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脑损伤时间推断的分子生物学研究进展 被引量:5
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作者 汪枫 李永宏 《皖南医学院学报》 CAS 2003年第3期232-234,共3页
关键词 脑损伤 时间推断 分子生物学 研究进展 胶质纤维酸性 神经元特异性烯醇化酶 纤维连接蛋
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手术病人血清C_3、C_4、CRP、Fn变化及其临床意义 被引量:3
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作者 杨辰 何广仁 孙常省 《苏州医学院学报》 1998年第8期802-803,共2页
57例腹腔肿瘤病人术后1周内.血清C3、C4浓度无明显变化,(反应蛋白)CRP浓度升高,纤维连接蛋白Fn浓度降低;1周后C3、C4浓度升高,CRP、Fn浓度恢复术前水平。若术后并发感染者上述变化更为明显,感染治愈后恢复;持续不恢复者预后差... 57例腹腔肿瘤病人术后1周内.血清C3、C4浓度无明显变化,(反应蛋白)CRP浓度升高,纤维连接蛋白Fn浓度降低;1周后C3、C4浓度升高,CRP、Fn浓度恢复术前水平。若术后并发感染者上述变化更为明显,感染治愈后恢复;持续不恢复者预后差。说明术后上述指标,是CRP和Fn,对发现深部感染、脓毒血症预后判断有一定价值。 展开更多
关键词 C3 C4 C反应 纤维连接蛋 手术后感染
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Surface modification of titanium plate enhanced fibronectin-mediated adhesion and proliferation of MG-63 cells
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作者 周征 戴瑶 +4 位作者 刘斌斌 夏磊磊 刘洪波 Pankaj VADGAMA 刘海蓉 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第4期1065-1071,共7页
An understanding of osteoblast adhesion and proliferation on biomaterials is crucial to optimizing the surfaces of artificial implants used in clinical practice. Polished, anodic oxidation (AO) and micro-arc oxidati... An understanding of osteoblast adhesion and proliferation on biomaterials is crucial to optimizing the surfaces of artificial implants used in clinical practice. Polished, anodic oxidation (AO) and micro-arc oxidation (MAO) treated titanium (Ti) plates were used as model surfaces to study the adhesion of MG-63 cells. Cells were monitored for 0.5 and 4 h; faster adhesion and spreading of MG-63 ceils were observed on the AO and MAO modified samples. Stimulated secretion of fibronectin (FN) influenced the adhesion rates. In addition, AO and MAO modified surfaces promoted cell proliferation through apparent up-regulation of FN and integrin a5 transcription via outside-in signaling. This strongly suggests that FN secretion by osteoblasts plays an essential role in enhanced cell adhesion, spreading and proliferation on these modified Ti surfaces. 展开更多
关键词 titanium surface modification Outside-in signaling FIBRONECTIN INTEGRIN
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严重腹部创伤患者的全肠外营养支持
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作者 舒志军 黎介寿 《医学研究生学报》 CAS 1995年第3期34-34,共1页
严重腹部创伤患者32例,平均腹部创伤指数(ATI)达20分,均接受全肠外营养(TPN)支持,提供非蛋白质热能134~176kJ·kg-1/d,氮0.21~0.30g·kg-1/d。平均使用TPN26.5d,其... 严重腹部创伤患者32例,平均腹部创伤指数(ATI)达20分,均接受全肠外营养(TPN)支持,提供非蛋白质热能134~176kJ·kg-1/d,氮0.21~0.30g·kg-1/d。平均使用TPN26.5d,其中胰十二指肠损伤患者应用TPN16d,腹部... 展开更多
关键词 腹部创伤 全肠外营养支持 前白 胰十二指肠损伤 转铁 纤维连接蛋 血清白 肠外瘘 腹腔脓肿 治疗效果
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Fibronectin: Functional character and role in alcoholic liver disease 被引量:5
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作者 Razia S Aziz-Seible Carol A Casey 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第20期2482-2499,共18页
Fibronectins are adhesive glycoproteins that can be found in tissue matrices and circulating in various fluids of the body. The variable composition of fibronectin molecules facilitates a diversity of interactions wit... Fibronectins are adhesive glycoproteins that can be found in tissue matrices and circulating in various fluids of the body. The variable composition of fibronectin molecules facilitates a diversity of interactions with cell surface receptors that suggest a role for these proteins beyond the structural considerations of the extracellular matrix. These interactions implicate fibronectin in the regulation of mechanisms that also determine cell behavior and activity. The two major forms, plasma fibronectin (pFn) and cellular fibronectin (cFn), exist as balanced amounts under normal physiological conditions. However, during injury and/or disease, tissue and circulating levels of cFn become disproportionately elevated. The accumulating cFn, in addition to being a consequence of prolonged tissue damage, may in factstimulate cellular events that promote further damage. In this review, we summarize what is known regarding such interactions between fibronectin and cells that may influence the biological response to injury. We elaborate on the effects of cFn in the liver, specifically under a condition of chronic alcohol-induced injury. Studies have revealed that chronic alcohol consumption stimulates excess production of cFn by sinusoidal endothelial cells and hepatic stellate cells while impairing its clearance by other cell types resulting in the build up of this glycoprotein throughout the liver and its consequent increased availability to influence cellular activity that could promote the development of alcoholic liver disease. We describe recent findings by our laboratory that support a plausible role for cFn in the promotion of liver injury under a condition of chronic alcohol abuse and the implications of cFn stimulation on the pathogenesis of alcoholic liver disease. These findings suggest an effect of cFn in regulating cell behavior in the alcohol-injured liver that is worth further characterizing not only to gain a more comprehensive understanding of the role this reactive glycoprotein plays in the progression of injury but also for the insight further studies could provide towards the development of novel therapies for alcoholic liver disease. 展开更多
关键词 FIBRONECTIN Liver disease Alcoholic liver disease ENDOCYTOSIS Cellular fibronectin
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Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation
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作者 Zhao Feng Li Li +2 位作者 Xu Zhiyun Huang Xing Zhou Yong 《Journal of Medical Colleges of PLA(China)》 CAS 2008年第1期26-30,共5页
Objectives: To explore possible mechanisms of connexin40 (Cx40) remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium (LA) in patients with rheumatic heart disease (RHD) associat... Objectives: To explore possible mechanisms of connexin40 (Cx40) remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium (LA) in patients with rheumatic heart disease (RHD) associated chronic atrial fibrillation (AF). Methods: Twenty patients were enrolled in this study, who underwent surgical operation for RHD-associated mitral disease, including l0 with sinus rhythms (rhythm group) and l0 with AF (AF group). Another 6 patients with non-RHD sinus rhythms were divided into the control group. A small amount of myocardial tissue was cut from the crista terminalis and the LA posterior wall during the valvular replacement operation. Cx40 mRNA expression was assayed by real-time fluorescent quantitation polymerase chain reaction (RT-PCR). Results: There was no significant difference in Cx40 mRNA expression in the crista terminalis and LA posterior wall between the 3 groups, and there was no significant difference in Cx40 mRNA expression between the crista terminalis and LA within each group. Conclusion: Based on the finding in previous studies that there existed evident remodeling of atrial Cx40 protein in patients with chronic RHD, the results of the present study suggest that the mechanism of Cx40 remodeling probably lies in the post transcriptional level. 展开更多
关键词 CARDIOLOGY Rheumatic heart disease Connexin40 Atrial fibrillation Real-time fluorescent quantitation polymerase chain reaction
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加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响 被引量:9
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作者 张义兵 熊玉兰 +1 位作者 杜贵友 刘莎 《中国实验方剂学杂志》 CAS 北大核心 2010年第15期168-171,共4页
目的:探讨加味真武汤对肾间质纤维化大鼠转化生长因子(TGF-β)及纤维连接蛋白(FN)表达的影响。方法:大鼠随机分为假手术组、模型组及治疗组,采用单侧输尿管梗阻(UUO)模型,术后7,14,21 d分别处死大鼠,测定肾脏指数、血肌酐(Cr)、尿素氮(B... 目的:探讨加味真武汤对肾间质纤维化大鼠转化生长因子(TGF-β)及纤维连接蛋白(FN)表达的影响。方法:大鼠随机分为假手术组、模型组及治疗组,采用单侧输尿管梗阻(UUO)模型,术后7,14,21 d分别处死大鼠,测定肾脏指数、血肌酐(Cr)、尿素氮(BUN);肾组织HE及Masson染色,观察肾脏病变;免疫组化法比较各组TGF-β及FN的表达。结果:术后随时间的延长,模型组和治疗组大鼠可见明显的肾间质纤维化改变,肾间质TGF-β,FN的表达明显高于假手术组(P<0.05)。治疗组大鼠肾间质纤维化程度及TGF-β,FN的表达均低于模型组(P<0.05)。结论:加味真武汤可降低UUO模型大鼠血Cr,BUN水平,抑制TGF-β表达,减少FN形成,对肾间质纤维化有积极的治疗意义。 展开更多
关键词 肾间质纤维 加味真武汤 转化生长因子 纤维连接蛋
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