A 40-year-old man with haemopbysis and serious spontaneous hemothorax. Chest computed tomography showed multiple flakes in his lungs, nodules shadow, right pleural effusion with right pulmonary atelectasis The patholo...A 40-year-old man with haemopbysis and serious spontaneous hemothorax. Chest computed tomography showed multiple flakes in his lungs, nodules shadow, right pleural effusion with right pulmonary atelectasis The pathological specimens obtained by thoracic surgery revealed pulmonary angiosarcoma. Primary pulmonary angiosarcoma is a rare malignant tumor and is lack of typical clinical symptoms and imaging features, diagnosis mainly depend on histopathologic features and immunohistochemical analysis. There is no effective therapy for pulmonary vascular sarcoma. Integrated treatment can may extend the survival time of patients.展开更多
Objective： We enrolled retrospective data to determine the efficacy of combined chemotherapy and surgery for local tumour control and survival in patients with high-risk soft-tissue sarcomas. Methods： We collected d...Objective： We enrolled retrospective data to determine the efficacy of combined chemotherapy and surgery for local tumour control and survival in patients with high-risk soft-tissue sarcomas. Methods： We collected data from 25 patients with high-risk soft-tissue sarcomas treated with four cycles of etoposide, ifosfamide and doxorubicin （EIA） followed by definitive surgery with or without postoperative radiotherapy and adjuvant chemotherapy. 21 patients received chemotherapy in a neoadjuvant/adjuvant clinical setting; eighteen of them completed adjuvant chemotherapy. Four patients received chemotherapy in an adjuvant setting only. Results： The objective response rate of neoadjuvant chemotherapy assessable in 21 patients was 43%. Including NED （n=7） and partial remissions （n=3）, the radiographic response rate was 47.6% with additional 42.9% stable diseases （n=9）. Surgery was performed in two patients before completing four neoadjuvant chemotherapy cycles because of disease progression. Median overall survival for all patients was 21.6＋ months. After completion of chemotherapy, in 62% of patients R0-resection could be performed. Conclusion： High proportion of R0-resections supports the idea of tumour down-staging after neoadjuvant treatment. Response to neoadjuvant chemotherapy is predictive for improved local tumour control resulting in long-term survival benefit.展开更多
During the 1990s India did not show much of an interest in Central Asia and its response to join multilateral organisations in the region had been lukewarm. However, in the last decade or so India＇s approach towards ...During the 1990s India did not show much of an interest in Central Asia and its response to join multilateral organisations in the region had been lukewarm. However, in the last decade or so India＇s approach towards the region has changed substantially and some important landmarks signify this shift. As a scholar interested in the region, the author looks at the reasons for India＇s changing approach to the Central Asian region. With this objective, this paper seeks to highlight the significance of Central Asia for India and defines the strategic interests of India in this region. It also discusses the changing geopolitics of Central Asia from India＇s perspective, various phases in India＇s engagement with the region, including the key dynamics and changing approaches. A proactive Central Asia policy also represents another instance of India＇s shift from being an idealist to a realist power. This paper enables us to understand the extent to which India as an emerging power is prepared to pursue its strategic objectives in the region. At the same time, India＇s willingness in recent years to participate in a multilateral regional organization such as the Shanghai Cooperation Organization （SCO） demonstrates that it is willing to work in a cooperative framework with other key players in the region--Russia and China.展开更多
文摘A 40-year-old man with haemopbysis and serious spontaneous hemothorax. Chest computed tomography showed multiple flakes in his lungs, nodules shadow, right pleural effusion with right pulmonary atelectasis The pathological specimens obtained by thoracic surgery revealed pulmonary angiosarcoma. Primary pulmonary angiosarcoma is a rare malignant tumor and is lack of typical clinical symptoms and imaging features, diagnosis mainly depend on histopathologic features and immunohistochemical analysis. There is no effective therapy for pulmonary vascular sarcoma. Integrated treatment can may extend the survival time of patients.
文摘Objective： We enrolled retrospective data to determine the efficacy of combined chemotherapy and surgery for local tumour control and survival in patients with high-risk soft-tissue sarcomas. Methods： We collected data from 25 patients with high-risk soft-tissue sarcomas treated with four cycles of etoposide, ifosfamide and doxorubicin （EIA） followed by definitive surgery with or without postoperative radiotherapy and adjuvant chemotherapy. 21 patients received chemotherapy in a neoadjuvant/adjuvant clinical setting; eighteen of them completed adjuvant chemotherapy. Four patients received chemotherapy in an adjuvant setting only. Results： The objective response rate of neoadjuvant chemotherapy assessable in 21 patients was 43%. Including NED （n=7） and partial remissions （n=3）, the radiographic response rate was 47.6% with additional 42.9% stable diseases （n=9）. Surgery was performed in two patients before completing four neoadjuvant chemotherapy cycles because of disease progression. Median overall survival for all patients was 21.6＋ months. After completion of chemotherapy, in 62% of patients R0-resection could be performed. Conclusion： High proportion of R0-resections supports the idea of tumour down-staging after neoadjuvant treatment. Response to neoadjuvant chemotherapy is predictive for improved local tumour control resulting in long-term survival benefit.
文摘During the 1990s India did not show much of an interest in Central Asia and its response to join multilateral organisations in the region had been lukewarm. However, in the last decade or so India＇s approach towards the region has changed substantially and some important landmarks signify this shift. As a scholar interested in the region, the author looks at the reasons for India＇s changing approach to the Central Asian region. With this objective, this paper seeks to highlight the significance of Central Asia for India and defines the strategic interests of India in this region. It also discusses the changing geopolitics of Central Asia from India＇s perspective, various phases in India＇s engagement with the region, including the key dynamics and changing approaches. A proactive Central Asia policy also represents another instance of India＇s shift from being an idealist to a realist power. This paper enables us to understand the extent to which India as an emerging power is prepared to pursue its strategic objectives in the region. At the same time, India＇s willingness in recent years to participate in a multilateral regional organization such as the Shanghai Cooperation Organization （SCO） demonstrates that it is willing to work in a cooperative framework with other key players in the region--Russia and China.
