in this study.As regards the values of the sera in both patients with parasite infection and controls,the IL-5 production was found to be higher in the cell culture supernatant (P<0.001 and P<0.05).When the IL-5 level of the patients with helminth parasites was compared with that of those with protozoon,it was determined that the IL-5 level in serum was more significant in the patients with protozoon than in those with helminth (P<0.05).In the study group,the patients were found to have parasites, the percentage of eosinophil was 7.0% compared to 6.5% in the control group.Thus,there was no significant difference between the eosinophil values (P>0.05). CONCLUSION:It was found that IL-5 cytokine levels in serum samples from the patients with helminth and protozoon displayed more measurable values as compared to the IL-5 levels after stimulation with mitogen.It is concluded that IL-5 acts as a triggering factor in the toxiallergic complaints commonly seen in helminth and protozoon infections. 展开更多
关键词 Adult Cells Cultured DIARRHEA EOSINOPHILIA Female HELMINTHIASIS Humans HYPERSENSITIVITY INTERLEUKIN-5 Male Middle Aged Protozoan Infections Th2 Cells
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Erythropoietin -induced proliferation of gastric mucosal cells 被引量:3
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作者 Kazuro Itoh Yoshio Sawasaki +10 位作者 Kyoko Takeuchi Shingo Kato Nobuhiro Imai Yoichiro Kato Noriyuki Shibata Makio Kobayashi Yoshiyuki Moriguchi Masato Higuchi Fumio Ishihata Yushi Sudoh Soichiro Miura 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第2期234-239,共6页
AIM: To analyze the localization of erythropoietin receptor on gastric specimens and characterize the effects of erythropoietin on the normal gastric epithelial proliferation using a porcine gastric epithelial cell c... AIM: To analyze the localization of erythropoietin receptor on gastric specimens and characterize the effects of erythropoietin on the normal gastric epithelial proliferation using a porcine gastric epithelial cell culture model. METHODS: Erythropoietin receptor was detected by RT-PCR, Western blotting and immunohistochermistry. Growth stimulation effects of erythropoietin on cultured gastric mucosal cells were determined by ELISA using bromodeoxyuridine (BrdU). RESULTS: Erythropoietin receptor was detected on cultured porcine gastric mucosal epithelial cells. Erythropoietin receptor was also detected histochemically at the base of gastric mucosal epithelium. BrdU assay demonstrated a dose-dependent increase in growth potential of cultured porcine gastric mucosal epithelial cells by administration of erythropoietin, as well as these effects were inhibited by administration of antierythropoietin antibody (P〈 0.01). CONCLUSION: These findings indicate that erythropoietin has a potential to proliferate gastric mucosal epithelium via erythropoietin receptor. 展开更多
关键词 ERYTHROPOIETIN Erythropoietin receptor Gastric epithelial cell proliferation Porcine gastric mucosal epithelial cells
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Cell cycles and proliferation patterns in Haematococcus pluvialis 被引量:4
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作者 张春辉 刘建国 张立涛 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2017年第5期1205-1211,共7页
Most studies on Haematococcus pluvialis have been focused on cell growth and astaxanthin accumulation;far less attention has been paid to cell cycles and proliferation patterns.The purpose of this study was to clarify... Most studies on Haematococcus pluvialis have been focused on cell growth and astaxanthin accumulation;far less attention has been paid to cell cycles and proliferation patterns.The purpose of this study was to clarify cell cycles and proliferation patterns in H.pluvialis microscopically using a camera and video recorder system.The complicated life history of H.pluvial i s can be divided into two stages:the motile stage and the non-motile stage.All the cells can be classifi ed into forms as follows:motile cell,nonmotile cell,zoospore and aplanospore.The main cell proliferation,both in the motile phase and non-motile phase in H.pluvialis,is by asexual reproduction.Under normal growth conditions,a motile cell usually produces two,sometimes four,and exceptionally eight zoospores.Under unfavorable conditions,the motile cell loses its fl agella and transforms into a non-motile cell,and the non-motile cell usually produces 2,4 or 8 aplanospores,and occasionally 20–32 aplanospores,which further develop into non-motile cells.Under suitable conditions,the non-motile cell is also able to release zoospores.The larger non-motile cells produce more than 16 zoospores,and the smaller ones produce 4 or 8 zoospores.Vegetative reproduction is by direct cell division in the motile phase and by occasional cell budding in the non-motile phase.There is,as yet,no convincing direct evidence for sexual reproduction. 展开更多
关键词 Haematococcus pluvialis cell cycle proliferation patterns
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Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species 被引量:1
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作者 Ryung-Ah Lee Hyun-Ah Kim +1 位作者 Bo-Young Kang Kwang-Ho Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第35期5644-5650,共7页
AIM: To study whether hemoglobin could amplify colon cancer cell proliferation via reactive oxygen species (ROS) production. METHODS: Colon cancer cell line HT-29 was grown in the conventional method using RPMI1640 me... AIM: To study whether hemoglobin could amplify colon cancer cell proliferation via reactive oxygen species (ROS) production. METHODS: Colon cancer cell line HT-29 was grown in the conventional method using RPMI1640 media. The viability of the cells was measured using the colorimetric MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide] assay after adding hemoglobin. We de- termined reactive oxygen species levels to be indicators of oxidative stress in HT 29 cell lines with and without hemoglobin and/or 5-fluorouracil (5-FU), 5’-deoxy-5-flu- orouridine (5-DFUR) using fluorometric dichlorofluorescin diacetate (DCFH-DA) assay. RESULTS: Cellular proliferation was increased with he- moglobin in a concentration-dependent manner. A signif- icant increment on ROS levels was found in HT 29 cells following hemoglobin incubation. The cytotoxic effects of 5-FU and 5-DFUR were significantly blunted by admin- istration of hemoglobin. There was a slight increase of peroxiredoxin 1, superoxide dismutase 1 concentration according to different hemoglobin concentrations. CONCLUSION: Hemoglobin has a cellular proliferative effect on HT-29 colon cancer cell line by production of ROS. Also, hemoglobin abates cytotoxic effects of che- motherapeutic agents such as 5-FU and 5-DFUR. 展开更多
关键词 Colon cancer HEMOGLOBIN Reactive oxygen species
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Functional significance of erythropoietin receptor on tumor cells 被引量:3
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作者 Kodetthoor B Udupa 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第46期7460-7462,共3页
Erythropoietin (Epo) is the regulator of red blood cell formation. Its receptor (EpoR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation ... Erythropoietin (Epo) is the regulator of red blood cell formation. Its receptor (EpoR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EpoR antagonist can reduce the growth of the tumor in vivo. In view of our current knowledge of Epo, its recombinant forms and receptor, use of Epo in cancer patients to enhance the recovery of hematocrit after chemotherapy treatment has to be carefully evaluated. 展开更多
关键词 ERYTHROPOIETIN Tumor cell RECEPTOR Cell signaling PROLIFERATION Erythroid cell
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A case of eosinophilic cholangitis:Imaging findings ofcontrast-enhanced ultrasonography, cholangioscopy, andintraductal ultrasonography 被引量:3
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作者 Naoki Matsumoto Kiyoshi Yokoyama +7 位作者 Kazuhiko Nakai Toshiki Yamamoto Takeshi Otani Masahiro Ogawa Naohide Tanaka Ariyoshi Iwasaki Yasuyuki Arakawa Masahiko Sugitani 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第13期1995-1997,共3页
A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the dist... A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the distal common bile duct to the bifurcation of the hepatic ducts. An endoscopic plastic biliary stent was inserted; the specimen obtained from the common bile duct wall revealed dense infiltration by eosinophils. Treatment was started with prednisolone 60 mg daily. The patient's biliary stenosis and eosinophilia gradually improved. Eosinophilic infiltration in the lungs or stomach is relatively common, but it is rare in the common bile duct. Most of the reported cases of eosinophilic cholangitis presented with eosinophilia; our patient's eosinophil count was over 1000/mm3. Since our patient had allergies to pollen and house dust, a relationship between the allergies and the eosinophilic cholangitis was suspected, but no cause was identified. 展开更多
关键词 Eosinophilic cholangitis Sclerosingcholangitis Contrast-enhanced ultrasonography Cholangioscopy Intraductal ultrasonography
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Decreased serum prohepcidin concentration in patients with polycythemia vera
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作者 Justyna KWAPISZ Ewa ■EKANOWSKA Joanna JASINIEWSKA 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2009年第11期791-795,共5页
Objective: Iron deficiency is a common complication in patients with polycythemia vera (PV). Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precurs... Objective: Iron deficiency is a common complication in patients with polycythemia vera (PV). Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precursor, and other iron status pa- rameters in the serum of PV patients. Methods: The study was performed in 60 patients (F/M 26/34) aged 38-84 (66+ 10) years. The control group consisted of 20 healthy volunteers, age and sex matched. The following parameters were determined in blood serum samples: prohepcidin concentration, iron content, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), transferrin saturation (TfS), and concentrations of ferritin and soluble transferrin receptor (sTfR). Results: All PV patients showed significantly lower levels of prohepcidin, higher levels of sTIR and TIBC compared to the control group. 40% of the patients from the study group showed concentrations of ferritin below the normal range and significantly lower levels of serum iron and TfS, and significantly higher levels of sTIR, UIBC and TIBC in comparison with the rest of the study group. In this group of patients, prohepcidin concentrations were significantly lower than those in other patients. Conclusion: The results indicate that PV patients suffer from iron metabolism disorders. The decreased serum level ofprohepcidin in PV patients may be a result of iron deficiency. 展开更多
关键词 Polycythemia vera (PV) Iron metabolism PROHEPCIDIN HEPCIDIN
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