滑石组方变化浅析

中国医药学将滑石作为药物,已有二千余年的历史,东汉末年的医学专著《神农本草经》已将滑石收入,论其疗效“主身热泄辟,女子乳难、癃闭、利小便,荡胃中积聚寒热”，明代李时珍《本草纲目》论滑石能“疗黄疸、脚气、吐血、呕血、金疮出血、诸疮肿毒”。

中药复方冠心Ⅱ的群体药物动力学研究(英文)

目的:以群体药物动力学原理分析复方冠心Ⅱ不同组成条件对主要组分芍药苷及阿魏酸体内过程的影响。方法:将大鼠随机分组后分别静脉注射芍药苷(PPE)或阿魏酸(FA)提取物水溶液、灌胃给予PPE或FA水溶液及不同组成的水煎液,HPLC法测定血浆中芍药苷和阿魏酸浓度,以非线性混合效应模型(NONMEM)法分别对芍药苷和阿魏酸的血药浓度数据进行群体药物动力学解析。结果:芍药苷的体内药物动力学过程可用吸收相包含一级降解过程的二室口服吸收模型进行表述,参数CL1、V1、CL2、V2、Ka0和Ka1分别为0.509 L/h, 0.104 L,0.113 L/h,0.123 L,0.135/h及0.0135/h;阿魏酸的体内过程可用二室口服吸收模型表述,参数CL1、V1、CL2、V2,、Ka及F分别为0.295 L/h、0.025 L、0.0331 L/h、0.0518 L、0.110/h及0.40。模型化中对个体间差异进行了估计,并以给药组方因素(DF)作为固定效应对参数进行了校正。结论:群体药物动力学方法可以用于分析中药复方冠心Ⅱ中组方变化对其中指标成分的体内吸收和分布产生的影响,较以往的方法有一定的优越性。

Existence of multi-bump solutions for coupled Schr dinger systems

The Schrodinger equation -△u＋λ2u=｜u｜2q-2u has a unique positive radial solution Uλ, which decays exponentially at infinity. Hence it is reasonable that the Schrolinger system -△u1＋u1=｜u1｜2q-1u1-εb（x）｜u2｜1｜u1｜q-1u1,-△u2＋u2=｜u2｜2q-2u2-εb（x）｜u1｜1｜u2｜q-1u2 has multiple-bump solutions which behave like Uλ in the neighborhood of some points. For u=（u1,u2）∈H1（R3）×H1（R3）, a nonlinear functional Iε（u）=I1（u1）＋I2（u2）-ε/q∫R3b（x）｜u1｜q｜u2｜qdx,is defined,where I1（u1）=1/2｜｜u1｜｜2-1/2q∫R3｜u1｜2qdx and I2（u2）=1/2｜｜u2｜｜2ω-1/2q∫R3｜u2｜2qdx. It is proved that the solutions of the system are the critical points of I,. Let Z be the smooth solution manifold of the unperturbed problem and TzZ is the tangent space. The critical point of I is rewritten as the form of z ＋ w, where w ∈ （TzZ）⊥. Using some properties of Iε, it is proved that there exists a critical point of I, close to the form which is a multi-bump solution.

Hot compressive deformation behavior and microstructure evolution of HIPed FGH96 superalloy

Hot deformation behavior and microstructure evolution of hot isostatically pressed FGH96 P/M superalloy were studied using isothermal compression tests. The tests were performed on a Gleeble-1500 simulator in a temperature range of 1000-1150 °C and strain rate of 0.001-1.0 s-1, respectively. By regression analysis of the stress—strain data, the constitutive equation for FGH96 superalloy was developed in the form of hyperbolic sine function with hot activation energy of 693.21 kJ/mol. By investigating the deformation microstructure, it is found that partial and full dynamical recrystallization occurs in specimens deformed below and above 1100 °C, respectively, and dynamical recrystallization （DRX） happens more readily with decreasing strain rate and increasing deformation temperature. Finally, equations representing the kinetics of DRX and grain size evolution were established.

Concave group methods for variable selection and estimation in high-dimensional varying coefficient models

The varying-coefficient model is flexible and powerful for modeling the dynamic changes of regression coefficients. We study the problem of variable selection and estimation in this model in the sparse, high- dimensional case. We develop a concave group selection approach for this problem using basis function expansion and study its theoretical and empirical properties. We also apply the group Lasso for variable selection and estimation in this model and study its properties. Under appropriate conditions, we show that the group least absolute shrinkage and selection operator （Lasso） selects a model whose dimension is comparable to the underlying mode], regardless of the large number of unimportant variables. In order to improve the selection results, we show that the group minimax concave penalty （MCP） has the oracle selection property in the sense that it correctly selects important variables with probability converging to one under suitable conditions. By comparison, the group Lasso does not have the oracle selection property. In the simulation parts, we apply the group Lasso and the group MCP. At the same time, the two approaches are evaluated using simulation and demonstrated on a data example.