The interaction between silver nanoparticles and Methylene Blue （MB） is studied by UV-Vis spectroscopy and fluorescence spec- trometry. The UV-Vis absorption of the silver nanoparticles changes dramatically with the...The interaction between silver nanoparticles and Methylene Blue （MB） is studied by UV-Vis spectroscopy and fluorescence spec- trometry. The UV-Vis absorption of the silver nanoparticles changes dramatically with the addition of MB. However, no obvious changes of absorption spectra of MB are observed when silver colloids are added into the MB solution. In the presence of surfactant SDS, the catalysis of the silver nanoparticles in the reduction of MB by sodium borohydride is exhibited by UV-Vis and fluorescence spectrosopy of MB displaying faster response compared with the absence of the silver nanoparticles. The results show that the activity of surfactant SDS modified silver nanoparticles is great and a strong physical adsorption to MB exists.展开更多
The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and thera...The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and therapy.Many novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or tissues.However,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in vivo.Many efforts have been paid to studying the interactions and mechanisms of NPs and cells.Unless deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological systems.In this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are summarized.By understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed.展开更多
The interaction of nanoparticles with proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. We have employed a combinatorial library of s...The interaction of nanoparticles with proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. We have employed a combinatorial library of surface modified gold nanoparticles to interrogate the relationships between the nanoparticle surface chemistry and the specific and nonspecific binding to a common, important, and representative enzyme, acetylcholinesterase （ACHE）. We also used Bayesian neural networks to generate robust quantitative structure-property relationship （QSPR） models relating the nanoparticle surface to the AChE binding that also provided significant understanding into the molecular basis for these interactions. The results illustrate the insights that result from a synergistic blending of experimental combinatorial synthesis and biological testing of nanoparticles with quantitative computational methods and molecular modeling.展开更多
Gold nanoparticles(AuNPs) interact with light and have strong and tunable surface plasmon resonance,which can be detected using multiple imaging modalities.These provide an unique opportunity for their potential appli...Gold nanoparticles(AuNPs) interact with light and have strong and tunable surface plasmon resonance,which can be detected using multiple imaging modalities.These provide an unique opportunity for their potential applications in optical imaging for early detection of cancer.In this review,we summarized nanoparticles targeting properties for cancer,plasmon optical properties of AuNPs,application of AuNPs for cancer optical imaging.Also discussed is the safety of AuNPs.展开更多
基金supported by the National Natural Science Foundation of China(No.20875059)
文摘The interaction between silver nanoparticles and Methylene Blue （MB） is studied by UV-Vis spectroscopy and fluorescence spec- trometry. The UV-Vis absorption of the silver nanoparticles changes dramatically with the addition of MB. However, no obvious changes of absorption spectra of MB are observed when silver colloids are added into the MB solution. In the presence of surfactant SDS, the catalysis of the silver nanoparticles in the reduction of MB by sodium borohydride is exhibited by UV-Vis and fluorescence spectrosopy of MB displaying faster response compared with the absence of the silver nanoparticles. The results show that the activity of surfactant SDS modified silver nanoparticles is great and a strong physical adsorption to MB exists.
基金financially supported by the National Natural Science Foundation of China(51120135001)the National Basic Research Program of China(2011CB606203)+1 种基金Ph.D.Programs Foundation of Ministry of Education of China(20110101130005)Open Project of State Key Laboratory of Supramolecular Structure and Materials(sklssm201303)
文摘The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and therapy.Many novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or tissues.However,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in vivo.Many efforts have been paid to studying the interactions and mechanisms of NPs and cells.Unless deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological systems.In this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are summarized.By understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed.
文摘The interaction of nanoparticles with proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. We have employed a combinatorial library of surface modified gold nanoparticles to interrogate the relationships between the nanoparticle surface chemistry and the specific and nonspecific binding to a common, important, and representative enzyme, acetylcholinesterase （ACHE）. We also used Bayesian neural networks to generate robust quantitative structure-property relationship （QSPR） models relating the nanoparticle surface to the AChE binding that also provided significant understanding into the molecular basis for these interactions. The results illustrate the insights that result from a synergistic blending of experimental combinatorial synthesis and biological testing of nanoparticles with quantitative computational methods and molecular modeling.
基金supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘Gold nanoparticles(AuNPs) interact with light and have strong and tunable surface plasmon resonance,which can be detected using multiple imaging modalities.These provide an unique opportunity for their potential applications in optical imaging for early detection of cancer.In this review,we summarized nanoparticles targeting properties for cancer,plasmon optical properties of AuNPs,application of AuNPs for cancer optical imaging.Also discussed is the safety of AuNPs.
