Both exercise and aging increase reactive oxygen species （ROS）, which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies...Both exercise and aging increase reactive oxygen species （ROS）, which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been shown that ROS are essential signaling molecules which are required to promote the health benefits of exercise and longevity. In young individuals, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptations in endurance performance, as well as for the induction of the endogenous defense systems. Thus, taking antioxidants during training, in young athletes, seems to be detrimental. However, antioxidant supplementation may be expected to be beneficial and is receiving growing attention in the active old population. In this manuscript we review the literature associated with the main areas of interest in this topic.展开更多
Elimination of human losses is the main and immediate task in the seismic vulnerability problem.The authors suggest the ways of development of seismic research and discussion of defense problems for reducing of seismi...Elimination of human losses is the main and immediate task in the seismic vulnerability problem.The authors suggest the ways of development of seismic research and discussion of defense problems for reducing of seismic vulnerability. It is the ways of nonlinear seismology region. Unconditionally seism zoning and the theory of catastrophes allow reduce human losses and building destruction. But well-known isoseists are the private case of caustic catastrophe theory or seismo-acoustics, so seism zoning can be amounted to 6 elementary catastrophe forms. It will better help to predict seismic actions. The short-time local prediction of seismic events is general method for strong reducing of human losses. This method takes into account chaotic properties of stress fields and waves and the peculiarities of urban area. It bases on the natural seismo-emission phenomenon and is realized by long-time monitoring, which gives statistically and geographically continuous picture （chart） of seismic noise level inside geologic media. The instruments of this strategy are shock and pressure-proofed seismometers for long-time monitoring and control the state of geological media including underwater shelf areas. The authors think that the active protecting for cities and buildings as the best modem form of people safety consists in stress discharge of geologic media. Ultrasonic wave defense includes and bases on strong interaction between powerful waves from earthquake and ultrasonic wave train. The authors want to point out that the technical objects may be used lbr the investigation of earthquakes induced and some reasons of seismic vulnerability. Also reducing of seismic vulnerability contains as component kinetic acting on volcano at the pre-explosive stage. The interesting and important aspect of defense problem is observation of the inharmonic wave processes in the soil and quasi-constant forces as the nearest seismic analogue of radiation forces in nonlinear acoustics under powerful earthquake seismic tremor.展开更多
基金supported by grants SAF2010-19498 from the Spanish Ministry of Education and Science(MEC(gsl))ISCIII2006-RED13-027 from the Red Tematica de investigacion cooperativa en envejecimiento y fragilidad (RETICEF(gs2))+3 种基金P2011/02 RM from Catedra Real Madrid-UEM (gs3)PROMETEO2010/074 from Conselleria de Sanitat de la Generalitat Valenciana(gs4)35NEURO Gentx Gent from Fundacio Gent Per Gent de la Comunitat Valenciana(gs5) and EU(gs6) Funded COSTB35 and CM 1001co-financed by funds from the European Union
文摘Both exercise and aging increase reactive oxygen species （ROS）, which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been shown that ROS are essential signaling molecules which are required to promote the health benefits of exercise and longevity. In young individuals, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptations in endurance performance, as well as for the induction of the endogenous defense systems. Thus, taking antioxidants during training, in young athletes, seems to be detrimental. However, antioxidant supplementation may be expected to be beneficial and is receiving growing attention in the active old population. In this manuscript we review the literature associated with the main areas of interest in this topic.
文摘Elimination of human losses is the main and immediate task in the seismic vulnerability problem.The authors suggest the ways of development of seismic research and discussion of defense problems for reducing of seismic vulnerability. It is the ways of nonlinear seismology region. Unconditionally seism zoning and the theory of catastrophes allow reduce human losses and building destruction. But well-known isoseists are the private case of caustic catastrophe theory or seismo-acoustics, so seism zoning can be amounted to 6 elementary catastrophe forms. It will better help to predict seismic actions. The short-time local prediction of seismic events is general method for strong reducing of human losses. This method takes into account chaotic properties of stress fields and waves and the peculiarities of urban area. It bases on the natural seismo-emission phenomenon and is realized by long-time monitoring, which gives statistically and geographically continuous picture （chart） of seismic noise level inside geologic media. The instruments of this strategy are shock and pressure-proofed seismometers for long-time monitoring and control the state of geological media including underwater shelf areas. The authors think that the active protecting for cities and buildings as the best modem form of people safety consists in stress discharge of geologic media. Ultrasonic wave defense includes and bases on strong interaction between powerful waves from earthquake and ultrasonic wave train. The authors want to point out that the technical objects may be used lbr the investigation of earthquakes induced and some reasons of seismic vulnerability. Also reducing of seismic vulnerability contains as component kinetic acting on volcano at the pre-explosive stage. The interesting and important aspect of defense problem is observation of the inharmonic wave processes in the soil and quasi-constant forces as the nearest seismic analogue of radiation forces in nonlinear acoustics under powerful earthquake seismic tremor.
