Background Hypoxemia sometimes occurs in the emergency room in the patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI）, even in those with administration of conventional ...Background Hypoxemia sometimes occurs in the emergency room in the patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI）, even in those with administration of conventional high-flow oxygen inhalation. The objective of the present study was to evaluate the effectiveness of non-invasive ventilation （NIV） in improving blood oxygen content and hemorheology in patients with AMI and hypoxemia. Methods This prospective study enrolled 50 consecutive eligible patients with AMI （aged 72.3 ± 9.5 years）, who had undergone PCI and been administered high-flow oxygen but still had hypoxemia. Blood was taken before NIV and at 0.5, 1, and 2 h after NIV. Blood gases, hemorheological variables including erythrocyte deformability, erythrocyte aggregation, erythrocyte osmotic fragility, membrane fluidity, and oxidative stress level were measured. Results Blood PaO2 increased to normal by 1 h after NIV. Assessed hemorheological variables had all improved and plasma malondialdehyde concentration decreased significantly after 2 h of NIV. Conclusions Our data suggest that NIV can help to improve blood oxygen content, hemorheological status, and minimize plasma lipid peroxidation injury in hypoxemic patients with AMI who have undergone PCI.展开更多
The purpose of this study was to determine the effects of road transportation under heat conditions on some haematological [Ht （haematocrit）, blood cells count and EOF （erythrocytes osmotic fragility）] and physiol...The purpose of this study was to determine the effects of road transportation under heat conditions on some haematological [Ht （haematocrit）, blood cells count and EOF （erythrocytes osmotic fragility）] and physiological [Tr （rectal temperature）, HR （heart） and RR （respiratory rates）, and circulating levels of Cor （cortisol）, Glu （glucose） and minerals] parameters in Moroccan dromedary camels. The animals were subjected to road transportation stressor for 2 h by truck during the hot-dry season. Blood samples were collected before loading and transport, and at the end of transport. Transportation induced a significant increase （P 〈 0.05） of erythrocytes count, Ht, EOF, Tr, HR and RR by comparison to values observed before transportation. The same stress conditions induced a significant increase （P 〈 0.05） of plasma Cor （ng/mL） and blood Glu （mM） （220 ± 30 vs. 137 ± 20, 9.7 ± 1.2 vs. 6.4 ± 1. 1 respectively） and a significant decrease （P 〈 0.05） of plasma magnesium （mM） （0.5 ± 0.1 vs. 0.9 ± 0.1） comparatively to pre-transportation values. These results indicate that road transportation associated to heat may be considered as a potent stressor which is able to induce several cellular alterations in camels. Further studies of an eventual protective role of vitamin C against haemolysis induced by transportation stress in camel are needed.展开更多
文摘Background Hypoxemia sometimes occurs in the emergency room in the patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI）, even in those with administration of conventional high-flow oxygen inhalation. The objective of the present study was to evaluate the effectiveness of non-invasive ventilation （NIV） in improving blood oxygen content and hemorheology in patients with AMI and hypoxemia. Methods This prospective study enrolled 50 consecutive eligible patients with AMI （aged 72.3 ± 9.5 years）, who had undergone PCI and been administered high-flow oxygen but still had hypoxemia. Blood was taken before NIV and at 0.5, 1, and 2 h after NIV. Blood gases, hemorheological variables including erythrocyte deformability, erythrocyte aggregation, erythrocyte osmotic fragility, membrane fluidity, and oxidative stress level were measured. Results Blood PaO2 increased to normal by 1 h after NIV. Assessed hemorheological variables had all improved and plasma malondialdehyde concentration decreased significantly after 2 h of NIV. Conclusions Our data suggest that NIV can help to improve blood oxygen content, hemorheological status, and minimize plasma lipid peroxidation injury in hypoxemic patients with AMI who have undergone PCI.
文摘The purpose of this study was to determine the effects of road transportation under heat conditions on some haematological [Ht （haematocrit）, blood cells count and EOF （erythrocytes osmotic fragility）] and physiological [Tr （rectal temperature）, HR （heart） and RR （respiratory rates）, and circulating levels of Cor （cortisol）, Glu （glucose） and minerals] parameters in Moroccan dromedary camels. The animals were subjected to road transportation stressor for 2 h by truck during the hot-dry season. Blood samples were collected before loading and transport, and at the end of transport. Transportation induced a significant increase （P 〈 0.05） of erythrocytes count, Ht, EOF, Tr, HR and RR by comparison to values observed before transportation. The same stress conditions induced a significant increase （P 〈 0.05） of plasma Cor （ng/mL） and blood Glu （mM） （220 ± 30 vs. 137 ± 20, 9.7 ± 1.2 vs. 6.4 ± 1. 1 respectively） and a significant decrease （P 〈 0.05） of plasma magnesium （mM） （0.5 ± 0.1 vs. 0.9 ± 0.1） comparatively to pre-transportation values. These results indicate that road transportation associated to heat may be considered as a potent stressor which is able to induce several cellular alterations in camels. Further studies of an eventual protective role of vitamin C against haemolysis induced by transportation stress in camel are needed.
