By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
We propose a method that can achieve the Naxi-English bilingual word automatic alignment based on a log-linear model.This method defines the different Naxi-English structural feature functions,which are English-Naxi i...We propose a method that can achieve the Naxi-English bilingual word automatic alignment based on a log-linear model.This method defines the different Naxi-English structural feature functions,which are English-Naxi interval switching function and Naxi-English bilingual word position transformation function.With the manually labeled Naxi-English words alignment corpus,the parameters of the model are trained by using the minimum error,thus Naxi-English bilingual word alignment is achieved automatically.Experiments are conducted with IBM Model 3 as a benchmark,and the Naxi language constraints are introduced.The final experiment results show that the proposed alignment method achieves very good results:the introduction of the language characteristic function can effectively improve the accuracy of the Naxi-English Bilingual Word Alignment.展开更多
Based on the log-linear virtual age process, an imperfect preventive maintenance policy for numerical control(NC)machine tools with random maintenance quality is proposed. The proposed model is a combination of the Ki...Based on the log-linear virtual age process, an imperfect preventive maintenance policy for numerical control(NC)machine tools with random maintenance quality is proposed. The proposed model is a combination of the Kijima type virtual age model and the failure intensity adjustment model. Maintenance intervals of the proposed hybrid model are derived when the failure intensity increase factor and the restoration factor are both random variables with uniform distribution. The optimal maintenance policy in infinite time horizon is presented. A numerical example is given when the failures of NC machine tools are described by the log-linear process. Finally, a discussion is presented to show how the optimal results depend on the different cost parameters.展开更多
Nine Platanus acerifolia (Ait.) Willd. trees growing in the Nanjing Children Teacher’s School, Nanjing,China, were selected to determine the contents of 13 chemical elements both in the 1994’s growth rings,C(Z, t), ...Nine Platanus acerifolia (Ait.) Willd. trees growing in the Nanjing Children Teacher’s School, Nanjing,China, were selected to determine the contents of 13 chemical elements both in the 1994’s growth rings,C(Z, t), and in the soils near the roots, C’(Z, t), of the trees. The results showed that the relationship between C(Z, t) and C’(Z, t) followed the logarithmic linear correlation model, lgC’(Z, t)=a(Z)+b(Z) ig C (Z, t).Based on this model the chrono-sequences of chemical element contents in the soils were reproduced from those in the tree rings; i.e., the dynamic variations in the chemical element contents of the soils at the sites were traced. In this study the chrono-sequences of the chemical elements including Cd, Ph, Mn, Co and Zn in the soils near the roots of a Platanus acerifolia tree from 1957 to 1994 were established, and the background values of Cd, Pb, Mn, Co and Zn in the soil were calculated by taking the lowest values of the chrono-sequences of the element contents as upper limits of the background values.展开更多
The theoretical model of axial ultrasonic vibration grinding force is built on the basis of a mathematical model of cutting deforming force deduced from the assumptions of thickness of the undeformed debris under Rayl...The theoretical model of axial ultrasonic vibration grinding force is built on the basis of a mathematical model of cutting deforming force deduced from the assumptions of thickness of the undeformed debris under Rayleigh distribution and a mathematical model of friction based on the theoretical analysis of relative sliding velocity of abrasive and workpiece. Then, the coefficients of the ultrasonic vibration grinding force model are calculated through analysis of nonlinear regression of the theoretical model by using MATLAB, and the law of influence of grinding depth, workpiece speed, frequency and amplitude of the mill on the grinding force is summarized after applying the model to analyze the ultrasonic grinding force. The result of the above-mentioned law shows that the grinding force decreases as frequency and amplitude increase, while increases as grinding depth and workpiece speed increase; the maximum relative error of prediction and experimental values of the normal grinding force is 11.47% and its average relative error is 5.41%; the maximum relative error of the tangential grinding force is 10.14% and its average relative error is 4.29%. The result of employing regression equation to predict ultrasonic grinding force approximates to the experimental data, therefore the accuracy and reliability of the model is verified.展开更多
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
基金supported by the National Nature Science Foundation of China under Grants No.60863011,No.61175068,No.61100205,No.60873001the Fundamental Research Funds for the Central Universities under Grant No.2009RC0212+1 种基金the National Innovation Fund for Technology-based Firms under Grant No.11C26215305905the Open Fund of Software Engineering Key Laboratory of Yunnan Province under Grant No.2011SE14
文摘We propose a method that can achieve the Naxi-English bilingual word automatic alignment based on a log-linear model.This method defines the different Naxi-English structural feature functions,which are English-Naxi interval switching function and Naxi-English bilingual word position transformation function.With the manually labeled Naxi-English words alignment corpus,the parameters of the model are trained by using the minimum error,thus Naxi-English bilingual word alignment is achieved automatically.Experiments are conducted with IBM Model 3 as a benchmark,and the Naxi language constraints are introduced.The final experiment results show that the proposed alignment method achieves very good results:the introduction of the language characteristic function can effectively improve the accuracy of the Naxi-English Bilingual Word Alignment.
基金Project(51465034)supported by the National Natural Science Foundation of China
文摘Based on the log-linear virtual age process, an imperfect preventive maintenance policy for numerical control(NC)machine tools with random maintenance quality is proposed. The proposed model is a combination of the Kijima type virtual age model and the failure intensity adjustment model. Maintenance intervals of the proposed hybrid model are derived when the failure intensity increase factor and the restoration factor are both random variables with uniform distribution. The optimal maintenance policy in infinite time horizon is presented. A numerical example is given when the failures of NC machine tools are described by the log-linear process. Finally, a discussion is presented to show how the optimal results depend on the different cost parameters.
文摘Nine Platanus acerifolia (Ait.) Willd. trees growing in the Nanjing Children Teacher’s School, Nanjing,China, were selected to determine the contents of 13 chemical elements both in the 1994’s growth rings,C(Z, t), and in the soils near the roots, C’(Z, t), of the trees. The results showed that the relationship between C(Z, t) and C’(Z, t) followed the logarithmic linear correlation model, lgC’(Z, t)=a(Z)+b(Z) ig C (Z, t).Based on this model the chrono-sequences of chemical element contents in the soils were reproduced from those in the tree rings; i.e., the dynamic variations in the chemical element contents of the soils at the sites were traced. In this study the chrono-sequences of the chemical elements including Cd, Ph, Mn, Co and Zn in the soils near the roots of a Platanus acerifolia tree from 1957 to 1994 were established, and the background values of Cd, Pb, Mn, Co and Zn in the soil were calculated by taking the lowest values of the chrono-sequences of the element contents as upper limits of the background values.
基金Project(51275530)supported by the National Natural Science Foundation of China
文摘The theoretical model of axial ultrasonic vibration grinding force is built on the basis of a mathematical model of cutting deforming force deduced from the assumptions of thickness of the undeformed debris under Rayleigh distribution and a mathematical model of friction based on the theoretical analysis of relative sliding velocity of abrasive and workpiece. Then, the coefficients of the ultrasonic vibration grinding force model are calculated through analysis of nonlinear regression of the theoretical model by using MATLAB, and the law of influence of grinding depth, workpiece speed, frequency and amplitude of the mill on the grinding force is summarized after applying the model to analyze the ultrasonic grinding force. The result of the above-mentioned law shows that the grinding force decreases as frequency and amplitude increase, while increases as grinding depth and workpiece speed increase; the maximum relative error of prediction and experimental values of the normal grinding force is 11.47% and its average relative error is 5.41%; the maximum relative error of the tangential grinding force is 10.14% and its average relative error is 4.29%. The result of employing regression equation to predict ultrasonic grinding force approximates to the experimental data, therefore the accuracy and reliability of the model is verified.
