The microstructural evolution and phase transformations during partial remelting of in-situ Mg2Sip/AM60B composite modified by SiC and Sr were investigated. The results indicate that SiC and Sr are effective for refi...The microstructural evolution and phase transformations during partial remelting of in-situ Mg2Sip/AM60B composite modified by SiC and Sr were investigated. The results indicate that SiC and Sr are effective for refining primary α-Mg grains and Mg2Si particles. After being partially remelted, a semisolid microstructure with small and spheroidal primary α-Mg particles can be obtained. The microstructural evolution during partial remelting can be divided into four stages： the initial rapid coarsening, structural separation, spheroidization and final coarsening, which are essentially caused by the phase transformations of β→α, α＋β→L and α→L, α→L, and α→L and L→α, respectively. The Mg2Si particles have not obvious effect on the general microstructural evolution steps, but can slower the evolution progress and change the coarsening mechanism. During partial remelting, Mg2Si particles first become blunt and then become spheroidal because of melting of their edges and corners, and finally are coarsened owing to Ostwald ripening.展开更多
Endometrial cancer （EC） is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but ...Endometrial cancer （EC） is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but it may also originate in the lower uterine segment or spread in endometrium with necrosis and hemorrhage. The analysis was performed using a custom panel containing all DNA sequences loci coding pre-miRNAs and genes related to biogenesis and regulation of sncRNAs in normal and tumor tissues extracted from 6 unrelated patients with endometrial carcinoma. The identified variations were correlated with mature miRNAs differentially expressed in the same normal and tumor endometrial tissues. The comparison analysis confirmed the high degree of cellular and genetic intratumoral heterogeneity with a temporal and spatial miRNA expression distribution in association with genomic variants identified. The classification of specific DNA mutations, onto the loci identified, should be suitable to characterize possible instability genome regions and help classification of tumors to ameliorate the clinical management of patients affected by endometrial carcinoma.展开更多
In this paper,the Fourier spectrum-based strain energy damage detection method for beam-like structures is proposed based on the discrete Fourier transform.The classical strain energy damage detection method localizes...In this paper,the Fourier spectrum-based strain energy damage detection method for beam-like structures is proposed based on the discrete Fourier transform.The classical strain energy damage detection method localizes damage by the comparison of the strain energy between the intact and inspected structures.The evaluation of the 2nd-order derivative term in the strain energy plays a crucial part in the comparison.The classical methods are mostly based on a numerical derivative estimation for this term.The numerical derivative,however,introduces additional disturbances into damage indications.To address this problem,a discrete Fourier transform-based strain energy is proposed with the emphasis of enhancing the performance in noisy condition.The validations conducted on the simulated and experimental data show that the developed method is effective enough for composite beam damage detection in noisy environments.展开更多
基金Project(G2010CB635106)supported by the National Basic Research Program of ChinaProject(NCET-10-0023)supported by the Program for New Century Excellent Talents in University of ChinaProject supported by the Program for Hongliu Outstanding Talents of Lanzhou University of Technology,China
文摘The microstructural evolution and phase transformations during partial remelting of in-situ Mg2Sip/AM60B composite modified by SiC and Sr were investigated. The results indicate that SiC and Sr are effective for refining primary α-Mg grains and Mg2Si particles. After being partially remelted, a semisolid microstructure with small and spheroidal primary α-Mg particles can be obtained. The microstructural evolution during partial remelting can be divided into four stages： the initial rapid coarsening, structural separation, spheroidization and final coarsening, which are essentially caused by the phase transformations of β→α, α＋β→L and α→L, α→L, and α→L and L→α, respectively. The Mg2Si particles have not obvious effect on the general microstructural evolution steps, but can slower the evolution progress and change the coarsening mechanism. During partial remelting, Mg2Si particles first become blunt and then become spheroidal because of melting of their edges and corners, and finally are coarsened owing to Ostwald ripening.
文摘Endometrial cancer （EC） is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but it may also originate in the lower uterine segment or spread in endometrium with necrosis and hemorrhage. The analysis was performed using a custom panel containing all DNA sequences loci coding pre-miRNAs and genes related to biogenesis and regulation of sncRNAs in normal and tumor tissues extracted from 6 unrelated patients with endometrial carcinoma. The identified variations were correlated with mature miRNAs differentially expressed in the same normal and tumor endometrial tissues. The comparison analysis confirmed the high degree of cellular and genetic intratumoral heterogeneity with a temporal and spatial miRNA expression distribution in association with genomic variants identified. The classification of specific DNA mutations, onto the loci identified, should be suitable to characterize possible instability genome regions and help classification of tumors to ameliorate the clinical management of patients affected by endometrial carcinoma.
基金supported by the National Natural Science Foundation of China(Grant Nos.51405369&51421004)the National Key Basic Research Program of China(Grant No.2015CB057400)+1 种基金the National Natural Science Foundation of Shaanxi Province(Grant No.2016JQ5049)the Postdoctoral Science Foundation of Shaanxi Province
文摘In this paper,the Fourier spectrum-based strain energy damage detection method for beam-like structures is proposed based on the discrete Fourier transform.The classical strain energy damage detection method localizes damage by the comparison of the strain energy between the intact and inspected structures.The evaluation of the 2nd-order derivative term in the strain energy plays a crucial part in the comparison.The classical methods are mostly based on a numerical derivative estimation for this term.The numerical derivative,however,introduces additional disturbances into damage indications.To address this problem,a discrete Fourier transform-based strain energy is proposed with the emphasis of enhancing the performance in noisy condition.The validations conducted on the simulated and experimental data show that the developed method is effective enough for composite beam damage detection in noisy environments.
