Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases ...Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods: The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted. Results: Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined: in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 (SE=0.0S), with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 (SE=0.04), with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated: in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 (SE=0.05), with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 (SE=0.05), with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 (SE=0.05), with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined: in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 (95% CI: 0.0159-0.322); gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 (9$% CI: -0.0866-0.198); and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 (9S% CI: 0.137-0.415). Conclusion: CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.展开更多
This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the ...This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the mean oil volume fraction is up to 23.1%. A sensitivity coefficient back-projection (SBP) algorithm was adopted to reconstruct the flow distributions and a cross correlation method was applied to obtain the oil velocity distributions. The oil volume fraction and velocity distributions obtained from both measurement techniques were compared and good agreement was found, which indicates that the ERT tech- nique can be used to measure the low fraction oil-water flows. Finally, the factors affecting measurement precision were discussed.展开更多
A distributed feedback fiber laser based Bragg grating vibration sensor system is proposed.Demodulated by using an unbalanced M-Z interferometer,experiment demonstrates that the system runs at a sensing sensitivity of...A distributed feedback fiber laser based Bragg grating vibration sensor system is proposed.Demodulated by using an unbalanced M-Z interferometer,experiment demonstrates that the system runs at a sensing sensitivity of about 257.2 rad·s2/m and a resolution of 4.2×10-5 m/s2 for monitoring acceleration.Experimental results show that the phase-shift changes with the acceleration linearly.展开更多
Magnetometric resistivity(MMR)method is a new way to detect dam leakage.The coil sensor is generally used to collect data in geophysical exploration methods.Given the characteristics of accurate vector data requiremen...Magnetometric resistivity(MMR)method is a new way to detect dam leakage.The coil sensor is generally used to collect data in geophysical exploration methods.Given the characteristics of accurate vector data requirements and high sensitivity requirement,a three-component MMR air-core coil sensor is designed.Through the analysis of sensor sensitivity and coil structure parameters,the coil structure and turn number are designed.By analyzing the noise source of the sensor,a suitable amplifier is selected to reduce the background noise of the system.Through the analysis of the three-component non-orthogonal angles,the parameters of the non-orthogonal angles of the coils are corrected.Finally,a three-component MMR induction magnetic field sensor is designed.The volume of the sensor is controlled at 0.027 m 3.The background noise of X、Y and Z are 5.030435 nV/Hz@380 Hz and magnetic field sensitivities are 0.18995 pT/Hz@380 Hz.The three channels have good consistency,and the three-component nonorthogonal angles correction error of three components is controlled within 0.2%.展开更多
In this paper an efficient computational method based on extending the sensitivity approach(SA) is proposed to find an analytic exact solution of nonlinear differential difference equations.In this manner we avoid sol...In this paper an efficient computational method based on extending the sensitivity approach(SA) is proposed to find an analytic exact solution of nonlinear differential difference equations.In this manner we avoid solving the nonlinear problem directly.By extension of sensitivity approach for differential difference equations(DDEs),the nonlinear original problem is transformed into infinite linear differential difference equations,which should be solved in a recursive manner.Then the exact solution is determined in the form of infinite terms series and by intercepting series an approximate solution is obtained.Numerical examples are employed to show the effectiveness of the proposed approach.展开更多
A shallow water tomography scheme based on the modal wave number inversion technique is considered in this paper. The scheme is based on the assumption that modal wave number for trapped modes can be measured in a sui...A shallow water tomography scheme based on the modal wave number inversion technique is considered in this paper. The scheme is based on the assumption that modal wave number for trapped modes can be measured in a suitable way. The tomographic inversion is accomplished in two steps: firstly, the bottom parameters are inverted by using the bottom reflection phase shift with the known sound speed profile; secondly, the variation of sound speed profile at different time is inverted provided the bottom parameters are known. A numerical simulation shows that the proposed scheme works well, and the sensitivity analysis of sound speed profile inversion is performed for shallow water environmental parameters: sound speed, density and attenuation coefficient of the bottom.展开更多
In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and t...In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and the assumptions of Langmuir isotherms and axial dispersion controlled mass transfer process were confirmed. The axial dispersion coefficient in Ca(Ⅱ)-CS microspheres packed column was found to be almost proportional to the linear velocity and fit for prediction through single breakthrough test. Sensitivity analysis for breakthrough curve indicated the axial dispersion coefficient as well as Langmuir coefficient was sensitive variable for deep removal requirement. The retrieval of the adsorption isotherms of Ca(Ⅱ)-CS microspheres from breakthrough curve was fulfilled by modelling calibration. A strategy based on the correlation between adsorption isotherms and breakthrough performance was further proposed to simplify the column adsorption design using absorbents with small/uniform size and fast adsorption kinetics like Ca(Ⅱ)-CS microspheres to cut down the gap between lab and industry.展开更多
In this work, a binary-mixed-brushes-coated (BBC) capillary with switchable protein adsorption/desorption properties was developed and applied for on-line preconcentration of proteins. Firstly, amine-terminated poly(2...In this work, a binary-mixed-brushes-coated (BBC) capillary with switchable protein adsorption/desorption properties was developed and applied for on-line preconcentration of proteins. Firstly, amine-terminated poly(2-methyl-2-oxazoline)(PMOXA-NH2) and thiolterminated poly(acrylic acid)(PAA-SH) were synthesized by using cationic ring-opening polymerization (CROP) and reversible addition fragmentation chain transfer (RAFT) polymerization, respectively. Then, the BBC capillary based on poly(2-methyl-2-oxazoline)(PMOXA) and poly(acrylic acid)(PAA) was prepared by sequentially grafting of PMOXA-NH2 and PAA-SH onto fused-silica capillary inner surface through poly(dopamine)(PDA) as an anchor. The obtained PMOXA/PAA coating formed on the capillary or capillary's raw material was characterized in terms of the thickness, surface chemical composition by using scanning electron microscope (SEM) and X-ray photoelectron spectrum (XPS). The switchable protein adsorption/desorption performance of the BBC capillary was investigated by using fluorescence microscope under di erent solutions with certain pH and ionic strength(I). The results showed that bovine serum albumin (BSA) could be adsorbed on BBC capillary at pH=5.0 (I=10^-5 mol/L), and then the adsorbed BSA could be released at pH=9.0 (I=0.1 mol/L). This switchable protein adsorption/desorption property of coated capillary was then used to preconcentrate proteins on-line for increasing the detection sensitivity of BSA in capillary electrophoresis (CE). With this method, a sensitivity enhancement factor (SEF) more than 5000 for BSA detection was obtained.展开更多
Species sensitivity analysis is one of the major techniques applied to derive water quality criteria. Presently, the toxicity data used for development of water quality criteria are mainly in the biological individual...Species sensitivity analysis is one of the major techniques applied to derive water quality criteria. Presently, the toxicity data used for development of water quality criteria are mainly in the biological individual level. With the increase of ecotoxicogenomics toxicity data, it is worth studying whether the gene expression effect data can be used to derive water quality criteria. Taking cadmium, copper and zinc as examples, we analyzed the toxic effects of the three heavy metals by constructing the species sensitivity distribution curves on the basis of extensive toxicity data. The results showed that the rank of species sensitivity for the acute, chronic and gene expression effect toxicity data of cadmium is "chronic>gene>acute". Although the gene expression effect data of copper and zinc are insufficient, the trend of data sensitivity of zinc is similar to cadmium. However, the trend of species sensitivity of copper is different from that of cadmium and zinc with higher sensitivity of gene expression data. It suggested that though the existing data of gene expression effects are not sufficient enough, they have the potential to be used in the development of chronic water quality criteria. For application in the derivation of water quality criteria, illogical test concentration design and insufficient target genes are two main weaknesses in the study of gene expression effects.展开更多
In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,w...In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.展开更多
InAs is a direct, narrow band gap (0.354 eV) material with ultrahigh electron mobility, and is potentially a good optoelectronic device candidate in the wide UV-visible-near-infrared region. In this work we report t...InAs is a direct, narrow band gap (0.354 eV) material with ultrahigh electron mobility, and is potentially a good optoelectronic device candidate in the wide UV-visible-near-infrared region. In this work we report the fabrication of InAs nanowire-based photodetectors, which showed a very high photoresponse over a broad spectral range from 300 to 1,100 nm. The responsivity, external quantum efficiency and detectivity of the device were respectively measured to be 4.4 × 103 AW , 1.03 × 106%, and 2.6 × 1011 Jones to visible incident light. Time dependent measurements at different wavelengths and under different light intensities also demonstrated the fast, reversible, and stable photoresponse of our device. Theoretical calculations of the optical absorption and the electric field component distribution were also performed to elucidate the mechanism of the enhanced photoresponse. Our results demonstrate that the single-crystalline InAs NWs are very promising candidates for the design of high sensitivity and high stability nanoscale photodetectors with a broad band photoresponse.展开更多
In this paper,the force-distance curves have been employed to investigate the force sensing properties of the probe-type microforce sensors.In the preliminary studies,two kinds of probe-type microforce sensors have be...In this paper,the force-distance curves have been employed to investigate the force sensing properties of the probe-type microforce sensors.In the preliminary studies,two kinds of probe-type microforce sensors have been used to load the objects with dry and wetted surfaces.One is a developed piezoresistive cantilever force sensor with sensitivity of 35 μN/V and the other an atomic force microscope(AFM) cantilever beam probe with sensitivity of 10.4 nN/V.The force outputs corresponding to the regimes of approaching,indenting,and loading are obtained,and the properties of the stability in the approaching regime of the sensors,local mechanical behavior of the tested objects in the indenting regime,and the force sensing of the global samples are analyzed.Experimental results of this analysis are also presented.展开更多
基金the financial support provided by the Biotechnology Information Service–Sub-Distributed Information Centre(supported by the Department of Biotechnology,Government of India)Advanced Bioinformatics Centre(supported by the Government of Rajasthan)at Birla Institute of Scientific Research for the infrastructure and facilities for conducting statistical work
文摘Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods: The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted. Results: Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined: in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 (SE=0.0S), with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 (SE=0.04), with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated: in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 (SE=0.05), with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 (SE=0.05), with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 (SE=0.05), with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined: in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 (95% CI: 0.0159-0.322); gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 (9$% CI: -0.0866-0.198); and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 (9S% CI: 0.137-0.415). Conclusion: CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.
基金Project (No. 15933) supported by the Royal Society-Chinese Acad-emy of Sciences Joint Project
文摘This paper presents the use of a high performance dual-plane electrical resistance tomography (ERT) system and a local dual-sensor conductance probe to measure the vertical upward oil-in-water pipe flows in which the mean oil volume fraction is up to 23.1%. A sensitivity coefficient back-projection (SBP) algorithm was adopted to reconstruct the flow distributions and a cross correlation method was applied to obtain the oil velocity distributions. The oil volume fraction and velocity distributions obtained from both measurement techniques were compared and good agreement was found, which indicates that the ERT tech- nique can be used to measure the low fraction oil-water flows. Finally, the factors affecting measurement precision were discussed.
基金supported by the Science Fund for Young Scholars of Heilongjiang University,China(No.QL200901)
文摘A distributed feedback fiber laser based Bragg grating vibration sensor system is proposed.Demodulated by using an unbalanced M-Z interferometer,experiment demonstrates that the system runs at a sensing sensitivity of about 257.2 rad·s2/m and a resolution of 4.2×10-5 m/s2 for monitoring acceleration.Experimental results show that the phase-shift changes with the acceleration linearly.
文摘Magnetometric resistivity(MMR)method is a new way to detect dam leakage.The coil sensor is generally used to collect data in geophysical exploration methods.Given the characteristics of accurate vector data requirements and high sensitivity requirement,a three-component MMR air-core coil sensor is designed.Through the analysis of sensor sensitivity and coil structure parameters,the coil structure and turn number are designed.By analyzing the noise source of the sensor,a suitable amplifier is selected to reduce the background noise of the system.Through the analysis of the three-component non-orthogonal angles,the parameters of the non-orthogonal angles of the coils are corrected.Finally,a three-component MMR induction magnetic field sensor is designed.The volume of the sensor is controlled at 0.027 m 3.The background noise of X、Y and Z are 5.030435 nV/Hz@380 Hz and magnetic field sensitivities are 0.18995 pT/Hz@380 Hz.The three channels have good consistency,and the three-component nonorthogonal angles correction error of three components is controlled within 0.2%.
文摘In this paper an efficient computational method based on extending the sensitivity approach(SA) is proposed to find an analytic exact solution of nonlinear differential difference equations.In this manner we avoid solving the nonlinear problem directly.By extension of sensitivity approach for differential difference equations(DDEs),the nonlinear original problem is transformed into infinite linear differential difference equations,which should be solved in a recursive manner.Then the exact solution is determined in the form of infinite terms series and by intercepting series an approximate solution is obtained.Numerical examples are employed to show the effectiveness of the proposed approach.
文摘A shallow water tomography scheme based on the modal wave number inversion technique is considered in this paper. The scheme is based on the assumption that modal wave number for trapped modes can be measured in a suitable way. The tomographic inversion is accomplished in two steps: firstly, the bottom parameters are inverted by using the bottom reflection phase shift with the known sound speed profile; secondly, the variation of sound speed profile at different time is inverted provided the bottom parameters are known. A numerical simulation shows that the proposed scheme works well, and the sensitivity analysis of sound speed profile inversion is performed for shallow water environmental parameters: sound speed, density and attenuation coefficient of the bottom.
基金the National Natural Science Foundation of China(2117613621422603)the National Science and Technology Support Program of China(2011BAC06B01)
文摘In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and the assumptions of Langmuir isotherms and axial dispersion controlled mass transfer process were confirmed. The axial dispersion coefficient in Ca(Ⅱ)-CS microspheres packed column was found to be almost proportional to the linear velocity and fit for prediction through single breakthrough test. Sensitivity analysis for breakthrough curve indicated the axial dispersion coefficient as well as Langmuir coefficient was sensitive variable for deep removal requirement. The retrieval of the adsorption isotherms of Ca(Ⅱ)-CS microspheres from breakthrough curve was fulfilled by modelling calibration. A strategy based on the correlation between adsorption isotherms and breakthrough performance was further proposed to simplify the column adsorption design using absorbents with small/uniform size and fast adsorption kinetics like Ca(Ⅱ)-CS microspheres to cut down the gap between lab and industry.
基金supported by the National Natural Science Foundation of China (No.21674102)
文摘In this work, a binary-mixed-brushes-coated (BBC) capillary with switchable protein adsorption/desorption properties was developed and applied for on-line preconcentration of proteins. Firstly, amine-terminated poly(2-methyl-2-oxazoline)(PMOXA-NH2) and thiolterminated poly(acrylic acid)(PAA-SH) were synthesized by using cationic ring-opening polymerization (CROP) and reversible addition fragmentation chain transfer (RAFT) polymerization, respectively. Then, the BBC capillary based on poly(2-methyl-2-oxazoline)(PMOXA) and poly(acrylic acid)(PAA) was prepared by sequentially grafting of PMOXA-NH2 and PAA-SH onto fused-silica capillary inner surface through poly(dopamine)(PDA) as an anchor. The obtained PMOXA/PAA coating formed on the capillary or capillary's raw material was characterized in terms of the thickness, surface chemical composition by using scanning electron microscope (SEM) and X-ray photoelectron spectrum (XPS). The switchable protein adsorption/desorption performance of the BBC capillary was investigated by using fluorescence microscope under di erent solutions with certain pH and ionic strength(I). The results showed that bovine serum albumin (BSA) could be adsorbed on BBC capillary at pH=5.0 (I=10^-5 mol/L), and then the adsorbed BSA could be released at pH=9.0 (I=0.1 mol/L). This switchable protein adsorption/desorption property of coated capillary was then used to preconcentrate proteins on-line for increasing the detection sensitivity of BSA in capillary electrophoresis (CE). With this method, a sensitivity enhancement factor (SEF) more than 5000 for BSA detection was obtained.
基金supported by the Great Program of National Water Body Pollution Control and Treatment (Grant No. 2012ZX07501-003-006)Special Project of Revolution Startup of CRAES (Grant No. 2011GQ-02)
文摘Species sensitivity analysis is one of the major techniques applied to derive water quality criteria. Presently, the toxicity data used for development of water quality criteria are mainly in the biological individual level. With the increase of ecotoxicogenomics toxicity data, it is worth studying whether the gene expression effect data can be used to derive water quality criteria. Taking cadmium, copper and zinc as examples, we analyzed the toxic effects of the three heavy metals by constructing the species sensitivity distribution curves on the basis of extensive toxicity data. The results showed that the rank of species sensitivity for the acute, chronic and gene expression effect toxicity data of cadmium is "chronic>gene>acute". Although the gene expression effect data of copper and zinc are insufficient, the trend of data sensitivity of zinc is similar to cadmium. However, the trend of species sensitivity of copper is different from that of cadmium and zinc with higher sensitivity of gene expression data. It suggested that though the existing data of gene expression effects are not sufficient enough, they have the potential to be used in the development of chronic water quality criteria. For application in the derivation of water quality criteria, illogical test concentration design and insufficient target genes are two main weaknesses in the study of gene expression effects.
基金supported by the National Natural Science Foundation of China(Grant Nos.1123200511172086)
文摘In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.
基金Acknowledgements This work was supported by the National Natural Science Foundation (Nos. 91123008, 51002059, 21001046), the 973 Program of China (No. 2011CB933300), and the Program for New Century Excellent Talents of the Universities in China (grant No. NCET-11-0179). We thank the Analytical and Testing Center of Huazhong University of Science and Technology for measurements.
文摘InAs is a direct, narrow band gap (0.354 eV) material with ultrahigh electron mobility, and is potentially a good optoelectronic device candidate in the wide UV-visible-near-infrared region. In this work we report the fabrication of InAs nanowire-based photodetectors, which showed a very high photoresponse over a broad spectral range from 300 to 1,100 nm. The responsivity, external quantum efficiency and detectivity of the device were respectively measured to be 4.4 × 103 AW , 1.03 × 106%, and 2.6 × 1011 Jones to visible incident light. Time dependent measurements at different wavelengths and under different light intensities also demonstrated the fast, reversible, and stable photoresponse of our device. Theoretical calculations of the optical absorption and the electric field component distribution were also performed to elucidate the mechanism of the enhanced photoresponse. Our results demonstrate that the single-crystalline InAs NWs are very promising candidates for the design of high sensitivity and high stability nanoscale photodetectors with a broad band photoresponse.
基金supported by the National Natural Science Foundation of China (Grant Nos 10972113 and 10732080)the National Basic Research Program of China (Grant Nos 2007CB936803 and 2010CB631005)SRFDP (Grant No 20070003053)
文摘In this paper,the force-distance curves have been employed to investigate the force sensing properties of the probe-type microforce sensors.In the preliminary studies,two kinds of probe-type microforce sensors have been used to load the objects with dry and wetted surfaces.One is a developed piezoresistive cantilever force sensor with sensitivity of 35 μN/V and the other an atomic force microscope(AFM) cantilever beam probe with sensitivity of 10.4 nN/V.The force outputs corresponding to the regimes of approaching,indenting,and loading are obtained,and the properties of the stability in the approaching regime of the sensors,local mechanical behavior of the tested objects in the indenting regime,and the force sensing of the global samples are analyzed.Experimental results of this analysis are also presented.