AIM:To assess whether in ulcerative colitis (UC) patients with ileo-rectal anastomosis (IRA), ileal lesions may develop in the neo-terminal-ileum and their possible relation with phenotypic changes towards colonic epi...AIM:To assess whether in ulcerative colitis (UC) patients with ileo-rectal anastomosis (IRA), ileal lesions may develop in the neo-terminal-ileum and their possible relation with phenotypic changes towards colonic epithelium. METHODS: A total of 19 patients with IRA under regular follow up were enrolled, including 11 UC and 8 controls (6 Crohn’s disease, CD; 1 familial adenomatous polyposis, FAP; 1 colon cancer, colon K). Ileal lesions were identifi ed by ileoscopy with biopsies taken from the ileum (involved and uninvolved) and from the rectal stump. Staining included HE and immunohistochemistry using monoclonal antibodies against colonic epithelial protein CEP (Das-1) and human tropomyosin isoform 5, hTM5 (CG3). Possible relation between development of colonic metaplasia and ileal lesions was investigated.RESULTS: Stenosing adenocarcinoma of the rectal stump was detected in 1 UC patient. The neo-terminal ileum was therefore investigated in 10/11 UC patients. Ileal ulcers were detected in 7/10 UC, associated with colonic metaplasia in 4/7 (57.1%) and Das-1 and CG3 reactivity in 3/4 UC. In controls, recurrence occurred in 4/6 CD, associated with colonic metaplasia in 3/4 and reactivity with Das-1 and CG3 in 2/3. CONCLUSION: Present fi ndings suggest that in UC, ileal lesions associated with changes towards colonic epithelium may develop also after IRA. Changes of the ileal content after colectomy may contribute to the development of colonic metaplasia, leading to ileal lesions both in the pouch and in the neo-terminal ileum after IRA.展开更多
A new （29-1）-dimensional lattice equation is presented based upon the first two members in the hierarchy of the combined Toda lattice and relativistic Toda lattice （TL-RTL） equations in （19991） dimensions. A Dar...A new （29-1）-dimensional lattice equation is presented based upon the first two members in the hierarchy of the combined Toda lattice and relativistic Toda lattice （TL-RTL） equations in （19991） dimensions. A Darboux transformation for the hierarchy of the combined TL-RTL equations is constructed. Solutions of the first two members in the hierarchy of the combined TL-RTL equations, as well as the new （29-1）-dimensional lattice equation are explicitly obtained by the Darboux transformation.展开更多
Microstructures of a duplex-phase Zr-2.5Nb alloy treated by pulsed laser were characterized by electron backscatter diffraction （EBSD） and electron channeling contrast （ECC） imaging techniques. Major attention has...Microstructures of a duplex-phase Zr-2.5Nb alloy treated by pulsed laser were characterized by electron backscatter diffraction （EBSD） and electron channeling contrast （ECC） imaging techniques. Major attention has been paid to non-equilibrium hybrid microstructure consisting of both prior a and β phases, and a plates transformed from new β phases to probe α→β transformation characteristics in the alloy. The origin of the hybrid microstructure is attributed to the specific thermodynamic conditions induced by the pulsed laser treatment. ECC observation shows that newly formed [3 phases during laser heating prefer to nucleate and grow at the expense of edges of prior α grains rather than their interiors. EBSD analyses further reveal that orientations of the new β phases are not determined by the prior a grains according to the Burgers relationship but maintain those of the prior β phases in an epitaxial growth way.展开更多
Conversion of non-edible biomass into fuels and value-added chemicals has achieved great attention to cope the world's energy requirements. Lignocellulose based sugar alcohols such as sorbitol, mannitol, xylitol, ...Conversion of non-edible biomass into fuels and value-added chemicals has achieved great attention to cope the world's energy requirements. Lignocellulose based sugar alcohols such as sorbitol, mannitol, xylitol, and erythritol can be potentially used as emerging fuels and chemicals. These sugar alcohols can be converted into widely used products(e.g. polymer synthesis, food and pharmaceuticals industry). The heterogeneous catalytic production of sugar alcohols from renewable biomass provides a safe and sustainable approach. Hydrolysis, coupled with hydrogenation and hydrogenolysis has been proved to be more effective strategy for sugar alcohols production from biomass. This review summarizes the recent advances in biomass upgrading reactions for the production of sugar alcohols and their comprehensive applications.展开更多
基金The Fondazione Umberto Di Mario,Largo Marchiafava n.1, ZIP code 00161,Roma,Italy
文摘AIM:To assess whether in ulcerative colitis (UC) patients with ileo-rectal anastomosis (IRA), ileal lesions may develop in the neo-terminal-ileum and their possible relation with phenotypic changes towards colonic epithelium. METHODS: A total of 19 patients with IRA under regular follow up were enrolled, including 11 UC and 8 controls (6 Crohn’s disease, CD; 1 familial adenomatous polyposis, FAP; 1 colon cancer, colon K). Ileal lesions were identifi ed by ileoscopy with biopsies taken from the ileum (involved and uninvolved) and from the rectal stump. Staining included HE and immunohistochemistry using monoclonal antibodies against colonic epithelial protein CEP (Das-1) and human tropomyosin isoform 5, hTM5 (CG3). Possible relation between development of colonic metaplasia and ileal lesions was investigated.RESULTS: Stenosing adenocarcinoma of the rectal stump was detected in 1 UC patient. The neo-terminal ileum was therefore investigated in 10/11 UC patients. Ileal ulcers were detected in 7/10 UC, associated with colonic metaplasia in 4/7 (57.1%) and Das-1 and CG3 reactivity in 3/4 UC. In controls, recurrence occurred in 4/6 CD, associated with colonic metaplasia in 3/4 and reactivity with Das-1 and CG3 in 2/3. CONCLUSION: Present fi ndings suggest that in UC, ileal lesions associated with changes towards colonic epithelium may develop also after IRA. Changes of the ileal content after colectomy may contribute to the development of colonic metaplasia, leading to ileal lesions both in the pouch and in the neo-terminal ileum after IRA.
基金The project supported by National Natural Science Foundation of China under Grant No. 10471120, the NCET-04-0518, FANEDD （No. 200013）, the Excellent Young Teachers Program of the Ministry of Education, the Project-Sponsored by SRF for R0CS, and the ＂333 Project＂ of Jiangsu Province
文摘A new （29-1）-dimensional lattice equation is presented based upon the first two members in the hierarchy of the combined Toda lattice and relativistic Toda lattice （TL-RTL） equations in （19991） dimensions. A Darboux transformation for the hierarchy of the combined TL-RTL equations is constructed. Solutions of the first two members in the hierarchy of the combined TL-RTL equations, as well as the new （29-1）-dimensional lattice equation are explicitly obtained by the Darboux transformation.
基金supported by the National Natural Science Foundation of China(Grant No.51401040)China Postdoctoral Science Foundation(Grant No.2015M572446)+1 种基金Postdoctoral Science Foundation of Chongqing(Grant No.Xm2015003)Scientific and Technological ResearchProgram of Chongqing Municipal Education Commission(Grant No.KJ1500901)
文摘Microstructures of a duplex-phase Zr-2.5Nb alloy treated by pulsed laser were characterized by electron backscatter diffraction （EBSD） and electron channeling contrast （ECC） imaging techniques. Major attention has been paid to non-equilibrium hybrid microstructure consisting of both prior a and β phases, and a plates transformed from new β phases to probe α→β transformation characteristics in the alloy. The origin of the hybrid microstructure is attributed to the specific thermodynamic conditions induced by the pulsed laser treatment. ECC observation shows that newly formed [3 phases during laser heating prefer to nucleate and grow at the expense of edges of prior α grains rather than their interiors. EBSD analyses further reveal that orientations of the new β phases are not determined by the prior a grains according to the Burgers relationship but maintain those of the prior β phases in an epitaxial growth way.
基金supported by the National Natural Science Foundation of China(21325208,21172209,21272050,21402181,21572212)Chinese Academy of Science(KJCX2-EW-J02,YZ201563)+5 种基金the Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX006)China Postdoctoral Science Foundation(2014M561835)the Specialized Research Fund for the Doctoral Program of Higher Education(20123402130008)Fundamental Research Funds for the Central Universities(WK2060190025,WK2060190033,WK2060190040,WK6030000023)the Key Technologies R&D Programme of Anhui Province(1604a0702027)Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China
文摘Conversion of non-edible biomass into fuels and value-added chemicals has achieved great attention to cope the world's energy requirements. Lignocellulose based sugar alcohols such as sorbitol, mannitol, xylitol, and erythritol can be potentially used as emerging fuels and chemicals. These sugar alcohols can be converted into widely used products(e.g. polymer synthesis, food and pharmaceuticals industry). The heterogeneous catalytic production of sugar alcohols from renewable biomass provides a safe and sustainable approach. Hydrolysis, coupled with hydrogenation and hydrogenolysis has been proved to be more effective strategy for sugar alcohols production from biomass. This review summarizes the recent advances in biomass upgrading reactions for the production of sugar alcohols and their comprehensive applications.
